BackgroundThe aim of this study was to investigate the relationship between depression and healthy lifestyle behaviors of patients with a history of transplant. MethodsThis was a descriptive study. The study was conducted on 110 patients who received organ transplant and attended a university hospital in Istanbul, Turkey. Data were collected using a patient information form, the Beck Depression Inventory, and the Healthy Lifestyle Behaviors Scale-II. ResultsThe mean age of the patients in years ± SD was 45.8 ± 12.35; 60.9% of them were men; and the mean body mass index (kg/m2) was 26.9 ± 4.84. There was a statistically significant difference between nutrition subscale and body mass index. A statistically significant difference was found between the total score of healthy lifestyle behaviors, nutrition, and interpersonal relationships subdimension with education status. There was a statistically significant difference between health responsibility, nutrition, and interpersonal relationships subdimension with marital status. There was a statistically significant difference between health responsibility subdimension and income status. A statistically significant difference was found between nutrition, spiritual growth, interpersonal relationships, stress management subdimension with living alone or living with someone. There was a statistically significant difference between depression scores and elapsed time after transplantation. There was a significant moderate negative correlation between depression and healthy lifestyle behaviors scores. ConclusionAccording to results of this study, healthy lifestyle behaviors of patients with a history of organ transplant were affected by factors such as body mass index, education status, income status, and marital status. Depression levels decreased as healthy lifestyle behaviors improved for the patients of organ of the transplant.