Due to its key position within the Africa–Europe convergence zone, Tunisia is marked by thrusting, folding, and faulting and has a major rupture zones associated with active faults. Consequently, most of Tunisian land is seismically active with significant active deformations, showing recent seismic events and their relative surface effects. This paper reports on several aspects of the seismotectonics, historical, and present-day seismicity and places them in the general tectonic and geodynamic framework of Tunisia. Field investigations, based on an integrated multidisciplinary approach, included (1) the identification of active faults, their motion and displacement, geomorphic aspects, and scarps and their relation with the general structural map of Tunisia and (2) an extensive analysis of brittle tectonic deformation affecting Quaternary deposits in several sites throughout Tunisia. The integration of field data within the existing data related to the seismic events that took place during the last decades allowed the establishment of an earthquake distribution map, as well as major seismic zones for better understanding of the seismicity database of Tunisia. To establish microzonation maps in seismic regions such as Gafsa and its surroundings, we have analyzed surface effects and secondary structures associated with active faults and correlated them with deformation rates, reconstructed for significant seismic events. Most faults exhibited typical left-stepping en-echelon with strike-slip component pattern suggesting that Tunisia is presently subjected to NNW–SSE compression. The focal mechanism of most Tunisia earthquakes combined with the existing tectonic and structural information and reconstruction of the Quaternary stress tensor allowed (a) better understanding of seismic zoning, (b) provided better assessment of the seismic hazard, and (c) facilitated the interpretation of the relationship between seismic zones and the geodynamic African–Eurasian plate boundary.