Wild edible plants are vital for the survival and sustainable livelihoods of rural people of Ethiopia. Thus, this study compiled wild edible plants, their use, threats, and management practices in Metema District, northwestern Ethiopia. Eight sample kebeles were selected purposively based on vegetation coverage and key informants availability. A total of 128 informants were selected using purposive and random sampling techniques. Data were collected using individual interviews, guided field walks, focus group discussion, and market surveys through semistructured questionnaires. Ethnobotanical data collected from the informants were summarized by descriptive statistics, and further verified by using informant consensus, preference, and direct matrix ranking. Knowledge difference among age and sex groups was evaluated by independent sample t-test. A total of 44 wild edible plant species distributed in 34 genera and 25 families were documented. Most (88.64%) of these plant species were found in the wild habitat. Fabaceae and Moraceae accounted for higher proportion of edible plant species. Trees were the dominant habit (59.09%). From the total recorded wild edible plants, 33 (75%) species were used as supplementary foods and 11 (25%) species were used during famine. Fruits were the most edible plant parts (66%) and raw fresh forms were the main conditions of consumption (81.8%). Diospyros abyssinica was the most cited (60.94%) and first ranked. Some edible species such as Adansonia digitata and Balanites aegyptiaca were marketable. Ziziphus spina-christi was found the most multipurpose wild edible plant species. Most of the species (33, 75%) were used as animal fodder followed with traditional medicines (25, 56.82%) and firewood (20, 45.45%). Tamarindus indica, Moringa stenopetala, Balanites aegyptiaca, Grewia ferruginea, Corchorus olitorius, and Cordia africana had nutraceutical values. Significant knowledge differences ( P < 0.05 ) were obtained among sexes and age groups of informants on the number of wild edible plant species they listed. As a result of their multiple roles, wild edible plants are threatened by various anthropogenic activities. Despite this, Metema District still supports good numbers of wild edible plants from which the poor inhabitants complement their basic needs by consuming and marketing them. For sustainable utilization, conservation, value addition, and market linkage practices shall be strengthened to improve the livelihoods of local people and sustainable forest management.