Significant Changes In Position Research Articles

Improved analysis of NMR chemical shift perturbations through an error estimation method

In solution NMR, chemical shift perturbation (CSP) experiments are widely employed to study intermolecular interactions. However, excluding the nonsignificant peak shift is difficult because little is known about errors in CSP. Here, to address this issue, we introduce a method for estimating errors in CSP based on the noise level. First, we developed a technique that involves line shape fitting to estimate errors in peak position via Monte Carlo simulations. Second, this technique was applied to estimate errors in CSP. In intermolecular interaction analysis of VAP-A with SNX2, error estimation of CSP enabled the evaluation of small but significant changes in peak position and yielded detailed insights that are unattainable with conventional CSP analysis. Third, this technique was successfully applied to estimate errors in residual dipolar couplings. In conclusion, our error estimation method improves CSP analysis by excluding the nonsignificant peak shift.

Abstract PO2-22-08: Nipple areolar complex changes after breast-conserving surgical therapy and periareolar mastopexy: a three-dimensional Surface Analysis

Abstract Objectives: The position and configuration of the nipple-areolar complex (NAC) have a high impact on satisfaction (objective and subjective) after breast-conserving therapy (BCT). The aim of this study is to objectively measure the changes in the NAC after breast conservation surgery by the use of the 3D whole body scanner and compare its results with the outcome reported by the patients. This will support further patients and help physicians to tailor their technique prior to breast-conserving surgery. Methods: In a unicentric pilot project 6 months after BET with periareolar mastopexy and adjuvant radiation between 2019 and 2022, 38 women were studied. The mean age was 56.3 ±11.6 and BMI was 24.6 ± 4.5 kg/m². Objective 3D parameters were collected using the Vectra Whole Body Surface Imaging System (WB360) based on breast and NAC dimensions. In addition, the patients received the BCT module and the mastopexy module items about satisfaction with the NAC from the BREAST Q questionnaire. Results: In a group of 38 women, BCT with periareolar mastopexy and irradiation showed a small but significant change in NAC position and shape (see Table 1). This small change is matched by the high satisfaction with the nipple and areola surveyed in the BREAST-Q questionnaire. More than 66% of the women were rather satisfied or very satisfied. The BREAST-Q results from the Items about satisfaction with the nipple and areola are shown in Table 2. However, 34% of participants reported being somewhat dissatisfied to very dissatisfied with the symmetry of placement. This could be due to a significant cumulative small change in nipple-sternal notch distance and nipple-midline distance. No significant difference was found when measuring the nipple-inframammary fold distance (p=0.649). The absolute difference was of 0.13 ± 1.22 mm. The change in breast diameter was of 0.55 ± 1.54 mm (relative 2,75 ± 7.95%). There was also no significance (p=0.042). This indicates that after BCT, the nipple-inframammary fold distance and breast diameter did not change significantly. Breast volume decreases insignificantly by 49.2 ± 136.1 cc (relative 12,96 ± 33.51) on the operated side (p=0.009). In particular, a difference in vertical diameter of the NAC of -4,79 mm (14,27%) was observed between the non-operated and the operated breast (p=0.005 by Wilcoxon-test). The BREAST-Q BCT Module consists of 8 domains. The higher the score, the higher the satisfaction with the questioned item. In our sample of 38 women, satisfaction with the surgeon(s) was highest (BREAST-Q score of 83,97 ± 19,12). The mean Q score for satisfaction with "psychosocial well-being" is 67,47 ± 22,03. For the item "sexual well-being", only 35 women answered sufficient questions and the mean Q score was 54,42 ± 16,43. “Satisfaction with breast” had a Q-score of 61,03 ± 19,36. The questions about "physical well-being" had a mean of 70,11 ± 16,69. The Q-score for “satisfaction with medical team”, “with office staff”, and “with information” can be seen in Table 3. Conclusions: In a nutshell, the conclusion of this study is that the Vectra XT 3D-Imaging is a useful tool to assess the cosmetic outcome in terms of NAC position and shape. Hence, it is a helpful tool to support the planning of the surgery and may have a positive impact on the outcome. Postoperatively, there was only a slight change in the NAC dimension and position compared with intraoperative planning. The 3D Surface Analysis is most useful in assessing the quality of reconstruction after BCT and additionally the NAC is therefore an important factor for patient satisfaction. Results of a multicenter study are pending. Table 1: Descriptive statistic and Wilcoxon-test Results from the measures from the Breast and from NAC Dimension and Position (n=38) The 3D Measures from the Breast and from NAC Dimension and Position Table 2: Results from the BREAST-Q mastopexy modul about satisfaction with the nipples (n=38) Satisfaction with the nipples Table 3: Results from the BREAST-Q BCT Modul after BCT and periareolar mastopexy und adjuvant radiation (n=38) BREAST-Q Scores Citation Format: Therese Peter, Konstantin Koban, Denis Ehrl, Pamina Geiger, Nadia Harbeck, Steffen Kahlert, Carolin Luczak, Johannes Schmid, Rachel Wuerstlein, Friederike Hagemann. Nipple areolar complex changes after breast-conserving surgical therapy and periareolar mastopexy: a three-dimensional Surface Analysis [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-22-08.

Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.

The ADP-ribosylation factors (Arfs) constitute a family of small GTPases within the Ras superfamily, with a distinguishing structural feature of a hypervariable N-terminal extension of the G domain modified with myristate. Arf proteins, including Arf1, have roles in membrane trafficking and cytoskeletal dynamics. While screening for Arf1:small molecule co-crystals, we serendipitously solved the crystal structure of the non-myristoylated engineered mutation [L8K]Arf1 in complex with a GDP analogue. Like wild-type (WT) non-myristoylated Arf1•GDP, we observed that [L8K]Arf1 exhibited an N-terminal helix that occludes the hydrophobic cavity that is occupied by the myristoyl group in the GDP-bound state of the native protein. However, the helices were offset from one another due to the L8K mutation, with a significant change in position of the hinge region connecting the N-terminus to the G domain. Hypothesizing that the observed effects on behavior of the N-terminus affects interaction with regulatory proteins, we mutated two hydrophobic residues to examine the role of the N-terminal extension for interaction with guanine nucleotide exchange factors (GEFs) and GTPase Activating Proteins (GAPs. Different than previous studies, all mutations were examined in the context of myristoylated Arf. Mutations had little or no effect on spontaneous or GEF-catalyzed guanine nucleotide exchange but did affect interaction with GAPs. [F13A]myrArf1 was less than 1/2500, 1/1500, and 1/200 efficient as substrate for the GAPs ASAP1, ARAP1 and AGAP1; however, [L8A/F13A]myrArf1 was similar to WT myrArf1. Using molecular dynamics simulations, the effect of the mutations on forming alpha helices adjacent to a membrane surface was examined, yet no differences were detected. The results indicate that lipid modifications of GTPases and consequent anchoring to a membrane influences protein function beyond simple membrane localization. Hypothetical mechanisms are discussed.

Comparing Video Analysis to Computerized Detection of Limb Position for the Diagnosis of Movement Control during Back Squat Exercise with Overload.

Incorrect limb position while lifting heavy weights might compromise athlete success during weightlifting performance, similar to the way that it increases the risk of muscle injuries during resistance exercises, regardless of the individual's level of experience. However, practitioners might not have the necessary background knowledge for self-supervision of limb position and adjustment of the lifting position when improper movement occurs. Therefore, the computerized analysis of movement patterns might assist people in detecting changes in limb position during exercises with different loads or enhance the analysis of an observer with expertise in weightlifting exercises. In this study, hidden Markov models (HMMs) were employed to automate the detection of joint position and barbell trajectory during back squat exercises. Ten volunteers performed three lift movements each with a 0, 50, and 75% load based on body weight. A smartphone was used to record the movements in the sagittal plane, providing information for the analysis of variance and identifying significant position changes by video analysis (p < 0.05). Data from individuals performing the same movements with no added weight load were used to train the HMMs to identify changes in the pattern. A comparison of HMMs and human experts revealed between 40% and 90% agreement, indicating the reliability of HMMs for identifying changes in the control of movements with added weight load. In addition, the results highlighted that HMMs can detect changes imperceptible to the human visual analysis.

Simultaneous standard total joint prosthesis reconstruction with SSRO and Le Fort I osteotomy in the treatment of unilateral temporomandibular joint ankylosis with jaw deformity: a case cohort study.

Unilateral temporomandibular joint ankylosis with jaw deformity (UTMJAJD) may require simultaneous total joint prosthesis (TJP) reconstruction, sagittal split ramus (SSRO), and Le Fort I osteotomies. The purpose of this study was to evaluate outcomes in patients treated with these procedures. Patients diagnosed UTMJAJD between 2016 and 2018 were selected for the study. Mandible-first procedure was performed after ankylosis release with TJP on the ankylosed side and SSRO on the contralateral side. Le Fort I osteotomy with and without genioplasty was lastly performed. Maximal incisor opening (MIO), facial symmetry, and jaw and condyle stability were compared before, after operation, and during follow-ups. Seven patients were included in the study. Their average chin deviation was 9.5 ± 4.2mm, and maxillary cant was 5.1 ± 3.0°. After operation, jaw deformity significantly improved, with chin deviation corrected 7.6 ± 4.1mm (p = 0.015) and advanced 5.9 ± 2.5mm (p = 0.006). After an average follow-up of 26.6 ± 17.1months, MIO significantly increased from 11.4 ± 9.3 to 35.7 ± 2.6mm (p = 0.000). The occlusion was stable with no significant positional or rotational changes of the jaw (p > 0.05). There was no obvious condylar resorption during follow-ups. Simultaneous TJP reconstruction, SSRO, and Le Fort I osteotomy are reliable and effective methods for the treatment of UTMJAJD.

Lumbar Spine Anatomy in Supine versus Weight- Bearing Magnetic Resonance Imaging: Detecting Significant Positional Changes and Testing Reliability of Quantification.

Testing between and within group differences and assessing reliability of measurements. To study and compare lumbar spine morphology in supine and weight-bearing (WB) magnetic resonance imaging (MRI). Upright lumbar MRI may uncover anatomical changes that may escape detection when using conventional supine imaging. This study quantified anatomical dimensions of the lumbar spine in the supine and WB MRI, compared specific morphometric differences between them, and tested the intra-rater reliability of the measurements. Repeated measures analysis was used to compare within- and between-session measurements performed on the supine and WB images. Reliability and agreement were assessed by calculating intraclass correlation (ICC) coefficient. Data from 12 adults without any history of back pain were used in this study. Sagittal T2-weighted images of the lumbar spine were acquired in the supine and WB positions twice (in two separate sessions scheduled within a week). Linear, angular dimensions, and cross-sectional areas (CSAs) were measured using proprietary software. Supine and WB data acquired from the two imaging sessions were tested for intra-rater reliability. Quantified data were normalized for each session to test the significance of differences. ICC was calculated to test the reliability of the measurements. Linear, angular, and CSA measurements demonstrated strong within-position (supine and WB) correlations (r -values, 0.75-0.97). Between-position (supine vs. WB) differences were significant for all measured dimensions (p<0.05). Between-session measurements demonstrated a strong correlation (r -values, 0.64-0.83). Calculated ICC showed strong agreement among the measurements. Anatomical dimensions of the lumbar spine may demonstrate consistent and significant differences between supine and WB MRI for specific structural parameters.

Intraoperative liver deformation and organ motion caused by ventilation, laparotomy, and pneumoperitoneum in a porcine model for image-guided liver surgery

BackgroundImage-guidance promises to make complex situations in liver interventions safer. Clinical success is limited by intraoperative organ motion due to ventilation and surgical manipulation. The aim was to assess influence of different ventilatory and operative states on liver motion in an experimental model.MethodsLiver motion due to ventilation (expiration, middle, and full inspiration) and operative state (native, laparotomy, and pneumoperitoneum) was assessed in a live porcine model (n = 10). Computed tomography (CT)-scans were taken for each pig for each possible combination of factors. Liver motion was measured by the vectors between predefined landmarks along the hepatic vein tree between CT scans after image segmentation.ResultsLiver position changed significantly with ventilation. Peripheral regions of the liver showed significantly higher motion (maximal Euclidean motion 17.9 ± 2.7 mm) than central regions (maximal Euclidean motion 12.6 ± 2.1 mm, p < 0.001) across all operative states. The total average motion measured 11.6 ± 0.7 mm (p < 0.001). Between the operative states, the position of the liver changed the most from native state to pneumoperitoneum (14.6 ± 0.9 mm, p < 0.001). From native state to laparotomy comparatively, the displacement averaged 9.8 ± 1.2 mm (p < 0.001). With pneumoperitoneum, the breath-dependent liver motion was significantly reduced when compared to other modalities. Liver motion due to ventilation was 7.7 ± 0.6 mm during pneumoperitoneum, 13.9 ± 1.1 mm with laparotomy, and 13.5 ± 1.4 mm in the native state (p < 0.001 in all cases).ConclusionsVentilation and application of pneumoperitoneum caused significant changes in liver position. Liver motion was reduced but clearly measurable during pneumoperitoneum. Intraoperative guidance/navigation systems should therefore account for ventilation and intraoperative changes of liver position and peripheral deformation.

Investigation of Condyle Positions in Patients with Temporomandibular Joint Disorder by Cone-Beam Computed Tomography

Objective: The condylar position refers to the location of the mandibular condyle within the glenoid fossa when the teeth are in maximum intercuspal, and it is an important indicator of the temporomandibular joint (TMJ) function. This study aimed to assess the condylar position of the TMJ in patients with TMJ disorder using cone-beam computed tomography (CBCT). Methods: The present study utilized CBCT to evaluate the condylar position of the TMJ in a sample of 56 patients. Among them, 28 patients were asymptomatic while the remaining 28 had been diagnosed with TMJ disease. To evaluate the presence of TMJ disorders, the Research Diagnostic Criteria for Temporomandibular Disorders was employed. This diagnostic tool is widely used in clinical and research settings to assess TMJ-related pain and dysfunction. Results: The agreement was excellent, according to the intra-observer and inter-observer correlation values obtained. There was no statistically significant difference between the two groups in terms of age and gender distribution. The results showed that the anterior and posterior joint spaces were significantly higher in the symptomatic group compared to the asymptomatic group. However, there was no statistically significant difference between the two groups in terms of superior joint space and articular eminence inclination values. Gender did not create a significant difference in any parameter. Conclusion: The results of this study emphasize that CBCT images have an important role in detecting significant changes in condyle position in patients with TMJ disorders. However, further large-scale studies are necessary to validate and enhance the findings.

Assessment and Validation of Anterior Humeral Line for Diagnosing Supracondylar Humerus Fractures in the Pediatric Population.

Pediatric supracondylar humerus fractures are commonly evaluated using the anterior humeral line (AHL) on a lateral radiograph. Rotational variations in radiographic projection are common due to child discomfort and could lead to changes in management based on where the AHL intersects the capitellum. The purpose of this study was to establish whether rotational variations in elbow rotation leads to significant changes in AHL position and whether drawing the AHL based on the distal humerus versus shaft is more tolerant to rotation. Fifty children with nonoperative supracondylar humerus fractures were identified with sub optimally positioned injury and well positioned follow-up lateral radiographs. The proportion of the bone anterior to the intersection of the AHL and the capitellum was measured using the humeral shaft versus distal humerus to guide position of the AHL. This process was repeated on ten pediatric humerus dry cadaveric specimens which were imaged in 5-degree rotational increments along the axis of the humeral shaft from -20 to +20 degrees. AHL position correlated poorly when measured on rotated lateral radiographs of clinical patients versus non-rotated lateral radiographs when using the distal humerus as a guide (intraclass correlation coefficient 0.14), compared with when using the humeral shaft as a guide (intraclass correlation coefficient 0.81). When assessing the pediatric humerus dry cadavers between the 2 techniques, there was greater statistically significant variation in rotated positions compared with the neutral position in the distal humerus AHL measurement approach compared with the humeral shaft AHL measurement approach, with the mean AHL within the central third of the capitellum for more rotational positions when using the shaft compared with the distal humerus. With rotated lateral elbow radiographs in supracondylar humerus fractures, utilizing the humeral shaft provides more consistent AHL measurements than utilizing the distal humerus, and thus drawing the line starting at the shaft of the humerus is recommended for surgical decision making.

An integrated satellite characterization and hydrodynamic study in assessing coastal dynamics in Cirebon, West Java

Located on the northern coast of Java Island, the coastal area of Cirebon is an area with rapid population growth and extensively developed as settlement areas, industrial estates, fisheries, agriculture, and public service infrastructures. Coastal dynamics issues have been occurring in the coastal area of Cirebon, which is characterized by significant changes in shoreline position. Moreover, some critical infrastructures are not functioning properly and may cause high maintenance costs and economic loss to the related stakeholders. This study aims to provide a greater understanding of the coastal dynamics along the 73.16 km of Cirebon shoreline through remote sensing and GIS methods supported by hydrodynamic analysis. This study applied coastal characterization, coastal structure identifications, and coastal processes assessments, including erosion and accretion analysis, hydrodynamic and tidal analysis, and inundation projection. The study indicates that some areas have been subject to significant erosion and accretion during the last two decades, with the total lengths of the eroded and accreted shoreline being −21.9 km (35.6%) and ＋39.6 km (64.4%), respectively. Furthermore, the coastal structures significantly influence the coastline’s dynamic and mitigate the negative impacts of coastal floods. Jetty access channels in the west area have caused partial coastal erosion, while the breakwaters in the east area accelerated sedimentation processes and improved the growth of mangroves simultaneously. This study also simulated the potentially inundated areas by 2050 in four scenarios based on projected sea level rise, land subsidence, and extreme wave events. Policies to prevent such potential hazards are needed to avoid negative impacts on the living quality and vital economic sectors. This study provides insight into coastal characterization, potential coastal hazards, and their driving processes in time and space scale for coastal adaptation planning policies and sustainable coastal hazard management and mitigation.

Spin-Current-Driven Permeability Variation for Time-Varying Magnetic Metamaterials

We study permeability ($\ensuremath{\mu}$) variation of a lithographically prepared magnetic meta-atom consisting of $\mathrm{Ta}$/Py/$\mathrm{Pt}$ trilayers by means of spin-torque ferromagnetic resonance (ST FMR). With an injection of a direct current up to $\ifmmode\pm\else\textpm\fi{}20\phantom{\rule{0.2em}{0ex}}\mathrm{mA}$ together with an alternating current in GHz frequencies, the meta-atom under external magnetic fields shows significant changes in position and width of ST FMR signals due to a massive spin-current injection. This leads to the spin-current-driven $\ensuremath{\mu}$ variation, which is verified by analytical calculation based upon the experimentally obtained resonance field and Gilbert-damping parameter. The present study paves a way to time-varying spintronic metamaterials with a high modulation frequency for realizing microwave sources toward the post-fifth-generation mobile-communication system.

Mobility of the arytenoid cartilage in glottic carcinoma: a CT image study

Background Laryngeal carcinomas cause vocal cord (VC) mobility problems. Other than evaluation through flexible laryngoscopy, rare reports concerning CT findings for the motion of the VC or arytenoid cartilage (AC) are found. Aims/objectives To explore a novel evaluation of the mobility of the AC in glottic carcinoma. Material and Methods In 39 patients with glottic carcinoma grouped upon lesion locations and AC mobilities, laryngeal CT scans were collected during inspiration and phonation. AC static position and motion data were compared between paired lesion and control sides. Results No significant difference showed in the group with glottic carcinoma invading the anterior 2/3 of VC. In the abnormal mobility group, significant AC position changes and weaker motion of most measurements were proved on the lesion side. Lesion invading the posterior 1/3 of VC also resulted in an adducted, medially rotated and forward-tilted AC, rotation of axial angle (RAA) was the only motion item that decreased significantly. Conclusions and Significance In most glottic cancer cases, CT and laryngoscope had similar judgments for AC mobility. For lesions extending to the cartilaginous VC with laryngoscopically confirmed normal mobility, CT measurement of RAA showed the feasibility of being an indicator for the earliest motion problem.

Fatigue Increases Muscle Activations but Does Not Change Maximal Joint Angles during the Bar Dip.

The purpose of this study was to profile and compare the bar dip's kinematics and muscle activation patterns in non-fatigued and fatigued conditions. Fifteen healthy males completed one set of bar dips to exhaustion. Upper limb and trunk kinematics, using 3D motion capture, and muscle activation intensities of nine muscles, using surface electromyography, were recorded. The average kinematics and muscle activations of repetitions 2-4 were considered the non-fatigued condition, and the average of the final three repetitions was considered the fatigued condition. Paired t-tests were used to compare kinematics and muscle activation between conditions. Fatigue caused a significant increase in repetition duration (p < 0.001) and shifted the bottom position to a significantly earlier percentage of the repetition (p < 0.001). There were no significant changes in the peak joint angles measured. However, there were significant changes in body position at the top of the movement. Fatigue also caused an increase in peak activation amplitude in two agonist muscles (pectoralis major [p < 0.001], triceps brachii [p < 0.001]), and three stabilizer muscles. For practitioners prescribing the bar dip, fatigue did not cause drastic alterations in movement technique and appears to target pectoralis major and triceps brachii effectively.

Safer road users: Investigating the influence of PRIME road markings on motorcycle rider behaviour

Innovative road markings for motorcyclists, designed as Perceptual Rider Information for Maximising Expertise and Enjoyment (PRIMEs) were installed on the approach to demanding left-hand bends at six trial sites and a comparison site across the West Highlands of Scotland. These road markings were presented as a series of ‘gateways’ to encourage safer riding. Video data were collected to measure motorcycle speed, lateral position, braking and use of the road markings, before and after the PRIMEs were installed. A total of 9,594 motorcyclists were observed. Across the six trial sites, statistically significant reductions in speed were observed (at three sites). Significant changes in lateral position were observed at the final PRIME gateway marking (at one site), and at the apex of the bend (at three sites). Reduced braking was observed at three sites and there was a statistically significant increase in the use of PRIME road markings across four of the sites. No statistically significant effects were observed at the comparison site. These findings are discussed in relation to sustained effects and aspects of the ‘Safe System’ approach that are relevant to reducing motorcycle casualties.

Study the Impact of Magnetic Field on Dosimetry of Proton Therapy Using Monte Carlo Simulation

<h3>Purpose/Objective(s)</h3> Using Monte-Carlo simulation to study the dosimetry of proton therapy under the environment of magnetic field. The results of this study will provide knowledge for us to design and build the MRI system that is integrated to proton therapy to form an MRI-guided proton therapy system using our new developed medium temperature superconductors (MTS) and high temperature superconductors (HTS). <h3>Materials/Methods</h3> We performed Monte Carlo calculations using version 3.26 of the PHITS code to simulate and investigate various proposed configurations of MRI-guided proton therapy. The first thing to study is the dosimetry under the environment of magnetic field. In simulation we used a cylindrical water phantom 60 cm in diameter and 2 m in length to imitate a patient and irradiated it with the proton beam with an energy of 250 ± 5 MeV under the environment of a dipole magnetic field. We started the study first with simple and uniform magnetic fields, and then with a more realistic magnetic field that is close to or similar to what we are going to design: 1) simple and uniform magnetic fields with different strength varies from 0.5 to 3.5 Tesla along X, Y or Z direction in respectively; 2) a more realistic magnetic field of a designed magnet using MTS and HTS technology. The track of particles and the dose distribution were investigated. <h3>Results</h3> For magnetic field in only X or Y direction (Bx≠0 or By≠0), the proton beam was bent and the coordinates of the maximum absorbed dose (Bragg peak) position shifted. The displacement of Bragg peak position increases with the magnetic field strength. For magnetic field along Z direction (Bz≠0, Bx=By=0), the change in Bragg peak position and the absorbed dose are small. For the magnetic field using MTS and HTS technology and the magnet was aligned along the beam direction, our simulation shows no significant change in Bragg peak position as well as the absorbed dose such as the maximum dose D_max. <h3>Conclusion</h3> Using Monte Carlo simulation to study the dosimetry of the proton beam interacting with medium (water) under the environment of magnetic fields with different directions and various strengths allowed us to understand the trajectories of proton beam and other secondary particles as well as the impact to the absorbed dose, which provide us important information to assist the design of MRI-guided proton therapy system.

Postural-respiratory function of the diaphragm assessed by M-mode ultrasonography.

ObjectivesThe diaphragm changes position and respiratory excursions during postural loading. However, it is unclear how it reacts to lifting a load while breath-holding or breathing with simultaneous voluntary contraction of the abdominal muscles (VCAM). This study analyzed diaphragm motion in healthy individuals during various postural-respiratory situations.Methods31 healthy participants underwent examination of the diaphragm using M-mode ultrasonography, spirometry, and abdominal wall tension (AWT) measurements. All recordings were performed simultaneously during three consecutive scenarios, i.e., 1. Lifting a load without breathing; 2. Lifting a load and breathing naturally; 3. Lifting a load and breathing with simultaneous VCAM.ResultsUsing paired-samples t-tests, lifting a load without breathing displaced the diaphragm’s expiratory position more caudally (P < .001), with no change noted in the inspiratory position (P = .373). During lifting a load breathing naturally, caudal displacement of the diaphragm’s inspiratory position was presented (P < .001), with no change noted in the expiratory position (P = 0.20) compared to tidal breathing. Total diaphragm excursion was greater when loaded (P = .002). Lifting a load and breathing with VCAM demonstrated no significant changes in diaphragm position for inspiration, expiration, or total excursion compared to natural loaded breathing. For all scenarios, AWT measures were greater when lifting a load (P < .001).ConclusionIn healthy individuals, caudal displacement and greater excursions of the diaphragm occurred when lifting a load. The postural function of the diaphragm is independent of its respiratory activity and is not reduced by the increase in AWT.

Comparison of the Post-Surgical Position of the Temporomandibular Joint after Orthognathic Surgery in Skeletal Class III Patients and Patients with Cleft Lip and Palate.

Objective: The purpose of our research is to compare the post-surgical position of the temporomandibular joint in skeletal Class III patients and patients with cleft lip and palate treated with two-jaw orthognathic surgery using a three-dimensional computer tomography image. Materials and Methods: Twenty-three skeletal Class III patients with mandibular prognathism associated with maxillary retrognathism in group 1 and twenty cleft mid-face retrusion skeletal Class III patients in group 2 were enrolled in this study. All subjects were treated with two-jaw orthognathic surgery. Computed tomography scans were taken in all subjects at 3 weeks preoperatively and 6 months postoperatively. Three-dimensional craniofacial skeletal structures were build-up, and assessed the temporomandibular joint position changes before and after surgery. Results: Forty-three selected patients were separated into two groups. The mean age of patients was 22.39 ± 4.8 years in group 1 and 20.25 ± 3.8 years in group 2. The range of mean three-dimensional discrepancy of the selected condylar points was 0.95–1.23 mm in group 1 and 2.37–2.86 mm in group 2. The mean alteration of intercondylar angle was 2.33 ± 1.34° in group 1 and 6.30 ± 2.22° in group 2. The significant differences in the discrepancy of TMJ and changes in intercondylar angle were confirmed within the intra-group and between the two groups. Conclusions: Significant changes in postoperative TMJ position were present in both groups. Furthermore, the cleft group presented significantly more postoperative discrepancy of TMJ and more changes in intercondylar angle after surgery. This finding may be a reason leading to greater postoperative instability in cleft patients compared with skeletal Class III non-cleft patients. Clinical Trial Registration Number: IRB No: 202201108B0.

Clinical Implication of Cervical Pain on Posture among Teaching Professionals Aged Between 25-35 Years- A Cross Sectional Study

Cervical pain is amongst the incessant musculoskeletal disorders having a prevalence of 30% up to 60 % among teaching professionals. Cervical pain also known as neck pain; have consequences which are very severe among several working populations. Primary objective of study was to find out consequences of cervical neck pain on scapula position. Present study will embrace us about clinical implications of cervical pain on static scapular position further significant positive result lead to formation of specific scapular rehabilitation program for teaching professionals keeping all risk factors and their work ergonomics. Cross-sectional Comparative study design was used to identify the effect of cervical pain over resting position of scapula position with respect to scapula protraction and scapula upward rotation among 107 school teachers further to mention it is an extension of research work of primary author on school teachers. Scapula protraction was assessed at three different positions i.e at rest, 45-degree shoulder flexion and 90-degree glenohumeral abduction and scapula upward rotation was examined with the help of baseline digital inclinometer at four different positions. Results exhibit changes in scapula protraction and upward rotation among school teachers keeping p value &lt; 0.001. Since school teachers primarily work on computer screen for teaching and preparation of lesson plans, this executes enormous load on teachers as they have to work continuously in static cervical posture for long hours continuously which executes significant load on neck and scapulothoracic musculature and alters the mechanics cervical pain results in statistically significant changes in scapula position i.e., scapula protraction, and scapula upward rotation in primary school teachers in all examined positions.

Comparison of short-term condylar positional changes in mandibular prognathism after surgery-first approach: Symmetric setback versus asymmetric setback

The aim of this study was to compare how the displacement of the mandibular condyle changed after symmetric or asymmetric mandibular setback surgery using the surgery-first approach (SFA). Patients who underwent mandibular setback surgery using the SFA were selected and divided into a symmetry group (n = 18) with differences of less than 2 mm between the right and left setback, and an asymmetry group (n = 18) with a difference of greater than 2 mm. Cone-beam computed tomography (CBCT)-generated cephalograms were obtained after three-dimensional superimposition of CBCT images taken before surgery (T0), within one week after surgery (T1), and seven months after surgery (T2). The condylar positions were measured. Condylar positional changes according to time were compared between the two groups and correlation analysis was performed. There were significant positional changes in mandibular condyles over time in both groups. However, most of these changes returned to their initial state. In the asymmetry group, there was a greater internal rotation of the mandibular condyle on the lesser setback side. The correlation analysis results revealed that only the setback difference was associated with rotational displacement of the condyle on the lesser setback side at two time points (T1-T0, T2-T0). In the SFA, significant condylar displacement occurred immediately after both symmetric and asymmetric mandibular setback surgery, and the right/left difference in mandibular setback showed a significant positive correlation with rotational displacement. Although more significant rotational displacement of the mandibular condyle was observed after asymmetric mandibular setback surgery, the amount was not large enough to be clinically significant.

Linguistic Naturalism and Anti-Naturalism in Bergson’s Course L’Idée de Temps: Language, Society, and Life

Since the beginning of his intellectual journey, Bergson has always shown an enormous distrust of language. Allied to space, communication, social life and conceptual thinking, it was considered, except in its artistic dimension, as an obstacle, not a vehicle, to the expression of duration. However, despite the verisimilitude of this general view, if we compare the assertions about language made in 1889, in Time and Free Will, to those made in Creative Evolution, eighteen years later, we will notice a significant change in position that goes from considering it as an element of “dissimulation” to an “instrument of liberation.” Based on the recently published course “L’idée de temps” given at the Collège de France in the years of 1901-1902, and having as a common thread the relationship between language, society and life, I intend to demonstrate that the causes that motivated this adjustment of position occur from the abandonment, by Bergson, of a certain anti-naturalist conception of language and, consequently, from the philosopher's gradual assimilation (and formulation) of what we could call linguistic naturalism.