Significant Positive Association Research Articles

The impact of social comparison orientation on malicious envy among high school students: The chain mediating role of avoidance goal orientation and negative rumination

The high school stage is a critical period for students to develop their perspectives on life and to form healthy relationships with others. This study aimed to investigate the relationship between social comparison orientation and malicious envy among high school students, as well as the mediating effects of avoidance goal orientation and negative rumination. A survey was conducted with 643 high school students, employing the Iowa-Netherlands Comparison Orientation Measure, the Avoidance Goal Orientation Scale, the Negative Rumination Scale, and the Malicious Envy Scale. The findings indicated that: (1) there is a significant positive association between social comparison orientation, avoidance goal orientation, negative rumination, and malicious envy; (2) social comparison orientation does not directly and significantly predict malicious envy among high school students when avoidance goal orientation and negative rumination are considered as mediating factors; (3) social comparison orientation indirectly affects the negative rumination of high school students through the independent and chain mediating effects of avoidance goal orientation and negative rumination. This research sheds light on the underlying mechanisms by which social comparison orientation influences malicious envy.

Magnetic resonance imaging findings in dogs with steroid-responsive meningitis-arteritis in the UK and their clinical significance: 53 cases (2013-2021).

To describe the MRI findings in a UK referral population of dogs with steroid-responsive meningitis-arteritis and to determine if they were associated with any specific clinical features or outcomes. We performed a multi-centre retrospective case series of dogs diagnosed with steroid-responsive meningitis-arteritis in the UK that underwent MRI. Blinded consensus review of the MRI studies was performed and the findings described. The presence or absence of specific MRI abnormalities were analysed for significant associations with presenting signs, results of investigations or case outcomes. Fifty-three dogs were included. The most common MRI findings were paravertebral muscle changes (30/53; 56.6%), meningeal contrast enhancement (13/41; 31.7%) and spinal cord parenchymal T2-W hyperintensity (15/53; 28.3%). Haemorrhage was observed in five of 53 (9.4%) cases - three intradural-extramedullary, one intramedullary and one extradural. Following binary logistic regressions, T2-W spinal cord parenchymal hyperintensity had a significant positive association with paresis/paralysis (odds ratio 14.86, 95% confidence interval 1.42 to 154.99) as did haemorrhage (odds ratio 16.12, confidence interval 2.05 to 126.73). Fifty-two (98.1%) dogs survived to discharge. Relapse occurred in nine of 29 (31.0%) dogs with sufficient follow-up, and no MRI finding had a significant relationship with its occurrence. Magnetic resonance imaging findings for steroid-responsive meningitis-arteritis can be severe and extensive, as can the clinical presentation. The presence of paresis/paralysis should raise concern for haemorrhage, though most dogs still have a good prognosis.

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The present study tested the mediating role of problematic TikTok use in the relationship between academic stress and academic procrastination, as well as any gender differences. A total of 590 Chinese university students, aged between 17 and 24 years, completed questionnaires measuring their levels of academic stress and academic procrastination at Time 1 (T1), reported on problematic TikTok use at Time 2 (T2) six months later, and academic procrastination at Time 3 (T3) another six months later, while also providing demographic information. The results revealed significant positive associations between T1 academic stress, T1 academic procrastination, T2 problematic TikTok use, and T3 academic procrastination. Moreover, after controlling for age, urban-rural background, family income, TikTok use time, and T1 academic procrastination, T2 problematic TikTok use was found to mediate the longitudinal relationship between T1 academic stress and T3 academic procrastination. Furthermore, gender played a significant moderating role, with the mediating effect being observed only among male university students. The present study is one of the first to explore how problematic TikTok use and gender contribute to the longitudinal effects of academic stress on academic procrastination. The results offer valuable insights into strategies for preventing and managing problematic TikTok use and academic procrastination among university students.

Prospective associations between an empirically derived dietary pattern and life satisfaction in Malaysian adolescents

BackgroundLittle is known on the prospective associations between an empirically derived dietary pattern (DP) and life satisfaction among adolescents. This PUTRA-Adol follow-up study aimed to assess the prospective associations between the empirically derived DP and life satisfaction during adolescence.MethodsA total of 585 and 262 adolescents participated in the baseline PUTRA-Adol study in 2016 and PUTRA-Adol follow-up study in 2019–2020, respectively. These adolescents were recruited from three southern states in peninsular Malaysia, namely Negeri Sembilan, Melaka and Johor. Dietary assessments were estimated using a validated food frequency questionnaire (FFQ) while a Multidimensional Students’ Life Satisfaction Scale (MSLSS) was used to measure life satisfaction at baseline in 2016 as well as at follow-up in 2019–2020. A DP characterised by foods high in free sugar and energy dense was identified using reduced rank regression (RRR), cross-sectionally at baseline and was reported elsewhere. Similar RRR analysis was used to find a DP that best explained the variation in response variables linked to poorer life satisfaction, including dietary energy density (DED), fiber density, and percentage of energy from total fat and sugar at the PUTRA-Adol follow-up study. Prospective relationship between adherence to the identified DPs and overall life satisfaction scores as well as its domains between 2016 and 2019–2020 were evaluated using generalized estimating equation models (GEE).ResultsA DP characterized by high intakes of percentage energy from sugar, fibre and low in DED and percentage energy from total fat was identified at the 2019–2020 follow-up. The identified DP explained 11% of total variations in the response variables and was characterized by high intakes of sweets, sugar sweetened beverages (SSB) and fruits. Female adolescents [67.6(8.9)] had a mean (SD) of life satisfaction that was higher than male adolescents [67.5(10.8)] p < 0.05 in 2019–2020. Prospective analysis found a significant positive association between the identified DP and school domain, in male adolescents (β = 0.117; 95% CI 0.001, 0.234) and an inverse relationship between the DP z-score and self-domain in all adolescents (β = − 0.060; 95% CI − 0.115, − 0.005) from 2016 to 2019–2020.ConclusionsAn increasing score for the predominant ‘High sugar and High fibre’ DP was prospectively associated with increasing life satisfaction score for the school domain in male adolescents and decreasing score for self-domain in both male and females during adolescence. A lifestyle intervention targeting reduced dietary intakes, particularly sugar, may improve life satisfaction in adolescents and promote healthier future without compromising dietary intakes for chronic disease prevention later in life.

The moderating role of corporate governance mechanism on the relationship between product market competition and earnings management: evidence from Bangladesh

ABSTRACT This article evaluates the moderating effects of corporate governance mechanisms on the relationship between earnings management and product market competition. Market concentration, as measured by the HHI has shown significantly negative association with accrual and real earnings management. In contrast, product market power, as measured by the industry size, demonstrates a significant positive association. The result further illustrates that the cost of industry entry significantly impacts accrual earnings management. The corporate governance mechanism (CGI) significantly decreases earnings manipulation. Moreover, the corporate governance mechanism (CGI) considerably moderates the association between market concentration, industry entry cost, and earnings management. Compared to high and low-competitive industries, the impact of market competition on earnings management in moderately competitive industries is more significant. After establishing the Bangladesh Competition Commission, product market competition has shown more impact on earnings management. This research is the initial attempt to examine the moderating effect of corporate governance mechanisms on the relationship between product market competition and earnings management from the perspective of Bangladesh.

Associations between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hyperuricemia: a cross-sectional study

Background and objectiveThe value of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) assessment in the context of metabolic abnormalities is growing in importance. Nevertheless, the relationship between NHHR and hyperuricemia (HUA) is unknown. This study seeks to investigate the relationship between NHHR and HUA.MethodsThe data derived from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) included 7,876 adult participants. The multivariable logistic regression model, subgroup analysis and smooth fitting curve were utilized in order to investigate the association between NHHR and HUA.ResultsIn the fully adjusted model 3, NHHR was significantly associated with HUA. Specifically, participants in the highest quartile of NHHR had 1.95 times higher odds of HUA prevalence compared to those in the lowest quartile [2.95 (2.39, 3.64), P < 0.0001]. Although the overall trend suggested a positive association, further analysis using smooth fitting curves and threshold effect analysis indicated that this association was nonlinear, with an inflection point at 5.8. The positive association persisted across different HUA definitions and after removing outliers. Subgroup analysis showed significant interactions between NHHR and HUA in different races and diabetes statuses. The odds of HUA prevalence were higher among non-diabetic participants [1.40 (1.32, 1.49), P < 0.0001] compared to diabetic participants [1.18 (1.06, 1.32), P = 0.0031]. Mexican Americans had the lowest odds of HUA prevalence [1.09 (0.92, 1.27), P = 0.2413] compared to other races.ConclusionsThere is a significant positive association between NHHR and HUA, indicating that NHHR may serve as a potential risk assessment maker for HUA, although further prospective studies are needed for validation.

Age has an independent association with total cost of care in adults admitted to pediatric hospitals.

Previous studies in adults admitted to pediatric hospitals primarily investigated associations between complex chronic condition characteristics and patient outcomes. Our study explored the association of age with length of stay (LOS) and total cost in these adults, accounting for other patient factors. Using the Pediatric Health Information System, we included 1,215,736 patient encounters from 2021 to 2022. Unadjusted and adjusted analyses were performed using bivariable and multivariable log-linear regression. There was a significant positive association between age and total cost, with adults 18-20 years having 13% higher total cost (95% confidence interval [CI]: 12%-15%), 21-25 years with 25% higher total cost (95% CI: 22%-29%), and 25-99 years having 72% higher total cost (95% CI: 66%-79%) than 1-17 years. Our findings suggest expanding upon the existing status quo to identify the most appropriate environment to care for this unique and growing population, especially given the anticipated reduction in pediatric beds and subspecialty expertise.

Succession of Major Pests and Predatory Fauna in Okra

Investigations on pest succession in okra crops were carried out during kharif, 2023 at the Department of Entomology, B. A. College of Agriculture, Anand Agricultural University, Anand. Pest succession based on crop growth stages showed that the population of sucking insect-pests viz., jassid (Amrasca biguttula biguttula Ishida), aphid (Aphis gossypii Glover), whitefly (Bemisia tabaci Gennadius.) observed from vegetative stage and remained up to crop matured while, red spider mite, Tetranychus cinnabarinus incidence appeared from reproductive stage to maturity stage. Among the lepidopteran pests, the infestation of semi-looper, Anomis flava (Fabricius) started in the second week after germination and remained till maturity of the crop whereas, shoot and fruit borer (Earias insulana Boisd.) and fruit borer (Helicoverpa armigera (Hubner) Hardwick) damaged the crop from the vegetative stage and remained up to crop maturity. Coccinellids and spider activity initiated with sucking insect-pest incidence and remained up to crop maturity. The weather parameters, Bright sunshine hours and maximum minimum temperature had significant relationships with A. biguttula biguttula, T. cinnabarinus, E. vittella and H. armigera. Whereas, relative humidity significantly negatively influenced the activity of red spider mite, E. vittella, H. armigera and positively on predator coccinellids. Furthermore, windspeed had a significant positive association with A. biguttula biguttula and E. vittella (shoot damage) while, negative with H. armigera larva.

Urine metabolomic profiles of autism and autistic traits-A twin study.

Currently, there are no reliable biomarkers for autism diagnosis. The heterogeneity of autism and several co-occurring conditions are key challenges to establishing these. Here, we used untargeted mass spectrometry-based urine metabolomics to investigate metabolic differences for autism diagnosis and autistic traits in a well-characterized twin cohort (N = 105). We identified 208 metabolites in the urine samples of the twins. No clear, significant metabolic drivers for autism diagnosis were detected when controlling for other neurodevelopmental conditions. However, we identified nominally significant changes for several metabolites. For instance, phenylpyruvate (p = 0.019) and taurine (p = 0.032) were elevated in the autism group, while carnitine (p = 0.047) was reduced. We furthermore accounted for the shared factors, such as genetics within the twin pairs, and report additional metabolite differences. Based on the nominally significant metabolites for autism diagnosis, the arginine and proline metabolism pathway (p = 0.024) was enriched. We also investigated the association between quantitative autistic traits, as measured by the Social Responsiveness Scale 2nd Edition, and metabolite differences, identifying a greater number of nominally significant metabolites and pathways. A significant positive association between indole-3-acetate and autistic traits was observed within the twin pairs (adjusted p = 0.031). The utility of urine biomarkers in autism, therefore, remains unclear, with mixed findings from different study populations.

An examination of the ohio scales, short form, hopefulness domain, youth- and caregiver-report versions in a community care setting

The current study examined the utility of the Ohio Scales, Hopefulness Scale (OS Hopefulness Scale; Ogles et al., 2004), a free multi-informant four-item measure of hopefulness used within a large statewide public mental health care system. Collectively, the six aims of this study (done for both youth- and caregiver-report versions) examined (a) the measure’s factor structure and (b) internal consistency, (c) the relationship between youth- and caregiver-reported hopefulness, (d) the measure’s relationships with numerous domains of psychopathology (e.g., depression, anxiety, delinquency) and (e) functioning, and (f) sensitivity to change. Using a sample of 986 participants, who were ethnically diverse (30.5 % multiethnic, n = 301), 61.0 % male (n = 601), with an average age of 12.74 (SD=3.46), the study found good factor structure, acceptable internal consistency, and a significant positive association between youth-reported and caregiver-hopefulness. Additionally, significant inverse relationships were found between caregiver-reported hopefulness with youth mental health problems and youth functioning; while youth-reported hopefulness was found to be significantly inversely related to youth mental health problems but not youth functioning. Finally, significant positive changes in hopefulness and significant inverse relationships with youth functioning were also evident at three-month follow up for both youth- and caregiver-reported hopefulness. The constellation of our findings demonstrates potential for this four-item measure of hopefulness to be a useful, efficient, and cost-effective tool with ethnically diverse samples, which are substantially different from samples included in previous studies of hopefulness. Implications and suggestions for future research are discussed.

Navigating the entrepreneurial landscape: The interplay of government support and self-efficacy in entrepreneurial education

Building upon the core concept of Ajzen's Theory of Planned Behavior, this study aims to investigate the dynamic relationship between Entrepreneurial Education (EED) and business success, considering the mediating roles of Government support and entrepreneurs' self-efficacy beliefs. The study collected data from a sample of 300 small business owners in the Peshawar district of Pakistan, utilizing adapted constructs and analyzing the data through measurement and structural modeling using Smart PLS. The results reveal a significant positive association between EED and business success among business owners. Similarly, Government support is found to play a role in fostering a culture of EED among these business owners. When examining mediating factors, Government support is shown to mediate the relationship between an individual's EED and their business success, whereas it does not significantly mediate the relationship between an individual's Entrepreneurial Self-Efficacy (ESE) and business success. Conversely, Entrepreneurial self-efficacy is identified as a potential mediator between EED and business success. However, it does not mediate the relationship between Government support and business success. Based on the findings, it is concluded that government support significantly contributes to shaping the relationship between Entrepreneurship Education (EED) and business success within the SME sector in developing countries. Likewise, the self-efficacy of business owners is identified as a pivotal individual element that positively influences business success in various circumstances. The study suggests that the SME sector in developing countries can thrive with the support of government initiatives promoting Entrepreneurial Education.

Prognostic Significance and Biologic Associations of Senescence-Associated Secretory Phenotype Biomarkers in Heart Failure.

The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach. We measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in these proteins to generate SASP factor scores and assessed the relationship between these SASP factor scores and (1) all-cause death and (2) the composite of death or HF hospital admission. We also assessed the relationship of each SASP factor to 4746 other proteins, correcting for multiple comparisons, followed by pathway analyses. Two SASP factors were identified. Both factors were associated with older age, lower estimated glomerular filtration rate, and more advanced New York Heart Association class, among other clinical variables. Both SASP factors exhibited a significant positive association with the risk of death independent of the Meta-Analysis of Global-Group in Chronic HF score and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. The 2 identified SASP factors were associated with 1201 and 1554 proteins, respectively, belonging to various pathways including the coagulation system, complement system, acute phase response signaling, and retinoid X receptor-related pathways that regulate cell metabolism. Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.

Carotid Intima-Media Thickness in Indian Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and a Meta-Analysis.

There is a significant association of non-alcoholic fatty liver disease (NAFLD) with cardiovascular disease (CVD). Most CVDs beginwith atherosclerosis in the arteries, which can be reliably measured as the carotid intima-media thickness (CIMT) by ultrasound. Given that ethnic and regional differences have an impact on NAFLD, we aimed to evaluate the association of NAFLD patients from India with subclinical atherosclerosis, measured as CIMT. A thorough literature search was performed on four electronic databases using combinations of several keywords. The relevant data were pooled in a random or fixed-effect model, based on heterogeneity,to calculate the pooled standardised mean difference (SMD), or odds ratio (OR) with 95% confidence interval (CI). The final analysis included a total of 15 studies with 1196 NAFLD and 1482 control subjects. NAFLD patients had a 21.3% higher mean CIMT than the controls. The pooled SMD was 1.001 (95% CI: 0.627-1.375, p < 0.001). Three studies that balanced cardiometabolic risk factors found a similar association (p = 0.037). Furthermore, NAFLD was significantly associated with the presence of high (>0.8 mm) CIMT (pooled OR = 5.4, 95% CI: 2.0-14 .9) and carotid plaques (pooled OR = 10.24, 95% CI: 5.74-18.26). The mean CIMT was also higher in diabetic NAFLD than in the diabetic control (pooled SMD = 1.07, 95% CI = 0.818-1.324, p < 0.001). There is a significant positive association between the marker of subclinical atherosclerosis and NAFLD in India. This might give more light on screening and follow-up plans for such patients.

The association between Internet use and intrinsic capacity among older adults in China: The mediating role of social participation.

This study aims to explore the relationship between Internet use and intrinsic capability among Chinese older adults, and the potential mediating role of social participation. We verified the correlation between Internet use and intrinsic capacity using multiple linear regression and verified the mediating role of social participation using the Sobel and Bootstrap tests. The results of multiple linear regression show that there is a significant positive association between Internet use and intrinsic capacity (B=0.717, p<.001); and social participation plays a mediating role, explaining a total of 20.5% of the association (indirect effect=0.147, 95% CI: 0.067-0.227). Our findings suggest that Internet use significantly improves intrinsic capacity among Chinese older adults, with social participation playing a mediating role. Increasing Internet adoption rates and promoting social participation may help improve intrinsic capacity among older adults.

The correlation between nutritional status and diet quality with acute respiratory infections in preschool children aged 5 to 7 years.

To investigate the relationship between nutritional status (NS) and diet quality (DQ) with the frequency of acute respiratory infections (ARIs) in children aged 5 to 7 years. Data were obtained through questionnaires. Anthropometric measurement, correlations between body mass index (BMI) and DQ with frequency of ARIs were analysed. A total of 129 children with an average age of 72.2±4.2 months were examined. Malnourished children had a 3.4 times higher probability of ARIs (OR=3.449; p=0.025, 95% CI=0.109-29.049) and a 5.6 times higher probability of bronchopneumonia compared to those with normal weight (OR=5.643; p=0.049, 95% CI=0.874-36.434). There was a significant positive association between the consumption of meat and meat products with bronchitis (p=0.030; OR 9.921; 95% CI -1.252, +78.610) and a significant negative relationship between the consumption of cooked meals and ARIs in total (p=0.015; OR 0.046; 95% CI -0.004, +0.552). Unexpectedly, a significant positive association was found between the consumption of fresh fruits and vegetables and some respiratory infections, which needs to be verified with additional analyses. DQ and NS are associated with the frequency of ARIs in preschool children. Additional analyses are needed with a larger number of participants in order to form more precise conclusions.

Causal Association of Rheumatoid Arthritis With Adverse Pregnancy Outcomes: Genetic Evidence From Mendelian Randomization.

Although the association of rheumatoid arthritis (RA) to multiple adverse pregnancy outcomes has been well-studied, the association between serum antibody levels in patients with RA and multiple adverse pregnancy outcomes has not been conclusively demonstrated. Here, we comprehensively assessed the causal impact of RA, serologic antibody-positive RA (pRA), and serologic antibody-negative RA (nRA) on the risk of 14 adverse pregnancy outcomes. The causal impact of RA, pRA, and nRA on 14 adverse pregnancy outcomes was comprehensively assessed using two-sample Mendelian randomization (MR). Evidence maps based on the results of these two-sample MR analyses were developed. Data from the UK Biobank and FinnGen databases were utilized for this analysis. The inverse variance weighted (IVW) test was employed as the primary method to estimate causality. "TwoSampleMR" and "MR-PRESSO" packages were used for data analysis in this study. Using two-sample MR analysis, we found a significant positive causal association between RA and increased risk of cesarean section (p=0.003), gestational hypertension (p < 0.001), number of spontaneous miscarriages (p=0.041), preeclampsia (p=0.008), premature rupture of membranes (p=0.030), and preterm (p=0.010). pRA had a significant positive causal association with an increased risk of cesarean section (p=0.012), gestational hypertension (p < 0.001), preeclampsia (p=0.002), and preterm (p=0.007). A significant positive causal association was also established between nRA and gestational hypertension (p=0.010), the number of spontaneous miscarriages (p=0.024), and placental abruption (p=0.027). In addition, we found a causal association between nRA and birth weight (p=0.007), but not between RA and pRA and birth weight. The results of this study have important implications for the individualized treatment of RA patients, especially those with positive serum antibody levels.

Did COVID-19 risk perceptions influence the handwashing behavior of the Filipino population?

The COVID-19 pandemic reminded people of the importance of proper handwashing. The degree of health risk perceptions and handwashing behavior during the COVID-19 pandemic opens essential lessons for delivering water, sanitation, and hygiene (WASH) programs across the globe. We measured the relationship between COVID-19 risk perception and the handwashing behavior of 386 Filipinos in a highly urbanized city in the Philippines. Self-made COVID-19 risk perception scale (CRPS) (Cronbach's α 0.93) and handwashing behavior scale (HBS) (Cronbach's α 0.84) were administered face-to-face. The results show that the overall handwashing behavior has a median of 4.1 (frequently), while the interquartile range (IQR) is 0.5. Regression analysis revealed that COVID-19 risk perception has a significant positive association with overall handwashing behavior (B=0.369, p-value &amp;lt;0.05). The COVID-19 risk perception accounts for 36.9% of the variance in handwashing behavior, F (1, 384) =11.6360, p-value=0.0007. This study proposes that public health authorities target people's experiential learning style in designing and delivering intervention programs against non-compliance with proper handwashing.

Relationship between sensory processing skills and motor skills in 12-month-old infants.

Identifying sensory processing problems of 12-month-old preterm and term children and defining their relationship with motor skills are essential for appropriate interventions and optimal sensory-motor development. This study aimed to determine sensory processing difficulties in 12-month-old babies and examine their relationship with motor skills. This cross-sectional study included 61 infants (28 preterm and 33 full-term, ages 12 months). The infants' sensory processing skills were evaluated using the Test of Sensory Functions in Infants (TSFI), and their gross and fine motor skills were assessed with the Peabody Developmental Motor Scales-2 (PDMS-2). Sensory processing difficulties were more common in preterm babies. Multiple linear regression models indicated a significant positive association between PDMS-2 gross/fine motor scores and TFSI total scores, reactivity to tactile deep pressure, and ocular-motor control in the total sample. Furthermore, there was a relationship between gross motor and adaptive motor function, and fine motor scores were found to be associated with visual-tactile integration sensory scores. Preterm babies are more likely than their full-term peers to have sensory processing problems around the age of one, which can affect their motor skills. The results support the relationship between children's sensory and motor processing skills. Practitioners such as occupational and physical therapists should be alert to this relationship in infants with sensory processing and motor problems. Taking this relationship into consideration when planning intervention programs can be a guide for an effective intervention.

Assessing the Utility of the Metabolic Score for Insulin Resistance (METS-IR) in Evaluating Metabolic Risk Among Individuals Undergoing Master Health Checkups in a Tertiary Care Hospital in South India: A Retrospective Cohort Study.

Background The metabolic score for insulin resistance (METS-IR) is a neoteric score for assessing insulin resistance that has been used as a non-insulin-based, objectively measured method. It is an easily accessible tool that can be used on a large scale to detect insulin resistance in a community. Methods We conducted a retrospective cohort study to explore the utility of this score in identifying metabolic risk in those individuals attending a master health checkup in a tertiary care setting. Data were collected from 254 individuals between October and December 2023. Results According to the univariate regression analysis, METS-IR had a strong correlation in predicting cardiovascular health risks, as evidenced by its positive linear association with an increase in age (β=0.186, p=0.003), weight (β=0.534, p<0.001), waist circumference (β=0.405, p<0.001), and body mass index (BMI; β=0.635, p<0.001). This explained the value of this score in depicting adiposity and insulin resistance. Lab parameters that showed a significant association were fasting blood sugar (β=0.176, p=0.005) and fasting triglycerides (β=0.175, p=0.005). According to the multivariate regression analysis, METS-IR had a significant positive association with fasting blood sugar (B=0.489, p<0.001) and fasting triglycerides (B=0.022, p=0.003), implicating its importance in cardiovascular health. High-density lipoprotein cholesterol (HDL-c; B=-0.168, p=0.005) confirmed its protective role with its negative association in higher quartile groups. An increase in serum albumin levels (B=-0.168, p=0.005) and raised gamma-glutamyl transpeptidase (GGT) (B=0.059, p=0.022) portrays its due diligence in liver health. METS-IR had a weak association with the estimated glomerular filtration rate (eGFR) with Pearson's correlation coefficient of 0.020 (p=0.756) and Spearman's rho of 0.021 (p=0.739). However, raised serum creatinine had a significant association in higher quartile groups, with a p-value of 0.018. Conclusions METS-IR is useful as a screening tool for predicting cardiovascular disease. However, the complex interplay of other confounding factors in identifying renal dysfunction has yet to be explored when considering this score in our study population.

The relationship between the tertiary lymphoid structure and immune-infiltrating cells in gastrointestinal cancers: A systematic review and meta-analysis.

This study systematically evaluated the relationship between tertiary lymphoid structures (TLS) and clinical pathological features as well as immune infiltrating cells in gastrointestinal cancers. We searched Web of science, Pubmed, Embase, and Cochrane Library for studies that met the requirements as of July 1, 2023, and the odds ratio, the corresponding 95% confidence interval or mean and standard deviation, were included in the analysis. We eventually included 20 studies, involving a total of 4856 patients. TLS were found to be significantly associated with T stage, N stage, TNM stage, and tumor size. Moreover, patients with positive TLS showed significantly elevated expression of T-cell related markers, including CD3, CD4, CD8, CD45RO; B-cell related markers, such as CD11c and CD20; and dendritic cell-related marker CD103. On the other hand, positive TLS correlated significantly with low expression of FOXP3 and CD68. Additionally, there was a significant positive association between TLS and overall infiltration of tumor-infiltrating lymphocytes. The presence of TLS is significantly correlated with the infiltration of various immune cells in gastrointestinal cancers. To determine the ideal balance between the presence of mature TLS and appropriate immune cell infiltration, further high-quality and multicenter clinical studies need to be conducted.