Abstract
ObjectiveThis randomized controlled clinical trial aimed to evaluate the effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) in the treatment of dentin hypersensitivity (DH), and the impact of this on the health-related quality of life (HRQL).MethodsEighty teeth with DH were randomized into four groups and received three treatment sessions: PLACEBO = placebo + LASER application mimicking; CPP-ACPF = CPP-ACPF + LASER application mimicking; PBM = placebo + LASER active application; CPP-ACPF+PBM = CPP-ACPF + LASER active application. Tactile (exploratory probe) and evaporative (triple syringe) stimuli were used to measure DH and were recorded with the aid of a visual analogue scale (VAS) after the 1st, 2nd and 3rd treatment sessions and one-month follow-up. The HRQL was recorded in the DH experience questionnaire (DHEQ).ResultsThe intragroup comparison showed a significant reduction in DH (p < 0.05) with both stimuli after one-month follow-up. The intergroup comparison with the evaporative stimulus showed that CPP-ACPF+PBM significantly reduced DH when compared to the rest of treatments, after one-month follow-up. CPP-ACPF+PBM group statistically differed from the other treatment groups in the DHEQ evaluation after one-month follow-up.ConclusionAfter one-month follow-up, the association of CPP-ACPF with PBM was effective in the reduction of DH and promoted a positive impact on the HRQL of the participants of this study.
Highlights
Dentin hypersensitivity (DH) is characterized by an acute and short-term pain, arising from vital dentin exposed to the oral medium, in response to thermal, evaporative, tactile, osmotic, or chemical stimulation [1,2]
The intergroup comparison with the evaporative stimulus showed that Casein phosphopeptide (CPP)-ACPF+PBM significantly reduced DH when compared to the rest of treatments, after one-month follow-up
CPP-ACPF+PBM group statistically differed from the other treatment groups in the DH experience questionnaire (DHEQ) evaluation after one-month follow-up
Summary
Dentin hypersensitivity (DH) is characterized by an acute and short-term pain, arising from vital dentin exposed to the oral medium, in response to thermal, evaporative, tactile, osmotic, or chemical stimulation [1,2]. Brannstrom’s hydrodynamic theory reports that DH pain is generated when the stimulus application, over the exposed dentin, changes the dentinal tubules fluid’s histophysiology. This rapid movement excites A-β and A-δ nerve fibers from the pulp’s periphery and transmits a signal that is perceived as pain [3,4]. Casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), a complex derived from the milk protein with fluoride addition has been introduced as a remineralizing agent [11]. CPP-ACPF can be useful in reducing DH by promoting the deposition of high concentrations of calcium, phosphate, and fluoride ions occluding the dentinal tubules [12]
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