Background : Infection Prevention expertise and support are vital to healthcare organizations. Typical workflow of site-based Infection Preventionists (IPs) is already overwhelming, especially during a pandemic and providing emergent support off-hours can be burdensome to the IPs. An existing site-based model for emergent off-hours support represents an opportunity to improve work-life balance. Methods : A regionalized model was implemented to replace existing site-based model. This model allowed IPs to rotate every six weeks compared to everyone to three weeks. Data was collected using pre- and post-implementation surveys with questions to determine the impact of the new model on work-life balance. A statistical t-test was conducted to determine significance difference with a p-value of .05. Results : Since implementation of the regionalized model at three hospitals part of a multi-site healthcare system, IPs voiced a significant difference in stress level, t(6)=-4.8, p=.003. They also noted that their work is significantly more impactful, t(6)=-3.13, p=.020. During their scheduled shift to provide off-hours support, the IPs did not express a significant difference in how often they disengaged from personal activities, t(4)=0.64, p=.055. Conclusions : It has been demonstrated that a regionalized model for emergent off-hours support improves the IPs’ work-life balance. This robust program represents an ideal model to reduce stress, decrease disengagement from life outside of work, and to promote sense of impact for the Infection Preventionists.