INTRODUCTION: Our purpose was to compare quality of life (QOL) and recurrence after modified Lichtenstein (ML), transabdominal preperitoneal (TAPP), or totally extraperitoneal inguinal hernia repair (TEP IHR). METHODS: Prospective, multicenter, international data were queried for ML, TAPP, and TEP IHR outcomes. QOL data, with “Symptomatic” defined as a Carolinas Comfort Scale (CCS) score ≥2, was derived from third party–collected, patient-reported outcomes. Regression and subgroup analyses were used to determine confounders and significant predictors of QOL. RESULTS: A total of 2,619 patients were included (1,467 ML vs 628 TAPP vs 524 TEP). CCS was completed preoperatively (97.6%) and at 1 (87.6%), 6 (76.0%), 12 (83.4%), and 24 months (72.1%) postoperatively. Comparing techniques (ML vs TAPP vs TEP), there were more symptomatic TEP patients preoperatively (50.4% vs 53.8% vs 60.5%; p < 0.001), but no difference at 1 (25.0% vs 29.6% vs 24.0%; p = 0.062), 6 (13.8% vs 13.3% vs 13.3%; p = 0.062), 12 (13.1% vs 12.9% vs 16.4%; p = 0.193), or 24 months (11.5% vs 9.5% vs 11.7%; p = 0.485). In regression analysis, predictors of being symptomatic at 1 month included younger age (1.02/y, 1.001 to 1.022; p = 0.003), bilateral (1.6, 1.2 to 2.2; p < 0.001), preoperative symptoms (1.9, 1.5 to 2.4; p < 0.001), open vs TEP (1.4, 1.01 to 2.0; p = 0.014), and TAPP vs TEP (1.7, 1.2 to 2.4; p = 0.014). At 24 months, it included younger age (1.02/y, 1.01 to 1.03; p < 0.001), recurrent hernia (2.4, 1.5 to 3.7; p < 0.001), and preoperative symptoms (1.7, 1.2 to 2.4; p = 0.002). Recurrence was similar (2.9% vs 2.1% vs 3.1%; p = 0.76). Odds of recurrence were increased for patients with previous failed IHR (3.0, 1.2 to 7.0; p = 0.014). Subgroup analyses showed no difference in recurrence or QOL at any time point (Table 1), except increased symptoms 1 month after TAPP for unilateral, recurrent hernia (21.9% vs 44.1% vs 24.5%; p = 0.03). Compared with asymptomatic patients, patients with preoperative symptoms were more likely symptomatic 24 months after ML (6.9% vs 15.2%; p < 0.001) or TEP (8% vs 14.8%; p = 0.027), with a similar trend for TAPP (7.0% vs 12.1%; p = 0.057) with no difference in recurrence (ML: 2.4% vs 3.5%; p = 0.195, TAPP: 1.0% vs 2.9%; p = 0.311, and TEP: 2.7% vs 3.3%; p = 0.836). Table 1. - Proportion of Symptomatic Patients at 24 Month Follow-Up Characteristic ML TAPP TEP p Value * All hernia types (N = 1467 vs 628 vs 524)† 11.5% 9.5% 11.7% 0.48 Subgroups Unilateral primary hernia (N = 1258 vs 373 vs 267) 10.5% 8.9% 9.2% 0.67 Unilateral recurrent hernia (N = 116 vs 36 vs 72) 15.2% 19.2% 21.4% 0.63 Bilateral primary hernia (N = 84 vs 191 vs 162) 14.7% 7.6% 12.1% 0.24 Symptomatic preoperatively (N = 722 vs 329 vs 309) 15.2% 12.1% 14.8% 0.51 Nonsymptomatic preoperatively (N = 710 vs 283 vs 202) 6.9% 7.0% 8.0% 0.84 *p value determined using chi-square test.†Number of patients in ML vs TAPP vs TEP.ML, modified Lichtenstein; TAPP, transabdominal preperitoneal; TEP, totally extraperitoneal. CONCLUSION: There was no difference in long-term QOL or recurrence after laparoscopic (TEP/TAPP) vs open ML. Preoperative asymptomatic patients had better QOL outcomes than patients with symptoms. Surgeons should perform IHR with the technique in which they are most confident.