AbstractBackgroundAlzheimer’s disease (AD) is a progressive and severely debilitating disease that negatively affects cognitive and memory function and is linked to increased disability in everyday functioning and risk of mortality. Neurodegeneration of focal brain areas in AD progressively impacts large‐scale brain circuits, leading to significant cognitive impairments. However, little is known regarding aberrant context‐dependent dynamic causal interactions between distributed brain regions, and their links to cognitive impairments and neuropathology, across AD clinical stages.MethodWe addressed critical gaps in our knowledge of functional circuit mechanisms underlying cognitive dysfunction in AD by leveraging innovative computational tools and state‐of‐the‐art clinical, phenotypic, cognitive, experimental, fMRI data from AD Human Connectome Project database.ResultTo this end, we identified that (1) dynamic causal interaction patterns between DMN‐MTL‐FPN‐SN nodes distinguish between clinical stages of AD in working memory task, (2) dynamic causal interactions between DMN‐MTL‐FPN‐SN nodes become progressively weaker along clinical AD disease stages in both memory tasks, and (3) dynamic causal interaction patterns between DMN‐MTL‐FPN‐SN nodes are significantly associated with task performance.ConclusionThese findings will identify aberrant dynamic causal circuits associated with episodic and working memory deficits across AD clinical stages.