Significant Changes Research Articles

Countermovement-Jump and Pull-Up Performance Before and After a Swimming Race in Preparatory and Competitive Phases of a Swimming Season.

Monitoring performance athletes' training responses can be efficiently completed at competitive events. This study aimed to explore the changes in swimming, countermovement-jump (CMJ), and pull-up (PU) performance following training across a competitive phase, as well as immediately before and after each race. Fourteen well-trained male sprint/middle-distance swimmers (height 179 [7]cm, mass 70 [8]kg, age 18 [2]y), from 3 regional training groups, completed CMJ and PU tests before and after the national competitions in October and May, when race performance was also assessed. Swimming race performance was significantly improved from before the national competitions in October to after the national competitions in May (1.8% [3.2%], P = .044, d = 0.60, moderate effect). Although there were no significant changes in PU velocity, CMJ performance significantly improved from before the national competitions in October to after the national competitions in May (mean difference 2.29cm, P = .004, d = 3.52) and showed before-to-after race decreases (mean difference -1.64cm, P = .04, d = 2.28). Swimming performance and CMJ performance improved as the season progressed, although these improvements were not directly correlated. PU performance did not appear to be sensitive to training or race-induced fatigue, in contrast to CMJ, in this group of male swimmers.

Has the Prevalence of Creaky Voice Increased Among Finnish University Students From the 1990'S to the 2010'S?

Everyday observations indicate that creaky voice has become common in Finland in recent years. Previous studies suggest that this trend is also occurring in other countries. This cross-sectional study investigates the use of creaky voice among Finnish university students from the 1990's to the 2010's. Material was obtained from a sound archive. It consisted of 200 samples from normophonic speakers (95 males, 105 females; mean age 23.7 years, SD 3.3 years, range 19-35 years). Normophonia was checked by two speech therapists in a preliminary perceptual analysis. Thereafter, two voice specialists rated the amount of creak and strain. A scale of 0-4 was used (0=none, 4=a lot). The inter- and intrarater reliability for the listening evaluations were satisfactory (for creaky phonation, rho=0.611, P < 0.001 for interrater reliability and rho=0.540, P < 0.001 for intrarater reliability; for strain, rho=0.463, P < 0.001 and rho=0.697, P < 0.001 for inter- and intrarater reliability, respectively). These results revealed a significant increase in the amount of perceived creak in females (from 1.04, SD 0.69 to 1.55, SD 1.06; P < 0.05, Mann-Whitney U test). In males, no significant change was found. However, the frequency of creaky voice use increased in both genders. No male speakers from the 1990's were rated as using "a lot" of creaky voice, but 2.3% of male speakers from the 2010's received this rating. Male speakers who were rated "quite a lot" increased from 5.9% in the 1990's to 18.1% in the 2010's. Female speakers rated "a lot" increased from 0% to 6%, and female speakers rated "quite a lot" increased from 7% to 25.8% over the studied time periods. Creaky phonation and strain correlated slightly in males (rho=0.24, P < 0.05) and moderately in females (rho=0.55, P < 0.001). Age did not correlate with the amount of creaky phonation (rho=0.005, P > 0.10 for males, rho=-0.011, P > 0.10 for females). It can be concluded that the prevalence of creaky voice has increased among young Finnish speakers, particularly females.

Five-year results of atropine 0.01% efficacy in the myopia control in a European population

AimsTo evaluate the efficacy and safety of 0.01% atropine eye-drops in controlling myopia progression over 5 years.MethodsExperimental, analytical, prospective, randomised and longitudinal study, in 361 right eyes from 361 children...

Sagittal Pelvic Tilt Directly Influences the Ischiofemoral Space: A Cadaveric Study.

Ischiofemoral impingement (IFI) is understood to be a pain generator in the deep gluteal space. Femoral position is known to influence the ischiofemoral space (IFS), but there has been no study examining the effect of sagittal pelvic tilt on the IFS. The purpose of this study was to determine whether changes in pelvic tilt in the sagittal plane lead to changes in the dimensions of the IFS. Five fresh frozen cadavers (10 hips) were used for this anatomic study. The specimens were skeletonized and placed in the prone position with the pelvis fixed to a custom-built hinged table. A digital inclinometer was used to tilt the pelvis -10°, 0°, and 10° simulating posterior, neutral, and anterior pelvic tilt, respectively. Digital calipers were used to measure the dimensions of the IFS in all three positions of sagittal pelvic tilt. Changes in pelvic tilt resulted in significant changes in the dimensions of the IFS. Mean IFS dimensions measured 29.3±9.7 mm, 37.2±9.0 mm, and 24.3±9.2 mm in the neutral, anterior, and posterior pelvic tilt positions, respectively (P<.0001). Changes in sagittal pelvic tilt influence the dimensions of the IFS, with posterior pelvic tilt noted to significantly decrease the IFS when compared with neutral and anterior pelvic tilt. These findings suggest that further evaluation of sagittal spinopelvic balance in the etiology of symptomatic IFI may be warranted. [Orthopedics. 2024;47(3):167-171.].

Molecular Mechanism for Regioselectivity of P450-BM3 Monooxygenase Towards Stearic Acid Hydroxylation

Hydroxy stearic acid is an important raw material for the synthesis of biobased materials, and the hydroxylation at different positions showed different properties. With the catalysis of P450-BM3 monooxygenase, (ω - 1)-Hydroxy stearic acid was generated, which is a precursor of macrocyclic musk. Experimental results have shown that the L188Q mutant can increase the yield of (ω - 1)-Hydroxy stearic acid by more than three times, but the reason and underlying molecular mechanism are still unclear. In this study, molecular dynamics (MD) simulations were conducted to study the structural characteristics of the P450-BM3 wild type and its three mutants (F87V, L188Q, and F87V-L188Q) in combination with stearic acid. The MD simulation results showed significant changes in the interactions between the three mutants and the carboxyl- and terminal-end of stearic acid. The results of the Molecular mechanics-Poisson-Boltzmann surface area (MMPBSA) binding free energies indicated that the L188Q mutant showed the most stable binding with the stearic acid. Finally, the H-abstraction free energy barriers of L188Q and wild type systems were calculated to study the regioselectivity, and the results indicated that the L188Q mutant shown a significant advantage in the hydroxylation of stearic acid at the ω - 1 position. Our research results not only explain molecular mechanism for regioselectivity of P450-BM3 towards stearic acid hydroxylation, but also provide some useful ideas for the synthesis of biobased materials from hydroxy fatty acids.

Ar-ion- and electron-irradiated ZrC layers in ZrC-SiC-coated surrogate TRISO fuel particles

Surrogate tristructural isotropic (TRISO) particles, including ZrC and SiC layers, were manufactured through fluidized-bed chemical vapor deposition and irradiated. ZrC layers exhibited C/Zr atomic ratio of 0.95 without distinct crevices at interfaces in microscopy, but underwent significant microstructural changes post-irradiation. Defects included black dots and Frank loops, with increasing irradiation doses augmenting their area fractions. Frank loop density reduced at 9.4dpa due to the formation of fewer, fully circular loops. The ZrC hardness and modulus rose by 25% and 26% following Ar-ion irradiation at 9.4dpa, linked to the formed defects and implanted Ar ions. Electron irradiation expanded the defect-prone zone up to 100nm from the ZrC grain boundary and led to ZrO2 formation. ZrC grains recrystallized post electron irradiation at 700 °C, causing initial grain decomposition, amorphization, and nanocrystal formation. These nanocrystals, formed at 3.3dpa, closely aligned with ZrC diffraction patterns with no preferred orientations.

A randomized controlled trial of a brief motivational interviewing-based group intervention for emerging adults experiencing homelessness: 24-month effects on alcohol use.

Despite rates of alcohol misuse being higher among emerging adults experiencing homelessness compared to those who are stably housed, there are few brief evidence-based risk reduction programs for this population that focus on alcohol use and assess outcomes for more than 1 year. This study examines alcohol outcomes from a 24-month evaluation of AWARE, a brief motivational interviewing-based group risk reduction intervention for emerging adults experiencing homelessness. In a cluster randomized crossover trial, 18- to 25- year-olds received AWARE (n = 132) or standard care (n = 144) at one of three drop-in centers serving young people experiencing homelessness in Los Angeles County. We evaluated intervention effects on past month alcohol use, consequences, and related cognitions such as motivation to change behavior. AWARE participants showed significant reductions over 24 months in alcohol use and negative consequences from drinking and reported significant increases in their use of drinking protective strategies. Except for drinking frequency, control group participants did not show a significant change in these outcomes. Findings build on earlier work by demonstrating that AWARE is effective in reducing alcohol use and related problems among emerging adults experiencing homelessness over a 2-year period. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Effect of series of periodic limb movements in sleep on blood pressure, heart rate and high frequency heart rate variability.

The phenomenon known as periodic limb movements in sleep (PLMS) has been linked to a change in autonomic nervous system (ANS) activity and its effect on circulatory regulation. Autonomic dysfunction or dysregulation in patients with PLMS has been described in some domains; however, any relationship between heart rate variability (HRV) and PLMS has not been clearly established. HRV analysis is a recognised, non-invasive research method that describes the influence of the ANS on heart rate (HR). The aim of our study was to further investigate the dysregulation of autonomic HR control in patients with PLMS. We undertook a retrospective analysis of the polysomnographic (PSG), demographic and medical data of five patients with a total number of 1,348 PLMS. We analysed HR, HRV HF, systolic blood pressure (SBP), and diastolic blood pressure (DBP) for 10 heartbeats before the series of PLMS and 10 consecutive heartbeats as beat-to-beat measurements. The presented method of using successive, short, 10 RR interval segments refers to the time-frequency measurement, which is very clear and useful for presenting changes in the calculated parameters over time and thereby illustrating their dynamics. This method allowed us to assess dynamic changes in HRV HF during successive PLMS series. Statistical analysis was performed using IBM SPSS Statistics (v. 28.0.0.0). The Kruskal-Wallis test was performed to find statistically significant changes from baseline. No statistically significant changes in HR, SBP, or DBP were found in our group, although an increase in the value of the HRV HF was noted, suggesting an increase in intracardiac parasympathetic activity during the subsequent series of PLMS. Our study indicates an increase in parasympathetic activity during the appearance of successive PLMS, which, with the simultaneous lack of changes in HR, may suggest an increase in sympathetic activity, and therefore the appearance of so-called 'autonomic co-activation' resulting in the possibility of life-threatening cardiac events. Our findings add to the literature information regarding HRV in PLMS, and highlight the need for further studies to elucidate the effects of these conditions on the ANS, and on cardiovascular health.

Parafoveal capillary density as a potential biomarker in the assessment of diabetic retinopathy progression

AbstractPurposeThe aim of this study was to assess longitudinal changes in retinal vessel density in diabetic patients using optical coherence tomography angiography (OCTA) to identify the most sensitive parameter for detecting retinopathy progression.MethodsPatients with diabetes mellitus were enrolled in this study. Each study subject underwent two imaging sessions, during which three OCTA images of the macular area and three images of the optic nerve head were obtained. The two sessions took place one year apart. The OCTA imaging was performed using an AngioVue device. Superficial vessel density was evaluated in the central 3 mm and parafoveal area, and the nonflow area was measured using the built-in automated AngioAnalytics software of the Optovue system.ResultsThis study included 78 eyes of 39 diabetic patients (age: 55.16 ± 13.73 years) with a mean of 7.70 ± 1.07 mmol L−1 HgA1c level at baseline. At the one-year visit, the eyes of the diabetic subjects had significantly lower superficial vessel density in the parafoveal macula compared to corresponding values at baseline (p &lt; 0.05). There was no statistically significant difference between the baseline and one-year results for the other vascular density parameters and the foveal avascular zone (p &gt; 0.05).ConclusionAt the one-year follow-up, we found that vessel density had decreased in the parafoveal ring in these patients, while there was no significant change in other vascular parameters. This result suggests that superficial parafoveal capillary density is the most sensitive OCTA parameter that can be used as a biomarker for diabetic retinopathy progression. None of the other vascular density parameters nor the foveal avascular zone were able to indicate the subtle changes in retinal microcirculation due to the progression of diabetic microvasculopathy.

Moving Beyond Practical Wisdom: Teacher Research in Secondary Education

Teaching in secondary education is mostly grounded in the practical wisdom of teachers. In general, teachers have limited knowledge of, access to, and interest in insights from scholarly work. Teacher research might be a way to move beyond practical wisdom as the only basis for good teaching. This study aimed to explore whether teacher research can encourage teachers’ learning process as professionals, improve teaching practices, and generate knowledge about these practices. Participants were 44 experienced secondary school teachers in the Netherlands following a 2-year Master of Science professional development program on teaching and learning. Data was gathered using questionnaires, learner reports, a group interview, and participants’ master theses. Data analyses showed that the teachers report significant changes in the way they teach and think about teaching: on the one hand, they reported being more focused on what they want to change in their teaching, but on the other hand, they mentioned that they take different perspectives when they are confronted with problems in teaching. In addition, they mentioned challenges that are common for starting researchers such as how to formulate a researchable question, how to select relevant literature, how to deal with peer review, and how to perform situated generalization. We discuss what kind of educational research is valuable for teachers as learning professionals in secondary schools.

The relationship between measurement and evaluation in physical education teaching based on intelligent analysis and sensor data mining

Assessing the effectiveness of physical education instruction, students’ learning, and the feedback received from the teaching process are all vital components of the physical education teaching process in colleges and universities. Improving the quality of physical education instruction in these settings is essential. With its ability to drive the digital revolution of physical education in schools, intelligent technology is bringing about significant changes in the field of education and drawing attention from people from all walks of life. To assess intelligent technology’s impact on physical education instruction in a scientific manner, this study utilizes the latest intelligent analysis and sensing data mining to design an intelligent physical education measurement and evaluation model, which utilizes GPS positioning, built-in maps, and gravity sensing to provide real-time feedback on the trajectory, distance, and time of the movement, and then calculates the real-time and average speed of the movement, as different students’ body postures to achieve the the same effect when the required speed is not the same, this paper randomly selected students with different BMI index for empirical analysis. The experimental results show that the principal components of the factor analysis extracted four common factors with a cumulative contribution rate of 69.5%, and the test-retest reliability of the four dimensions is 0.665–0.862.

HVAC energy consumption prediction based on RJITL deep neural network model

During the operation of HVAC (Heating, Ventilation, and Air-Conditioning) systems, precise energy consumption prediction plays an important role in achieving energy savings and optimizing system performance. However, the HVAC system is a complex and dynamic system characterized by a large number of variables that exhibit significant changes over time. Therefore, it is inadequate to rely on a fixed offline model to adapt to the dynamic changes in the system that consume tremendous computation time. To solve this problem, a deep neural network (DNN) model based on Just-in-Time learning with hyperparameter R (RJITL) is proposed in this paper to predict HVAC energy consumption. Firstly, relevant samples are selected using Euclidean distance weighted by Spearman coefficients. Subsequently, local models are constructed using deep neural networks supplemented with optimization techniques to enable real-time rolling energy consumption prediction. Then, the ensemble JITL model mitigates the influence of local features, and improves prediction accuracy. Finally, the local models can be adaptively updated to reduce the training time of the overall model by defining the update rule (hyperparameter R) for the JITL model. Experimental results on energy consumption prediction for the HVAC system show that the proposed DNN-RJITL method achieves an average improvement of 5.17% in accuracy and 41.72% in speed compared to traditional methods.

Ecology and Gender in Sir Launfal

ABSTRACT This article examines the relationship between landscape and gender in Marie de France’s Lanval and two of its adaptations: the fourteenth-century English romances Sir Launfal and Sir Landevale. Engaging with the ecofeminist principles of Val Plumwood, it contends that the character of the “fairy mistress” and the nature of her otherworldly realm undergo significant changes by adaptation into Middle English, specifically, changes that diminish female agency. As she is adapted into English texts, especially Sir Launfal, the Lanval fairy is made subject to patriarchal hierarchies, and the otherworld is similarly presented as an object of patrimony.

Effect of herding behavior and overconfidence bias on investor’s financial decisions: A case of investment in crypto currency in Pakistan

There are various behavioral aspects that influence the financial decisions of individual investors, such as overconfidence, herding behavior, loss aversion, and regret aversion. Other psychological elements may play a substantial influence in deciding the success or failure of any financial action. The primary aims of the present research article are to examine the effects of overconfidence bias and herding behavior on individual financial decisions regarding crypto currency investment. The markets for crypto currencies are extremely sensitive to any minute or significant changes in the economy, as well as to any changes in the individual behaviors of investors. To achieve these aims, 650 questionnaires were distributed to individual investors employed by various financial institutions, multinational corporations, including oil and gas exploration and production companies, operating in Pakistan, individual investors dealing in stocks, and students regardless of investment size. Purposive sampling was used to choose 311 valid responses from a total of 593. Those investors that engage in crypto currency investments were deemed valid responses. Classifications of investments were outlined, and demographic information was requested from respondents. SPSS-based empirical analysis provided the basis for the conclusions. The primary findings indicate that both overconfidence bias and herding tendency have a favorable and statistically significant impact on investors' financial decisions when investing in cryptocurrencies. In this study's sample, however, the majority of investors were overconfident in their crypto currency investing decisions.

Investigating Surgical Mask Thermal Degradation via X‐Ray Techniques for Efficient Reuse

AbstractThe Covid‐19 crisis has led to a massive surge in the use of surgical masks worldwide, causing risks of shortages and high pollution. Reusing the masks may be promising to reduce such risks, especially since various decontamination techniques are being investigated. In this study, the thermal degradation of surgical masks was investigated using X‐ray‐based techniques such as XRD and XPS. Additional characterization was performed using scanning electron microscopy and contact angle measurements. XRD experiments reveal an increase in both crystal size and crystallinity of the mask with temperature until it is destroyed at 160 °C. However, XPS results show that there was no significant change in the surface chemistry of the mask, as no other chemical element has been detected in the mask heated up. Breathability has been proven compliant with standards until 150 °C.

Free energy calculations reveal the interaction and stability of ligands in the vicinity of B-DNA dodecamer

The double stranded Deoxyribonucleic acid (DNA) is stated as one of the idyllic targets for cancer and other various diseases. The in-depth investigation of DNA-drug interaction plays a crucial role for the recognition of drug mechanism action as well as in advance scheming of more proficient drugs with minor aftermath. Imidazoles and molecules possessing them are well known for their antimicrobial action and also possess different therapeutic properties. With the intention to improve a computational protocol towards the development of novel improvised antimicrobial agent, di-cationic molecules. Primarily, four diarylfuran derivatives having varied substituted groups have been proposed, analysed and compared for antimicrobial potential by studying their binding strength and steady complex formation with DNA. Molecular docking analysis was used to forecast the binding mode involved for DNA-drug complex and molecular dynamics was employed for studying the kinetics of interaction. The docking investigation revealed AT rich region binding for all the proposed ligands which is the preferred location for DNA minor groove binders establishing Mol-1 and Mol-3 as lead molecules. The stability of drug-DNA complexes was inferred from an analysis of the data from Molecular dynamics (MD) analysis, which showed that ligands remained coupled to the preferred binding locations of DNA without experiencing any significant changes in the minor groove.

Adaptation and growth performance of different bamboo species in Dryland areas of Northern Ethiopia

Bamboos are among the large perennial grasses that are renowned for their remarkable vigor and quick development. However, the amount of bamboo available in natural settings is decreasing as a result of shifting agriculture, overexploitation, and forest fires. Furthermore, there is little genetic diversity in our country because just two species are found in a small number of agroecological zones. This makes it difficult to guarantee a steady supply of bamboo, despite its benefits to the environment and economy. Thus, the goal of this study was to evaluate the adaptability and growth performance of four bamboo species: Oxytenanthera abyssinica (A.Rich.) Munro, Phyllostachys edulis (Carrière) J Houz, Bambusa vulgaris Schrad. ex J.C. Wendl, and B-ambusa bambos (L) Voss'. The study was carried out at the Mekelle Agricultural Research Center compound for four years, from 2020 to 2023. Three replications of a strict RCBD design were used in the experiment. There were four plants each plot, for a total of 48 plants, and there was a three-meter gap between each plant and plot. A range of growth indicators, including new shoot emergence, culm diameter, internode length, culm height, and survival rate, were measured at three-month intervals in order to monitor changes among the species. B. bambos, B. vulgaris, and O. abyssinica showed no problems with survival or adaptation in the research locations, with the exception of small growth variances. Significant changes (p≤ 0.05) in the treatment parameters were shown by the statistical analysis. O. abyssinica displayed a noticeably greater quantity of freshly emerging bamboo shoots in comparison to other bamboo species. Conversely, P. edulis showed the lowest growth metrics in terms of internode length, culm height, culm diameter, and survival rate. P. edulis, B. vulgaris, O. abyssinica, and B. bambos had survival rates of 16.67 percent, 66.67 percent, 75 percent, and 91.67 percent, respectively. It is noteworthy that seasonal differences have a substantial impact on the height of culms and the growth of newly emergent shoots. B. vulgaris, B. bambos, and O. abyssinica all showed good growth and survival rates. As a result, it is advised to highlight and promote these species in related agroecological areas, as this can benefit multiple stakeholders’ livelihoods and economies.

Changes in Dynamic Balance Ability Among Firefighter Recruits: A Longitudinal Cohort Study.

Cornell, DJ, Gnacinski, SL, and Ebersole, KT. Changes in dynamic balance ability among firefighter recruits: A longitudinal cohort study. J Strength Cond Res 38(4): 734-741, 2024-It has been suggested that enhanced balance ability may mitigate the high musculoskeletal injury (MSKI) rate among firefighters, but the longitudinal changes in dynamic balance ability within this tactical athlete population have yet to be characterized. The purpose of this study was to examine the changes in dynamic balance ability of a cohort population of firefighter recruits completing a training academy and their probationary period as active-duty firefighters. Twenty-seven male firefighter recruits completed the modified Star Excursion Balance Test (mSEBT) at the beginning (W1) and at the end of their training academy (W14) and after completing their probationary period as active-duty firefighters (W38). After controlling for age and changes in body fat (BF) over time, significant changes in mSEBTANT ( p < 0.001), mSEBTPL ( p = 0.015), mSEBTPM ( p < 0.001), and mSEBTCOMP ( p = 0.003) were observed across time. Although mSEBTPL performance significantly increased ( p = 0.033) in from W1 to W14, significant decreases in all mSEBT reach directions were observed from W14 to W38 ( p < 0.05), with mSEBTANT ( p < 0.001) and mSEBTCOMP ( p = 0.002) also significantly decreasing from W1 to W38. However, the frequency of right vs. left asymmetries (>4 cm) did not significantly change over time in any mSEBT reach direction ( p > 0.05). Irrespective of age or changes in BF, minimal changes in the dynamic balance ability of firefighter recruits were observed during their training academy, but significant decreases in balance ability were noted by the end of their probationary period.

Quantifying hurricane impacts on United States Virgin Islands reef fishes using a catchability invariant approach to compare uncalibrated survey indices

The United States Virgin Island's (USVI) coral reefs support many economically and ecologically important fish species. Located in the Caribbean Sea, they are subject to frequent severe weather disturbances, including two category 5 hurricanes, Irma and Maria, in 2017. The overarching goal of this study was to identify reef fish community impacts following these extreme events using discontinuous survey indices. Long-term (2001–2021), in situ, fishery-independent survey data using two methods were standardized to the extent possible in two regions of the USVI, St. Thomas/St. John (STT/STJ) and St. Croix (STX). Comparable data were assessed, 73 species collected on hard- bottom habitat, to identify the number of these species with significant changes in density and/or mean length between 2-yr survey intervals over the historic baseline (2001–2015), disturbance (2017–2019), and postdisturbance (2019–2021) periods. The results varied by region: STT/STJ had no disturbance impact and STX had a significant disturbance impact. In STX, 20 species had significant changes in density in the disturbance period compared to an average of 9.7 (SD 3.8) species for the baseline period. The proportion of species with significant density increases and decreases were similar suggesting that overall disturbance impacts are nuanced. Mean length observations were less informative, likely due to survey method and sample size changes. However, in combination with density they provided useful insights into the possible causes of population change. The successful use of discontinuous survey indices to obtain meaningful biological insights has broader applications to ecosystem and fishery datasets with similar limitations.

Polydopamine Nanoparticles Activate Apelin/Apelin Receptor Signaling and Smad3 to Inhibit Tumor Cells in Lung Cancer

Lung cancer incidence is increasing and different concentrations of polydopamine nanoparticles may exert different anticancer effects. Apelin/APJ plays a certain role in lung cancer. This study focuses on the mechanism of polydopamine nanoparticles in Apelin/APJ signaling pathway activation Smad3 on tumor cells in lung cancer rats. 40 rats were randomly assigned into blank group, model group, low-dose, medium-dose, and high-dose groups of polydopamine nanoparticles followed by analysis of tumor weight, Apelin, APJ, Smad3 gene expression, tumor cell viability, cell apoptosis, Apelin, APJ, and Smad3 level. Polydopamine nanoparticles were successfully prepared. The polydopamine nanoparticle groups significantly inhibited tumor weight, and the medium-dose group decreased the most. And the groups significantly inhibited the gene expression of Apelin and APJ, with more inhibition in medium-dose group, P &lt; 0.05. The polydopamine nanoparticle groups significantly up-regulated Smad3, inhibited tumor cell viability, and promoted apoptosis with significant changes in medium-dose group. In addition, the groups inhibited the protein expression of Apelin and APJ, and up-regulated Smad3, with more increase of Smad3 in medium-dose group, P &lt; 0.05. Polydopamine nanoparticles may block the combination of Apelin and APJ by inhibiting the activity of Apelin/APJ pathway, which leads to further activation of Smad3, therefore inhibiting proliferation and promoting apoptosis of lung cancer cells. This process is related to down-regulation of Apelin expression.