Significance Of Copper Research Articles

Cuproptosis: A Copper-Mediated Programmed Cell Death.

It has been found that various heavy metals can initiate different types of regulated cell deaths. Among these metals, copper, an essential trace micronutrient that plays a major role in a lot of physiological processes, also can initiate cell death. It can act as a constituent of metalloenzymes, and can act as a mediator for signaling pathways to regulate proliferation and metastasis of tumor. It is also an integral part of some metal-based anticancer drugs. Recent studies have revealed that excessive intracellular copper accumulation leads to the aggregation of mitochondrial lipoylated proteins, causing proteotoxic stress and ultimately resulting in cell death. This newly discovered copper-induced cell death is termed as cuproptosis. In the last few, a lot of research has been done to understand the mechanism of copper-mediated cell death, and attempts have also been made to identify the relationship between cuproptosis and the development of cancer. In this review, we provide a comprehensive overview on the significance of copper, its regulation inside the body, the possible mechanism of cuproptosis, and how this cuproptosis can be employed as a therapeutic tool for cancer ablation.

Cuproptosis: A Copper-Triggered Unique Cell Death Targeting Cancer

A recently discovered type of copper-driven cell death is regarded as Cuproptosis. The significance of copper and copper-triggered cell death in the development of malignancies has garnered attention recently. Cuproptosis has shown remarkable promise for cancer therapy, which has sparked a great deal of interest in the cancer research community. Treatments based on copper have the potential to treat malignancies that are resistant to chemotherapy by impeding the growth of the tumor. We offer a critical examination of copper homeostasis and the part copper dysregulation plays in the onset and spread of cancer in this review. After outlining the fundamental molecular underpinnings of Cuproptosis and its connection to cancer, the present state of knowledge regarding copper-based cancer treatment agents - copper chelators, copper ionophores, and copper complexes-based dynamic therapy is summarized. We also provide an overview of the latest research on the use of copper ionophores and complexes-based medicines to reduce tumor treatment resistance in various cancer types. We also go over the small-molecule substances and nanoparticles (NPs) that have the potential to induce Cuproptosis in cancer cells, which will provide fresh insight into the future development of Cuproptosis-inducing anticancer medications. Ultimately, the key ideas and urgent issues surrounding Cuproptosis that need to be addressed in further research were covered. Targeting Cuproptosis may be a potential anticancer therapy and treatment approach to overcome drug resistance in cancer, according to this review article. Keywords: Cuproptosis, cancer, chemo-resistance, malignancies, Cu homeostasis, Cu chelators

A comparative performance of antibacterial effectiveness of copper and silver coated textiles

During current COVID-19 crises, the antimicrobial textiles primarily those utilized in hospital by doctors and paramedical staff have become increasingly important. Thus, there is an unmet requirement to develop antimicrobial textiles for infection control and hygiene practices. Metallic nanoparticles exhibit great effectiveness towards resistant microbial species making them a potential solution to the increasing antibiotic resistance. Due to this, nanoparticles particularly copper and silver have become most prevalent forms of antibacterial finishing agents for the development of antimicrobial textiles. This review is mainly focused on the significance of copper and silver nanoparticles for the development of antimicrobial textiles. The comparative analysis of the antibacterial effectiveness of copper and silver nanoparticles as well as the possible physical and chemical interactions responsible for their antibacterial action are explained. The negative impact of pathogenic microbes on textiles and possible interactions of antimicrobial agents with microbes have also been highlighted. The significance of nanotechnology for the development of antimicrobial textiles and their applications in medical textiles domain have also been discussed. Various green synthesis and chemical methods used for the synthesis of Ag and Cu nanoparticles and their application on textile substrates to impart antimicrobial functionality have also been discussed. The various qualitative and quantitative standard testing protocols utilised for the antimicrobial characterization of textiles have also discussed in this review. The developed Cu and Ag coated textiles could be effectively applied in the field of hospital textiles for the preparation of antibacterial scrub suits, surgical gowns, panel covers, protective clothing, bedding textiles, coveralls, wound dressings, table covers, curtains, and chair covers etc.

Quantitative analyses of copper in fine and solid particles of snow and hair in the population of Gorno-Altaysk

BACKGROUND: The significance of copper (Cu) in the human body and its toxicological effects in elevated concentrations have now been fully established, although the presence of Cu in the environment and in the body of different populations across different regions warrants further research.
 AIM: To identify the level of Cu accumulation in the fine and solid phases of snow and hair of the population of Gorno-Altaysk.
 MATERIAL AND METHODS: The concentration of Cu in snow water, the solid phase of snow, and hair in the population of Gorno-Altaysk was determined by atomic absorption spectrometry. Snow samples were collected from the areas of 10 coal-fired boiler houses, and hair samples were collected from 122 people aged 450 years.
 RESULTS: The Cu content in melted water from all snow intakes in the areas of coal-fired boilers (0.0190.049 mg/L) did not exceed the maximum permissible concentration (MPC 0.1 mg/L). In 3 (56.4067.20 mg/kg) of the 10 samples in the solid phase of snow (19.3767.42 mg/kg), an excess of MPC (55.0 mg/kg) was detected. The Cu content in the hair of the subjects did not depend on gender (U=1741; p=0.580); in a population aged 421 years, the concentration of Cu decreased with age (U=29; p=0.05). The concentration of Cu in the hair of the residents of Gorno-Altaysk, when compared with other regions of the world, corresponded to low values (10.0 mg/kg), low concentrations (7.5 mg/kg, 31.9%) were more common among the population than high concentrations (25.0 mg/kg, 5.7%). No correlation was noted between the concentration of Cu in the hair of the population and that in snow water and the solid phase of snow.
 CONCLUSION: The Cu content in the fine-dispersed phases of snow collected from across areas of coal-fired boilers did not pose any danger to the people, whereas, in the solid phases, increased concentrations were recorded. The hair of the population more often contained a low content of Cu (31.9%) than a high content (5.7%).

Effects of the influence of copper and zinc on living organisms (literature review)

Introduction. Scientists from Horbachevsky Ternopil National Medical University, Ternopil, and various countries, including state laboratories, have thoroughly studied the biological significance of copper and zinc ions in the body for many years. Nevertheless, the value of the shortage or excess of these metals and their compounds in the body remains mostly underestimated for health. Purpose of work: to study the pathogenesis of traumatic disease occurring due to an imbalance of copper and zinc in the body. Methods. Bibliosemantic and analytical methods were used. A literature search was conducted for the following queries as zinc, copper, heavy metals, negative impact. The investigation was performed with PubMed, Scopus, Web of Science, and Google Scholar for various articles. All publications have been analyzed and included in this review. The importance of these metals’ lack or excess and their compounds in the body remains mostly underestimated. Features of the pathogenesis of many diseases occurring due to imbalance of copper and zinc in the body have also been unexplored. The traumatic disorder was no exception, as this was not considered in experimental and clinical medicine. Conclusion. From the analysis of the available scientific literature, no messages were found about the features of the course of traumatic disease in conditions of excessive intake of copper and zinc ions in the body. We can only assume that a violation of the functional ability of the liver, lungs, brain and other organs that occurs against the background of heavy metal ion damage creates an unfavorable background for the occurrence of a serious injury.

Significance of Copper, Zinc, Selenium and Fluoride in Squamous Cell Carcinoma of Cervix- A Pilot Study

Significance of Copper, Zinc, Selenium and Fluoride in Squamous Cell Carcinoma of Cervix- A Pilot Study

Copper induces conformational changes in the N-terminal part of cell-surface PrPC

Prion diseases are caused by misfolding of the cellular prion protein, PrPC. In vitro studies have shown that PrP binds copper via the octarepeat region lying within the unstructured N-terminal segment of the protein, but the significance of copper in PrP metabolism remains unclear. Here, six specific antibodies recognizing different epitope regions of PrP were used to measure the effect of copper on the conformation of the molecule at the cell surface. Binding of an antibody, E149, to an epitope within the octarepeat domain of PrP is halved in the presence of copper, whereas binding of antibodies recognizing epitope motifs C-terminal to residue 90 of PrP remain relatively unaltered under equivalent conditions. These experiments strongly suggest that copper induces localized conformational change within the N-terminal portion of cell-surface PrPC.

Significance of Copper in Alcohol Production with Fermentation of Raisin Extracts by the Cell Recycle Process

ABSTRACTThe ethanol fermentation rate, cell growth and yield were reduced from one batch to the next in presence of 50 ppm copper as compared to 5 ppm. The decreases of these parameters are attributed to the increased uptake of copper causing lessening of the glucose uptake by yeast cells. These changes were studied through the uptake of 14C‐glucose in fermentations of synthetic media containing 14C‐glucose, in presence of various copper concentrations.

Význam mědi v pivovarské technologii.

Význam mědi v pivovarské technologii.

Distribution and significance of copper, lead, zinc and cadmium in the Corio Bay ecosystem

Levels of copper, lead, zinc and cadmium in sediments, waters and mussels (Mytilus edulis) from Corio Bay (Vic.) were measured on two occasions in 1977. The bay has restricted water exchange with Port Phillip Bay and is known to have received a major input of cadmium. The respective concentrations of copper, lead, zinc and cadmium in the sediments were 2-50,2-2l0,4-398 and up to 12.6 �g/g; in the unfiltered waters, I .5-25, <0.4-11, 3.9-67 and 0.11-5.6 �g/l; and in the mussels, 4.8-21. 1.2-9.7, 105-110 and 9.8-53 �g/g on a dry weight basis. The observed levels of heavy metals are compared with threshold levels reported in the literature as causing significant interference with growth of phytoplankton and nutrient cycling by bacterial processes.

The significance of copper for nitrogen fixation in nodulated alnus and casuarina plants

When supplied with copper, nodulated plants ofAlnus glutinosa in nitrogenfree culture solution showed significantly better growth than corresponding plants denied that element, the most marked effect being an increase in percent nitrogen in the leaf dry matter. Thus the nodular fixation of nitrogen appears to require an adequate level of copper, though the extent to which this is specific for the actual fixation process cannot be assessed from the data provided.

Content of copper in brain tissue under normal conditions and in some diseases of the nervous system

Copper content was determined spectrographi cally in various portions of the brain in 10 healthy patients who died accidentally, in the brain of a patient with hepatolenticular degeneration, as well as in various tumors of the brain and areas of the nervous system not affected by neoplasms. The greatest copper content was noted in the globus pallidus, nucleus caudatus and the cortex of the large hemispheres. The copper concentration in the brain of patients with hepatolenticular degeneration is considerably higher than in the accidentally dead persons. As shown, less copper is contained in the lateral portions of the optic thalamus than in the medial portions. The concentration of copper was almost even in the anterior and the posterior portions of the hypothalamic area. Copper content is increased in the areas of the brain not affected by neoplasms. Copper content in the brain tumors of membranous-vascular genesis is lower than in the white matter. Much copper was detected in benign neuroectodermic tumors. The highest copper content was noted in malignant neuroectodermal tumors (higher than in the brain tissue richest in copper). In malignant tumors copper content was higher at the periphery of the neoplasm, in the area of intensive cellular growth and glycolysis. The significance of copper for the activity of the nervous system and metabolism in tumors is discussed.

INFLUENCE OF COPPER AND A LIVER FRACTION ON RETENTION OF IRON

The influence of copper on the formation of hemoglobin is a problem which has not been completely solved, and the literature abounds in conflicting reports on the subject. Elvehjem 1 has recently summarized the work on the biologic significance of copper, and the reader is referred to this paper for a comprehensive review and bibliography. It has been found that in the experimental nutritional anemia of animals neither iron nor copper alone is effective in producing regeneration of hemoglobin, but when iron is given in combination with a small amount of copper a rapid increase in the hemoglobin content of the blood ensues. The work of Whipple 2 on experimental hemorrhagic anemia in dogs has not entirely confirmed these results. He found that in certain instances a combination of iron and copper was more beneficial than iron alone but that this was not consistently true. It is possible that a

Significance of Copper and Iron in Blood Restoration

Significance of Copper and Iron in Blood Restoration