Significant Age Group Differences Research Articles

RETRACTED ARTICLE: Prognostic factors for the outcome of arthroscopic capsular repair of peripheral triangular fibrocartilage complex tears

Little information is available about prognostic factors of arthroscopic capsular repair for peripheral triangular fibrocartilage complex (TFCC) lesions. The purpose of this study was to analyze factors that affect the treatment outcomes of arthroscopic capsular repair for peripheral TFCC tears. This study retrospectively enrolled 60 patients who were treated with arthroscopic outside-in capsular repair for peripheral TFCC tears. Functional survey, including pain numeric rating scale (NRS) on an ulnar provocation test, distal radio-ulnar joint (DRUJ) stress test, Disability of the Arm, Shoulder, and Hand (DASH) score, and satisfaction with treatment, was conducted at 12-month follow-up. Patients who were enthusiastic or satisfied comprised the satisfied group, and those who were noncommittal or disappointed the dissatisfied group. Demographic, clinical, and arthroscopic findings were compared between the satisfied and dissatisfied groups. The mean pain NRS and DASH scores exhibited significant clinical improvement at the 12-month follow-up. Out of the total participants, 46 were satisfied and 14 were dissatisfied about the treatment, with significantly more female subjects in the dissatisfied group than in the satisfied one. The patients in the satisfied group had a shorter duration of symptoms, were more likely to have trauma history, and exhibited positive DRUJ stress test results compared to the dissatisfied group. There were no significant group differences in age, hand dominance, work level, and the extent of ulnar plus variance. Multivariable analysis revealed that female gender, a longer duration of symptoms, or negative DRUJ stress test results were associated with an increased disability after arthroscopic TFCC repair. Female gender, a longer duration of symptom, and a negative DRUJ stress test are associated with a higher likelihood of treatment failure after arthroscopic outside-in capsular repair of peripheral TFCC tears.

Measuring health related quality of life (HRQoL) in community and facility-based care settings with the interRAI assessment instruments: development of a crosswalk to HUI3

BackgroundHealth-related quality of life (HRQoL) measures are of interest because they can be used to describe health of populations and represent a broader health outcome for population health analyses than mortality rates or life expectancy. The most widely used measure of HRQoL for deriving estimates of health-adjusted life expectancy is the Health Utilities Index Mark 3 (HUI3). The HUI3 is available in most national surveys administered by Statistics Canada, and has been used as part of a microsimulation model to examine the impact of neurological conditions over the life course. Persons receiving home care and nursing home services are often not well-represented in these surveys; however, interRAI assessment instruments are now used as part of normal clinical practice in these settings for nine Canadian provinces/territories. Building on previous research that developed a HUI2 crosswalk for the interRAI assessments, the present study examined a new interRAI HRQoL index crosswalked to the HUI3.MethodsinterRAI and survey data were used to examine the distributional properties of global and domain-specific interRAI HRQoL and HUI3 index scores, respectively. Three populations were considered: well-elderly persons not receiving home care, home care clients and nursing home residents.ResultsThe mean HUI3 and interRAI HRQoL index global scores declined from independent healthy older persons to home care clients, followed by nursing home residents. For the home care and nursing home populations, the interRAI HRQoL global estimates tended to be lower than HUI3 global scores obtained from survey respondents. While there were some statistically significant age, sex and diagnostic group differences in global scores and within attributes, the most notable differences were between populations from different care settings.DiscussionThe present study provides strong evidence for the validity of the interRAI HRQoL based on comparisons of distributional properties with those obtained with survey data based on the HUI3. The results demonstrate the importance of admission criteria for home care and nursing home settings, where function plays a more important role than demographic or diagnostic criteria. The interRAI HRQoL has a distinct advantage because it is gathered as part of normal clinical practice in care settings where interRAI instruments are mandatory and are used to assess all eligible persons in those sectors. In particular, those with severe cognitive and functional impairments (who tend to be under-represented in survey data) will be evaluated using the interRAI tools. Future research should build on this work by providing direct, person-level comparisons of interRAI HRQoL index and HUI3 scores, as well as longitudinal analyses to examine responsiveness to change.

Lack of association between the distribution of ABO blood groups and nasopharyngeal carcinoma in a population of Southern China

Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. The ABO blood group antigens are chemical constituents on the surface of red blood cells and various epithelial cells. Several studies have described the association of ABO blood types with multiple types of human cancer. In this study, we aimed to investigate the relationship between the incidence of NPC and ABO blood groups. We retrospectively analyzed the files of 1136 pathologically confirmed patients with NPC and 1024 cancer-free healthy controls, including the information of serologically determined blood group. The distribution of blood groups between patients with NPC and the control group was determined. The Chi-square test was applied to assess the distribution of age, gender, smoking, family history, and ABO blood groups between the NPC and the controls. Pearson's correlation was performed to evaluate the correlation between ABO blood groups and clinical stages. There was no significant difference in age, smoking, family history, and ABO blood group between patients with NPC and the control group (P > 0.05). ABO blood groups were also not associated with NPC stages (P = 0.506). However, the proportion of males with NPC was higher than that of control group (P < 0.01). The blood group types were not associated with increased risk of NPC and NPC stages in a population of Southern China.

Timing of tracheostomy in patients with prolonged endotracheal intubation: a systematic review.

The objective of this article is to evaluate the appropriate timing of tracheostomy in patients with prolonged intubationregarding the incidence of hospital-acquired pneumonia, mortality, length of stay in intensive care unit (ICU) and duration of artificial ventilation. The study included published articles yielded by a search concerning timing of tracheostomy in adult and pediatric patients with prolonged intubation. The search was limited to articles published in English language in the last 30years (between 1987 and 2017). For the 690 relevant articles, we applied our inclusion and exclusion criteria and only 43 articles were included. 41 studies in the adult age group including 222,501 patients and 2 studies in pediatric age group including 140 patients met our criteria. Studies in adult age group were divided into three groups according to the methodology of determining the cut off timing for early tracheostomy, they were divided into studies that considered early tracheostomy within the first 7, 14 or 21days of endotracheal intubation, while in pediatric age group the cut off timing for early tracheostomy was within the first 7days of endotracheal intubation. There was a significant difference in favor of early tracheostomy in adults' three groups and pediatric age group as early tracheostomy was superior regarding reduced duration of mechanical ventilation, with less mortality rates and less duration of stay in ICU. Regarding hospital-acquired pneumonia, it was significantly less in adult groups but with no significant difference in pediatric age group (3 patients out of 72 pediatric patient with early tracheostomy had pneumonia compared to 11 patients out of 68 with late tracheostomy). Studies defining early tracheostomy as that done within 7days of intubation had better results than those defining early tracheostomy as that done within 14 or 21days of intubation. In conclusion, early tracheostomy within 7days of intubation should be done for both adults and pediatric patients with prolonged intubation.

Reach and Effectiveness of the National Diabetes Prevention Program for Young Women

Reducing obesity and diabetes risks among women of child-bearing age is urgently needed to halt the transgenerational cycle of disease. Interventions among pregnant women have largely been ineffective and may be initiated too late to improve maternal and child health. The National Diabetes Prevention Program is a widely disseminated lifestyle intervention that may help mitigate risks before pregnancy. However, the program has targeted relatively older adults, and effectiveness among women of child-bearing age remains largely unknown. The National Diabetes Prevention Program was delivered in an urban safety net hospital. Reach and effectiveness were evaluated among 4,866 eligible women who were invited to participate in the program. The authors compared enrollment, attendance, and weight loss for women aged 18-39 years as compared to women aged ≥40 years. Data were collected between 2013 and 2016. Analyses were conducted in 2017. Women of child-bearing age were nearly half as likely to enroll than older women in adjusted models (OR=0.58, 95% CI=0.49, 0.69). Subsequently, younger enrollees were less likely to attend ≥1 session(s) than older women (OR=0.77, 95% CI=0.61, 0.99). There was no significant age group difference in program completion rates or weight-loss outcomes. Both groups lost an average of 3% body weight. Women of child-bearing age were less likely than older women to engage in the National Diabetes Prevention Program; however, they were equally likely to benefit from weight loss when they attended. Further efforts are needed to improve engagement of women of child-bearing age.

Prevalence of uncorrected refractive errors among children aged 3-10 years in western Saudi Arabia.

Objectives:To determine the prevalence of uncorrected refractive errors (URE) among children 3-10 years and to affirm the necessity of a national school-based visual screening program for school-aged children.Methods:This retrospective cross-sectional study was conducted in Medina, Saudi Arabia in 2015. Children were selected through a multistage stratified random sampling from 8 kindergarten and 8 primary schools. Those included were screened to diagnose UREs using a visual acuity chart and an auto refractometer according to American guidelines. The prevalence and types of UREs were estimated.Results:Of the 2121 children enumerated, 1893 were examined, yielding a response rate of 89.3%. The prevalence of UREs was 34.9% (95% CI = 32.8%-37.1%), with significant differences in different age groups. The prevalence of astigmatism (25.3%) was higher compared to that of anisometropia (7.4%), hypermetropia (1.5%), and myopia (0.7%). Risk of uncorrected refractive error was positively associated with age, and this was noted in astigmatism, myopia, and anisometropia. In addition, the risk of hypermetropia was associated with boys and that of myopia was associated with girls.Conclusions:The prevalence of UREs, particularly astigmatism, was high among children aged 3-10 years in Medina, with significant age differences. Vision screening programs targeting kindergarten and primary schoolchildren are crucial to lessen the risk of preventable visual impairment due to UREs.

Mediation role of self-efficacy between social support and depression of only-child-lost people

To investigate the relationship between social support and depression of only-child-lost (OCL) people, and the mediation role of self-efficacy in this relationship. Methods: By stratified cluster sampling, 214 OCL people were enrolled, with 80 males and 134 females, ages from 49 to 83 years old. They were assessed by General Self-Efficacy Scale, Social Support Rating Scale, and Self-rating Depression Scale. Results: Univariate analysis showed that there were significant differences in age groups (t=2.85, P<0.05), with or without spouse (t=5.62, P<0.05), family location (t=3.95, P<0.05), per capita monthly income (F=3.48, P<0.05) among the social support scores. There was significant difference between the per capita monthly income and self-efficacy scores in QCL people (F=5.46, P<0.05). Correlation analysis showed self-efficacy and social support were positively correlated (r=0.26, P<0.01). Self-efficacy (r=-0.59, P<0.01) and social support (r=-0.59, P<0.01) negatively correlated with depression in OCL people. Self-efficacy partially mediated the relationship between social support and depression. Conclusion: The person who is <60 years old, with spouse and the high per capita monthly income, and lives the rural area, would have high social support levels among QCL people. The person who has high per capita monthly income would have high self-efficacy. Self-efficacy is one of the direct prediction for depression, and plays an indirect role between social support and depression. Intervention of depression among OCL people could be applied to change their cognition, and to enhance their self-efficacy.

Demographic differences in using knowledge creation tools among faculty members

PurposeThe purpose of this study is to investigate and analyze demographic differences in using knowledge creation tools among faculty members. It also attempts to identify the most knowledge creation tool used by the participants. The tools comprised of 13 items including data mining, metadata, classifications, expert profiling, Mashup and blogs.Design/methodology/approachData were collected through an online survey questionnaire. A total of 300 faculty members from 26 universities and colleges accredited by the UAE Ministry of High Education participated in the study. The t-test and analysis of variance (ANOVA) test are used to validate the stated hypotheses.FindingsThe study found personal knowledge management to be the most used knowledge creation tool among the faculty members, followed by authoring tools and templates. Findings of the study indicate statistically no significant difference in using knowledge creation tools with respect to gender, qualification, academic rank, teaching experience and institutional affiliation. These findings support the stated null hypotheses (H1, H3, H4, H6 and H8) and suggest that the use of knowledge creation tools is independent from these variables. However, the results showed statistically a significant age group difference, academic specialization and research experience in using knowledge creation tools. The findings reject the assumed hypotheses (H2, H5 and H7) and suggest the impact of these variables on the use of knowledge creation tools.Research limitations/implicationsThe paper is based on the data collected through a survey questionnaire. Future studies may combine quantitative and qualitative data collection methods for the purpose of comparison and in-depth analysis.Practical implicationsFindings could be an important reference for knowledge management officers and knowledge intensive organizations and institutions to develop knowledge creation tools and promote usage among knowledge workers.Originality/valueThe paper represents one of the very few empirical studies conducted on the use of knowledge creation tools. Findings of the study may contribute to the process of knowledge creation among faculty members and also to the improvement of knowledge management in the academic environment and other knowledge organizations.

A cross-national study on gender differences in suicide intent

BackgroundSuicide accounts for over 58,000 deaths in Europe per annum, where suicide attempts are estimated to be 20 times higher. Males have been found to have a disproportionately lower rate of suicide attempts and an excessively higher rate of suicides compared to females. The gender difference in suicide intent is postulated to contribute towards this gender imbalance. The aim of this study is to explore gender differences in suicide intent in a cross-national study of suicide attempts. The secondary aims are to investigate the gender differences in suicide attempt across age and country.MethodsData on suicide attempts (acquired from the EU-funded OSPI-Europe project) was obtained from eight regions in Germany, Hungary, Ireland and Portugal. Suicide intent data was categorized into ‘Non-habitual Deliberate Self-Harm’ (DSH), ‘Parasuicidal Pause’ (SP), ‘Parasuicidal Gesture’ (SG), and ‘Serious Suicide Attempt’ (SSA), applying the Feuerlein scale. Gender differences in intent were explored for significance by using χ2-tests, odds ratios, and regression analyses.ResultsSuicide intent data from 5212 participants was included in the analysis. A significant association between suicide intent and gender was found, where ‘Serious Suicide Attempts’ (SSA) were rated significantly more frequently in males than females (p < .001). There was a statistically significant gender difference in intent and age groups (p < .001) and between countries (p < .001). Furthermore, within the most utilised method, intentional drug overdose, ‘Serious Suicide Attempt’ (SSA) was rated significantly more often for males than females (p < .005).ConclusionsConsidering the differences in suicidal intent between males and females highlighted by the current study, gender targeted prevention and intervention strategies would be recommended.

Cognitive Processing Speed across the Lifespan: Beyond the Influence of Motor Speed.

Traditional neuropsychological measurement of cognitive processing speed with tasks such as the Symbol Search and Coding subsets of the WAIS-IV, consistently show decline with advancing age. This is potentially problematic with populations where deficits in motor performance are expected, i.e., in aging or stroke populations. Thus, the aim of the current study was to explore the contribution of hand motor speed to traditional paper-and-pencil measures of processing speed and to a simple computer-customized non-motor perception decision task, the Inspection Time (IT) task. Participants were 67 young university students aged between 18 and 29 (59 females), and 40 older adults aged between 40 and 81 (31 females) primarily with a similar education profile. As expected, results indicated that age group differences were highly significant on the motor dexterity, Symbol Search and Coding tasks. However, no significant differences or correlations were seen between age groups and the simple visual perception IT task. Furthermore, controlling for motor dexterity did not remove significant age-group differences on the paper-and-pencil measures. This demonstrates that although much of past research into cognitive decline with age is confounded by use of motor reaction times as the operational measure, significant age differences in cognitive processing also exist on more complex tasks. The implications of the results are crucial in the realm of aging research, and caution against the use of traditional WAIS tasks with a clinical population where motor speed may be compromised, as in stroke.

KECEMASAN DAN GANGGUAN FUNGSI TIROID PADA WANITA USIA SUBUR

Background. Thyroid function disorders can be determined by thyroid levels and thyroid stimulating hormone (TSH) in the blood. In normal condition, thyroid hormones will play an important role in metabolism, system oxidation process, the growth process and protein synthesis. This hormones have an effect to all cells in the human body through the amino acids transport mechanism and electrolytes from extra cellular fluids into the cells, enzyme protein synthesis in cells and increase intracellular processes. Changes of thyroid function can interfere cognitive function, behavioral problems, and change of feeling (mood), included an anxiety. Objective. This study aimed to determine the differences of anxiety in patients with hyperthyroidism, euthyroid, and hypothyroidism in Klinik Litbang GAKI Magelang. Methods. This study was conducted using cross sectional method. Samples are 507 women of childbearing age who visited Klinik Litbang GAKI during 2013. The research variables are TSH status and level of anxiety. The level of anxiety was measured using the Beck Anxiety Inventory (BAI) which has 21 items and also measure the physical, cognitive, and emotional aspects. The socio-demographic data were obtained through interviews. The statistical analysis used was Anova test. Result. Subjects with hyperthyroidism, hypothyroid, and euthyroid were 33.3%, 7.3%, and 59.4% respectively. Many subjects especially above 36 years old experience moderate and severe anxiety level. There was no statistically significant differences in age group between hyperthyroid, euthyroid, and hypothyroid. Anova test results showed that the hyperthyroidism group has higher anxiety scores compared with euthyroid group. Conclusion. Impaired hyperthyroidism experienced by childbearing age women would be more prone to experience psychological problems particularly anxiety.

School transition and mental health among adolescents: A comparative study of school systems in Denmark and Australia

This study explores the influence of transition from primary to secondary schools in Australia versus no transition in Denmark by comparing age trends in students’ school connectedness, emotional symptoms and conduct problems. Survey data from 5067 students in Australia and Denmark were used to compare 11–12 (prior to transition in Australia), 13–14 (during transition) and 15 year-olds (post-transition) in each country. In Australia, no statistically significant age group differences in emotional symptoms, conduct problems or school connectedness were observed. In Denmark, low school connectedness, emotional symptoms and conduct problems increased with age. A continuation of efforts to support students through transition and beyond in Australia, and a stronger focus on mental health and school connectedness in Denmark is recommended.

Has VZV epidemiology changed in Italy? Results of a seroprevalence study

ABSTRACTThe aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera were collected and tested. In the studied period both incidence and hospitalization rates decreased and about 5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects passively protected by their mother, followed by an increase in the following age classes. The overall antibody prevalence was 84%. The comparison with surveys conducted with the same methodology in 1996–1997 and 2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection typically occurs in children. The impact of varicella on Italian population is changing. The comparison between studies performed in different periods shows a significant increase of seropositivity in age class 1 – 4 years, expression of vaccine interventions already adopted in some regions.

Sociodemographic, sexual, reproductive and relationship characteristics of adolescents having an abortion in Portugal: a homogeneous or a heterogeneous group?

Objectives: The aims of the study were to describe the sociodemographic, sexual, reproductive and relational characteristics of adolescents having an abortion in Portugal and to explore the differences between three adolescent age groups.Methods: We recruited a nationally representative sample of 224 adolescents (<16 years, n = 18; 16–17 years, n = 103; 18–19 years, n = 103) who had an abortion. Data were collected from 16 health care services that provide abortion.Results: The adolescents were predominantly single, were from non-nuclear families, had low-socioeconomic status and were students. Mean age at first sexual intercourse was 15 years and mean gynaecological age was 5 years. Most had had multiple sexual partners, and for most it was their first pregnancy. At conception, the majority were involved in a long-term romantic relationship, were using contraception but did not identify the contraceptive failure that led to the pregnancy. Significant age group differences were found. Compared with the younger age groups, the 18–19 year age group was more frequently married or living with a partner, had finished school, had attained a higher educational level (as had their partner), intended to go to university, and had a greater number of sexual partners. Compared with the other groups, those under 16 years of age reported earlier age at menarche and at first sexual intercourse, and had a lower gynaecological age.Conclusions: Our study characterises the life contexts of Portuguese adolescents who had an abortion. It highlights the need to recognise the heterogeneity of this group according to age. The findings have important implications for the development of age-appropriate guidelines to prevent unplanned pregnancy.

Toxicities and Related Outcomes of Elderly Patients (pts) (≥65 Years) with Hematologic Malignancies in the Contemporary Era (Alliance A151611)

Background: Contemporary approaches to non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) incorporate chemo-immunotherapy, biologic combinations, and immune modulating agents; toxicities in elderly pts (³65 years) receiving these therapies are not well studied. Further, clinical and biologic factors predicting these toxicities in pts receiving biologic therapy remain undefined.Methods: We reviewed data on NHL and/or CLL pts treated prospectively on 14 studies by the Alliance for Clinical Trials in Oncology from 2004-2014 (Table 1). Toxicity was assessed per the NCI CTCAE at the time of trial enrollment, and the probabilities of experiencing grade 3 and grade 4 hematologic (hem) and non-hematologic (non-hem) toxicities were modeled as a function of age (³65 years vs. < 65), time on study, treatment (biologics only vs. biologic + chemotherapy), gender, race, LDH, performance status (PS), stage, and an age-by-treatment interaction using logistic regression.Results: A total of 1199 pts (409 age ³ 65; 790 age < 65; 736=CLL and 463=NHL) were included. Among these patients, 493 received only biologic therapy (166 age ³ 65; 327 age < 65; 104 CLL; 389 NHL), and 706 received biologic + chemotherapy (243 age ³ 65; 463 age < 65; 632 CLL; 74 NHL). Among CLL pts (259 pts ³ 65), the effect of age on the probability of experiencing a grade 3 heme toxicity differed by treatment type (age-by-treatment interaction p = 0.047). Specifically, the adjusted odds ratio (OR) (age ³ 65 vs. < 65) for pts receiving only biologic therapy was 3.075 (95% CI: 1,15-8.25), and that for pts receiving biologic + chemotherapy was 1.044 (95% CI: 0.69 - 1.57). Similar results were seen in CLL pts for grade 4 heme toxicities (age-by-treatment interaction p = 0.033; biologic OR 6.937, 95% CI: 1.76-27.35; biologic + chemo OR 1.484, 95% CI: 1.04-2.13). No such interactions were found in CLL pts for grade 3 and 4 non-hem toxicities; however, older pts had significantly higher odds of experiencing a grade 3 non-hem toxicity than younger pts (adjusted OR 1.40; p = 0.047; 95% CI: 1.004-1.96). No age group differences were found in CLL pts for grade 4 non-hem toxicity. Similar analyses were performed for NHL pts (150 pts ³ 65), but no significant age group differences were found.Among CLL pts, women had significantly higher odds of experiencing a grade 3 heme toxicity than men (OR 2.01; p = 0.0007); no difference in grade 3 non-hem or any grade 4 toxicity was noted. Non-Caucasian CLL pts had higher odds of experiencing a grade 4 non-hem toxicity than Caucasians (OR 2.892; p = 0.0029), but no other toxicity differences were found. Worse PS was associated with increased toxicities (OR 1.871; p = 0.0009: grade 3 heme; OR 1.647; p = 0.0025: grade 3 non-hem; OR 1.410; p = 0.0448: grade 4 heme, and OR 1.931; p = 0.0252: grade 4 non-hem). CLL pts with advanced stage disease had higher odds of experiencing a heme toxicity (grade 3: OR 1.95; p = 0.0007, grade 4: OR 1.451; p = 0.0329), but no stage associations were found for non-hem toxicities.Among NHL pts, men had significantly higher odds of experiencing a grade 4 hematologic toxicity than women (OR 4.351; p = 0.0169), but no other toxicity differences were found. An increase in LDH was associated with significantly higher odds of experiencing grade 3 non-hem and grade 4 heme toxicities (grade 3 non-heme: OR 1.633; p = 0.021, grade 4 heme: OR 2.039, p = 0.0182), but no such effect was found for grade 3 heme or grade 4 non-hem. Worse PS was associated with higher odds of experiencing grade 3 toxicities (heme: OR 2.025; p = 0.0344, non-hem: OR 2.458; p = 0.0013), but no such differences were found for grade 4 toxicities. No significant stage or race effects were found in NHL patients.Conclusion: In pts ³65 years who have CLL or NHL, we identified several clinical and disease-related factors as potential predictors of developing grade 3 and/or 4 heme and non-hem toxicities (Table 2). A prognostic model is being constructed to predict toxicities in these under-studied pts to guide management and monitoring. Further, the impact of these toxicities on outcomes is being analyzed and will be presented at the meeting. [Display omitted] [Display omitted] DisclosuresHurria:Celgene: Other: Research; Optum Health Care SOlutions: Consultancy, Other: Conference panel, research; Boehringer Ingelheim Pharmaceuticals: Consultancy; Sanofi: Consultancy; Carevive: Consultancy; Novartis: Other: Research; GTx, Inc: Consultancy. Bartlett:Gilead: Consultancy. Cheson:Gilead: Research Funding; Acerta: Membership on an entity's Board of Directors or advisory committees, Research Funding; Pharmacyclics: Membership on an entity's Board of Directors or advisory committees, Research Funding. Nabhan:Infinity: Consultancy; Abbvie: Consultancy; Cardinal Health: Consultancy; Seattle Genetics: Research Funding; Genentech: Consultancy, Research Funding; Astellas: Research Funding; Celgene Corporation: Consultancy, Research Funding.

When depression is diagnosed, older adults are as likely as younger adults to be prescribed pharmacotherapy and psychotherapy.

This study examined age group differences in the rates of depression diagnosis and treatment using a national probability sample. Using data from the 2012 National Ambulatory Medical Care Survey (n=62,723 visits by patients aged 18+ years), we used bivariate and multivariable binary logistic regression analyses to test age group differences in antidepressant medication (ADM) and psychotherapy prescribed/ordered or provided at visits during which depression was diagnosed. Visits by older adults were less likely to result in a depression diagnosis than visits by younger individuals: 2.46% and 1.80% in the 65-74 and 75+ age groups, compared to 4.06%, 4.24% and 4.12% in the 18-29, 30-49 and 50-64 age groups, respectively. Of all visits involving diagnosed depression, 65.88% included prescribing/ordering or providing ADM and 19.01% included psychotherapy ordering or providing, without significant age group difference. Prescribing/ordering or providing ADM occurs frequently during visits to physicians regardless of specialty, while psychotherapy was ordered or provided mostly during visits to psychiatrists. During ambulatory care visits in which depression was diagnosed, older adults were as likely as younger adults to be prescribed/provided treatment; however, in more than 30% of visits by depressed older adults neither ADM nor psychotherapy was prescribed.

Pattern of pediatric Ear, Nose and Throat diseases at Arthur Davison Children’s Hospital, Ndola, Zambia

Background: Ear, Nose and Throat (ENT) disorders are very common in children mainly due to increased number of risk factors for these disorders in our environment. However, there is a lack of data on paediatric ENT disorders from Zambian population. This study aimed at determining the pattern of common paediatric ENT diseases and their relationship with socio-demographic factors in a tertiary hospital, Arthur Davison Children’s Hospital (ADCH), in Ndola Zambia. Method: This was a retrospective hospital-based descriptive study involving review of medical records of patients’ aged0-14 years who presented to the ENT outpatient clinic of ADCH with various ENT disorders from January 2014 to December 2015.Results: Within the study period, a total of 988 children were seen. ENT diseases were found to be more common among male children (52.8%), the female to male ratio is1:1.12.There was no significant difference in age groups. Ear disorders (47.1%) were found to be the commonest group of ENT problems, followed by pharyngeal disorders (40.1%) and nasal disorders (12.8%). The most common otologic disorder was Earwax obstructing the tympanic membrane (28.8%).Among rhinologic disorders, Nasal Foreign Bodies (27.0%) were the commonest while Tonsillitis (42.8%) was the commonest Pharyngeal disorder. There were more patients in lower socio-economic classes than in the upper classes. Conclusion: This study has demonstrated the broad spectrum of ENT disorders as observed at ADCH over a period of 2 years. Improvement of health education, socio-economic status and health facilities will be helpful in reducing the frequency of ENT diseases.

Age and Sex Differences in Temperament and Character Dimensions in a French Nonclinical Population

Abstract. The authors examined age and sex trends on the seven dimensions and 25 facets assessed by the Temperament and Character Inventory (TCI) collected between 2006 and 2014. This cross-sectional study sought to better understand personality differences according to age and sex cohorts in a French nonclinical community sample (1,181 participants). Our results show significant differences in age groups in Novelty Seeking, Reward Dependence, Harm Avoidance, and Self-Transcendence. Women scored higher than men in Harm Avoidance, Reward Dependence, and Cooperativeness. Men between 18 and 29 years old reported higher Novelty Seeking whereas older women had higher Harm Avoidance. Among all the dimensions of the TCI, only Self-Directedness presents a consistent Gender × Age interaction. Our study confirmed that there were personality-specific features in men and women. In addition, there were personality changes with age in both temperament and character dimensions. Our research highlighted the need to take into account both age and gender of subjects in the future analyses and interpretations of findings from the temperament and character inventories.

Evaluation of risk factors for the recurrence of ovarian endometriomas

ObjectivesTo evaluate the risk factors for the recurrence of ovarian endometrioma after laparoscopic cystectomy. Study designReproductive aged patients who underwent laparoscopic ovarian endometriotic cystectomy and with histopathologically confirmed diagnosis of ovarian endometrioma were evaluated retrospectively. Histopathologic specimens were reevaluated and histopathologic characteristics of ovarian endometriotic cysts (thickness of cyst wall, thickness of fibrosis [ToF], thickness of ovarian tissue, the number of follicles per cyst, the depth of penetration [DoP] of endometrial tissue into the cyst wall) were determined. Along the determined histopathologic findings, demographic characteristics (age at surgery, number of pregnancies), clinical symptoms (dysmenorrhea, infertility), intraoperative findings (revised American Society for Reproductive Medicine [rASRM] stage), imaging features (bilaterality, cyst diameter), and biochemical parameters (Ca125, Ca19.9, Ca15.3) were evaluated as possible risk factors for the recurrence of endometrioma. The variables with p<0.2 in univariate analysis were introduced into regression analysis to determine the risk factors for recurrence. ResultsThere were statistically significant differences in age group (≤35 years and >35 years), the ToF and DoP between patients with recurrence and those with no recurrence. In Cox regression analysis, age ≤35 years and DoP were significant risk factors for presence of recurrence. DoP, ToF, preoperative cyst diameters in ultrasonographic examination were inversely correlated with recurrence interval. In multivariate regression analysis, the DoP was found the only significant risk factor for the recurrence interval. 1.2mm of DoP was found as the optimum cut off value for presence of recurrence according to Youden index criteria in ROC curve analyze. The sensitivity (62.9%), specificity (75%) were obtained at the cut off value of 1.2mm for DoP. ConclusionHistopathological features of ovarian endometriotic cyst may have important roles on predicting the recurrence of the endometrioma. Predicting the recurrence risk of particular patient is very important in future management of the disease. Knowing the recurrence risk of an endometrioma will help in deciding the optimal treatment modalities for each individual patient. High risk patients should be offered appropriate treatments according to the clinical status without delay and low risk patients should be protected from overtreatment.

Does the Type of Aggression Matter? The Role of Culture in Understanding Direct and Indirect Aggression Among Children and Adolescents in Trinidad

The objective of this study was to examine the effects of age, gender, and ethnicity on direct and indirect aggression among children and adolescents in Trinidad. Through multistage sampling, 170 (N = 170) participants from Primary (Elementary) and Secondary (High) schools across Trinidad completed a demographic questionnaire and the Direct and Indirect Aggression Scale (DIAS). The data were analyzed using three separate General Linear Models (GLMs) for direct physical, direct verbal, and indirect aggression. The results revealed significant age-group, gender, and ethnic differences on the three types of aggression. When compared to age-group and ethnicity, the effect of gender was greatest on both direct and indirect aggression. The findings of the study were discussed within the socio-cultural context of Trinidad and had important implications for future researchers.