Abstract
The significance of cell type in relation to the aetiology of lung cancer.
Highlights
The histological data of the lung cancer cases reported by Doll and Hill (1952) have been re-examined to see whether the relationship observed between lung cancer and the consumption of tobacco was characteristic of the histological type
Additional information was obtained about cases for which the histological type had not originally been reported and a proportion of the growths was reexamined by one pathologist, who was kept in ignorance of the sex and previous smoking habits of the patient
A close relationship was found between the daily amount smoked and the development of squamous, large cell and small cell carcinomas, but only a slight, if any, relationship with the development of other histological types-principally adenocarcinomas and bronchiolar carcinomas
Summary
130 patients of the same sex and age distribution. It will be noted that the total number of cases differs from that given by Doll and Hill (1952) in their Table X, since the additional information obtained has enabled some of the cases previously described as "carcinoma of unclassified type" to be allocated to one or other of the histological groups; the remaining unclassified cases have been excluded determined from the study. Patients (1357 men and 108 women) of Doll and Hill's study (Doll and Hill, 1952) Each of these patients had been selected to be of the same sex and within the same 5 year age group as a lung cancer patient and was treated in the same hospital (or in a similar regional hospital) at or about the same time. The totals obtained gave the numbers of patients in each smoking category in a control population of the same size and age distribution as the male patients with Group I lung cancer and could be compared directly with them. The results obtained by the re-examination of the sections of a sample of the Group I growths in men (shown in Table III) suggest that the trend with amount
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