Significance Of Cell Types Research Articles

Atypical Glandular Cells of Undetermined Significance: Significance of Cell Type and Age on Patient Management

To compare the rate, accuracy, and histological correlation of cytological smears reported as atypical glandular cells of undetermined significance (AGUS) in different age groups. Cervical cytology smears reported as AGUS were reviewed and correlated with histologic follow-up and repeat cytology. A total of 40,464 Pap smears were performed at Long Island Jewish Medical Center between 1996 and 2000. Of those, 163 (0.4%) smears were diagnosed as AGUS, and 62% of the patients with AGUS had either histologic or cytologic follow-up or both. The highest AGUS rates occurred in the fifth (0.6%) and ninth (0.84%) decades of life. Eighty-eight patients had histologic follow-up. Significant endometrial lesions occurred in 15 patients. The mean age was 64 years. Significant cervical lesions occurred in 12 patients. The mean age was 45 years. Among women with AGUS-favor endometrial (AGFEM) cell origin, 9 of 34 women had a significant lesion (8 endometrial and 1 cervical). Four of 12 endometrial carcinomas were identified among women whose cytology suggested cervical origin. Older women were more likely to have significant endometrial lesions and younger women significant cervical lesions. However, neither cytologic criteria nor the patient's age is perfect in directing the clinician toward the likely origin of the atypical cells.

Significance of cell type in regenerating functional myocardium: In vivo comparison of myoblasts vs. fibroblasts in a rabbit model of cell transplant to cryoinjured myocardium

Significance of cell type in regenerating functional myocardium: In vivo comparison of myoblasts vs. fibroblasts in a rabbit model of cell transplant to cryoinjured myocardium

The significance of cell type and tumor growth markers in the prognosis of unscreened cervical cancer patients

ter Harmsel B, van Muyden R, Smedts F, Hermans J, Kuijpers J, Raikhlin N, Petrov S, Lebedev A, Ramaekers F, Trimbos B. The significance of cell type and tumor growth markers in the prognosis of unscreened cervical cancer patients. Int J Gynecol Cancer 1998; 8: 336–344. The clinical significance of p53, Ki-67-Ag, and BCL-2 as markers for patient prognosis in cervical carcinoma was compared to established prognostic tumor parameters. The examined population consisted of 159 unscreened Russian women, presenting with Stage I (n= 74) and Stage II (n= 85) cervical carcinoma. Relevant clinical information was available in all cases. Thirty-five percent of cases were either adenocarcinoma or contained an adenocarcinomatous component. Lymph node status and stage of disease appeared to be statistically significant parameters for patient survival. Depth of tumor infiltration was a significant indicator of 5-year relapse risk, while tumor size and histologic classification were not predictive. When analyzed separately, p53, Ki-67-Ag, and BCL-2 were not significantly correlated with clinical parameters. However, high Ki-67-Ag combined with high BCL-2 indices predicted a shorter relapse-free interval than did low Ki-67-Ag combined with low BCL-2 index. We conclude that the relatively high incidence of cervical adenocarcinomas is merely due to an increased awareness in the histologic classification criteria of this tumor subtype. Furthermore, histologic parameters are not of value in predicting patient outcome. Although tumor stage and lymph node status are superior to individual markers of tumor growth and genomic instability in determining patient prognosis, a combination of markers for proliferation index and protection from apoptotic cell death shows a tendency to predict clinical outcome.

The role and action of environmental agents in the pathogenesis of hung cancer. I. Air pollutants.

The role and action of environmental agents in the pathogenesis of hung cancer. I. Air pollutants.

The significance of cell type in relation to the aetiology of lung cancer.

The significance of cell type in relation to the aetiology of lung cancer.

The Significance of Cell Type in Cervical Cancer

Among the factors which have been investigated in an attempt to explain the differences in the curability of cervical cancer is the type of cell making up the growth. Whether or not growths composed of different types of cells actually react differently to treatment, either irradiation or operation, is unknown, but many have entertained the opinion that such is the case. If they are right, the determination of cell type becomes of great importance. There is a growing doubt that differences in cell type bear a relation to the degree of radiation sensitivity, but the opinion that they are related to curability by operation still prevails. This latter opinion would appear to rest on rather flimsy evidence. Logic certainly tells us that cure by operation should depend entirely upon whether or not all the cancer present is removed, without reference to the type of cell composing it. It is my purpose, however, to present a brief resume of investigations of the cell type in a series of cases for which five-year results were available. Cervical carcinomas may be divided into the squamous or epidermoid, which make up 90 to 95 per cent of the cases, and the cylindrical-cell or adenocarcinomas, which constitute the remainder. While the latter were formerly considered more resistant to treatment than the squamous-cell growths, the majority of authorities now consider that such is not the case. It is usually not possible to differentiate the two forms either by clinical examination or by their response to radiation. Since the number of cervical adenocarcinomas is quite small, few studies on the significance of variations in the cell type have been attempted. Norris' (6) recent article, in which he reports the details of 43 cases, summarizes the results of others. Such growths have been divided into ripe, mid-ripe, and unripe forms, into highly differentiated and undifferentiated forms, and into adenoma malignum, intermediate, and true adenocarcinoma forms, but attempts to correlate these various forms with curability have remained unconvincing. This may possibly be due to the fact that such deductions have of necessity been made from small numbers of cases. Norris believes that those growths with a high mitosis content are the most malignant and the most sensitive to radiation, and inclines to the belief that adenoma malignum carries a better prognosis than the true adenocarcinoma. He believes, too, that adenocarcinomas of the cervix as a group are no less sensitive to radiation than are squamous-cell cancers. Because of the small number I have not attempted to study our cases of cervical adenocarcinoma, but have confined my attention entirely to growths made up of squamous cells.