Significant Increase In Total Lipids Research Articles

Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients

It has been noticed that there is an increase in the number of women suffering from SLE. Most studies confirmed that serum DHEA (dehydroepiandrosterone) and DHEA sulphate are lower among patients with SLE than among controls even- during phases of inactive disease so we performed this study to detect the level of DHEA-S in the female patients with SLE. The overall results confirm that DHEA treatment was well- tolerated, significantly reduced the number of SLE flares, and improved patient’s global assessment of disease activity. Some serum parameters like liver and kidney functions were detected. Biochemical analysis showed that there is a significant increase of total lipids, cholestrol, triglycerides. But insignificant change in serum glucose, urea nitrogen and uric acid levels were recorded. From the present study three things were concluded. Firstly, there is a strong relationship between level of DHEA and the progression of SLE. Secondly, liver activity and kidney functions were not affected by SLE disease.Thirdly, DHEA treatment has a beneficial effect on female patients. So this study recommended to follow up DHEAS in female patients and use it in a proper dosage. In addition, further study must be done.

Lindane Treatment Alters both Intestinal Mucosa Composition and Brush Border Enzymatic Activity in Chickens

Body weight gain decreased in chickens treated over 7 days with lindane at 30 mg/kg body wt (ip); no changes were found in chickens injected with lower doses (10 and 20 mg/kg). Compared to control animals, relative liver and small intestine weights were higher in all groups of chickens treated with lindane. Analysis of the chemical composition of intestinal mucosa showed a significant increase in total lipids, phospholipids, protein, and nucleic acid content, but there was no change in the cholesterol content in chickens exposed to lindane at 30 mg/kg. The activities of brush border maltase and alkaline phosphatase were significantly decreased in treated animals; however, sucrase and aminopeptidase N activities were not modified.

Effect of depo -medroxyprogesterone acetate on coagulation factors and serum lipids in Egyptian women

The short-term (3 months) and long-term (15 months) effect of DMPA contraception on various coagulation parameters (predictive of thrombosis) and on serum lipids (predicitve of atherosclerosis) were prospectively studied in 30 Egyptian women, compared to their pretreatment levels. There were no significant changes in all the coagulation parameters studied after 3 months, and there was only a significant reduction in antithrombin III (AT III) level after 15 months ( p < 0.01). Concerning serum lipids, after 3 months, there were no significant changes in total lipids (TL), total cholesterol (TC) and triglycerides (Tg), while there was a significant decrease in high density lipoprotein cholesterol (HDL-C) ( p < 0.001), and a significant increase in low density lipoprotein cholesterol (LDL-C) ( p < 0.01). After 15 months there was a significant increase in TL, TC and LDL-C ( p < 0.001) and a significant decrease in HDL-C ( p < 0.001).Lipoprotein electrophoresis showed no significant change in pre-beta-lipoprotein percent, a significant decrease in alpha-lipoprotein percent and a significant increase in beta-lipoprotein percent after 3 and 15 months ( p < 0.001). Beta-lipoprotein band increased in 50% of DMPA users after 3 months and in 90% after 15 months and the type of hyperlipoproteinaemia was IIa. All callculated atherogenic indices showed significant changes ( p < 0.001) after 3 and 15 months of DMPA use. There was no significant correlation between AT III changes and changes in serum lipids. The study suggests no risk of thrombosis after 3 and 15 months of DMPA use. However, the risk of atherosclerosis appears to be possible as there were significant changes in serum lipids.

Effects of the level of dietary protein on the toxicity of hexachlorocyclohexane in rats

Male albino rats were fed for 28 days from weaning on diets containing 5% (group 1), 10% (group 2) and 21% (group 3, normal protein) protein as casein. At the end of dietary period, HCH was administered daily for 30 days to investigate the interaction between protein deficiency and pesticide toxicity. The results indicated that rats fed a lower protein diet and HCH had a higher mortality, lower rate of growth, increased liver weight and deposition of the pesticide in blood and tissues in larger amounts. Blood pressure (systolic and diastolic) was significantly increased and the heart rate showed tachycardia in low protein exposed animals. A significant increase of total lipids, cholesterol, triglycirides, free fatty acids in serum and tissues of animals exposed to low protein was observed. A close correlation existed between lipid accumulation and storage of HCH in tissues and dietary protein seemed to play an important role in detoxification.

Effect of colocasia leaves (Colocasia antiquorum) on serum and tissue lipids in cholesterol-fed rats.

Dried colocasia powder (10% and 20%) was fed to hypercholesterolemic rats for a period of one month to explore the effect on serum lipids and tissue lipids. The results indicated that there was a significant increase in total lipids, total cholesterol, and triglycerides levels in the cholesterol fed rats. Liver cholesterol showed a slight reduction which was non-significant, while an increase in liver triglyceride was observed in rats fed with 10% and 20% colocasia leaves diet with or without cholesterol. All these observations indicate an aggravating effect of colocasia leaves on serum and tissue lipids in cholesterol-fed rats.

Effect of corticosterone on rat epididymal lipids.

Corticosterone-induced changes in serum hormone profiles and the lipid composition of the caput and cauda epididymidis were studied. The analysis was conducted in both unwashed and washed (free from fluids and spermatozoa) epididymal tissues. Corticosterone treatment significantly depressed serum prolactin and testosterone but gonadotropins were unaltered. In the unwashed caput region, lipid analysis showed a significant decrease in total lipids, as well as in cholesterol, phospholipid, and the phosphatidyl inositol, phosphatidyl choline, and phosphatidyl ethanolamine fractions. However, in the unwashed cauda region, the total lipid and cholesterol content was not altered while total phospholipid and phospholipid fractions were significantly decreased. On the other hand, in the washed caput and cauda regions, corticosterone induced a significant increase in total lipid, glyceride, and the mono, di, and triglyceride fractions, leaving total phospholipid and its fractions unaltered. Following 20-day withdrawal of corticosterone treatment, all lipid classes returned to normal along with serum hormone profiles. Our findings imply that an excess of corticosterone influences epididymal lipids. These changes in the epididymal lipid pattern probably are reflected in fertility disorders in patients with glucocorticoid excess.

An energy budget for juvenile thick‐lipped mullet, Crenimugil labrosus (Risso)

A series of experiments were carried out to construct an energy budget for juvenile thick lipped mullet, Crenimugil labrosus Risso. A partial factorial experimental design was used to examine the effects of temperature, fish size and meal size on growth. The maximum ration that the fish were able to ingest completely per day was found to be 0·8, 1·4 and 2·3% wet body weight (b.w.) at 13,18 and 23°C, respectively. Ingested maintenance requirements (M.R.) were estimated to be 137, 205 and 288 cal fish‐1 day‐1 at 13, 18 and 23°C, respectively. At 18deg; C, M.R. varied as 25 W1.04 cal day‐1, where W= fish weight (g). Growth rate increased with increasing temperature. Maximal conversion efficiency was 21–24% and was achieved closer to the maximum ingested ration with increasing temperature.The relationship between respiration rate and W at 18deg; C for 3‐20 g fish is described by: respiration rate (ml O2 h‐1) = 0·128 W0.976The energy cost of apparent specific dynamic action at 18deg; C was found to vary between 5·1% and 23·6% of the calorific value of the ingested meal (1% wet b.w.), mean (± S.E.)=10·2 ± 2·0%.Post mortem analyses of groups of fish fed 0·2, 0·8 and 1·5% wet b.w. meals showed a significant increase in total lipid and a significant decrease in water content with increasing ratio size. A negative correlation was found between body water content and total lipid (and calories).The mean assimilation efficiency (±s.e.) for 5–10 g mullet at 18deg; C was 73·9 ± 3·6%.The observations reported in this study were brought together to construct an energy budget for juvenile C. labrosus which was found to give a reliable prediction (within 10%) of energy demand and growth under the prevailing experimental conditions. Both gross (K1) and net (K2) growth efficiencies, based on energy values, increased with increasing ratio size up to satiation and were independent of temperature. The maximum values of K1 and K2 observed were 0·33 and 0·46, respectively. The third order efficiency (K3) appeared to be independent of temperature and ration size; mean values ranged between 0·66 and 0·84.

Influence of hormones on testicular lipids of adult rats.

Testosterone, oestradiol-17 beta, progesterone and prolactin were administered for 1 and 7 days to adult rats to study the short- and long-term effects of these hormones on testicular lipids. Testosterone administration induced a marked increase in testicular phospholipids and a significant fall in glycerides. Oestrogen, on the other hand, provoked a significant increase in total lipids and glycerides with no marked changes in testicular phospholipids. Progesterone elicited significant changes in cholesterol fractions; a marked increase in esterified cholesterol with a concurrent fall in free cholesterol was observed. Prolactin treatment resulted in a significant fall in total lipids and phospholipids with no marked change in tissue weight. It also induced a marked fall in total and free cholesterol with a significant increase in esterified cholesterol.

The effect of an oral contraceptive on serum lipoproteins and skinfold thickness in young women

The effect of a six-month use of a pill containing 50 mcg ethinyloestradiol and 250 mcg d-norgestrel on total serum lipids, lipoproteins and skinfolds was studied in 26 young nulligravidae, who had never previously taken hormonal contraceptives. The following were noted: 1. 1. Significant increase of total lipids and β-lipoproteins (L.D.L.) 2. 2. No significant changes in α-lipoproteins (H.D.L.) and pre-β-lipoproteins (V.L.D.L.) 3. 3. Increase of the total bodyweight from 60.2 ± 6.5 to 61.5 ± 6.8 kg (mean ± s.d.) 4. 4. No changes in the total body fat percentage 5. 5. A shift of fat mass from the extremities to the trunk.

The unmasking of cytoplasmic lipids in rat livers as a consequence of dietary changes

ABSTRACT The livers from rats fed either on a normal diet containing 20% of protein or on a diet which facilitated liver carcinogenesis and which contained only 5 % of protein supplemented with methionine appeared histologically normal. Histochemical investigation of such livers showed that in the livers of animals fed on the protein-deficient diet there was a large increase in lipid staining. Biochemical investigation of these livers demonstrated that this increase in lipid staining was not due to a significant increase in total lipids nor to a significant decrease in total protein. These findings are discussed in terms of the ‘unmasking’ of the structural cytoplasmic lipids of the liver cells as the consequence of the feeding of an apparently protein-deficient diet.

Phospholipid analysis of cellular fractions of the liver following single dose of choline.

Summary1. The effect of a single dose of choline on total lipid phosphorus, lecithin P, and cephalin P of mitochondria, nuclei and homogenates of the liver was studied in choline deficient rats. 2. Administration of single dose of choline 40, 75 and 150 mg significantly increased in 6 hours the total lipid P. and lecithin P concentration of liver mitochondira. 3. A statistically significant increase in total lipid P and lecithin P of liver mitochondria and homogenates occurred in 3, 6, 10 and 18 hours following administration of a single dose of choline. 4. Diets low in protein reduce the level of total lipid P, lecithin P and cephalin P in liver mitochondria.