Significant Differences In Contrast Sensitivity Research Articles

Contrast sensitivity before and after refractive error correction among refractive error patients in Hawassa, Sidama, Ethiopia 2023

BackgroundContrast sensitivity is an important measure of vision quality. Risk of falling injury is strongly associated with poor contrast sensitivity compared with poor near- and distance visual acuity. Since good visual acuity is not necessarily associated with good visual performance in the “real world” it is important to consider contrast sensitivity when prescribing corrective lenses. There is limited evidence on how refractive error and its correction affect contrast sensitivity in the study area. Therefore, this study is important to understand how refractive correction affects contrast sensitivity, which is important baseline information for prescribing refractive error correction.Objective of this studyThis study aimed to measure the mean difference in contrast sensitivity with and without corrective lenses in patients with refractive error.MethodsObjective and subjective refractions were done for each patient, then Pelli- Robson contrast sensitivity was measured for them using computer based Pelli-Robson chart at 1 m. Pelli- Robson contrast sensitivity value (Log CS) with and without corrective lenses were recorded for each study participant. The collected data were checked for completeness and analyzed using SPSS 26. Descriptive analyses, independent sample t-tests, and one-way ANOVA were performed to compare CS means; the findings are presented using tables and pie charts. A P-value of ≤ 0.05 was used to indicate statistical significance.ResultsOne hundred sixty-two patients attending refraction clinics participated in this study with response rate 98.19% of which 51.9% were male. The mean age of the participants was 34.28 ± 12.79 (SD). The mean contrast sensitivity increased from 1.29 ± 0.35 (SD) to1.51 ± 0.28 (SD) LogCS units with refractive correction (p = 0.000). There is no significant difference in contrast sensitivity between the types of refractive errors.Conclusion and recommendationUncorrected refractive can affect contrast sensitivity; therefore, proper refractive correction is essential to improve visual acuity and contrast sensitivity.

Visual performance and quality of life in myopic adolescents with pupil-optimised multifocal versus single-vision contact lenses

ABSTRACT Clinical relevance Myopia control is a prominent area of global research, with multifocal contact lenses identified as an effective intervention for adolescents. Background This study aims to evaluate the visual performance and vision-related quality of life (QoL) of myopic adolescents when corrected with pupil-optimised multifocal soft contact lenses (MFSCLs) versus single-vision contact lenses (SVCLs), with each participant serving as their own control. Methods Thirty-five myopic adolescents, habitually wearing SVCLs and fitted with pupil-optimised MFSCL with mid-addition power, were recruited. The assessment included distance visual acuity (DVA), near visual acuity (NVA), maximum reading speed (MRS), reading acuity (RA), contrast sensitivity (CS), and stereoacuity (SA) in photopic conditions for both types of lenses. Vision-related QoL was quantified twice for both lens types using the National Eye Institute Visual Function Questionnaire (NEI VFQ-42), covering 13 vision-specific domains. Results Comparisons of visual outcomes between MFSCLs and SVCLs for the same subjects revealed statistically significant differences in DVA (p = 0.010), NVA (p = 0.014), MRS (p = 0.044), and RA (p < 0.001), with SVCLs outperforming in DVA only. No significant difference in CS and SA was observed between the two lens types. According to the NEI VFQ-42, scores for clarity of vision, far vision, glare, and satisfaction with correction were higher with SVCLs, while the score for near vision was higher with MFSCLs. When fitted with MFSCLs, no significant correlations were found between pupil size and age of the patient with any visual examination parameters. However, there was a significant negative correlation between the DVA, NVA and the spherical equivalent of the lens. Conclusion MFSCLs with mid-add power significantly improve NVA, MRS, and RA, albeit with a reduction in DVA compared to SVCLs. While SVCLs were associated with better clarity of vision, far vision, and satisfaction with correction, MFSCLs offered superior performance in near vision tasks, according to the NEI VFQ-42 scores.

Comparison of Contrast Sensitivity between Alternating and Monocular Intermittent Exotropia

Purpose: To determine if contrast sensitivity varies between alternating and monocular intermittent exotropia.Methods: The study conducted a retrospective analysis of medical records for children aged 5-9 years with intermittent exotropia who had uncorrected visual acuity of 1.0 or better, a spherical equivalent of ± 1.50 diopters (D) or less, and anisometropia of 1.00 D or less. Patients were categorized into two groups using the cover-uncover test: an alternating group without fixation preference and a monocular group with fixation preference. Contrast sensitivity tests were performed on each eye under mesopic and photopic conditions with glare. In the alternating group, eyes were classified as right or left while in the monocular group the non-deviated eye was labeled dominant and the deviated eye was non-dominant.Results: The study included 53 patients with 31 in the alternating group and 22 in the monocular group. In the alternating exotropia group, the left eye demonstrated significantly better contrast sensitivity at 1.1 cycles per degree (cpd) under mesopic conditions (&lt;i&gt;p&lt;/i&gt; = 0.043), with no significant differences noted under other conditions. In the monocular exotropia group, dominant eyes exhibited significantly better contrast sensitivity at 10.2 cpd under mesopic conditions (&lt;i&gt;p&lt;/i&gt; = 0.046) and at 1.1 cpd under photopic conditions (&lt;i&gt;p&lt;/i&gt; = 0.031). No significant differences were observed in the interocular contrast sensitivity between the monocular and alternating groups across all spatial frequencies under both mesopic and photopic conditions.Conclusions: Pediatric patients with monocular intermittent exotropia displayed no significant differences in contrast sensitivity between dominant and non-dominant eyes except at certain frequencies. Additionally, there were no significant interocular contrast sensitivity differences between the monocular and alternating groups suggesting that contrast sensitivity tests may not be effective for determining the dominant eye in these conditions.

Effects of different types of intraocular lens implantation on patient's visual quality and function after phacoemulsification

Objective: To explore the effects of different types of intraocular lens (IOL) implantation on patient's visual quality and function after phacoemulsification. Methods: The clinical data of patients with monocular cataract who underwent phacoemulsification in the Department of Ophthalmology, People's Hospital Affiliated to Shandong First Medical University between December 2021 and May 2023 were retrospectively analyzed. According to the types of IOL, the patients were divided into monofocal group, bifocal group and depth of focus extension group. Three months later, uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA), uncorrected intermediate visual acuity (UCIVA), best corrected intermediate visual acuity (BCIVA), uncorrected near visual acuity (UCNVA) and best corrected near visual acuity (BCNVA) were detected. Contrast sensitivity and total wavefront aberration were measured by visual function analyzer. Satisfaction with visual quality was evaluated by hospital-made satisfaction questionnaire. Results: A total of 92 patients were included, with 31 males and 61 females, and their age was (61.8±5.2) years. There were 43, 28 and 21 cases in monofocal group, bifocal group and depth of focus extension group, respectively. No statistically significant difference was found in clinical baseline data among the three groups. UCIVA, UCDVA, BCIVA and BCDVA in depth of focus extension group were 1.01±0.13, 0.92±0.18, 1.21±0.19 and 1.20±0.23, respectively, which were higher than those in monofocal group (0.62±0.12, 0.74±0.13, 1.02±0.17, 1.07±0.19, respectively) and bifocal group (0.67±0.15, 0.78±0.14, 1.01±0.16, 1.01±0.18, respectively), while absolute value of spherical equivalent [(-0.42±0.07) D] was lower than that in the other two groups [ (-0.49±0.05) D and (-0.45±0.08) D] (both P<0.05). UCNVA and BCNVA in bifocal group were 0.91±0.18 and 1.25±0.18, which were higher than those in depth of focus extension group (0.63±0.24 and 1.19±0.17) (both P<0.05). There were no significant differences in contrast sensitivity among the three groups under day vision or between monofocal group and bifocal group under night vision (all P>0.05), but the contrast sensitivity was higher in depth of focus extension group under night vision (3.0, 6.0, 12.0 c/d) than other two groups (all P<0.05). The score of ocular discomfort was the highest in bifocal group, followed by depth of focus extension group and monofocal group (both P<0.05). The score of visual interference in bifocal group was lower than that in monofocal group and depth of focus extension group (both P<0.05). The scores of subjective feeling in bifocal group and depth of focus extension group were higher than that in monofocal group (both P<0.05). The reading score was the highest in bifocal group, followed by depth of focus extension group and monofocal group (both P<0.05). There was no significant difference in total low-order aberration among the three groups (P=0.472). The total aberration and higher-order aberration [(0.74±0.35) μm and (0.41±0.12) μm] were the highest in monofocal group, followed by bifocal group [(0.61±0.21) μm and (0.22±0.09) μm] and depth of focus extension group [(0.46±0.13) μm and (0.06±0.09) μm] (all P<0.05). Conclusions: IOL implantation with depth of focus extension can enhance visual range, night vision and contrast sensitivity, and thus effectively improve postoperative visual quality and function in cataract patients. The bifocal IOL can better improve the patient's UCNVA and BCNVA, resulting in high satisfaction with visual quality.

The Effect of Ethambutol Therapy in terms of Visual Evoked Potential, Color Vision Test, and Contrast Sensitivity Test at the Subclinical Level

Abstract&#x0D; Introduction &amp; Objectives : Ethambutol is one of the first-line drugs in the treatment of tuberculosis and known to induce optic neuropathy. However, there are unknown protocols for detecting subclinical level of toxicity. The aim of this study was to assess the difference in amplitude and latency of visual evoked potential (VEP), color vision, and contrast sensitivity in tuberculosis patients before and after taking ethambutol for 1 and 2 months.&#x0D; Methods : This was a prospective observational cohort study of 38 eyes of 19 newly diagnosed patients with category-1 tuberculosis being treated with ethambutol. All patients were given ethambutol for 2 months at a dose of 15 - 20 mg/kg body weight/day. The participants underwent complete eye and visual function examination including pattern-reversal VEP, color vision with Farnsworth Munsell D-15 test, and contrast sensitivity with LEA Low Contrast Flip Chart before and after 1 and 2 months of treatment. Wilcoxon test was employed for data analysis.&#x0D; Results : During the study, no changes in visual acuity was observed. The results showed that the latencies of VEP after 1 month (p = 0.000) and 2 months (p = 0.000) of treatment were significantly delayed. There was a significant difference in contrast sensitivity after 2 months (p = 0.014) of treatment. However, no significant difference was found in color vision and amplitude of VEP.&#x0D; Conclusion : Latency of VEP and contrast sensitivity test could prove useful in detecting subclinical and hence very useful for monitoring patients under ethambutol therapy for ocular toxicity.

The Effect of Illumination on Positive Fusional Vergence.

Positive fusional vergence (PFV) is vital in maintaining fusion in critical and continuous near tasks such as reading or performing digital screen tasks. This study investigated how PFV changed under various lighting conditions. This cross-sectional study recruited 34 participants aged between 21 and 25 years, with best corrected visual acuity (BCVA) 0.0 logMAR and insignificant refractive error. Three different illuminations-low illumination (50 lux), medium lighting (100 lux), and high illumination (150 lux)-were used to examine the ocular parameters PFV (blur, break, and recovery points), contrast sensitivity and pupil diameter. Pupil diameter changed significantly in different room illuminations (p = 0.00). There was no significant difference in contrast sensitivity across the three levels of room illumination (p = 0.368). Mean PFV (SD) (blur) was 14.5 (2.5) in 50 lux, 10.2 (2.2) in 100 lux, and 8.2 (2.1) in 150 lux. Under 50, 100 and 150 lux, respectively, the mean PFV (SD) (break) values were 16.7 (2.4), 13.4 (1.8), and 10.8 (2.2), and the mean PFV (SD) (recovery) values were 13.3 (2.1), 10.7 (2.1), and 7.5 (2.7). With increased illumination levels, PFV blur, break, and recovery values were significantly lower (p < 0.001). PFV values were significantly higher in lower illumination. Clinicians should be aware that room illumination affected the PFV values measured.

Comparison of Contrast Sensitivity in Subjects Wearing Spectacles and Contact Lenses

Aims: The purpose of this study was to compare the contrast sensitivity level in people wearing soft contact lenses and spectacles. Study design: Cross sectional Duration and Study Setting: Six months, Ophthalmology Department, Hayatabad Medical Complex, Peshawar. Methods: Data were taken from participants having myopic refractive error only, wearing soft contact lenses and spectacles for correction of their myopia. All the participants underwent comprehensive eye examination. Contrast Sensitivity (CS) were measured with Lea contrast sensitivity chart for each eye separately at three meters, two meters and one meter distances with spectacles first and then with soft contact lenses. After complete assessment, mean change in CS in contact lenses and spectacles were compared with paired t-test using SPSS 17.0. Results: A total of 48 eyes were tested. The mean age of subjects was 22 ±1.45. Contrast sensitivity Mean in spectacle was 78 at 3m, 127 at 2m, and 160 at 1m. CS Mean in contact lens is 65 at 3m, 117 at 2m, and 156 at 1m. Paired T test (two tailed) for means and alpha 0.05 was applied and showed the results were insignificant at 3m with p= 0.095, at 2m p=0.185 and at 1m p=0.327. The higher mean change in CS was observed in the age group of 23 years and moderate myopia. Conclusion: There was no statistically significant difference in CS between spectacle and soft contact lens wearing at three, two and one meter. According to our results there is no preference for contact lenses and spectacles regarding contrast.

Effect of Yellow Filter On Contrast Sensitivity Function In High Myopes

Background: This study examines the influence of yellow filter on the contrast sensitivity function in individuals with high myopia. Through a comprehensive analysis, we explore the potential enhancement of visual perception and contrast sensitivity in this population. The findings con-tribute to our understanding of effective interventions to optimize visual outcomes for high myopes. Purpose: A cross-sectional study was conducted where thirty-four (n=34) healthy young subjects (age range 17-25 years old) having high myopia (SER ≥ 6.00D) without any ocular pathology. Contrast sensitivity func-tion (CSF) was assessed using the Functional Acuity Contrast Test (FACT). First, the CSF was measured without the filter (baseline) then immediately after using a yellow filter (50% transmittance) and then after five minutes of adaptation of the yellow filter. The room illumination was constant at 150lux across all the subjects. Results: One-way repeated measure ANOVA showed that there was no statistically significant difference in contrast sensitivity function for spa-tial frequencies 1.5cpd, and 12cpd. However, there was a statistically significant difference in contrast sensitivity for spatial frequencies 3cpd; F(1.46, 48.20) =28.80, 6cpd; F (1.44, 47.43) =39.99 and 18cpd F (1.53, 50.47) = 44.26. Conclusion: There was an improvement at the moderate and high spatial frequencies (3cpd, 6cpd and 18cpd) but no changes were found at other spatial frequencies. This shows that yellow filter can help to improve the contrast sensitivity function in high myopes at moderate and high spatial frequencies.

Impact of Perioperative Dry Eye Treatment with Rebamipide Versus Artificial Tears on Visual Outcomes After Cataract Surgery in Japanese Population.

IntroductionThe present study aimed to compare the effects of rebamipide and artificial tears during the perioperative period of cataract surgery on the postoperative visual outcomes.MethodsSeventy-two eyes from 36 patients with a cataract were enrolled. Rebamipide (group R) was administered in one eye and Mytear® artificial tear ophthalmic solution (group A) in the other eye from 4 weeks preoperatively to 3 months postoperatively. Tear breakup time (TBUT), high-order aberrations (HOAs), superficial punctate keratopathy in the central part of the cornea (C-SPK), and corrected distance visual acuity (CDVA) were assessed at baseline, 1 week, 1 month, and 3 months after cataract surgery with trifocal intraocular lens (IOL) implantation. Contrast sensitivity and disability glare with visual angle values compatible with spatial frequencies of 1.1, 1.8, 2.9, 4.5, 7.1, and 10.2 cycles/degree (CPD) were evaluated postoperatively. Between-group differences of all variables were analyzed.ResultsAt baseline, no significant differences in the variables were noted between the two groups. Mean TBUT was significantly higher, while mean C-SPK and HOAs were significantly lower in group R than in group A at each assessment. Mean CDVA was significantly higher at 1 week and 1 month postoperatively in group R compared with group A; this value was not significant at 3 months. Between-group differences in contrast sensitivity and disability glare were statistically significant at all spatial frequencies, 1 week and 1 month postoperatively. At 3 months postoperatively, there were significant differences in contrast sensitivity and disability glare at most spatial frequencies.ConclusionDry eye management with rebamipide in the perioperative period of cataract surgery with trifocal IOL implantation was significantly more effective than artificial tears in improving ocular surface condition, contrast sensitivity, and disability glare postoperatively.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40123-022-00523-w.

Comparison of Patient Outcomes following Implantation of Trifocal and Extended Depth of Focus Intraocular Lenses: A Systematic Review and Meta-Analysis.

Purpose The purpose is to compare the outcomes of implantation of trifocal intraocular lenses (TIOLs) and extended depth of focus (EDOF) intraocular lenses (IOLs). Methods A comprehensive search of PubMed, Cochrane Library, EMBASE, and ClinicalTrial.gov was conducted in March 2020 to identify relevant studies. A meta-analysis of the results was performed. Patients implanted with EDOF IOLs or TIOLs in previous studies were included. The primary outcomes of the study were uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), and defocus curve. Results TIOLs and EDOF IOLs provided comparable binocular UDVA (MD = -0.01, 95% CI: -0.04, 0.03, logMAR). However, EDOF IOLs provided better UIVA (MD: -0.08, 95% CI: -0.14, -0.01, logMAR) and worse UNVA (MD: 0.10, 95% CI: 0.06, 0.14, logMAR) than TIOLs. Fewer patients achieved spectacle independence after implantation of EDOF IOLs (RR: 0.74, 95% CI: 0.63, 0.87) than after implantation of TIOLs, especially for near vision (RR = 0.82, 95% CI: 0.68, 0.99). There was no statistically significant difference in contrast sensitivity (CS) under photopic or mesopic conditions with both IOLs. Patient satisfaction after implantation of both IOLs was high. Conclusion EDOF IOLs and TIOLs provide comparable distance vision. However, EDOF IOLs provide better intermediate vision and worse near vision than TIOLs. The advantages of EDOF IOLs over TIOLs in terms of CS, aberrations, and visual disturbance are not significant. Patients are satisfied with both types of IOLs.

Sensitivity of Visual System in 5-Day "Dry" Immersion With High-Frequency Electromyostimulation.

The aim of this work was to study the sensitivity of the visual system in 5-day “dry” immersion with a course of high-frequency electromyostimulation (HFEMS) and without it. “Dry” immersion (DI) is one of the most effective models of microgravity. DI reproduces three basic effects of weightlessness: physical inactivity, support withdrawal and elimination of the vertical vascular gradient. The “dry” immersion included in the use of special waterproof and highly elastic fabric on of immersion in a liquid similar in density to the tissues of the human body. The sensitivity of the visual system was assessed by measuring contrast sensitivity and magnitude of the Müller-Lyer illusion. The visual contrast sensitivity was measured in the spatial frequency range from 0.4 to 10.0 cycles/degree. The strength of visual illusion was assessed by means of motor response using “tracking.” Measurements were carried out before the start of immersion, on the 1st, 3rd, 5th days of DI, and after its completion. Under conditions of “dry” immersion without HFEMS, upon the transition from gravity to microgravity conditions (BG and DI1) we observed significant differences in contrast sensitivity in the low spatial frequency range, whereas in the experiment with HFEMS—in the medium spatial frequency range. In the experiment without HFEMS, the Müller-Lyer illusion in microgravity conditions was absent, while in the experiment using HFEMS it was significantly above zero at all stages. Thus, we obtained only limited evidence in favor of the hypothesis of a possible compensating effect of HFEMS on changes in visual sensitivity upon the transition from gravity to microgravity conditions and vice versa. The study is a pilot and requires further research on the effect of HFEMS on visual sensitivity.

Clinical Outcomes of Combined Implantation of an Extended Depth of Focus IOL and a Trifocal IOL in a Korean Population

Purpose To evaluate monocular and binocular visual performance and patient-reported outcomes following combined implantation of a diffractive extended depth of focus (EDoF) IOL (Carl Zeiss AT LARA 829MP) and a diffractive trifocal IOL (Carl Zeiss AT LISA tri 839MP). Methods This prospective study enrolled consecutive patients undergoing lens phacoemulsification of cataract and combined implantation of an EDoF IOL in the dominant eye and a trifocal IOL in the nondominant eye. Assessment included uncorrected visual acuity at near distances (UNVA), intermediate distances (UIVA), and far distances (UDVA), uncorrected defocus curve, contrast sensitivity (CS), reading speed, and patient satisfaction, evaluated six months after the surgery with the Visual Function Questionnaire (VFQ-25). Results A total of 25 patients were enrolled. At six months postoperatively, outcomes of binocular UNVA, UIVA, and UDVA were superior to those of monocular outcomes. The binocular defocus curve showed significantly better results in comparison with the AT LISA tri IOL eyes at defocus levels of −1.0 D and −1.5 D (P=0.008 and P=0.002, respectively) and compared to the AT LARA IOL eyes at defocus levels of −3.0, −3.5 D, and −4.0 D (P=0.019, P=0.019, and P=0.035, respectively). All of the patients were spectacle-free at far and intermediate distances, while 4% of patients needed spectacles at the near distance. Reading speed showed a rather high and gentle slope curve between 0.1 logMAR and 0.4 logMAR, and optical phenomena were improved after combined implantation of IOLs except halos. There were no significant differences in CS between the binocular and monocular results of each IOL. Conclusions The combined implantation of an EDoF IOL and a trifocal IOL seems to be a good option for patients with demands for spectacle independence in their daily life, with minimal photic phenomena.

Comparison of visual performance between extended depth of focus contact lens and single-vision contact lens in eyes with monofocal intraocular lens.

To assess the visual performance of extended depth of focus (EDF) contact lenses (CL) in eyes that had undergone monofocal intraocular lens (IOL) implantation, and compare that between EDF and single-vision (SV) contact lenses. Prospective, randomized, crossover study METHODS: Seventeen patients implanted with monofocal IOLs were enrolled. The study was conducted using 1dayPure EDOF as a test CL and 1dayPure moisture (both SEED Co., Ltd.) as a control CL. Binocular visual acuity from far to near distances, photopic and mesopic contrast sensitivity (with and without glare), and stereopsis were evaluated after wearing the two kinds of CLs in random order. The obtained results were compared between the EDF and SV CLs. Binocular visual acuity at 0.3, 0.4, 0.7, 1, and 5m was 0.24 ± 0.12, 0.07 ± 0.09, - 0.02 ± 0.08, - 0.02 ± 0.08, and - 0.06 ± 0.07 logMAR during the EDF CL wear, respectively, and 0.39 ± 0.17, 0.26 ± 0.15, 0.04 ± 0.12, - 0.02 ± 0.08, and - 0.09 ± 0.09 during the SV CL wear, respectively. The EDF CL showed better results than the SV CL at 0.3, 0.4, and 0.7m (p < 0.05). There were no significant differences in contrast sensitivity between the EDF and SV CLs at 1.5 cycles per degree under all conditions; however, the sensitivity of the EDF CL was generally worse than that of the SV CL from the middle to high spatial frequencies. Stereopsis at 40cm was significantly better in the EDF CL wear than in the SV CL wear (p < 0.05). The EDF CL substantially improved visual acuity at near to intermediate distances in IOL-implanted eyes. However, far visual acuity decreased under low-contrast conditions, and contrast sensitivity slightly declined at the middle to high spatial frequencies.

Correlation of contrast sensitivity with the severity of primary open angle glaucoma

Aims: To assess the contrast sensitivity (CS) in different stages of primary open angle glaucoma and to correlate it with the severity (mild, moderate & severe) of glaucoma. Materials and Methods: This prospective randomized study was conducted at Sapthagiri institute of medical sciences and research centre, Bangalore between June 2017 & December 2017. A total of 100 eyes of 55 individuals aged 25-80 years diagnosed with POAG were enrolled in this prospective study. Selected subjects underwent detailed ophthalmic examination including ocular history, slit lamp examination, objective & subjective refraction (if required) to obtain best corrected visual acuity (BCVA) on Snellen visual acuity chart and dilated fundus evaluation using indirect ophthalmoscopy. Eyes with clear media and ?BCVA 6/60 were included and contrast sensitivity was measured using Pelli Robson chart at 1 meter distance. HFA report of included subjects were collected from Glaucoma department to classify them in to mild, moderate and severe groups according to their visual field findings (pattern deviation of HFA report). Classification was done according to International statistical classification of disease and related health problem (ICD 10). One way ANOVA and t-test was used to analyze the data. Results: There was 36% mild, 26% moderate and 38% severe cases of POAG classified according to ICD 10. The mean value of contrast in mild, moderate and severe POAG was 1.4341, 1.3267 and 1.1326 respectively. An analysis of variance tested whether there were significant difference in contrast sensitivity among mild, moderate and severe POAG. Results indicated that these means differed significantly p < 0> Conclusion: There was decrease in contrast sensitivity with the severity of POAG. Thus the contrast sensitivity testing should be made mandatory in evaluating POAG patients which could help in screening/diagnosis (early detection) and to assess the progression of the disease as well as response to the tre

Efficacy and safety of Nd:YAG laser vitreolysis for symptomatic vitreous floaters: A randomized controlled trial.

Vitreous floaters are a common and inconvenient phenomena. This study aims to examine the efficacy and safety in treating vitreous floaters using Nd:YAG laser vitreolysis. In this prospective double-blinded randomized clinical trial 24 eyes of twenty-four patients were randomized into intervention with YAG laser vitreolysis and control groups. Primary outcomes were visual disturbance on a 10-point scale, qualitative changes in a 4-level scale, contrast sensitivity measured with the Pelli-Robson table and the National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25). Secondary results included objective change in vitreous opacities, best-corrected visual acuity (BCVA), variation in intraocular pressure (IOP) and other adverse events. Twenty-one patients (21 eyes; 5 male, 16 female) were enrolled in this study (mean age 62 ± 7.9 years), three were lost during follow-up. In the YAG laser group, the 10-point visual disturbance score improved a mean of 4.7 points (p < 0.001) compared to the control group that improved 2.1 (p = 0.09). The YAG laser group reported greater subjectively symptomatic improvement (77%) than controls (25%). NEI VFQ-25 revealed improved general vision (75.8 versus 59.2; p = 0.037) and in mental health at 6 months (84.3 versus 70.3; p = 0.048). There was no significant difference in contrast sensitivity (p = 0.848) and in IOP (p = 0.505). No differences in adverse events between groups were identified. Vitreolysis with Nd:YAG laser improves visual results in patients with symptomatic vitreous floaters, without adverse events considered clinically relevant. Other trials with a larger number of participants are required to corroborate these results.

Altered visual functions, macular ganglion cell and papillary retinal nerve fiber layer thickness in early-treated adult PKU patients

PurposeRetinal changes are poorly described in early treated phenylketonuria (ETPKU). We aimed to investigate possible visual functional and ocular microstructural changes in adult patients with ETPKU. Optical coherence tomography (OCT) and its angiography (OCTA) data from patients with PKU were compared to healthy controls.MethodsIn this prospective, monocentric, cross-sectional, case-control study 50 patients with ETPKU and 50 healthy subjects were evaluated with OCT and OCTA. Measurements were performed on right eyes. The following visual function parameters were studied: best corrected visual acuity (BCVA), spherical equivalent (SE), contrast sensitivity and near stereoacuity; microstructural parameters: retinal nerve fiber layer thickness (RNFLT), ganglion cell layer (GCC) thickness, focal loss of volume (FLV), global loss of volume (GLV), peripapillary, papillary vessel density (VD), ocular axial length (AL) and intraocular pressure (IOP).ResultsAmong functional tests there were significant differences in contrast sensitivity at 1.5 (p < 0.001), 6 (p < 0.013), 12 (p < 0.001), 18 (p < 0.003) cycles per degree, in near stereoacuity (Titmus Wirt circles, p < 0.001) and in best corrected visual acuity (BCVA, p < 0.001). A statistically significant, moderate positive linear correlation was observed between BCVA and average Phe levels over the last ten years (β = 0.49, p < 0.001). The average (p < 0.001), superior (p < 0.001) inferior GCC (p < 0.001), the FLV (p < 0.003), GLV (p < 0.001) and the average RNFLT (p < 0.004) values of the PKU group were significantly lower than the controls. The serum phenylalanine level (Phe) in the PKU group negatively correlated with inferior (−0.32, p < 0.007), superior (r = −0.26, p < 0.028) and average (−0.29 p < 0.014) RNFL and with AL (−0.32, p < 0.026). In AL we detected a significant difference (p < 0.04) between the good and suboptimal dietary controlled group. There was no significant difference between the ETPKU and control group in the measured vessel density parameters and in IOP.ConclusionsOur results suggest that functional and ocular microstructural defects are present in patients with PKU, and some of them may depend on dietary control. The mechanism is unclear, but the correlation indicates the importance of strict dietary control in terms of preservation of retinal functions.

Vegetable Freshness Perception in Dementia with Lewy Bodies and Alzheimer’s Disease

Introduction: Although various visual function deficits have been reported in patients with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), vegetable freshness perception has not been thoroughly examined. Objective: To investigate vegetable freshness perception in patients with AD and DLB and to clarify the relationship between vegetable freshness perception and various visuoperceptual functions. Methods: We enrolled 37 patients with probable DLB, 58 patients with probable AD, and 32 age-matched healthy controls. We assessed vegetable freshness perception and visuoperceptual functions, including vegetable brightness perception, contrast sensitivity, color perception, and stereopsis. Patients with DLB showed disproportionate deficits in vegetable freshness perception and vegetable luminance perception compared to patients with AD and controls. Analyses of the groups with higher and lower vegetable freshness perceptions revealed significant differences in contrast sensitivity and visual texture recognition. Results: In the vegetable freshness test, we found significant differences among the 3 groups (F = 30.029, p < 0.0001); the extent of impairment in patients with DLB was greater than that in patients with AD. In patients with DLB, the vegetable freshness judgments were significantly correlated with texture judgment scores and contrast sensitivity. Conclusion: Our findings revealed significantly impaired vegetable freshness perception in patients with DLB. Vegetable freshness perception may be related to visual texture recognition in patients with DLB.

Influence of angle kappa-customized implantation of rotationally asymmetric multifocal intraocular lens on visual quality and patient satisfaction.

To evaluate the visual outcomes and patient satisfaction with angle kappa-customized implantation of SBL-3 (Lenstec, Inc.; +3 D), a rotationally asymmetric multifocal intraocular lens (MIOL). This was a prospective randomized control study. Data from consecutive patients, who underwent bilateral implantation of SBL-3 MIOL from June 2017 to August 2018, were enrolled in the study. One eye of each patient was randomly chosen to receive a horizontal IOL placement (control group), while the other eye received angle kappa-customized placement (design group). The outcomes include uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), defocus curve, contrast sensitivity, quality of vision and patient satisfaction. The follow-up was 3months. The study enrolled 80 eyes of 40 patients. There was no significant difference in mean UDVA, UIVA and UNVA between the two groups. The design group showed significantly better visual acuity at -1.50 D of defocus, based on the defocus curve (p=0.022), and less vertical coma (p=0.002) than the control group. No significant differences in contrast sensitivity, modulation transfer function, Strehl ratio and patient satisfaction were found between the two groups. Angle kappa-customized implantation of SBL-3 had little impact on visual outcomes and patient satisfaction, except for a moderate impact on intermediate visual acuity.

Comparison of Visual Quality with Ocular Higher-Order Aberrations in Laser Epithelial Keratomileusis and Soft Contact Lens Wear

Purpose : To compare visual quality with ocular higher-order aberrations (HOA) in laser epithelial keratomileusis (LASEK) and soft contact lens wear for myopia. Methods : Eighty eyes of 40 subjects who had undergone LASEK, 40 eyes of 20 subjects who have successfully fitted soft contact lenses and 38 eyes of 19 emmetropes were enrolled. The subjects’ criteria were best unaided monocular visual acuity of 20/20 or better. High and low contrast visual acuities (HCVA and LCVA) test, and contrast sensitivity test were measured under photopic and mesopic conditions. Ocular HOAs were measured using Wavefront Analyzer (KR-1W, Topcon) for 4 mm and 6 mm pupils. Results : HCVA and LCVA under photopic conditions were not statistically different between LASEK and contact lens wear groups compared with an emmetropic group. However, HCVA and LCVA under mesopic conditions were statistically different among the three groups (HCVA; p=0.031, LCVA; p=0.025, respectively). There were statistically significant differences in contrast sensitivity at 6, 12, and 18 cpd both under photopic and mesopic conditions between LASEK and contact lens wear groups (6cpd; p=0.000, 12cpd; p=0.000, 18cpd; p=0.000, redpectively). There were significant differences in ocular HOAs for both 4 mm and 6 mm pupils between LASEK and contact lens wear groups (total HOAs; p=0.000, coma; p=0.000, spherical aberration; p=0.000). Conclusion : LASEK, soft contact lens wear and emmetropic groups could not affect the quality of vision under photopic conditions. Nevertheless, the higher pupil size in the LASEK, the larger the amount of HOAs, the more likely it would have an influence on the visual quality during the night.

Comparison of visual and refractive outcomes between hydrophilic and hydrophobic trifocal intraocular lenses sharing the same optical design

To compare clinical outcomes between two trifocal intraocular lenses (IOLs): the new FineVision POD FGF trifocal IOL made of hydrophobic acrylic glistening-free material, and the FineVision POD F IOL made of hydrophilic acrylic material with 26% water uptake in patients undergoing routine cataract surgery using standard phacoemulsification. Semmelweis University, Department of Ophthalmology, Budapest, Hungary. Prospective controlled randomized single-center single-surgeon study. Each patient had the hydrophilic POD F IOL implanted in one eye and the hydrophobic POD FGF IOL in the contralateral eye, according to a randomization table. Clinical outcomes included distance (4m), intermediate (70cm), and near (35cm) visual acuities, contrast sensitivity measured under photopic and mesopic conditions, and defocus curves under photopic conditions. The follow-up was 6months. The study comprised 25 patients. Under photopic conditions, there was no statistically significant difference between POD FGF and POD F IOLs for uncorrected distance (UDVA) (P=.607), uncorrected intermediate (UIVA) (P=.491), and uncorrected near (UNVA) (P=.414) visual acuities. Under mesopic conditions, there was no statistically significant differences between the 2 IOLs for UDVA (P=1.00), UIVA (P=.149), and UNVA (P=.551). No statistically significant differences in contrast sensitivity were found between the groups under photopic (P=.4347) and mesopic (P=.425) conditions. No safety issues were reported. The study demonstrated equally good visual andrefractive outcomes for the POD FGF IOL and the POD F IOL, giving the surgeon the option to choose the preferred material for the individual patient without compromising clinical outcomes.