Significant Preference Research Articles

Comparison of 4- or 6-implant supported immediate full-arch fixed prostheses: A retrospective cohort study of 217 patients followed up for 3-13 years.

Choosing four or six implants to support immediate full-arch fixed prostheses (FAFPs) is still controversial worldwide. This study aims to analyze and compare the long-term results of All-on-4 and All-on-6. This retrospective cohort study enrolled 217 patients rehabilitated with 1222 implants supporting 271 FAFPs, including 202 prostheses supported by 4 implants (All-on-4 group) and 69 prostheses supported by 6 implants (All-on-6 group), and followed up for 3-13 years. Implant survival, prosthesis survival, complications, and implant marginal bone loss (MBL) were evaluated and compared between two groups. Patient characteristics including age, gender, jaw, opposite dentition condition, smoking habit, bruxism, bone quantity and quality, cantilever length (CL), prosthesis material, and oral hygiene were analyzed to assess their influence on the clinical results of the two groups. Six surgeons and three prosthodontists who performed FAFPs more than 5 years were invited for questionnaires, to assess patient- and clinician-related influences on implant number. In general, All-on-4 group indicated no significant difference with All-on-6 group in the implant survival (implant-level: hazard ratio [HR]=1.0 [95% confidence interval (CI): 0.8-1.2], P=0.96; prosthesis-level: HR=0.8 [95% CI: 0.3-1.8], P=0.54), prosthesis survival (odds ratio [OR]=0.8 [95% CI: 0.3-2.8], P=0.56), biological complications (OR=0.9 [95% CI: 0.5-1.8], P=0.78), technical complications of provisional prosthesis (OR=1.3 [95% CI: 0.7-2.3], P=0.42), technical complications of definitive prosthesis (OR=1.1 [95% CI: 0.6-2.2], P=0.33) and the 1st, 5th, and 10th year MBL (P =0.65, P =0.28, P =0.14). However, for specific covariates, including elderly patients, opposing natural/fixed dentition, smoking, bruxism, long CL, low bone density, and all acrylic provisional prostheses, All-on-6 was more predictable in some clinical measurements than All-on-4. The implant prosthodontists and the medium-experienced clinicians showed significant preference for All-on-6 (P <0.05). Based on this study, the long-term clinical results showed no significant difference between All-on-4 and All-on-6 groups in general. However, for some specific characteristics, All-on-6 seemed to be more predictable in some clinical measurements than All-on-4. For the clinicians' decision-making, medium-experienced clinicians and the implant prosthodontists showed significant preference for All-on-6.

Color assortative shoaling in zebrafish, Danio rerio (Cypriniformes: Cyprinidae)

Zebrafish, Danio rerio, form shoals consisting of loosely aggregated individuals swimming in different directions. Shoal-mate composition in fish can be influenced by body size, shape, coloration, and pattern. The effect of transgenic body coloration on shoal-mate composition in wildtype D. rerio was examined. A test arena was divided into three equal sections with a wildtype zebrafish in the center compartment. For control trials, a wildtype shoal of seven individuals was placed in both side compartments. For experimental trials, one of the wildtype shoals was replaced with seven green transgenic fish. The number of visits made to each side and the time spent on each side were recorded. Control fish showed no significant difference (NSD) in the average number of visits to the left versus right side and NSD in the average time spent with either shoal. Experimental fish exhibited NSD between the average number of visits to the transgenic versus the wildtype shoal, but they spent significantly more time shoaling with the wildtype. Wildtype test fish consistently visited each side, which would enable assessment of shoal composition, but spent more time shoaling with phenotypically similar individuals, as predicted by the oddity effect. Previous studies show no significant preference by wildtype D. rerio for wildtype versus red transgenic conspecifics and indicate a more prominent role of striping pattern. This generates further questions about the influence of body coloration on shoal-mate preference. Future research could examine the effect of other transgenic colors on shoal-mate preference.

In search of cytotoxic selectivity on cancer cells with biogenically synthesized Ag/AgCl nanoparticles.

Green synthesis may be a useful approach to achieve selective cytotoxicity of silver nanoparticles on cancer cells and healthy cells. In this study, the concomitant biosynthesis of silver (Ag)/silver chloride (AgCl) nanoparticles from pineapple peel extracts and their behavior on the breast cancer cell line MCF-7 is shown. Bioreactions were monitored at different temperatures. Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), thermogravimetric analysis (TGA), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM) techniques were used to characterize nanoparticle development. The breast cancer cell line MCF-7 was used as a test model to study the cytotoxic behavior of Ag/AgCl nanoparticles and, as a counterpart, the nanoparticles were also tested on mononuclear cells. Ag/AgCl nanoparticles with spherical and triangular morphology were obtained. The size of the nanoparticles (10-70 nm) and the size distribution depended on the reaction temperature. A dose close to 20 µg/mL of Ag/AgCl nanoparticles considerably decreased the cell viability of the MCF-7 line. The best cytotoxicity effects on cancer cells were obtained with nanoparticles at 60 and 80 °C where cell viability was reduced up to 80% at a concentration of 50 µg/mL. A significant preference was observed in the cytotoxic effect of Ag/AgCl nanoparticles against cancer cells in comparison to monocytes.

Direct and indirect effects of banker plants on population establishment of Harmonia axyridis and aphid control on pepper crop.

Banker plant systems increase biological pest control by supporting populations of natural enemies, i.e., using non-pest arthropod species as alternative prey. However, the presence of alternative prey does not always result in improved control of the target pest species owing to the complexity of biotic interactions. To increase the effectiveness of banker plants in IPM programs, a fine understanding of the indirect interactions between target aphid and alternative prey mediated by biocontrol agents is necessary. In this study, we first established a banker plant system, banker plant (Vicia faba)-alternative prey (Megoura japonica)-predator (Harmonia axyridis), to control the target pest (Myzus persicae) on pepper. We found that M. japonica strongly preferred faba bean as a host plant and posed no risk to Solanaceous crops. Harmonia axyridis adults had no significant predation preference for the alternative prey. In the short term, the interaction direction of the two aphid species depended on the relative initial density and the timescale. Harmonia axyridis showed a stronger negative effect on M. persicae than that on M. japonica. In the long term, the presence of alternative prey, M. japonica, enhanced the control effect of H. axyridis to M. persicae with initial density of 100-500 aphids per plant. The presence of the alternative prey could proliferate the population of H. axyridis, with from 0.2- to 2.1-fold increase of H. axyridis eggs. Overall, we put forward a strategy for setting the initial density of alternative prey of the banker plant system to target the high and low density of aphids, which highlighted the importance of indirect interactions in designing a proper banker plant system.

Application of 3D Printing in Pharmaceutical Sciences, and Evaluation of Administration Routes for Drug-Loaded Composites

3D printing is a novel approach in the pharmaceutical field, but its usage has not been fully established. This method can promote drug therapy and overcome some traditional treatment challenges in different ways that are discussed in this paper. "One-size-fits-all", Large-scale production, and less patient and physician acceptability are some limitations that we will encounter in traditional therapy. Three-dimensional printing of pharmaceutical products is a versatile technology that needs specific attention. Droplet-based, extrusion-based, and laser-assisted 3D printers are three main techniques that can be used in this field. The limitations and advantages of this method have been discussed, highlighting potential innovative pathways towards the possibility of drug carriers’ usage in ink formulas. The administration pathway of drug-loaded composites is another critical issue in drug treatment strategies that have been discussed here. Oral drug delivery as a convenient method of systemic drug administration with significant patient preference is introduced as the most prevalent pathway that has been studied about 3D printed medicines. Finally, essential ethics and future directions of 3D printing in the pharmaceutical and healthcare industries are outlined.

Effect of process parameters on vitamins and sensory acceptability in micronutrient-fortified soymilk prepared by small-scale batch processing.

Effects of holding time before cooling, cooling method, and light or dark refrigerated storage on the stability of vitamin A, vitamin C, thiamine, riboflavin, and folate were investigated in fortified and unfortified soymilk. Vitamin C loss (6%) and mild vitamin A isomerization occurred when soymilk was held hot after fortification. Cooling bottled soymilk at ambient temperature or in an ice-water bath did not affect any vitamins. Loss of riboflavin (18%) and vitamin A isomerization occurred during 12 days of light-exposed refrigerated storage, in contrast to no vitamin degradation during dark refrigerated storage. A sensory panel of youth and children indicated no significant preferences between fortified and unfortified soymilk except for color, where the lighter-colored unfortified soymilk was preferred. Acceptable vitamin stability and sensory characteristics can be achieved in fortified soymilk produced in small-scale batch processes with appropriate management of production and storage conditions.

A high fat diet in glutamate 3-/Y mice causes changes in behavior that resemble human intellectual disability

Cognitive impairment in individuals with intellectual disability (ID) is characterized by developmental delay and deficits in language and memory. Ionotropic AMPA mediate the majority of excitatory synaptic transmission in the central nervous system and are essential for the induction and maintenances of long-term potentiation (LTP) and long-term depression (LTD), two cellular models of learning and memory underlie many the symptoms of ID. Clinical research has found obese male patients with GluA3 interrupted underlie the symptom of ID. We tested GluA3-/Y mice under high fat diet (HFD) stress on a series of behavioral paradigms associated with symptoms of ID: wild type mice showed significant levels of sociability, while GluA3-/Y mice did not. Wild type mice showed significant preference for social novelty, while GluA3-/Y mice did not. Normal scores on relevant control measures confirmed general health and physical abilities in both GluA3-/Y and wild type mice (WT), ruling out artifactual explanations for social deficits. GluA3-/Y mice also showed working spatial memory behavior impairment in Y-maze test and abnormal anxiety in open-field test, compared to wild-type littermate controls. GluA3-/Y mice had a significantly reduced spontaneous activities tested by elevated plus maze, display both low social approach and resistance to change in routine on the T-maze, consistent with an ID-like phenotype. These findings demonstrate that selective gene deletion of GluA3 receptor in male mice under oxidative stress induced phenotypic abnormalities related to ID-like symptoms.

Patient Preference, Visual Quality, and Multivariate Regression Analysis with Contralateral Bifocal and Trifocal Intraocular Lenses.

To compare patient preference and visual quality of a bifocal IOL versus a trifocal IOL when one of each lens is implanted in the same patient. Patients received a +3.25 Tecnis bifocal IOL in one eye and a PanOptix trifocal IOL in the opposite eye. Eyes were unilaterally evaluated and included UDVA, UIVA, UNVA, mesopic contrast sensitivity testing, and subjective questionnaires about overall satisfaction, and IOL preference. Regression was used to detect which objective or subjective metrics significantly predicted overall satisfaction for each eye. Sixty eyes of thirty patients were evaluated. Patients preferred (p=0.028) +3.25 to PanOptix. Overall satisfaction was significantly greater (p=0.05) for +3.25 (4.70 vs 4.43/5.00). UDVA (p=0.032) and "freq. of glasses use distance" (p=0.05) were significantly better for +3.25 eyes. Objective intermediate (Jaeger) vision was significantly better (p=0.034) for PanOptix eyes. "Freq. of glasses use intermediate" favored +3.25. Regression revealed variables related to intermediate vision and "ability to read fine print without glasses" were significant predictors of overall satisfaction for both IOLs. Variables related to contrast sensitivity both with and without glare were significant predictors exclusively for PanOptix eyes. Patient preference favored +3.25 eyes (p=0.022). Individual rankings for each eye of "overall satisfaction" were significantly greater (p=0.05) for +3.25 eyes. UNVA and distance vision trended in favor of +3.25. Regression strongly suggests issues related to contrast sensitivity with PanOptix may be responsible for the significant patient preference of +3.25.

Inclusive Technology Performance Evaluation in the Production of Teff (Eragrostis tef (Zucc.) Trotter)

Different management practices likely to enhance teff production are used in Ethiopia, however, evidence on their relative performance is little studied or unavailable. This on-farm experiment was conducted to assess the performance of different management practices for teff productivity, profitability, and acceptability in subtropical districts of North East Amhara. Four trial treatments (viz., IKIM, IBIM, LBIM, and LBFM) were laid out in an unreplicated simple block considering farmers as replication during the main cropping seasons of 2019 and 2020. Tukey’s (HSD) test following one-way ANOVA, partial budget analysis, and weighted matrix ranking were used to explain the significance level, profitability, and preference traits, respectively. Results presented a significant ( p ≤ 0.01) treatment difference across districts in days to maturity, grain, and biomass yields. Among treatments, IKIM had short maturity days at Sekota (94), Dehana (105), and Lasta (95) districts. The grain yields were on average 1.75 ton ha−1, 1.45 ton ha−1, and 1.63 ton ha−1 at Sekota, Dehana, and Lasta districts, respectively. The lowest grain yields of 0.70 ton ha−1, 0.58 ton ha−1, and 0.63 ton ha−1 were recorded from LBFM. Despite the higher total variable costs, IKIM was gainful having 51400 ETB, 40579 ETB, and 46928 ETB net benefits at Sekota, Dehana, and Lasta districts, respectively. The MRR showed that a marginal profit of 13.77, 9.76, and 9.23 ETB was gained per each 1.00 ETB investment for shifting the practice (LBFM to IKIM). Therefore, we recommend IKIM as best management practice for consistent teff production in similar agroecological conditions.

Deployment of Causal Effect Estimation in Live Games of Dota 2

In this article, we provide an application that produces consistent in-game estimates of win probabilities in <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Dota 2</i> . Previous work shows that common methods of identifying the effect of in-game features are strongly inconsistent, which we corroborate here with a large dataset. We further provide an in-game application for players to see these estimates during the game as a training tool, along with displaying the estimated marginal impact of the primary actions (kills, last hits, and tower damage), which are previously known only by intuition. In a double-blind setting, we are the first to identify that users observe a difference between estimates produced by an inconsistent and consistent approach. Users show a significant preference for the consistent approach along several dimensions. Participants specifically identified the consistent approaches as having better quality advice by a large and significant margin, about four points on a ten-point scale.

The GAPS Programme at TNG

Aims. We present a novel method for studying the thermal emission of exoplanets as a function of orbital phase at very high spectral resolution, and use it to investigate the climate of the ultra-hot Jupiter KELT-9b. Methods. We combine three nights of HARPS-N and two nights of CARMENES optical spectra, covering orbital phases between quadratures (0.25 &lt; φ &lt; 0.75), when the planet shows its day-side hemisphere with different geometries. We co-add the signal of thousands of Fe I lines through cross-correlation, which we map to a likelihood function. We investigate the phase-dependence of two separate observable quantities, namely (i) the line depths of Fe I and (ii) their Doppler shifts, introducing a new method that exploits the very high spectral resolution of our observations. Results. We confirm a previous detection of Fe I emission, and demonstrate a precision of 0.5 km s−1 on the orbital properties of KELT-9b when combining all nights of observations. By studying the phase-resolved Doppler shift of Fe I lines, we detect an anomaly in the planet's orbital radial velocity well-fitted with a slightly eccentric orbital solution (e = 0.016 ± 0.003, ω = 150−11+13°, 5σ preference). However, we argue that this anomaly is caused by atmospheric circulation patterns, and can be explained if neutral iron gas is advected by day-to-night atmospheric wind flows of the order of a few km s−1. We additionally show that the Fe I emission line depths are symmetric around the substellar point within 10° (2σ), possibly indicating the lack of a large hot-spot offset at the altitude probed by neutral iron emission lines. Finally, we do not obtain a significant preference for models with a strong phase-dependence of the Fe I emission line strength. We show that these results are qualitatively compatible with predictions from general circulation models (GCMs) for ultra-hot Jupiter planets. Conclusions. Very high-resolution spectroscopy phase curves are of sufficient sensitivity to reveal a phase dependence in both the line depths and their Doppler shifts throughout the orbit. They constitute an under-exploited treasure trove of information that is highly complementary to space-based phase curves obtained with HST and JWST, and open a new window onto the still poorly understood climate and atmospheric structure of the hottest planets known to date.

Evaluation of prey stage preference of the phytoseiid predator, Neoseiulus longispinosus (Evans) to the spider mite pest, Tetranychus macfarlanei Baker and Pritchard (Acari: Tetranychidae)

Tetranychus macfarlanei Baker and Pritchard is considered as a major spider mite pest infesting various agricultural crops across the globe. It is a highly polyphagous species, inducing heavy yield loss annually, thereby affecting the agriculture sector drastically. As an eco-friendly pest management strategy, biological control using phytoseiid predators is gaining significant attention all over the world during the past few decades. Evaluation of predatory potential and prey stage preference provides valuable information on the efficacy of the predatory species in controlling the pest population. Considering this, a comparative evaluation of the feeding preference of a phytoseiid predator, Neoseiulus longispinosus (Evans), was made on different life stages of T. macfarlanei under laboratory conditions of 30±20C and 70±5% RH. The experimental arena used for the feeding experiments consisted of mulberry leaf discs (2 cm2) uniformly arranged over 2% semi-solidified agarose medium placed inside a glass Petri dish. The results revealed that the feeding preference of the adult predator towards the prey stages after 24 hours of experiment followed a decreasing sequence of egg (68%)&gt; nymph (13.3%)&gt; larva (6.6%). The predator nymph also followed a similar order of preference with respective consumption rates of 22%, 6.6% and 6.6% on the egg, larva and nymph of the prey mite, indicating that both the nymphs and the adult females of the predator displayed a significant preference to feed on the eggs of T. macfarlanei. Both predatory life stages showed no preference to the adult females of T. macfarlanei. Statistical analysis using ANOVA revealed a significant variation (p &lt; 0.05) in the feeding preference of the predatory life stages towards the varied prey stages. Thus, the results of the study clearly showed the bio-control potential of N. longispinosus against T. macfarlanei.

The effectiveness of Foley catheter balloon tamponade versus expanding sponges and hemostatic granules for catastrophic penetrating groin hemorrhage with small skin defect: A comparative study in a live tissue porcine model with evaluation of a concise training program.

Prompt bleeding control in the prehospital phase is essential to improve survival from catastrophic junctional hemorrhage. This study aimed to compare the effectiveness and practicality of Foley catheter balloon tamponade (FCBT), Celox-A, and XSTAT for the treatment of catastrophic hemorrhage from penetrating groin injuries with a small skin defect in a live-tissue porcine model. In addition, this study aimed to determine whether a training program could train military personnel in application of these advanced bleeding control adjuncts. A standardized wound was created in 18 groins from 9 anesthetized swine. Eighteen military medics participated in the training program and performed a bleeding control procedure after randomization over the swine and test products and after transection of the femoral neurovascular bundle. Primary endpoints were bleeding control, time to bleeding control, rebleeding, blood loss, medic performance, and user product rating. No significant differences were found in vital signs and laboratory values between the groups. In the Celox-A group, 3/6 groins achieved hemorrhage control. This was 6/6 in the XSTAT and FCBT groups. XSTAT scored best on application time, time to obtain hemorrhage control, hemorrhage control score, and practicality. No significant differences were found between groups for rebleeding, amount of blood loss, and medic performance. Military medics had a significant higher preference for XSTAT over Celox-A. This was not significant for FCBT. All tested products proved effective in obtaining hemorrhage control. XSTAT has the highest effectivity and shortest application time for the treatment of catastrophic bleeding from nonpackable, penetrating junctional groin injuries with a small skin defect, compared with Celox-A and FCBT. XSTAT scored best on practicality. This study shows that our training curriculum can be used to train military medics with limited prior experience in the use of advanced bleeding control techniques for penetrating junctional groin injuries with small skin defect.

Regulating cobalt chemical state by CeO2 facets preferred exposure for improved ethanol steam reforming

Regulating the chemical state of Co sites to develop high-performance Co-based catalysts for ethanol steam reforming reaction is desirable but challenging. Herein, we report an effective strategy of tuning chemical states of Co sites by preferred exposure of CeO2 facets. The as-prepared Co/CeO2-(M) and Co/CeO2-(U) catalysts have exposure preference of (111) facet and (100) facet of CeO2 supports, respectively. The results demonstrate that the Co/CeO2-(M) has Co sites in lower oxidation state and exhibits higher CC bond cleavage capability and more excellent catalytic performance for ethanol steam reforming reaction than Co/CeO2-(U), the hydrogen selectivity reaches as high as 97% at ethanol conversion of 100%. In situ synchrotron radiation photoionization mass spectrometry and density functional theory calculations reveal that Co site in low oxidation state has a significant preference for carbon chain shortening by CC cleavage over carbon chain lengthening by condensation reaction, thus improving the hydrogen production efficiency of ethanol steam reforming reaction. This work provides an effective strategy to enhance the catalytic performances of Co-based catalysts for ethanol steam reforming reaction and expands the understanding about ethanol steam reforming reaction mechanism.

Color preference of Sergentomyia minuta (Diptera: Phlebotominae) determined using Flebocollect Do It Yourself light traps based on LED technology

Whether phlebotomine sand flies show a preference for different light colors remains controversial. As light-capture methods are widely used to study sand flies, knowing the visual stimuli they respond to could help the design of novel control tools to prevent their attraction to hosts. We have detected a significant preference of male Sergentomyia minuta for green and red light sources. Accordingly, male S. minuta were 2.16 and 2.01 times more likely to be lured by Flebocollect model traps with green and red diode-lights, respectively, than the commercial CDC traps. Flebocollect traps are homemade light traps developed through citizen science. Dipterans are widely considered unable to distinguish the color red so this finding was unexpected. To our knowledge, this is the first description of a color preference in a species of the genus Sergentomyia. Our research also confirms the great potential of Flebocollect light traps for use in medical entomology studies.

Consumer Preferences for Animal Welfare in China: Optimization of Pork Production-Marketing Chains.

Consumption demands for pork produced by farms that employ strategies to improve animal welfare ("animal welfare pork") will be an important indicator for predicting domestic pig feeding standards and pork industry development. This paper analyzes consumer preferences for animal welfare pork based on the choice experiment data of 1274 pork consumers in Guangdong province, China. The results show that consumers had a significant preference for animal welfare pork and that they were willing to pay a premium of 2.359-10.477 CNY/500 g (5.27-23.39%) on average. There is heterogeneity in consumer preferences regarding age, education level, and income. Producers of animal-derived products can not only adjust the mix of production conditions to improve pig welfare and innovate contractual arrangements for industry chain stakeholder groups, but they can also develop differentiated marketing strategies for animal welfare products to meet consumer demands for animal welfare.

PSAT097 Patient Preference Research: Preferred Adjunctive Medication Attributes of Adult Patients with Classic Congenital Adrenal Hyperplasia

Abstract Background People with classic congenital adrenal hyperplasia (CAH) often require supraphysiologic doses of glucocorticoids (e.g., hydrocortisone, dexamethasone) to treat cortisol deficiency and excess androgen production. Healthcare providers and patients continually try to balance androgen control with side effects from supraphysiologic glucocorticoids. This study aimed to understand the preferences of adults with classic CAH regarding benefits of a potential new adjunctive medication that may provide better androgen control and allow for lower glucocorticoid doses. Methods Discrete choice experiment (DCE) methodology was used to calculate the relative stated preferences for the additional therapy's hypothetical benefits (attributes). Seven attributes were developed for the DCE after review of relevant data and qualitative literature, interviews with eight adults with classic CAH and input from two endocrinologists. The online DCE survey was piloted via interviews with three adults with classic CAH and a soft launch, which confirmed survey content and functioning. Preference data and subgroup differences were analyzed using conditional logit and scale assessment modelling, respectively. Results US adults with classic CAH (N=118, 75% female, age 19–69) valued avoidance of glucocorticoid-induced weight gain by twice the magnitude of other treatment attributes (all coefficients p&amp;lt;0.001 compared to baseline levels of no avoidance/decrease/improvement): complete avoidance of weight gain from glucocorticoids (1.109); moderate decrease in risk of developing health conditions from long-term glucocorticoids: type 2 diabetes (0.540), osteopenia, osteoporosis, fractures (0.521) and cardiovascular disease (0.502); moderate improvement in: fatigue (0.439), fertility (0.437) and excessive body hair (females only) and acne (0.410). Avoidance of glucocorticoid-induced weight gain remained the most preferred attribute across all subgroup analyses. Avoidance of glucocorticoid-induced weight gain was relatively much more important to females (n=89) than males (n=28) and participants with a body mass index ≥30 (n=70) than &amp;lt;30 (n=48). Improvement in fertility was more important to males than females, was valued by participants aged 18–45 (n=82) but was not a significant preference in participants &amp;gt;45 (n=36) and was relatively more important to participants with fertility problems (n=31) than without (n=87). Improvement in hirsutism and acne was highly valued by participants with excessive hair growth (n=38) but had the lowest preference among those without (n=80). Improvement in fatigue was a significant preference for participants with energy problems (n=73) but was not significant for those without (n=45). Conclusions The strong and consistent preference for avoiding glucocorticoid-induced weight gain suggests that patients with classic CAH would most value a novel adjunctive therapy that helps mitigate glucocorticoid-induced weight gain. In relation to other potential adjunctive therapy benefits, reduced risk of glucocorticoid-driven side effects may be valued more than improvement in fatigue or androgen-driven adverse events (fertility and hirsutism/acne). However, subgroup analyses indicated that individuals’ characteristics impact their treatment preferences and priorities, after avoidance of glucocorticoid-induced weight gain. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m.

An Ant-Mimicking Jumping Spider Achieves Higher Predation Probability with Lower Success Rate When Exposed to Ethanol.

Ethanol (ETOH) affects many animals' behaviour in nature; for example, honeybees become more aggressive after consuming ETOH. In previous studies, scientists have used honeybees and fruit flies as models to determine if they showed a strong preference to ETOH. Moreover, ETOH could affect their locomotion and learning abilities. However, whether and how ETOH affects spiders is unclear as of yet. In this study, we used empirical experiments to determine whether spiders showed preference for ETOH, as well as the potential benefits of spiders choosing ETOH, by using a common spider, Myrmarachne gisti, which has a high probability of contacting ETOH in their habitat. In our experiment, M. gisti showed a significant preference for ETOH. Although the success rate of the first attack was significantly decreased when M. gisti were exposed to ETOH, they had a significantly higher predation probability, since fruit flies also showed a significant preference for ETOH. Our findings suggested that ETOH could affect the prey capture efficiency of M. gisti, and indicated that spiders might evolve to use ETOH to locate a potential hunting place. Taken together, our findings suggested that M. gisti evolved to adapt to ETOH and could use it as a signal of the presence of food resources.

A comparative DFT study of ethanol steam reforming over Co(1 0 0) and CoO(1 0 0) surfaces: Molecular reaction mechanism

Unraveling the roles of cobalt sites with different oxidation states is crucial for understanding mechanism of cobalt-catalyzed ethanol steam reforming (ESR) reaction. In this work, the roles of Co(0) and Co(II) sites in ESR reaction are comparatively explored by DFT calculation studies about reaction pathways over Co(100) and CoO(100) surfaces, and a novel molecular reaction mechanism has been provided. The results demonstrate that the Co(II) site in Co-based catalyst exhibits distinct preference for dehydrogenation over dehydration of ethanol especially in the presence of H2O molecule. For the conversion of acetaldehyde, the Co(0) site exhibits significant preference for decomposition and water addition over aldol addition of acetaldehyde, thus facilitating the carbon chain shortening to improve ethanol steam reforming. Therefore, the Co(0) and Co(II) sites exhibit synergistic effects on ESR reaction, especially the role of Co(0) site in selective conversion of acetaldehyde is more crucial for high-efficiency reforming of ethanol.

Owner preference for insulin delivery device and glycaemic control in diabetic dogs.

To assess treatment satisfaction and owner preference for two delivery devices (VetPen, MSD Animal Health, and U40 insulin syringes) and the effect on glycaemic control in diabetic dogs treated with porcine insulin zinc suspension. Randomised prospective cross-over study with two arms, each of 8 weeks. Twenty client-owned diabetic dogs on insulin treatment by U40 syringe were enrolled. Dogs were randomly assigned to receive insulin by syringe or pen injector for 2 months, followed by 2 months of the other injection method. Treatment satisfaction and owners' insulin delivery device preference were assessed using a questionnaire. Glycaemic control was assessed using a clinical score, serum fructosamine and glycated haemoglobin (HbA1c%) at the time of the enrolment (T0) and the end of each arm of treatment (T2 and T4). Treatment satisfaction differed for the two types of the delivery device when the order that each device was used was taken into consideration. Owners who used the syringe first did not have a significant preference for an injection device. In contrast, owners who used the pen injector first expressed a significant preference for VetPen compared to syringes. No significant differences in the number of dogs of Groups 1 and 2 with good and poor glycaemic control at T2 and T4 were detected. Overall treatment satisfaction and preference for the two delivery methods were similar. However, VetPen was preferred by owners who were randomised to use this device first. Glycaemic control did not appear to be affected by the insulin delivery device used.