Significant Fatigue Research Articles

Assessment of Sleep Disorders in Patients with CVID.

Inborn errors of immunity have been associated with reduced health-related quality of life and increased fatigue. Sleep disorders, which have been shown to contribute to fatigue and other health concerns, are prevalent in the general population, but there are limited studies evaluating these conditions in patients with common variable immunodeficiency (CVID). Our aim was to evaluate the prevalence of fatigue, sleep disturbances, and sleep-disordered breathing in adults with CVID. Patients completed 4 validated, self-administered questionnaires and a 1-night disposable home sleep apnea test. Our results demonstrated increased median Patient-Reported Outcomes Measurement Information System fatigue scores of 58.7 in patients with CVID in addition to clinically significant fatigue as measured by Fatigue Severity Scale score (median, 5.2) and overall poor sleep quality based on global Pittsburgh Sleep Quality Index score (median, 9.0). For CVID patients who completed the home sleep apnea test, 76.9% met criteria for sleep-disordered breathing with an Apnea-Hypopnea Index score of 5 or greater. The results of our study indicate that patients with CVID may have increased rates of undiagnosed sleep disorders that may contribute to increased fatigue and reduced health-related quality of life.

Unveiling the link: exploring muscle oxygen saturation in fibromyalgia and its implications for symptomatology and therapeutic strategies.

Fibromyalgia, characterized as a complex chronic pain syndrome, presents with symptoms of pervasive musculoskeletal pain, significant fatigue, and pronounced sensitivity at specific anatomical sites. Despite extensive research efforts, the origins of fibromyalgia remain enigmatic. This narrative review explores the intricate relationship between muscle oxygen saturation and fibromyalgia, positing that disruptions in the oxygenation processes within muscle tissues markedly influence the symptom profile of this disorder. Muscle oxygen saturation, crucial for muscle function, has been meticulously investigated in fibromyalgia patients through non-invasive techniques such as near-infrared spectroscopy and magnetic resonance imaging. The body of evidence consistently indicates substantial alterations in oxygen utilization within muscle fibers, manifesting as reduced efficiency in oxygen uptake during both rest and physical activity. These anomalies play a significant role in fibromyalgia's symptomatology, especially in terms of chronic pain and severe fatigue, potentially creating conditions that heighten pain sensitivity and accumulate metabolic byproducts. Hypothesized mechanisms for these findings encompass dysfunctions in microcirculation, mitochondrial irregularities, and autonomic nervous system disturbances, all meriting further research. Understanding the dynamics of muscle oxygen saturation in fibromyalgia is of paramount clinical importance, offering the potential for tailored therapeutic approaches to alleviate symptoms and improve the quality of life for sufferers. This investigation not only opens new avenues for innovative research but also fosters hope for more effective treatment strategies and improved outcomes for individuals with fibromyalgia.

Changes of Anaerobic Power and Lactate Concentration following Intense Glycolytic Efforts in Elite and Sub-Elite 400-meter Sprinters.

400-m races are based on anaerobic energy metabolism, they induce significant muscle fatigue, muscle fiber damage, and high blood lactate (LA) concentration. Despite extensive research on sprint training, our understanding of the training process that leads to world-class sprint performance is rather limited. This study aimed to determine differences in LA concentration and anaerobic power using jumping tests after an intense glycolytic effort in a group of elite and sub-elite 400-m runners. One hundred thirty male runners were divided into two groups: elite (n = 66, body mass = 73.4 ± 7.8 kg, body height = 182.1 ± 6.2 cm, age = 20.8 ± 4.0 y) running the 400-m dash below 50 s and sub-elite (n = 64, body mass = 72.0 ± 7.1 kg, body height = 182.1 ± 5.2 cm, age = 20.8 ± 4.0 y) with a 400-m personal best above 50 s. The power of the countermovement and the sequential squat jumps was measured in two sets after a warm-up, followed by two intermittent 30-s Wingate tests. LA concentration was measured eight times. It was observed that elite athletes achieved significantly higher power in both types of jumps. The maximum post-exercise LA concentration was significantly lower in the sub-elite group after the 3rd, the 6th, the 9th, and the 20th min after the cessation of two Wingate tests (p < 0.001). The rate of LA accumulation after exercise and the rate of LA utilization did not differ between the groups. It can be concluded that elite and non-elite runners differ in higher LA production but not in LA utilization. Anaerobic power and LA concentration seem to differentiate between 400 elite and sub-elite performance.

Return to Work in Breast Cancer Patients following an Interdisciplinary Rehabilitation Program in a Community-Based Cancer Rehabilitation Center: A Pilot Study.

Despite curative treatment and discharge from acute hospital settings, breast cancer patients often have cancer- and treatment-related morbidity which impairs them from returning to work. Hence, the role of community-based return to work rehabilitation programs is important to help these patients transition back to work. This was a retrospective cohort study involving patients with breast cancer conducted at a community-based cancer rehabilitation center. Patients were involved in an interdisciplinary vocational rehabilitation program involving physiatrists, occupational therapists, physiotherapists and social workers. We recruited 63 patients for this study cohort, with 46 (73.0%) patients ≤ 60 years old. After undergoing the rehabilitation program, there were 37 (58.7%) participants who successfully returned to work. These participants returned to work at either within 6 months (27.0%), 12 months (29.7%) or 24 months (43.2%) after enrollment into the program, with a majority enrolling in white collar jobs. Multivariate regression analysis revealed that significant negative factors for return to work were advanced stage of cancer (p = 0.004), along with clinically significant fatigue, measured on the Brief Fatigue Inventory (p < 0.001). However, perceived work ability (p = 0.020) was found to be a positive factor.

Could nutrition status predict fatigue one week before in patients with nasopharynx cancer undergoing radiotherapy?

Patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy experience significant fatigue, which is frequently underestimated due to the lack of objective indicators for its evaluation. This study aimed to explore the longitudinal association between fatigue and nutrition status 1 week in advance. From January 2021 to June 2022, a total of 105 NPC patients who received intensity-modulated radiation therapy were enrolled in the observational longitudinal study. The significant outcomes, including the Piper Fatigue Scale-12 (PFS-12), the Scored Patient-Generated Subjective Global Assessment (PG-SGA), four body composition indices, and the Hospital Anxiety and Depression Scale (HADS), were assessed weekly from pre-treatment until the completion of radiotherapy (T0-T7) to explore their relationship. The trajectories of PFS-12 and all dimensions for 105 participants reached a peak during the fifth week. Sensory fatigue consistently received the highest scores (T0 = 1.60 ± 2.20, T5 = 6.15 ± 1.57), whereas behavior fatigue exhibited the fastest increase over time (T0 = 1.11 ± 1.86, T5 = 5.47 ± 1.70). Higher PG-SGA scores were found to be weakly explainable for aggravating fatigue (β = 0.02 ~ 0.04). Unlike generalized additive mixed models, marginal structural models (MSM) produced larger effect values (β = 0.12 ~ 0.21). Additionally, body composition indices showed weakly negative relationships with fatigue in MSMs one week in advance. The PG-SGA may be a more accurate predictor of future-week fatigue than individual body composition indicators, particularly when HADS is controlled for as a time-dependent confounder.

Optimization system for training efficiency and load balance based on the fusion of heart rate and inertial sensors

ObjectivesTo enhance the daily training quality of athletes without inducing significant physiological fatigue, aiming to achieve a balance between training efficiency and load. Design methodsFirstly, we developed an activity classification training model using the random forest algorithm and introduced the “effective training rate” (the ratio of effective activity time to total time) as a metric for assessing athlete training efficiency. Secondly, a method for rating athlete training load was established, involving qualitative and quantitative analyses of physiological fatigue through subjective fatigue scores and heart rate data. Lastly, an optimization system for training efficiency and load balance, utilizing multiple inertial sensors, was created. Athlete states were categorized into nine types based on the training load and efficiency ratings, with corresponding management recommendations provided. ResultsOverall, this study, combining a sports activity recognition model with a physiological fatigue assessment model, has developed a training efficiency and load balance optimization system with excellent performance. The results indicate that the prediction accuracy of the sports activity recognition model is as high as 94.70%. Additionally, the physiological fatigue assessment model, utilizing average relative heart rate and average RPE score as evaluation metrics, demonstrates a good overall fit, validating the feasibility of this model. ConclusionsThis study, based on relative heart rate and wearable devices to monitor athlete physiological fatigue, has developed a balanced optimization system for training efficiency and load. It provides a reference for athletes’ physical health and fatigue levels, offering corresponding management recommendations for coaches and relevant professionals.

Seismic behaviour of a steel moment resisting frame structure featuring hourglass double split tee joints

The occurrence of brittle fractures in welds of full-strength joints of steel moment-resisting frames (MRFs) during earthquakes in Northridge (1994) and Kobe (1995) marked a turning point in seismic design philosophies for steel structures. This led to the development of new strategies focusing on enhancing structural resilience and energy dissipation. While Reduced Beam Sections (RBS) were traditionally favoured, recent approaches include partial-strength joints and replaceable dissipative fuses, in some cases also equipped with self-centring components. These systems often employ friction or yielding dampers, ensuring that the weakest joint component comprises well-designed dampers for optimal ductility and energy dissipation.In this context, the present study evaluates the performance of a large-scale structure featuring MRFs with partial-strength double-split tee (DST) joints and hourglass dampers. These joints are conceptually similar to ADAS dampers and the Simpson Strong Tie moment connection prequalified by AISC 358–16. The research involves conducting a pseudo-dynamic test campaign on a two-storey steel structure designed according to EC8 provisions. Findings from experiments and a numerical model developed using OpenSees are discussed. Incremental Dynamic Analyses (IDAs) compare structures with hourglass DST joints to those with full-strength joints, showing enhanced self-centring capacity in DST-equipped structures despite lacking dedicated self-centring components. Additionally, structures with hourglass DST joints demonstrate significant low-cycle fatigue life, potentially reducing the need to replace dissipative components after severe seismic events.

Fatigue damage recovery and enhanced fatigue limit of austenitic stainless steel using multiple high-density pulsed electric currents

The damage evolution and fatigue life of austenitic stainless steel subjected to high-density pulsed electric currents (HDPECs) were investigated in this study. The change in the fatigue damage evolution owing to the application of HDPECs was evaluated using the cumulative fatigue damage model. Fatigue damage recovery was successfully demonstrated in the low-cycle fatigue and high-cycle fatigue (HCF) regimes. In particular, significant fatigue damage was recovered in the HCF regime when more than six HDPECs were applied. The microstructural features modified by the effect of the HDPEC indicated specific fatigue fracture patterns during fatigue crack initiation, which tended to prefer a transgranular fracture instead of an intergranular fracture. Furthermore, unique fish-eye patterns generated on the subsurface indicated a significant recovery of fatigue damage in the HCF regime owing to the effect of multiple HDPECs. A full fatigue test of R= 0.5 was performed within a fatigue cycle of < 108, resulting in an enhanced fatigue life owing to fatigue damage recovery. Therefore, the application of multiple HDPECs improved the fatigue limit. This study sheds light on the efficiency assessment of the application of HDPECs based on the type of fatigue regime.

Psychosocial consequences of head and neck cancer symptom burden after chemoradiation: a mixed-method study.

Patients with head and neck cancer (HNC) experience significant symptom burden from combination chemotherapy and radiation (chemoradiation) that affects acute and long-term health-related quality of life (HRQOL). However, psychosocial impacts of HNC symptom burden are not well understood. This study examined psychosocial consequences of treatment-related symptom burden from the perspectives of survivors of HNC and HNC healthcare providers. This was a cross-sectional, mixed-method study conducted at an NCI-designated comprehensive cancer center. Participants (N = 33) were survivors of HNC who completed a full course of chemoradiation (n = 20) and HNC healthcare providers (n = 13). Participants completed electronic surveys and semi-structured interviews. Survivors were M = 61years old (SD = 9) and predominantly male (75%), White (90%), non-Hispanic (100%), and diagnosed with oropharynx cancer (70%). Providers were mostly female (62%), White (46%) or Asian (31%), and non-Hispanic (85%) and included physicians, registered nurses, an advanced practice nurse practitioner, a registered dietician, and a speech-language pathologist. Three qualitative themes emerged: (1) shock, shame, and self-consciousness, (2) diminished relationship satisfaction, and (3) lack of confidence at work. A subset of survivors (20%) reported clinically low social wellbeing, and more than one-third of survivors (35%) reported clinically significant fatigue, depression, anxiety, and cognitive dysfunction. Survivors of HNC and HNC providers described how treatment-related symptom burden impacts psychosocial identity processes related to body image, patient-caregiver relationships, and professional work. Results can inform the development of supportive interventions to assist survivors and caregivers with navigating the psychosocial challenges of HNC treatment and survivorship.

Comparison of Neuromuscular Fatigue in Powerlifting Paralympics in Different Training Methods.

Mean propulsive velocity (MPV) has been associated with neuromuscular fatigue; however, its suitability for strength training in Paralympic powerlifting (PP) remains uncertain. The objective of this work was to evaluate the MPV in two training methods (traditional-TRAD and eccentric-ECC). Eleven PP athletes were evaluated pre, during the intervention and post intervention at a load of 80% of the 1RM for TRAD and 110%-80% of 1 RM for ECC. The results demonstrated that there was no significant neuromuscular fatigue for the TRAD (~5% performance loss), as well as no significant decline in MPV during the intervention. For the ECC, there is a significant reduction in MPV before and after training (~12% loss of performance). A difference between TRAD and ECC after the intervention was also identified (0.87 m/s±0.22, 95% CI 0.72-1.02 vs. 0.72±0.20, 95% CI 0.59-0.86 p=0.042, F(3.30)=10.190, η2p=0.505 - very high effect). During the intervention for ECC, no significant decline in MPV was observed. The results of this study suggest that the mechanical indices of MPV do not seem to be effective indicators of neuromuscular fatigue in the sample studied or in the context of this specific training regime, being more indicated as a control of training volume.

Impact of a resilience-building energy management intervention for people with systemic sclerosis: a mixed methods study.

People with SSc often experience fatigue, which significantly affects daily life functioning and quality of life. We aimed to explore participants' experiences of a peer health-coached resilience-building energy management to enhance well-being (RENEW) intervention on symptoms and well-being and to use mixed methods to compare how SSc duration influenced the experiences of participants who had clinically significant fatigue improvement vs those who did not. Semi-structured interviews were conducted with 21 participants from the parent clinical trial randomized to the RENEW intervention. Data were analysed using the rigorous and accelerated data reduction technique combined with thematic content analysis. A mixed methods approach used a joint display to identify themes related to the impact of SSc duration on fatigue improvement status. Participants were categorized into short/improvement, short/limited improvement, long/improvement, and long/limited improvement. Our team generated four themes: participant and peer health-coach relationship, physical and psychological well-being improvement, need for a tailored approach and easy program access through technology. Mixed methods analysis revealed that, regardless of SSc duration, participants with improved fatigue reported increasing self-awareness of SSc-related symptoms and learning coping strategies to manage fatigue. Participants in the short/improvement group reported preferences for slower pacing of the program and pairing with a coach with similar symptom severity. Participants in the long/limited improvement group sought SSc-specific symptom management information. Incorporating peer health coaches and technology is beneficial for self-management interventions for people with SSc. Future tailoring of RENEW based on SSc duration and symptom severity is needed. clinicatrials.gov, NCT04908943.

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank

ObjectivesHFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y and p.H63D variant cumulative incidence of multiple clinical outcomes in...

Research of the emotional state of young tutors working with children with autism spectrum disorders

Introduction. The work of specialists involved in psychological, medical and pedagogical support of children with autism spectrum disorders (ASD) has an impact on the emotional state of educators, often causing professional burnout. It is widely discussed in the literature among educators with a long work experience. The authors consider it relevant to isolate and investigate the initial symptoms of burnout. Materials and methods. The study involved 14 tutors, women aged 24 to 30 years, working in resource classes for children with ASD and 14 teachers of inclusive classes. Research methods: questionnaire survey, psychological testing. The authors used the “Methodology for diagnosing the level of emotional burnout” (Boyko, 1998), “Scale of psychological well-being” by K. Riffe in adaptation of T.D. Shevelenkova, T.P. Fesenko (2005), Clinical questionnaire for identifying neurotic states by K.K. Yakhin, D.M. Mendelevich (1998). Statistical processing was performed using IBM SPSS Statistics 26 program. The nonparametric Mann-Whitney criterion (p≤0,05) was used to compare indicators. Results. All tutors noted significant fatigue after the working day, half of them also experienced psychological discomfort, difficulties in communication, less optimistic assessment of their abilities. According to V.V. Boyko’s test, the phase of tension is formed in three tutors, it is in the stage of formation in eleven; the phase of resistance – in three, and it is in the stage of formation in nine; the phase of exhaustion – in one tutor, it is in the stage of formation in four. The most pronounced symptoms are “Dissatisfaction” and “Emotional disorientation” – in 71.4%. Eight teachers (57.1%) felt the presence of problems hindering their psychological well-being and emotional comfort. Eight out of fourteen revealed painful symptoms on the scales of vegetative disorders, neurotic depression, and anxiety. Comparison of indicators in the groups of tutors and teachers of inclusive classes showed reliable differences in many parameters (p≤0.05), but the tutors of inclusive classes also showed forming symptoms of tension and vegetative disorders. Conclusion. The results obtained in the study of tutors with less than three years experience of work with children with ASD indicated the presence or formation of their suboptimal functional state of the body, which requires timely detection and correction with the participation of psychological and medical specialists.

Listening-Related Fatigue in New and Experienced Adult Cochlear Implant Users.

Active listening in everyday settings is challenging and requires substantial mental effort, particularly in noisy settings. In some cases, effortful listening can lead to significant listening-related fatigue and negatively affect quality of life. However, our understanding of factors that affect the severity of fatigue is limited. Hearing aids and cochlear implants (CIs) can improve speech understanding and thus, potentially, reduce listening effort and fatigue. Some research supports this idea for adult hearing aid users with mild-to-moderate hearing loss, but similar work in CI users is very limited. This study examined (1) longitudinal changes in listening-related fatigue in new and established CI users, and (2) relationships between demographic and audiologic factors and preimplantation and postimplantation listening-related fatigue. Participants included an experimental group of 48 adult CI candidates receiving either a unilateral implant (n = 46) or simultaneous, bilateral implants (n = 2) and a control group of 96 experienced (>12 months experience) adult CI users (50 unilateral, 46 bilateral). Listening-related fatigue was evaluated using the 40-item version of the Vanderbilt Fatigue Scale for Adults. Experimental group ratings were obtained before implantation and again at 0.5-, 1-, 2-, 3-, 6-, and 12-month(s) postactivation. Control group participants completed the scale twice-upon study entry and approximately 3 months later. Additional measures, including a social isolation and disconnectedness questionnaire, hearing handicap inventory, and the Effort Assessment Scale, were also administered at multiple time points. The role of these measures and select demographic and audiologic factors on preimplant and postimplant fatigue ratings were examined. Adult CI candidates reported significantly more fatigue, greater self-perceived hearing handicap, greater listening effort, and more social isolation than experienced adult CI users. However, significant reductions in fatigue and effort were observed within 2 weeks postimplantation. By 3 months, there were no significant differences in fatigue, effort, hearing handicap, or social isolation between new CI recipients and experienced CI users. Secondary analyses revealed that age at onset of hearing loss (before or after 2 years of age) and subjective hearing handicap contributed significantly to the variance of preimplantation fatigue ratings (those with higher handicap reported higher fatigue). In contrast, variance in postimplantation fatigue ratings was not affected by age of hearing loss onset but was affected by gender (females reported more fatigue than males) and subjective ratings of effort, handicap, and isolation (those reporting more effort, handicap, and isolation reported more fatigue). Listening-related fatigue is a significant problem for many CI candidates, as well as for many experienced unilateral and bilateral CI users. Receipt of a CI significantly reduced listening-related fatigue (as well as listening effort, hearing handicap, and social isolation) as soon as 2 weeks post-CI activation. However, the magnitude of fatigue-related issues for both CI candidates and experienced CI users varies widely. Audiologic factors, such as hearing loss severity and aided speech recognition, were not predictive of individual differences in listening-related fatigue. In contrast, strong associations were observed between perceived hearing handicap and listening-related fatigue in all groups suggesting fatigue-related issues may be a component of perceived hearing handicap.

Изменения качества жизни у пациентов с хронической иммунной тромбоцитопенией в процессе терапии ромиплостимом, его эффективность и безопасность в условиях реальной клинической практики: результаты многоцентрового наблюдательного исследования

Aim. To study the quality of life in patients with chronic immune thrombocytopenia (ITP) in the process of romiplostim therapy and to assess the efficacy and safety of this drug in real-world setting.&#x0D; Materials &amp; Methods. The study enrolled adult patients with the confirmed chronic ITP diagnosis and indications for romiplostim therapy. Clinical parameters, RAND SF-36 and FACT-Th6 quality of life as well as FACIT-Fatigue scores were evaluated prior to romiplostim administration vs. 3, 6, and 12 months after the treatment onset. Patient satisfaction checklist was also administered at all study points after the start of therapy. The clinical efficacy of romiplostim was analyzed along with assessing response and time to response. To study the quality of life and fatigue changes, the Generalized Estimating Equation (GEE) method was used during the observation period. Significant fatigue changes were determined and compared in terms of the perception differences from patient’s and physician’s perspective.&#x0D; Results. The study enrolled 60 chronic ITP patients treated with romiplostim in the real-world setting (mean age 51.9 years, 70 % women). The median thrombocyte count prior to romiplostim therapy was 18.5 × 109/L (interquartile range 10.8–22.3 × 109/л). On the enrollment date, 90 % of patients showed hemorrhagic syndrome. Overall response to romiplostim therapy was 98.3 % (complete response was achieved in 93.3 % of patients). After 6 months of therapy, 89.5 % of patients preserved response. After 3 months of therapy, hemorrhagic syndrome was eliminated in 81 % of patients, after 6 months the same was achieved in 93 % of patients. The median time to response was 4.4 weeks (95% confidence interval 3.6–5.3 weeks). Adverse events of grades 1/2 associated with romiplostim were reported in 6.7 % of patients. On romiplostim therapy, pronounced positive changes in quality of life were shown by all scales of the general questionnaire SF-36 and the targeted questionnaire FACT-Th6 (p &lt; 0.001). The clearest improvements were observed in role-physical and role-emotional functioning. Already after 3 months of therapy, a considerable fatigue reduction was observed and sustained for the next 6 and 12 months of romiplostim administration (p &lt; 0.001). During the therapy, the proportion of patients with fatigue impacting various aspects of functioning became considerably smaller. The vast majority of patients (85 %) were satisfied with the treatment. Discrepancies between patients’ and physicians’ evaluations of fatigue were also identified during the treatment.&#x0D; Conclusion. The results of the present multi-center observational study demonstrate high efficacy and safety of romiplostim for chronic ITP patients in the real-world setting. Romiplostim therapy yields considerable quality of life improvement and fatigue reduction. To optimize the patient monitoring system and patient-centered ITP treatment in the real-world setting, it is advisable to use the standardized questionnaires assessing quality of life and fatigue.

Підвищення ефективності перед-змагальної підготовки кваліфікованих спортсменів у тхеквондо WTF за рахунок застосування засобів високо-інтенсивного фітнес-тренінгу

Purpose: to theoretically substantiate and experimentally identify the most effective means of modern high-intensity interval fitness training of pre-competitive training of qualified athletes in WTF taekwondo. Material and methods. The following methods were used in the research: the analysis of the special scientific and methodical literature; pedagogical observations; pedagogical experiment; pedagogical testing; physiological testing; the method of expert estimations; methods of mathematical statistics. Results: the explosive growth of lactate concentration from 1,16±0,5 mM/l to 15,5±2,1 mM/l causes the next repetition of this exercise after 5 minutes of rest. The obtained data of HR (HR, bpm +26,2 %), VE, l/min (+128,6 %), VCO2, l/min (+135,5 %), VO2, l/min (+56,1 %), KIO2 (-27,5 %) indicate that at insufficient recovery between approaches at performance of rather short interval segments of submaximal power (high-intensity work up to 1 min) leads to the significant decrease of special working capacity of sportsmen. Taking into account the specifics of the sport, for the improvement of this parameter of preparedness it is considered expedient to perform 3-5 times specially developed blocks of exercises of high intensity, borrowed (mainly) from modern methods of health-improving fitness training. The results of the competitive activity of qualified taekwondo athletes confirmed the effectiveness of the use of high-intensity fitness training HIIT to improve their pre-competitive fitness. Conclusions. When planning the direct pre-competitive training of qualified taekwondo sportsmen in the annual cycle of preparation it is necessary to be guided by the information received as a result of the conducted researches and to approach in a regulated way to the definition and combination of intensity and duration of the performed exercises of a specific orientation which, in turn, model the process of competition. It is proved that to improve aerobic endurance of athletes it is necessary to plan 2-3 times in a weekly microcycle different interval training exercises performed without significant fatigue and decreased performance. For improvement of high-speed and power capabilities of sportsmen it is necessary to perform 1-2 times during a microcycle different interval training exercises with shortened segments of work of maximum intensity lasting up to 30 s. Keywords: fitness training, high-intensity interval training (HIIT), taekwondo, WTF, physical fitness, control, speed and strength capabilities, aerobic capabilities.

Identifikasi Tingkat Kesegaran Jasmani Tim Futsal Awam FC

Physical freshness is the ability of a person's body to carry out various activities without experiencing significant fatigue and still have spare energy to do other activities. The problem in this study is the low level of physical freshness in Awam Fc players which has an impact on the time of conducting matches. Therefore, it is necessary to conduct research to measure the level of physical freshness of futsal players Awam Fc. The method used in this study is a quantitative approach method, while the collection process uses survey, test and measurement methods with the age category of 16-19 years, the sample in this study is Awam Fc futsal players totaling 10 people. The results of this study show that the level of physical freshness of Awam Fc futsal players is in the good category, with details of 6 players classified in the good category with a percentage of 60%, and 4 players classified as medium category with a percentage of 40%. This can be seen based on the results of tests and physical fitness measurements such as: Running 60 meters, Hanging body lift, Lying sitting 60 seconds, Jumping upright, and Running 1200 meters.

Evaluating myelophil, a 30% ethanol extract of Astragalus membranaceus and Salvia miltiorrhiza, for alleviating fatigue in long COVID: a real-world observational study.

Persistent post-infectious symptoms, predominantly fatigue, characterize Long COVID. This study investigated the efficacy of Myelophil (MYP), which contains metabolites extracted from Astragalus membranaceus and Salvia miltiorrhiza using 30% ethanol, in alleviating fatigue among subjects with Long COVID. In this prospective observational study, we enrolled subjects with significant fatigue related to Long COVID, using criteria of scores of 60 or higher on the modified Korean Chalder Fatigue scale (mKCFQ11), or five or higher on the Visual Analog Scale (VAS) for brain fog. Utilizing a single-arm design, participants were orally administered MYP (2,000mg daily) for 4weeks. Changes in fatigue severity were assessed using mKCFQ11, Multidimensional Fatigue Inventory (MFI-20), and VAS for fatigue and brain fog. In addition, changes in quality of life using the short form 12 (SF-12) were also assessed along with plasma cortisol levels. A total of 50 participants (18 males, 32 females) were enrolled; 49 were included in the intention-to-treat analysis with scores of 66.9 ± 11.7 on mKCFQ11 and 6.3 ± 1.5 on the brain fog VAS. After 4weeks of MYP administration, there were statistically significant improvements in fatigue levels: mKCFQ11 was measured at 34.8 ± 17.1 and brain fog VAS at 3.0 ± 1.9. Additionally, MFI-20 decreased from 64.8 ± 9.8 to 49.3 ± 10.8, fatigue VAS dropped from 7.4 ± 1.0 to 3.4 ± 1.7, SF-12 scores rose from 53.3 ± 14.9 to 78.6 ± 14.3, and plasma cortisol levels also elevated from 138.8 ± 50.1 to 176.9 ± 62.0/mL. No safety concerns emerged during the trial. Current findings underline MYP's potential in managing Long COVID-induced fatigue. However, comprehensive studies remain imperative. https://cris.nih.go.kr, identifier KCT0008948.

General physical fitness of powerlifters as a basis for effective strength development

The article, based on the analysis and synthesis of data from the source base and practical experience, identifies the main features of the general physical fitness of powerlifting athletes as the basis for effective strength development. The attention is focused on the issues related to the individualization of the training process and the management of the physical condition of athletes, the importance of various forms of manifestation of strength abilities. It is emphasized that the growth of sports achievements i s primarily due to the improvement of the methodology of strength development. It is noted that the level of strength development in powerlifters is one of the most urgent problems of the educational and training process in this sport, and the solution of this problem will significantly increase the effectiveness of sports training in powerlifting.&#x0D; The most important physical quality to develop in the process of general physical training of powerlifters is strength. In general, "strength" is defined as the ability to overcome external resistance or to counteract it with the help of muscle effort. The following specific forms of strength are distinguished by the nature of the effort and the mode of muscle function: fast strength, maximum strength, power endurance, and explosive strength.&#x0D; Muscular effort in the conditions of the training process of powerlifters can manifest itself in different ways: once or repeatedly, in cyclic or variable work with high or low resistance, at high speed or slowly, in a relaxed or tense state of muscles. An important physical quality that needs to be developed in the process of general physical training of powerlifters is endurance. Endurance is usually equated with the powerlifter's ability to perform muscle work (squats with a barbell, bench press, deadlift) for a long time during competitions without signs of significant fatigue.

Understanding experiences of cancer-related fatigue in patients with lung cancer after their cancer treatment: a qualitative content analysis.

Cancer-related fatigue (CRF) is an important symptom affecting the quality of life of patients with lung cancer. However, research on the characteristics of CRF in lung cancer and their relationship to cancer treatment is limited. We aimed to explore the unique features of CRF in patients with lung cancer, and investigate the influencing factors. Semi-structured interviews were conducted with 21 adult patients with lung cancer until data saturation was reached. The collected data were analyzed using qualitative content analysis. An inductive coding process and deductive content analysis incorporating the established CRF domains were employed. Patient data from electronic medical records were used for data triangulation. The analysis revealed five themes of CRF: (1) energy depletion, the double burden of illness and treatment, and daily life impediments; (2) feeling down and anxious; (3) neurovascular disturbances and changes in sensory perception; (4) cognitive impairment; and (5) personal and social isolation. CRF tended to improve over time, except for persistent emotional fatigue beyond 6months. Patients who underwent surgery followed by adjuvant cancer treatment exhibited the most diverse CRF symptoms. The concurrent chemoradiation therapy group experienced significant physical fatigue, whereas the radiosurgery group reported distinct emotional fatigue. Certain factors, such as exercise, can serve as both alleviating and aggravating factors for CRF. Tailored interventions that take into account the multidimensional symptoms of CRF and patient characteristics are crucial. These findings will guide healthcare professionals when implementing patient-centered symptom management and patient education.