Cancer is a complex disease that imposes a significant economic burden on populations globally. Curcumin, the active ingredient in turmeric, has anti-cancer properties that hold promise for preventing cancer. By affecting key intracellular signalling pathways and proteins like NF-κB and STAT3, Curcumin shows potential for thwarting cancer growth.Our research utilizes molecular docking and dynamics simulations to investigate how Curcumin interacts with Phosphatase and tensin homolog (PTEN) and mutated PTEN. PTEN, a tumor suppressor protein containing 403 amino acids, plays a vital role in various cancers due to its enzymatic activities. Our results suggest that Curcumin binds more strongly to mutated PTEN, indicating its potential to target cancer cells with mutated PTEN.Additionally, molecular dynamics simulations demonstrate that Curcumin effectively interacts with mutated PTEN, forming stable hydrogen bonds and van der Waals interactions. These findings suggest that Curcumin could serve as a safe and efficient natural compound for exploring as a therapeutic agent to reactivate mutated PTEN in cancer treatment.