Significant Reduction In BMI Research Articles

Selected pro-inflammatory cytokines, bone metabolism, osteoprotegerin, and receptor activator of nuclear factor-kB ligand in girls with anorexia nervosa.

It has been indicated that disturbances in the production of certain pro-inflammatory cytokines might contribute to the development of osteoporosis in girls with anorexia nervosa (AN). The aim of the study was to determine whether girls with AN exhibited a relationship between IL-1β, IL-6, TNF-α, bone turnover markers (OC and CTx), OPG, sRANKL, and the OPG/sRANKL ratio. Serum IL-1β, IL-6, TNF-α, OC, CTx, OPG, and sRANKL were determined by ELISA in 59 girls with AN and in 17 healthy counterparts, aged 13 to 17 years. Girls with AN showed significant reduction in body weight, BMI, BMI-SDS, and Cole index compared to the controls. These changes were associated with a significant increase in IL-1β, IL-6, TNF-α, OPG, and sRANKL concentrations and a decrease in bone markers and the OPG/sRANKL ratio. Significant negative correlations were found between BMI, the Cole index and CTx, OPG (girls with AN); between BMI and OC, CTx as well as the Cole index and CTx (the control group - C); between BMI, the Cole index and IL-β1, IL-6, TNF-α, CTx in all study participants (group AN+C). The combined group AN+C also exhibited positive correlation between BMI, the Cole index, and the OPG/sRANKL ratio. Girls with AN showed positive correlations between IL-1β, IL-6, and CTx as well as between TNF-α and sRANKL whereas the correlation between TNF-α and the OPG/sRANKL ratio was negative (IL-6 and IL-1β were identified to be independent predictors of CTx, TNF-α and IL-6 independently predicted sRANKL while TNF-α, IL-6, and IL-1β were independent predictors of the OPG/sRANKL ratio). The control participants exhibited negative correlations between IL-1β and OPG and positive correlations between IL-1β and sRANKL (IL-1β was found to be an independent predictor of OPG and sRANKL). In the AN+C group, IL-1β correlated negatively with OC and OPG and positively with sRANKL, while IL-6 and TNF-α positively correlated with CTx (IL-6 and TNF-α turned out to be independent predictors of CTx, IL-1β of OPG while IL-6, TNF-α, and IL-1β were independent predictors of sRANKL and the OPG/sRANKL ratio). The relationship between the nutritional status and IL-1β, IL-6, and TNF-α concentrations as well as bone status indicators seems to indicate that abnormalities observed regarding the concentrations of pro-inflammatory cytokines and bone remodelling in girls with AN might result from malnutrition. Correlations between IL-1β, IL-6, TNF-α, bone markers, OPG, its ligand sRANKL, and/or the OPG/sRANKL ratio suggest potential involvement of these cytokines in the mechanism underlying the lack of the expected bone mineral density increase in adolescent girls.

Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials.

The independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive. The objective of this systematic review and meta-analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity. MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for literature published from 1966 to March 2014. A systematic search was conducted for randomized clinical trials with ≥ 50 participants aged ≥ 18 years at baseline who had received at least 12 weeks of treatment. Among the inclusion criteria were supplementation with vitamin D with or without calcium and measurement of adiposity (weight, body mass index [BMI], and/or fat mass). The primary endpoints assessed were changes in weight, BMI, or fat mass. Of 953 trials identified, 26 randomized clinical trials (n = 12, vitamin D alone; n = 10, vitamin D plus calcium versus calcium control; n = 4, vitamin D plus calcium versus placebo) with a total of 42,430 participants (median duration, 12 months) met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant effect on BMI (weighted mean difference [WMD], -0.06 kg/m(2); 95% confidence interval [95%CI], -0.14 to 0.03), weight (WMD, -0.05 kg; 95%CI, -0.32 to 0.23), or fat mass (WMD, -0.43 kg; 95%CI, -1.69 to 0.84). Likewise, no significant reduction in BMI (WMD, 0.02 kg/m(2); 95%CI, -0.11 to 0.14), weight (WMD, 0.12 kg; 95%CI, -0.24 to 0.49), or fat mass (WMD, 0.12 kg; 95%CI, -0.22 to 0.45) was observed in participants who received vitamin D plus calcium compared with those who received calcium control. Supplementation with vitamin D showed no effect on adiposity measures in adults.

Evaluation of an Exercise is Medicine on Campus Pilot Program

Exercise is Medicine (EIM) on Campus programs have the potential to improve the health of students through exercise and other wellness interventions. PURPOSE: The purpose of this study was to evaluate a pilot exercise and wellness program designed to improve fitness and reduce cardiovascular disease risk factors. Specifically, we sought to determine whether this EIM program was successful in targeting students who were obese and/or unfit and to evaluate the effectiveness of an exercise program for promoting weight loss and improving fitness. METHODS: Subjects were 13 students (age 23.4±5.1 y) who completed a six-week intervention that included an individualized exercise program delivered through the campus wellness center. The students in this program volunteered to participate, as opposed to receiving referrals from the student health center. Body weight, BMI, waist circumference, submaximal estimation of VO2max (Rockport one mile walk test), and assessments of muscular strength, endurance, and flexibility were completed in all subjects at the beginning and end of the program. RESULTS: The subjects who enrolled were obese and had a low estimated VO2max, indicating that the program attracted students who could benefit from the exercise intervention. Following the six-week program, subjects experienced modest but significant reductions in body weight (95.8±19.8 to 94.3±20.3 kg, p<0.01), BMI (34.2±6.5 to 33.7±6.6 kg•m-2, p<0.01), and waist circumference (103.4±18.4 to 98.0±15.9 cm, p<0.05). Fitness indicators also improved, including VO2max (25.4±8.0 to 30.3±7.8 ml•kg-1•min-1, p<0.01), push-ups to fatigue (12.9±10.2 to 16.2±10.7, p<0.05), plank time (35.3±18.7 to 43.4±20.3 s, p<0.05), wall sit time (34.8±45.6 to 45.6±33.4 s, p<0.05), and sit and reach distance (46.0±49.3 to 49.3±9.5 cm, p<0.01). CONCLUSION: This EIM program was effective at targeting students who needed to lose weight and improve their fitness. Additionally, participants realized improvements in body weight, BMI, waist circumference, and fitness during the short, six-week program.

Effects of a community based weight loss intervention in rural New York: A pilot study

OBJECTIVE: The purpose of this longitudinal study is to evaluate the outcomes of a weight loss intervention in a rural community wellness center.METHODS: This six month (Oct'13‐ April'14) community based weight loss program was coordinated by the Plattsburgh City Recreation Department and SUNY Plattsburgh. Nineteen overweight adults (18 female, 1 male) aged 18 to 60 years (43.7 ± 12.2 years) residing in Clinton County, NY were recruited through local advertisements. Participants were charged a one time @100 fee. The program comprised twice‐weekly group exercise and bi‐monthly nutrition education classes. Paired samples t‐test and McNemer tests were performed to examine the pre‐post program outcomes.RESULTS: Individuals completing the program averaged a weight loss of 29.2 ± 22.5 pounds and inches loss of 22.04 ± 12.2. Significant reduction in BMI (3.4 ± 2.2, p &lt; 0.001), % body fat (3.4 ± 2.3, p &lt; 0.001), systolic blood pressure (11.3 ± 13.6, p &lt; 0.05), diastolic blood pressure (7.75 ± 8.3, p &lt; 0.05) and total cholesterol (20.33 ± 33.1, p &lt; 0.10) were observed at 6 months. Prevalence of prehypertension and hypertension reduced from 80% to 46% (n =11, McNemar test: NS). Although not statistically significant, fasting lipids and blood glucose improved regardless of age. While there was no significant change in diet, consumption of roots and tubers decreased significantly.CONCLUSIONOur program results indicate that participants who complete a self‐paid, structured rural community‐based weight loss program can achieve significant weight loss with improvement in cardiovascular risk factors regardless of age.Funding: Presidential Research Award, SUNY Plattsburgh

The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial.

A randomized, double-blind, placebo-controlled clinical trial. To assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI). Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Fifty-eight men with chronic SCI participated in the study. Participants were divided in two groups: one group received 600 mg of supplemental ALA (n=28) and the other group received placebo (n=30) for 12 weeks. At the beginning and end of the study, biochemical parameters, anthropometric indices, blood pressure and dietary intakes were measured. Dietary intake was measured using N4 software, and statistical analyses were carried out using SPSS16. No significant reduction was found in IL-6 (P=0.97) and hs-CRP levels (P=0.23). There was significant reduction in fasting blood sugar (P=0.001), body weight (P=0.001), BMI (P=0.001), waist circumference (P=0.001) and blood pressure (P=0.001). Dietary intake was significantly reduced, including fat (P=0.001), carbohydrate (P=0.001), protein (P=0.002) and energy intakes (P=0.001). Lipoic acid supplementation had no significant effect on the measured inflammatory markers but it reduces fasting blood sugar, anthropometric parameters, food intake and blood pressure in men with chronic SCI.

Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?

BackgroundNearly 50% of diabetic patients worldwide use complementary medicines to treat or supplement their conventional diabetes treatment. Salacia reticulata (Kothala himbutu) is a woody climber used widely in the Ayurvedic system to treat diabetes and obesity.ObjectiveIn this review I critically analyze the evidence for using Salacia reticulata for treating type 2 diabetes and obesity. The available evidence is described in terms of in-vitro studies, animal studies and clinical trials.Results and conclusionsIn vitro studies demonstrate the ability of Salacia to inhibit intestinal alpha glucosidase. In mouse mesenteric fat it enhances the mRNA expression for hormone sensitive lipase (HSL) and adiponectin; thus increasing lipolysis and reducing insulin resistance respectively. In 3 T3-L-1 adipocytes lipogenesis factors are down regulated and lipolysis factors are up regulated with Salacia reticulata treatment. Animal studies and clinical trials are consistent in demonstrating improvement of glucose concentrations in the fasted and sucrose and maltose loaded states. Clinically significant reductions of HbA1C and plasma Insulin are reported with treatment of 6 weeks to 3 months. One clinical trial reported significant reduction of weight and BMI when Salacia is used in combination with vitamin D.Salacia reticulata effectively improves insulin resistance, glucose metabolism and reduces obesity. A larger evidence base is required from well-planned studies to confirm its efficacy and safety.

The Feasibility and Efficacy of Healthy Weight Management Program for Low Income Chinese American Overweight and Obese Children in a Primary Care Clinic

Childhood obesity is one of the most prevalent public health concerns. A pre and post study design was used to explore the efficacy of an obesity prevention program. Children had weight, height, blood pressure, and waist circumference measured, and completed self-reported questionnaires on food intake, knowledge, self-efficacy, and health-related quality of life. Parents completed demographic and acculturation surveys. Seventy children participated in the study. Results demonstrated significant reduction of BMI, systolic blood pressure, and fast food consumption and improvement of self-efficacy, knowledge, and quality of life. Childhood obesity intervention is feasible and has short-term efficacy.

Coalesced Impact of Green Tea and Cinnamon on Metabolic Parameters of Overweight Subjects

Obesity is pandemic worldwide and even in developing countries significantly shares the proportion of its prevalence. Beyond pharmaco-therapy, overweight individuals have been seeking functional food supplements to manage their weight. Several functional foods have been suggested for the management of obesity. Particularly, certain functional foods that contain bio active compounds are believed to interfere in cell metabolism that brings changes in the metabolic parameters. The two functional foods green tea and cinnamon have been intensively studied individually on insulin sensitivity, blood glucose, body weight and lipid fractions using animal and human models. However, there has been seldom study available experimenting with both the functional ingredients (Green Tea and Cinnamon) together in over weight individuals. The inmates of St. Joseph Prasanth Nivas Ashramam, Jeppu Mangalore, India were selected as participants. A total of forty volunteers were recruited according to predetermined inclusion criteria were grouped into experimental and control groups equally. Supplementation of green tea with cinnamon twice a day for 30 days yielded a significant reduction in BMI (P<0.05) waist circumferences (P<0.05) and lipid parameters like TGL (P=0.000), HDL (P=0.000) and that of LDL (P<0.05). Thus, it is imperative that regular consumption of Green Tea with Cinnamon can modulate lipids favourably and moderately reduce body weight which on a long run may help one to prevent or decrease the risk of CVD.

Weight loss and reductions in body mass index, abdominal-girth and -depth after a 12 week dietary intervention of soya beans (edamame)

Weight loss strategies utilising dietary protein have been extensively studied. Some success has been evident with highprotein-low-carbohydrate diets; however these by nature include high fat meat or dairy produce and as such contain large amounts of saturated fat and cholesterol and may not sustain a quality diet. Literature suggests that protein supresses hunger beyond what would be estimated from its energy content. Substituting even modest amounts of protein for carbohydrate is thought to reduce abdominal obesity and could therefore be of benefit in replacing some carbohydrates with sources of protein which are low in saturated fat. The aim of this study was to examine the efficacy in maintaining energy balance or weight loss in a free-living population while incorporating frozen soya beans (edamame) into the diet and to assess changes in body weight and composition. Overweight and obese women (BMI > 25 kg/m) were recruited from East Lothian, Scotland and randomised to test or control groups. Both groups were given healthy lifestyle advice while the test group were also given soya beans and asked to consume 80 g/day. Participants were reviewed at baseline, 4, 8 and 12 weeks when body weight (Wt), BMI, waist circumference (WC) and sagittal abdominal depth (SAD) were measured. Median (M) and interquartile range (IQR) values are presented below. Sixteen women median age 49 (IQR 18) years completed the intervention programme. Significant reductions in BMI, body weight, WC and SAD were evident p< 0·05.

The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome – a proof-of-concept study

The aim of this proof-of-concept study was to determine the effects of three-month Metformin therapy on the expression of tumor-regulatory genes (p53, cyclin D2 and BCL-2) in the endometrium of women with polycystic ovary syndrome (PCOS). A total of 40 women, aged between 21 and 45 years with PCOS (Rotterdam criteria) were recruited. The participants were assessed at pre- and 3-month-post-Metformin therapy for the menstrual regularities, weight reduction, Ferriman Galway scores, fasting blood glucose (FBG), total cholesterol, LDL, HDL and p53, BCL-2 and cyclin D2 gene expression. Five participants conceived spontaneously after the initial recruitment. Majority (68%) resumed regular menstrual cycles after Metformin. There were significant reduction in BMI (p = 0.001), weight (p = 0.001) and Ferriman Galway scores (p = 0.001). A significant improvement was seen in mean FBG (p = 0.002), total cholesterol (p = 0.001), LDL (p = 0.003) and HDL cholesterol levels (p = 0.015). Tumor suppressor gene (p53) was significantly up-regulated after Metformin (10 out of 14 women), with p value 0.016. BCL-2 and cyclin D2 (oncogenes) were slightly up-regulated without significant difference (p = 0.119 and 0.155, respectively). In conclusion, Metformin therapy improved clinical and metabolic parameters in women with PCOS and up-regulated p53 tumor suppressor gene significantly. Further studies are however required to independently validate our findings.

Rates of reflux before and after laparoscopic sleeve gastrectomy for severe obesity.

A current management dilemma in laparoscopic sleeve gastrectomy (LSG) patients is the development of significant gastroesophageal reflux symptoms after surgery. Treatment is typically directed towards reducing acid reflux despite the surgical removal of parietal cell mass. In contrast, laparoscopic Roux-en-Y gastric bypass (LRYGB) has been known to reduce or resolve preoperative reflux symptoms. The objective of this study was to determine the incidence of preoperative and postoperative reflux of LSG and LRYGB patients, and review reflux treatment type and response. A retrospective chart review was performed for patients undergoing either LSG or LRYGB between January 2010 and December 2012 as part of the Weight Wise program, Royal Alexandra Hospital, Edmonton, Canada. A total of 387 cases were included in our review. We observed a significant reduction in BMI postoperatively for both LSG and LRYGB groups (p < 0.001). Between surgical groups, preoperative proton-pump inhibitor (PPI) use was not significantly different; however, at 1 month (p < 0.05) to 1-2 years (p < 0.001), there was significantly increased PPI use in patients after LSG in comparison to LRYGB. Of the LSG patients that continued their PPI treatment after surgery, 58% increased, 42% continued the same, and 0% decreased their dose 1 year after surgery. Reflux symptoms are significantly increased after LSG in comparison to LRYGB patients. In addition, LSG patients more frequently require initiation of reflux treatment after surgery than that of LRYGB patients. Patients reported postoperative reflux symptom relief with acid-suppressant therapies.

Positive effects of Nordic Walking on anthropometric and metabolic variables in women with type 2 diabetes mellitus

Summary Objectives Lack of physical activity predisposes people to chronic diseases including diabetes mellitus, obesity, and coronary artery diseases. Identifying forms of physical activity is warranted for prevention of these chronic diseases. Daily exercise has also been considered a significant contributing factor in the management of type 2 diabetes. Nordic Walking is shown to be easy to teach and learn, simple and adaptable to subjects with diabetes and metabolic syndrome. Nordic Walking allows training of about 90% of body muscles in the active propulsion phase, thus increasing energy expenditure by 30 to 50%. Aim of our study was to evaluate the effects of Nordic Walking structured training in a group of female patients with type 2 diabetes, looking at changes in anthropometric, metabolic and bioelectrical variables pre- and post-activities. A follow-up of 6 months after the end of the program was also performed. Equipment and methods Twenty women with type 2 diabetes, aged 40–65 years, were enrolled. The participants were randomized in two groups: (1) 10 women in the Nordic Walking active group, (2) 10 women receiving counseling alone to perform physical activity (control group). Results Results show that diabetic women involved in a 12-week structured Nordic Walking program obtain a significant reduction in HbA 1c (–0.7%), BMI (–0.8 kg·m −2 ) and body weight (–2.4 kg), and a significant increase in HDL cholesterol (+5.8 mg·dL −1 ). Also Handgrip strength was significantly improved (+4.3 kg). At follow-up all changes returned to baseline values. Conclusions Our study shows that a supervised Nordic Walking program determines a significant improvement in metabolic and anthropometric parameters in women with type 2 diabetes.

Efeito do acompanhamento nutricional e treinamento físico em pessoas com síndrome metabólica

Introdução: A síndrome metabólica é um transtorno que reúne um conjunto de fatores de risco cardiovasculares, acometendo boa parte da população acima de 40 anos. Alimentação inadequada e falta de exercícios físicos são consideradas precursores dessa síndrome. Objetivos: Avaliar os efeitos de duas intervenções distintas, programa de acompanhamento nutricional e programa de treinamento físico, em pessoas com síndrome metabólica. Métodos: Participaram do estudo 14 adultos, de ambos os sexos, com idade de 40 a 65 anos, divididos em dois grupos: grupo 1 – acompanhamento nutricional e grupo 2 – programa de exercícios físicos. Realizaram-se coletas no início da pesquisa e após 16 semanas de intervenção. Resultados: Houve redução significativa de massa corporal, IMC, circunferência da cintura, HDL e colesterol total, nos componentes do grupo 1. No grupo 2, não houve diminuições significantes. Conclusões: O acompanhamento nutricional gerou resultados positivos no perfil antropométrico, pressão arterial e perfil lipídico dos sujeitos após 16 semanas de intervenção.

Pentoxifylline for the treatment of nonalcoholic fatty liver disease: a meta-analysis of randomized double-blind, placebo-controlled studies.

Pentoxifylline has been used to treat nonalcoholic fatty liver diseases (NAFLDs) due to its anti-tumor necrosis factor-α effects. We conducted a meta-analysis of randomized, double-blinded, placebo-controlled trials to investigate the effect of pentoxifylline on the biochemical and histological parameters of NAFLD patients. A comprehensive literature search was conducted in the database including PubMed, Embase, ISI web of knowledge, the Cochrane Library, and Google Scholar to identify randomized, double-blind, placebo-controlled clinical trials about the effects of pentoxifylline on NAFLD. The pooled weighted mean difference (WMD) with 95% confidence interval (CI) was calculated to compare the effects of pentoxifylline and placebo. Five well-designed studies were retrieved. Pooled results showed that pentoxifylline significantly reduced the serum alanine transaminase activity (WMD=-27.97; 95% CI: -42.59, -13.34) and aspartate transaminase activity (WMD=-13.97; 95% CI: -23.31, -4.63) in NAFLD patients compared with placebo. In addition, pentoxifylline significantly improved steatosis (WMD=-0.68; 95% CI: -1.01, -0.34), lobular inflammation (WMD=-0.49; 95% CI: -0.86, -0.12), and fibrosis (WMD=-0.60; 95% CI: -0.99, -0.21). Furthermore, pentoxifylline also led to significant reduction in BMI (WMD=-0.51; 95% CI: -0.96, -0.06) and fasting glucose (WMD=-8.97; 95% CI: -14.52, -3.42), but did not significantly affect the serum tumor necrosis factor α and adiponectin levels when compared with placebo. Pentoxifylline could reduce the aminotransferase activities and improve the histological parameters in NAFLD patients. Large well-designed, randomized, placebo-controlled studies are needed to confirm these results.

Estudo comparativo da evolução nutricional de pacientes candidatos à cirurgia bariátrica assistidos pelo Sistema Único de Saúde e pela Rede Suplementar de Saúde

A cross-sectional comparative study was conducted on the nutritional evolution of severely obese patients who are candidates for bariatric surgery attended by the Unified Health System (SUS) and the Supplemental Health Network (RS). The average preoperative follow-up period was 14.3 ± 7.7 months in the SUS and 2.4 ± 1.7 months in the RS. There was a predominance of females among patients attended by the SUS (80.6%) and by the RS (75.7%). A significant reduction in weight, BMI and waist circumference (WC) and total cholesterol values of patients of both health networks was observed. Patients attended by the SUS showed no significant decrease in LDL, Triglycerides and Fasting Glycemia, while patients assisted by the RS showed a significant reduction of these values. The greater weight loss among SUS patients is explained by the fact that they had been monitored for a longer period. The insignificant reduction of most biochemical indicators of SUS patients can be justified by the fact that they had a more advanced degree of obesity.

Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity

Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity

The Effects of Supervised Exercise Program on Health-Related Physical Fitness in Kuwait

Aims :Physical activity improves health in terms of cardiovascular fitness, musculo skeletal fitness, body composition, and metabolism. The study aims to examine the effects of supervised exercise training on metabolic profile and health -related physical fitness parameters in Kuwait. Study Design:A prospective observational study . Place and Duration of Study:Fitness and Rehabilitation Center (Dasman Diabetes Institute,Kuwait) between January 2012 and December 2013. Methodology :We included90 participants(44women), mean age 48.6 (±14.4) years with adherence exceeding 50%. Outcome measures health-related physical fitness (measured by cardiopulmonary exercise testing) and other secondary outcome measures including anthropometric data, vital signs, and glycemic profile values. Results:Paired t -test was used to evaluate the effects of exercise training. Both diabetic and non-diabetic participants showed significant increase in peak oxygen consumption (3.0 ml�min -1 � kg -1 ; 95%CI: 2.3 to 3.7; p<0.001). There was significant reduction in BMI (0.6 kg/m 2 ; 95%CI:-0.9 to-0.3;p<0.001), waist circumference ( -2.2cm; 95% CI:-3.4 to1.0;p = 0.002) and body fat percentage ( -0.9%; 95% CI:-1.4 to-0.3;p = 0.002).The

Eficacy and Sfety Human Study of the Ethanol Extracts from Lythrum Salicaria L. and Aceriphyllum Rossii for Reducing Body Fat Percentage of Korean Adult

This research, as a basic preliminary study for development of functional health food, is aimed at assessing the body fat reduction effect and for application to human body for such reduction in actual clinical settings by preliminary extraction of 2 types of wild edible greens, Lythrum salicaria L. and Aceriphyllum rossii. Subjects over the age of 19 and less than 60 years old with BMI value range of 23.0 kg/㎡∼29.9 kg/㎡ were recruited through screening were divided into experimental group and control group, each with 25 subjects, through randomized allocation. With both patients and evaluators wearing blindfold, the experimental group was orally administered with 4 capsules of 500mg of composite preparation containing the extracts of Lythrum salicaria L. and Aceriphyllum rossii 3 times a day for a period of 8 weeks while the control group was orally administered with 4 capsules of 500mg of placebo (fake food) with the same appearance as the preparation administered to the experimental group 3 times a day for a period of 8 weeks. After having carried out evaluation on physical examinations (body weight, BMI and body fat ratio, etc.), laboratory tests (general blood test, biochemical test of blood and urine test), lipid test, the changes were analyzed. There was no significant change between the 2 groups and within the groups in BMI and body fat ratio, which are the primary effectiveness evaluation at each time. There was no significant difference between the 2 groups in serum lipid and WHR, obesity related KOQOL, KEAT-26 which are the secondary effectiveness evaluations. There was no change between the 2 groups and within the groups in vital sign, CBC, BC and urin test. These results suggest that Lythrum salicaria L. and Aceriphyllum rossii ext. showed no significant reduction in BMI, body fat ratio and serum lipid. Additional confirmative clinical application test is needed in the future.

Avaliação da qualidade de vida tardia após gastroplastia vertical

To evaluate the quality of life in patients undergoing vertical sleeve gastroplasty. We conducted a historical cohort study including patients with morbid obesity the in the Unified Health System (SUS), registered in the database of the General University Hospital, University of Cuiabá. All patients underwent vertical sleeve gastroplasty and were followed for at least one year after the operation. The study variables were: quality of life, weight loss, improvement of hypertension and diabetes, and mortality. The sample comprised 41 patients, 13 (31.7%) men and 28 (61.3%) women, mean age was 37 years, the average weight was 136.4 kg and mean BMI 50.3 kg/m²; mean follow-up was 19.1 months (12-32). There was a significant reduction in weight (96.7 kg, p < 0.001) and BMI (35.835 kg/m², p < 0.001). The rate of blood pressure decreased from 56% to 31.7%, and diabetes from 14.6% to 4.8% (p < 0.001). Quality of life improved in 92.5% of patients. There was an improvement in the quality of life in the majority of patients, achieved by means of weight loss and clinical improvement of diabetes and hypertension.

Atividade da butirilcolinesterase e fatores de risco cardiovascular em adolescentes obesos submetidos a um programa de exercícios físicos

To evaluate the effect of 12 weeks of physical exercise (PE) on cardiovascular risk factors and BChE activity in obese adolescents. The sample consisted of 24 obese adolescents and 51 normal weight controls. The following variables were measured in the initial stage and after 12 weeks: weight, height, BMI, waist circumference (WC), fat percentage (% F), maximal oxygen uptake (VO2max), systolic (SBP) and diastolic (DBP) blood pressure, glucose (GLY) and insulin (INS) at baseline and after 120 min, triacylglycerol (TG), total cholesterol (TC), LDL cholesterol, HDL cholesterol, and BChE activity (kU/l). After the intervention, there was significant reduction in BMI, WC, %F, TG, GLI 120, INS 120 min, and BChE activity. The reduction in BChE activity, observed after physical exercise, was accompanied by the reduction of the variables associated with cardiovascular risk and obesity, indicating that BChE can be used as a secondary marker for the risk associated with early onset obesity.