Significant Reduction In Dentin Hypersensitivity Research Articles

Effect of Iontophoresis on the Effectiveness of Nano-Hydroxyapatite and Pro-argin in In-Office Treatment of Dentin Hypersensitivity: A Split-Mouth Randomized Clinical Trial.

Background and objectives Dentin hypersensitivity (DH) treatment is one of the main challenges dentists facein their daily clinical practice. Current therapies provide only temporary relief and require multiple applications to exhibit results, and there is a lack of evidence related to the long-term effects of these agents. Nano-hydroxyapatite (n-HA) and pro-argin (8.0% arginine-calcium carbonate) have recently been used fordentin desensitization with a one-time in-office application, but the effects are interim. However, a standard treatment protocol demandsdefinitive or enduring results. Since iontophoresis amplifiesthe transportof neutral and ionized drugsacross a membrane, the use of these desensitizing agents with iontophoresis may be beneficial to accomplish satisfactory results.This study was conducted to evaluate whether iontophoresis could enable better penetration of nano-hydroxyapatite and pro-argin into the dentin, enhancing and prolonging their therapeutic effect. Materials and methods Forty-five participants with dentin hypersensitivity in the age group of 20 to 60 years were included. In each individual, four teeth with cervical lesions (one from each quadrant) were selected and divided randomly into four groups: group I: desensitizing paste containing nano-hydroxyapatite, group II: desensitizing paste containing nano-hydroxyapatite with iontophoresis, group III: desensitizing paste containing pro-argin, and group IV: desensitizing paste containing pro-argin with iontophoresis; followed by one-time application of the agents. Sensitivity was assessed by tactile, air blast, and cold-graded thermal tests(CGTTs) before and immediately after application, after one week, and at the end of the first, third, and sixth months. Statistical analysis Statistical analysis was done by repeated measures ANOVA for within-group comparison. Intergroup comparison was done using one-way ANOVA and Tukey's post-hoc test. Results All the groups showed a statistically significant reduction in dentin hypersensitivity (p<0.001). The reduction inhypersensitivity in various groups can be graded as group II (3.578/1.800/1.556) > group IV (3.367/1.755/1.555) > group I (2.3781/1.022/0.822) > group III (2.222/0.911/0.778) as evaluated by tactile, air blast, and cold-graded thermal tests, respectively. Group II and group IV presented a significant reduction in sensitivity levels consistent for up to six months. Conclusion Nano-hydroxyapatite and pro-argin can be used effectively for reducing dentin hypersensitivity. Iontophoresis can be a valuable adjunct for their improved delivery, enhancing and prolonging their effectiveness.

Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study.

Propolis is a natural resinous substance collected by honeybees, chiefly from buds and the leaves, branches, and bark of trees. Its role as a wound-healing gel has been studied, but the use of a propolis hydrogel in the treatment of dentinal hypersensitivity has not been evaluated. Dentin hypersensitivity (DH) is commonly treated via iontophoresis using fluoridated desensitizers. The aim of the present study was to compare and evaluate the effects of a 10% propolis hydrogel, 2% sodium fluoride (NaF), and 1.23% acidulated phosphate fluoride (APF) when used in conjunction with iontophoresis for the treatment of cervical dentin hypersensitivity (DH). Systemically healthy patients complaining of DH were selected for this single-centre, parallel, double-blind randomized clinical trial. Three substances were selected as desensitizers for study in the present trial: a 10% propolis hydrogel, 2% sodium fluoride, and 1.23% acidulated phosphate fluoride, all in conjunction with iontophoresis. Any decrease in DH following the application of specific stimuli was assessed at baseline, before and after application, on the 14th day following use, and on the 28th day following the intervention. Intra-group comparisons show diminished values of DH at maximum post-op follow-up intervals which were significantly trimmed down from the baseline (p < 0.05). The 2% NaF demonstrated a significant reduction in DH over 1.23% APF and the 10% propolis hydrogel (p < 0.05). However, there was no statistically significant difference in the mean difference between the APF and propolis hydrogel groups assessed via tactile, cold, and air tests (p > 0.05). All three desensitizers have proved to be useful when used in conjugation with iontophoresis. Within the limitations of this study, a 10% propolis hydrogel can be used as a naturally occurring alternative to commercially available fluoridated desensitizers.

Clinical Evaluation of Pro-Argin and Low Level Laser Therapy in the Treatment of Dentinal Hypersensitivity: A Splitmouth Randomised Clinical Trial

Introduction: Dentinal Hypersensitivity (DH) is the most prevalent condition that causes patients discomfort for patients, leading them to frequently visit dental offices. A wide range of methods and therapeutic procedures have evolved for pain alleviation have evolved. In recent decades, desensitising therapy has been coupled with newer therapies such as Pro-Argin and LowLevel Laser Therapy (LLLT). Pro-Argin therapy occludes the openings of dentinal tubules, while Diode Lasers (DL) cause a melting effect, crystallisation of dentine inorganic components, and coagulation of fluids trapped inside the dentinal tubules, thereby reducing the hypersensitivity. Aim: To compare the efficacy of Pro-Argin and LLLT -475 nm (Bluelase) in providing immediate relief in the treatment of dentinal hypersensitivity. Materials and Methods: This was a double-blind randomised split-mouth clinical trial involving from December 2021 to March 2022, including 12 patients (120 teeth) with bilateral hypersensitivity. They were divided into Group A (Pro-Argin) and Group B (LLLT-475 nm) both with 12 patients and 60 teeth each. Hypersensitivity was recorded using the Schiff cold air sensitivity scale and the Visual Analog Pain Scale (VAS) at baseline and at 15 minutes after desensitising therapy. Results: The study included 12 subjects with bilateral dentinal hypersensitivity, categorised into Group A (Pro-Argin) (Colgate Sensitive Pro-relief) and Group B (LLLT at 475 nm), with 60 teeth each. The Results were assessed using the independent t-test for inter-group comparison and the t-test for intra-group comparison. On inter-group comparison of the Schiff cold air sensitivity score, there was a statistically significant reduction in dentinal hypersensitivity in both the groups (p&lt;0.001) with no statistical significance in VAS scores. However, on intra-group comparison; there was a statistically significant reduction in VAS scores in Group B (p≤0.001). Conclusion: LLLT has provided a significant reduction in dentinal hypersensitivity when compared with Pro-Argin.

A short term comparative evaluation of the efficacy of diode laser with desensitizing toothpastes and mouthwashes in the treatment of dentinal hypersensitivity.

BackgroundTreatment of dentinal hypersensitivity (DH) has always been challenging with a wide variety of therapeutic options, in-office and home care. The study objective was to compare the clinical efficacy of diode laser [DL] with four commercially available desensitizing agents (two toothpastes and two mouthwashes) in the treatment of DH. Material and MethodsThis study involved 75 participants (25-45 years) who were categorized as Group 1 (n=15) treated with DL, and Groups 2, 3,4 and 5 (n=15 in each) who were prescribed 3% potassium nitrate mouth rinse, a herbal mouth rinse, potassium nitrate tooth paste and a herbal tooth paste, respectively. DH was assessed by air blast stimulation using air blast syringe, and evaluation of DH was done based on the patient’s subjective response using the Visual Analog Scale (VAS) at baseline, 1 week and 1 month. ResultsDL and the desensitizing agents showed significant reduction in DH at 1 month when compared with baseline, except potassium nitrate mouth wash. However, DL showed more percentage reduction in DH when compared with potassium nitrate tooth paste, herbal mouth wash and paste. ConclusionsThe study implies that even though all five groups showed improvement in terms of DH reduction, DL showed the best results among all the groups. Key words:Dentinal Hypersensitivity, Diode Laser, Potassium Nitrate, Herbal, Visual analog scale.

Comparative efficacy of diode laser, Iontophoresis and desensitizing agent in the treatment of dentinal hypersensitivity: A randomized clinical trial

Aim: The aim of this randomized clinical trial was to evaluate and compare the clinical efficacy of diode laser in combination with topical Potassium nitrate (KNO3) gel, Iontophoresis and KNO3 topical gel alone in the treatment of dentinal Hypersensitivity.Materials and Methods: 30 systemically healthy patients with Dentinal Hypersensitivity were enrolled in the randomized clinical trial. The patients with dentinal hypersensitivity were randomly allocated into 3groups: Group I was treated with diode laser and KNO3 gel; Group II with Iontophoresis using Sodium Fluoride (NaF) gel and Group III was treated with KNO3 topical gel alone. Sensitivity was recorded using the verbal rating scale before treatment, 10 min after treatment and 7, 15 and 21 days post therapy.Results: The mean difference among three groups showed a maximum reduction (-1.100) of dentinal hypersensitivity in group I as compared to group III and group II (-.300) after 15 days. On comparison of group II and group III, it showed reduction (-.800) of dentinal hypersensitivity after 15 days. A statistically significant difference was observed among all the three groups. All the groups showed significant reduction in Dentinal Hypersensitivity. However, the use of diode laser with KNO3 gel showed statistically significant reduction in sensitivity (P < 0.05) when compared to Iontophoresis and KNO3 topical gel alone

Blocking tubules technologies for dentin hypersensitivity in periodontal patients – pilot study

Periodontal patients often report dentin hypersensitivity (DH) caused by root surface exposure or periodontal treatment. Tubular blocking technologies in toothpastes are effective for pain relief, but no specific chemical/physical agent has been reported for periodontal patients. This double-blind randomized clinical trial compared the effects of three technologies in reducing DH in periodontal patients. Eighteen (18) participants were randomly assigned into three groups: SEN (NOVAMIN technology); REG (REFIX technology); REGK (REFIX technology + potassium citrate). Periodontal patients presenting with DH were evaluated at 6 moments: T1 and T2 - immediately before and after scaling and root planing procedures (SRP); T3 - after polishing sensitive areas with their assigned dentifrice and T4, T5, T6 - after 2, 4 and 8 weeks of SRP respectively. Sensitivity was assessed by air blast (Schiff scale) and patients’ perceptions using the visual analogue scale (VAS). Data were analyzed by two-way repeated measures ANOVA complemented by the Tukey test with significance set at 5% (p &lt;0.05). Preliminary outcomes revealed SEN, REG and REGP reduced DH in periodontal patients (n=18). All patients initially presented moderate to severe pain (64.3) and after treatment they reported mild pain (21.3). Similarly, the dentist evaluation showed significant reduction in DH with the use of the three technologies (2.26 to 0.56). No statistically significant differences were found between the three study groups for patients (p=0.751) and dentist evaluations (p=0.632). According to these preliminary outcomes, all three technologies equally reduced DH in periodontal patients. Clinical trials #NCT04422184

Effect of commercially available nano-hydroxy apatite containing desensitizing mouthwash on dentinal tubular occlusion: an in vitro FESEM analysis.

Background and aimDentinal hypersensitivity is a significant clinical problem encountered in daily dental practice. The management of this condition requires a good understanding of the complexity of the problem, as well as the variety of treatments currently available. The treatment approaches can be either home care products or professionally applied desensitizing agents. The present in-vitro study was designed to investigate the dentinal tubule occluding ability of commercially available nano HA containing mouthwash using FESEM analysis.MethodsIn the present in vitro study, 15 human premolars and canines were taken and sectioned mesiodistally. A total of 30 dentinal samples were obtained. All the dentinal discs were etched with 6% citric acid for 2 minutes. The treated samples were washed thoroughly with distilled water for 30 seconds. Samples were divided in two groups of 15 each. The specimens in Group I were shaken vigorously in the Vitis Sensitive mouthwash for 2 min twice daily for 14 days. After this intervention samples were placed in distilled water. Group II specimens were immersed in distilled water. Samples were subjected to FESEM to analyze for tubular occlusion.ResultsIn group I nearly complete dentinal surface occlusion was present on the 7th and 14th day and precipitates were seen covering a large part of the dentinal surface. In group II no dentinal tubular occlusion was observed.ConclusionThe results of the present study support the ability of nHA containing Vitis sensitive mouthwash to occlude the dentinal tubules and thus it may demonstrate a significant reduction in dentinal hypersensitivity when used clinically.

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

BackgroundDentine hypersensitivity (DH) could occur or intensify after non-surgical periodontal therapy because of the exposure of dentine tubules, but currently no gold standard exists to treat DH. It has been demonstrated that nano-sized particles presented potential for dentine tubules blocking and remineralization. This randomized controlled trial aimed to investigate the efficacy of dentifrice containing nano-carbonate apatite (n-CAP) in reducing dentine hypersensitivity (DH) after non-surgical periodontal therapy.Methods48 periodontitis patients with DH were included in this clinical trial. After non-surgical periodontal therapy, patients included were randomized to test and control group and the respective dentifrices were applied at chairside, after which they were instructed to brush teeth with the allocated dentifrices twice a day at home. Periodontal parameters were recorded at baseline and the last follow-up. DH was measured by air-blast test and recorded by visual analogue scale (VAS) and Schiff sensitivity scale at baseline, after polishing (0 week) and 2/4/6 weeks.Results45 participants completed the follow-up. Periodontal parameters were improved and comparable between groups. Significant reduction in DH was observed in both groups at all time-points compared to baseline in terms of VAS and Schiff score. The test group achieved significantly greater relief from hypersensitivity compared with the control group after 4-week at-home use (for change of VAS, test group: 2.27 ± 2.47 versus control group: 1.68 ± 2.24, p = 0.036; for change of Schiff, test group: 0.94 ± 0.92 versus control group: 0.61 ± 0.83, p < 0.001). The 6-week results showed borderline significance between groups in terms of change of Schiff (p = 0.027) and no significance in terms of change of VAS (p = 0.256).ConclusionsHome-use of n-CAP based dentifrice had some benefit on alleviation of DH following non-surgical periodontal therapy after 4 weeks compared to the control product.Trial registrationChinese Clinical Trials Registry (No. ChiCTR-IPR-17011678, http://www.chictr.org.cn/, registered 16 June, 2017).

Effectiveness of Toothpaste Containing REFIX Technology against Dentin Hypersensitivity: A Randomized Clinical Study

This clinical study aimed to evaluate the efficacy of a toothpaste containing a proprietary REFIX technology (Regenerador + Sensitive DentalClean, Rabbit Corp) against dentin hypersensitivity. Fifty-three volunteers who fulfilled the inclusion criteria and signed the consent form were included. They were examined for dentin hypersensitivity. The participants received a 1-second blast of air, and the tooth sensitivity, from 0 to 10, was immediately evaluated using a visual analog scale (VAS). Then, the participants brushed their teeth with the multifunctional toothpaste, and dentin hypersensitivity was tested a second time using the same scale. The participants continued to use the toothpaste three times a day for 1 week, after which dentin hypersensitivity was recorded for the third time. Data were statistically analyzed using analysis of variance (ANOVA) and Tukey's test (α = 0.05). The mean patient age was 40 years, and 70% of the 53 subjects were female. There was a significant reduction in dentin hypersensitivity immediately after using the toothpaste and after 1 week. The baseline mean patient-reported pain score was severe (6.5 ± 2.4). Immediately after the first use of the toothpaste, the mean reported pain significantly decreased to mild pain (2.5 ± 2.5) (p < 0.05). After 1 week of consistent use of the toothpaste, the pain score reduced significantly (0.7 ± 1.2) (p < 0.05), and most participants reported no pain, demonstrating the effectiveness of the REFIX technology against dentin hypersensitivity. This clinical trial shows that the use of the phosphate-based desensitizing toothpaste containing REFIX technology significantly reduces dentin hypersensitivity after 1 week of consistent use. The absence of pain, a desired clinical condition in patients with dentin hypersensitivity, was reached with the use of desensitizing toothpaste containing REFIX technology after 1 week of use. Such condition positively impacts quality of life, providing a healthier daily routine for patients.

Treatment of Dentinal Hypersensitivity using desensitizing agents plus soft laser irradiation. A Randomized Comparative Clinical Trial

This study aimed to evaluate the efficacy of diode laser combined with two in-office desensitizing agents 8% Arginine-CaCO3 and 1.23 NaF varnish on reducing dentine hypersensitivity (DH) in periodontitis patients. Materials and Methods: Forty patients having stage I and Stage II periodontitis were selected according to the criteria of AAP (2017) with complaint of (DH) after routine periodontal therapy . Patients were randomly divided into two groups: group1- received NaF varnish then diode laser application at 1 W (PW) ,(CW) for 30 seconds using 320µ fiber. Group-2, treated with 8%Arginine-CaCO3 plus same laser irradiation. Each tooth received three application Dentine hypersensitivity evaluation was by tactile, air-blast, and thermal stimuli and measured using VAS scores. The patient’s response was recorded at baseline, one month and 3 month after the application.Results and conclusions: The results were statistically analyzed, and it was found that 8% Arginine-CaCO3 plus laser treatment was more effective than 1.23% NaF-varnish plus laser at time intervals. Sensitivity score differences between the groups were statistically significant at one and three months. The 8% Arginine-CaCO3 group exhibited statistically significant reduction in dentine hypersensitivity on three stimuli at baseline to one and three months. It was concluded that 8% Arginine- CaCO3 plus laser irradiation is more effective than 1.23% NaF varnish plus laser irradiation in reduction of patients’ pain in periodontitis patients.

Effectiveness of fluoride varnish, diode laser, and their combination in treatment of dentin hypersensitivity: A randomized split-mouth clinical trial.

Background:Dentin hypersensitivity is a common dental problem with no permanent cure and predictable prognosis.Aim:The aim of this study was to evaluate the effectiveness of fluoride varnish (sodium fluoride [NaF]), diode laser, and the combination of NaF and diode laser in the treatment of dentin hypersensitivity.Settings and Design:This was a randomized split-mouth clinical trial.Materials and Methods:Sixty patients aged 20–60 years suffering from dentin hypersensitivity to air-blast, cold, and tactile stimulation corresponding to 4 cm and above on the Visual Analog Scale (VAS) in three quadrants with at least two hypersensitive teeth per quadrant were selected. Hypersensitive teeth were allotted to Group 1 – 5% NaF varnish application alone, Group 2 – 810-nm gallium–aluminum–arsenide laser (GaAlAs) diode laser (0.5 W) irradiation alone, and Group 3 – NaF varnish application, followed by diode laser irradiation. VAS score was recorded at baseline, 1 week, 2 weeks, 1 month, 3 months, and 6 months.Results:A statistically significant reduction in dentin hypersensitivity was observed in all the three groups, from the baseline to the 1st-, 3rd-, and 6th-month follow-ups (P < 0.05). Group 2 and Group 3 demonstrated a significantly higher reduction (P < 0.05) in dentin hypersensitivity for all the stimuli as opposed to Group 1 at all follow-up intervals. However, no statistically significant difference (P > 0.05) was present between Group 2 and Group 3 at all follow-ups.Conclusion:Diode laser is significantly more effective than fluoride varnish alone in the treatment of dentin hypersensitivity over a period of 6 months.

Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: A randomized controlled clinical trial.

ObjectiveThis randomized controlled clinical trial aimed to evaluate the effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) in the treatment of dentin hypersensitivity (DH), and the impact of this on the health-related quality of life (HRQL).MethodsEighty teeth with DH were randomized into four groups and received three treatment sessions: PLACEBO = placebo + LASER application mimicking; CPP-ACPF = CPP-ACPF + LASER application mimicking; PBM = placebo + LASER active application; CPP-ACPF+PBM = CPP-ACPF + LASER active application. Tactile (exploratory probe) and evaporative (triple syringe) stimuli were used to measure DH and were recorded with the aid of a visual analogue scale (VAS) after the 1st, 2nd and 3rd treatment sessions and one-month follow-up. The HRQL was recorded in the DH experience questionnaire (DHEQ).ResultsThe intragroup comparison showed a significant reduction in DH (p < 0.05) with both stimuli after one-month follow-up. The intergroup comparison with the evaporative stimulus showed that CPP-ACPF+PBM significantly reduced DH when compared to the rest of treatments, after one-month follow-up. CPP-ACPF+PBM group statistically differed from the other treatment groups in the DHEQ evaluation after one-month follow-up.ConclusionAfter one-month follow-up, the association of CPP-ACPF with PBM was effective in the reduction of DH and promoted a positive impact on the HRQL of the participants of this study.

Effect of a stannous fluoride toothpaste on dentinal hypersensitivity: In vitro and clinical evaluation

BackgroundThe authors conducted an in vitro and a clinical study to assess the effect of a toothpaste containing stannous fluoride to occlude dentin tubules and reduce dentinal hypersensitivity. MethodsFor the in vitro study, the authors treated the surface of human dentin specimens with test or control toothpaste slurries and then evaluated them by using various spectroscopic techniques. For the clinical study, male and female participants who met the inclusion criteria brushed their teeth twice daily for 1 minute with test or control toothpaste. The authors assessed dentinal hypersensitivity by using tactile and air blast stimuli at baseline and after 4 and 8 weeks. All statistical tests of hypotheses were 2 sided, with a significance level of α set at .05. ResultsResults from in vitro studies showed that the test toothpaste effectively occluded the dentinal tubules with a deposit consisting of tin, zinc, phosphate, and silicon. The test and control toothpastes occluded the tubules 82% and 35%, respectively. Clinically, at the 4- and 8-week examinations, the test toothpaste provided statistically significant (P < .001) improvements in tactile dentinal hypersensitivity scores of 27.8% and 42.0% and in air blast hypersensitivity scores of 21.4% and 32.3%, respectively, relative to the control toothpaste. ConclusionsThe in vitro results indicate the toothpaste containing 0.454% stannous fluoride effectively coated dentin surfaces and occluded patent dentin tubules. Compared with the control toothpaste, the test toothpaste provided a significant reduction in dentinal hypersensitivity after 8 weeks of product use. Practical ImplicationsA multi-benefit option for patients with dentinal hypersensitivity.

Diode laser in the treatment of dentinal hypersensitivity: A reliable approach

Aim: The purpose of this prospective clinical study was to compare the clinical efficacy of diode laser and topical 0.4% stannous fluoride (SnF2) gel in the management of dentinal hypersensitivity (DH). Materials and Methods: A total of 8 patients contributing 200 teeth with DH were enrolled in the study. The sensitive teeth were randomly allocated into 4 groups of 50 each: Group I teeth were treated with 0.4% SnF2 only; Group II with 0.4% SnF2 and diode laser irradiation in continuous, noncontact mode; Group III with diode laser only in continuous, noncontact mode; and Group IV with SnF2 and diode laser in continuous, contact mode. Pain/sensitivity was recorded using the visual analog scale before treatment, 10 min after treatment and 7, 15, and 30 days posttherapy.Results: All the groups showed significant reduction in DH. However, the use of both 0.4% SnF2 and diode laser in contact and noncontact mode showed statistically significant reduction in sensitivity (P < 0.001) when compared to SnF2 gel and diode laser alone. Conclusion: The adjunctive use of diode laser with SnF2 appears to be a promising treatment alternative in alleviating sensitivity.

Comparative Evaluation of Desensitizing Efficacy of Dentifrice Containing 5% Fluoro Calcium Phosphosilicate versus 5% Calcium Sodium Phosphosilicate: A Randomized Controlled Clinical Trial.

Background:A considerable number of agents are effective in the treatment of dentin hypersensitivity (DH). The present 2 months' randomized clinical trial compared the desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate in participants with sensitive teeth.Materials and Methods:A total of 60 participants above 18 years of age with a history of DH who displayed a visual analog scale (VAS) score of ≥ 4 to both subjective and thermal sensitivity in at least two teeth at the qualifying as well as baseline visit were considered eligible. Participants were randomly allocated to one of the following dentifrices: 5% fluoro calcium phosphosilicate; 5% calcium sodium phosphosilicate; and a standard dentifrice containing fluoride. Sensitivity scores (VAS) were measured at baseline, immediately after scaling and root planning, at 15, 30, and at 60 days.Results:A statistically significant reduction in symptoms for all treatment groups from baseline to 15, 30, and 60 days for both measures of sensitivity was observed. A significant reduction in DH with time for all the variables during the 8 weeks of the active phase of the study independent of treatment groups was noted. However, the fluoro calcium phosphosilicate group showed a higher degree of effectiveness in reducing DH, followed by calcium sodium phosphosilicate then standard fluoride dentifrices.Conclusion:Under the conditions of a clinical trial, the fluoro calcium phosphosilicate group showed a comparable reduction in the symptoms of DH.

A randomized clinical trial on the efficacy of a new oxalate-containing sensitivity relief strip following professional vs self-application.

The purpose of this study was to determine the efficacy of 3.14% dipotassium oxalate monohydrate-containing strip on the relief of dentinal hypersensitivity (DH). A second objective was to determine whether there was a difference in DH levels when the strip was self-applied vs applied by a dental professional. Sixty subjects were randomized into self-applied, professionally applied or placebo-strip groups. Dentinal hypersensitivity was evaluated by a blinded examiner, using the Schiff Air Scale (SAS). A verbal rating scale (VRS) was also used to measure the subjects' perception of pain. Measures were taken at baseline, 30minutes, 4 and 8weeks post-treatment. There was a significant reduction in DH in all three groups (P≤.05) at 30minutes and 8weeks post-treatment. At the 4-week follow-up, only the self- and professionally applied (active ingredient) groups had a significant reduction in DH compared to baseline. When comparing the reduction in DH levels between groups, the only significant difference occurred between the professionally applied treatment group and the placebo group at the 4-week follow-up. There were no significant differences in DH reduction levels achieved between the self- and professionally applied groups (P>.05). This study confirmed the short-term (4weeks) effectiveness of a single application of 3.14% dipotassium oxalate monohydrate-containing strip. Self- and professional application were not shown to be different.

Comparative Evaluation of Effect of Nano-hydroxyapatite and 8% Arginine Containing Toothpastes in Managing Dentin Hypersensitivity: Double Blind Randomized Clinical Trial.

This double blind randomized clinical trial was conducted with the purpose of evaluating the effects of Nano-hydroxyapatite toothpaste as compared to 8% Arginine containing toothpaste in the management of Dentin hypersensitivity (DH). Patients (30 in each group) suffering from DH and eliciting a VAS score higher than 2 in air blast and tactile test were randomly allocated (block randomization) into either a group 1 (arginine toothpaste) or group 2 (nHA toothpaste). The primary outcome evaluated was the reduction of DH as measured by the electrical stimulus reading on the digital pulp tester. Current required for eliciting a VAS score of 2 was recorded before application of dentifrice. 1 cm of toothpaste was then expressed on the tooth surface for two minutes in each group and rinsed off. The electrical stimulus required to elicit a VAS score of 2 was recorded after 5 minutes, 1 week and 4 weeks. The desensitizing paste containing arginine provided a statistically significant reduction in DH and so did the paste containing nHA. Mean increase in amperage value (reduction in DH) was higher for nHA based than the arginine containing dentifrice. This difference was not statistically significant showing that both toothpastes are equally effective. The findings of the present study encourage the use of Nano-hydroxyapatite and arginine containing dentifrice as an effective desensitizing agent providing relief from symptoms 5 minutes after application and after 1 and 4 weeks.

New toothpaste to deal with dentine hypersensitivity: double-blind randomized controlled clinical trial.

The purpose was to evaluate a combined effect of active ingredients contained in new toothpaste in reducing dentine hypersensitivity. The tested toothpaste contained active ingredients potassium nitrate (5.00%) and zinc citrate (0.50%). Pain to water stimulus and blowing air was reported on hypersensitive teeth and measured using the VAS (Visual Analogue Scale). The degree of pain to water stimulus was detected after each subject drank a few sips of water which was boiled to the room temperature. Data were collected on each subject's dental history. A significant reduction in dentine hypersensitivity (26-29% after 2 weeks versus 40% after 4 weeks) was detected in the tested group. The controls also showed significant reduction to both stimuli, but at lower rate. A statistically significant difference to blowing air and water stimuli showed the highest impact for the tested group after 4 weeks (P = 0.033, P = 0.006). This study supports the efficacy of the tested toothpaste in reducing the phenomenon of dentine hypersensitivity after 4 weeks of usage.

A comparative evaluation to assess the efficacy of 5% sodium fluoride varnish and diode laser and their combined application in the treatment of dentin hypersensitivity.

Background:Dentin hypersensitivity (DH) is an age old complaint with a great number of treatment modalities, but none of these are totally effective till date. Lasers being one of the latest treatment options in periodontics, a study was conducted to test the efficacy of diode laser (DL) in DH alone and in comparison with 5% sodium fluoride (NaF) varnish.Aim:The aim of the present study was to compare the effectiveness of 5% topical NaF varnish and 980 nm gallium aluminum arsenide (GaAlAs) DL alone and combination of 5% NaF + 980 nm GaAlAs DL in the management of DH.Materials and Methods:The study was conducted on 120 teeth in thirty patients with DH assessed by tactile and air blast (AB) stimuli measured by visual analog scale (VAS). Teeth were randomly divided into Group 1 (P) placebo-treated control group, Group 2 (NaF) treated by 5% NaF varnish, Group 3 (DL) treated with 980 nm DL, and Group 4 (NaF + DL) treated with both 5% NaF varnish and 980 nm DL (combination group).Results:There was a significant reduction in DH. The VAS reduction percentages were calculated, and there was a significant decrease in DH above all in G4 (NaF + DL) than G3 (DL) and G2 (NaF).Conclusion:Even though all the three groups (2, 3, and 4) showed improvement in terms of DH reduction, 5% NaF varnish with DL showed the best results among all the groups.

Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study.

Aim:To evaluate the effectiveness of three different pastes containing 5% NovaMin, 8% arginine, and 15% hydroxyapatite nanoparticles (n-HA) respectively in the treatment of dentin hypersensitivity (DH).Materials and Methods:A 4 weeks study was conducted on 45 adult patients with cervical abrasions leading to hypersensitivity of two or more teeth anterior to molars. Patients were divided into three toothpaste groups. Group I: 5% NovaMin, Group II: 8% arginine, Group III: 15% n-HA. Sensitivity was assessed at baseline, immediately after application and after 1-week and 4 weeks. Tactile stimuli response using a visual analog scale and standard cold air blast using Schiff cold air sensitivity scale were used to compare the efficacies of toothpastes after a single application.Statistical Analysis:Two-way analysis of variance and post-hoc Tukey test were used and P ≤ 0.05 was considered statistically significant.Results:Visual analog scale analysis: Group III and Group II showed statistically significant reduction in DH at all-time intervals when compared with Group I. In SCA analysis there is no statistically significant difference between Group II and Group III immediately after application.Conclusion:Toothpaste containing 15% n-HA was found to be most effective in reduction of DH after a single application up to a period of 4 weeks followed by 8% arginine and 5% NovaMin toothpastes.