Signal Attenuation Research Articles

Image post-processing for SILMAS: structured illumination light sheet microscopy with axial sweeping.

In this article, we propose a post-processing scheme for the novel volumetric microscopy technique SILMAS. We demonstrate this scheme on data from an alpha-synuclein transgenic mouse brain. By combining structured illumination and axial sweeping, a SILMAS measurement provides a prerequisite for quantitative data extraction through improved contrast and optical sectioning. However, due to the technique's efficient removal ofb multiple scattered light, image artifacts such as illumination inhomogeneity, shadowing stripes, and signal attenuation, are highlighted in the recorded volumes. To suppress these artifacts, we rely on the strengths of the imaging method. The SILMAS data, together with the Beer-Lambert law, allow for an approximation of real light extinction, which can be used to compensate for light attenuation in a near-quantitative way. Shadowing stripes can be suppressed efficiently using a computational strategy thanks to the large numerical aperture of an axially swept light sheet. Here, we build upon prior research that employed wavelet-Fourier filtering by incorporating an extra bandpass step. This allows us to filter high-contrast light sheet microscopy data without introducing new artifacts and with minimal distortion of the data. The combined technique is suitable for imaging cleared tissue samples of up to a centimeter scale with an isotropic resolution of a few microns. The combination of a thin and uniform light sheet, scattered light suppression, light attenuation compensation, and shadowing suppression produces volumetric data that is seamless and highly uniform.

Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells

The aim of the present study was to investigate the effects of Oncostatin M receptor (OSMR) subunit gp130 knockdown on insulin-stimulated glucose metabolism-related signaling pathways and glucose uptake in skeletal muscle cells. siRNA-mediated gp130 knockdown was conducted in C2C12 muscle cells, and insulin was added and incubated for 1 h. The cells were cultivated to analyze the mRNA levels of gp130, phosphorylation of STAT3, and glucose metabolism-regulated signaling pathways, and OSM levels in the culture medium were analyzed. The phosphorylation of STAT 3 was significantly decreased in gp130−/− cell. The insulin stimulation was significantly increased in both gp130−/− and gp130+/+ and the phosphorylation of IRS-1 Ser 1101 was significantly decreased in gp130−/−. PI3-kinase activity and Akt Thr 308 phosphorylation were significantly decreased in gp130−/−. The insulin-stimulated increase in glucose uptake rate was significantly attenuated in gp130−/−. In the culture medium, OSM levels were significantly lower in gp130+/+compared to gp130−/− cell. In conclusion, the knockdown of gp130 caused a decrease in STAT 3 phosphorylation and resulted in the attenuation of insulin-mediated glucose metabolism signaling in skeletal muscle cells. Thus, an excessive increase in extracellular OSM may induce blunted insulin action in skeletal muscle cells.

Attenuation of sound signals in foams for the basic oxygen furnace using physical modelling techniques

Attenuation of sound signals in foams for the basic oxygen furnace using physical modelling techniques

Multi-peak soliton dynamics and decoherence via the attenuation effects and trapping potential based on a fractional nonlinear Schrödinger cubic quintic equation in an optical fiber

Fiber optic research continues to develop due to the need for fast information technology. The input signal in an optical fiber is in the form of a soliton wave that propagates in the fiber with a balanced index of refraction, dispersion, and diffraction. Fiber optics may lose some of the signal over time if they solely use a nonlinear refractive index. This study aims to examine into the dynamics and decoherence of multi-peak solitons caused by electromagnetic signal attenuation and potential trap in the propagation via optical fibers. The methods used start with the stationary solution of the nonlinear Schrödinger Cubic Quintic equation, the Newton-Raphson method, and the fourth-order Runge-Kutta. In stationary solutions, the p (state energy) and ρ (Lèvy index) values affect the number, pulse width, and height of soliton peaks. Increased p and ρ values lead to increased instability, causing the data transmitted into the optical fiber to collapse and become unreadable by the receiver. In the excited state (p > 0), the decoherence phenomenon occurs and causes wave instability and destruction. In term of energy intensity, a stable form of transmission in the ground state has a pattern of continuously weakening, decreasing, and smoothing, while in the excited state there is a spike in the intensity of the electromagnetic wave. Based on this study, multi-peak solitons can only be applied for propagation distances, which tend to be short due to their dynamics and decoherence.

Highly Efficient Hybrid Reconfigurable Intelligent Surface Approach for Power Loss Reduction and Coverage Area Enhancement in 6G Networks

This paper introduces a novel efficient hybrid reconfigurable intelligent surface (RIS) approach designed to significantly reduce power loss and enhance coverage area in 6G networks. The core innovation of this approach lies in an advanced iterative algorithm introduced as the Hybrid reconfigurable intelligent surface decision-making algorithm (HRIS-DMA) that integrates precise user location data into the RIS configuration process. By dynamically adjusting RIS elements to reflect and direct signals based on real-time user positions, this method minimises signal attenuation and optimises signal propagation. The mechanism driving the performance gains includes precise beamforming and intelligent reflection, continuously refined through iterative updates. This technique ensures robust signal strength and expanded coverage, addressing the challenges of dense and diverse deployment scenarios in 6G networks. The proposed scheme’s application in 6G networks demonstrates substantial improvements in signal quality and network reliability, paving the way for enhanced user experiences and efficient communication infrastructures. This novel approach was tested using MATLAB R2023a , and its performance was evaluated using three downlink scenarios: zero to few, few to moderate, and moderate to many obstacles. The three scenarios show higher coverages than conventional simultaneous transmitting and reflecting reconfigurable intelligent surfaces (STAR-RISs) and base station (BS) handover. Based on the evaluation metrics, the analysis results of the novel HRIS-DMA show 70% less signal power loss, 0.17 μs less system delay, 25 dB and 12 dB channel gain compared with the conventional STAR-RIS and BS handover, respectively, and 95% improvement in the overall system’s efficiency compared to STAR-RIS and 13% compared to BS-BS handover.

A survey on node localization technologies in UWSNs: Potential solutions, recent advancements, and future directions

SummaryLocation‐based underwater communication applications such as strategic surveillance, disaster prevention, marine research, and mine detection have given the field of underwater wireless sensor networks (UWSN) a head start. Node localization is a prerequisite for accurate data collection, target monitoring, and network management in UWSNs. However, the unique characteristics of the underwater environment, such as signal attenuation, multipath propagation, and variable acoustic properties, pose a major challenge to effective node localization. Accurate sensor node location data is essential for successful underwater data collection, but difficult to achieve as the GPS system cannot be used in an underwater environment. In this paper, existing node localization techniques such as ALS, SLUM, MASL, SLMP, UDB, USP, etc., and recent advances such as the fusion of range‐based and range‐free techniques, the fusion of RSSI and AoA to improve localization accuracy by using directional information in addition to signal strength, and the use of optimization techniques such as PSO, COA, and WOA algorithms to improve the accuracy of the applied node localization algorithm, e.g., TP‐TSFLA, and challenges related to UWSN are discussed. Also, different localization algorithms that affect the accuracy of UWSN localization techniques have been evaluated and compared with NS2 in terms of localization error, localization coverage, energy consumption, and average communication cost metrics. In addition, this paper also provides an up‐to‐date investigation of localization techniques. Finally, the tools available for simulation are presented, followed by open research questions that need to be addressed in the localization of nodes.

On the performance of OFDM-IM systems in the presence of CFO effects

This study presents a comprehensive analysis of the performance degradation effects of carrier frequency offset (CFO) on orthogonal frequency division multiplexing with index modulation (OFDM-IM) systems operating over frequency-selective multipath fading channels. CFO is an impairing factor that degrades the signal-to-noise ratio (SNR) through signal attenuation and inter-carrier interference (ICI). We derive a closed-form expression to quantify the SNR degradation under CFO for OFDM-IM systems. Additionally, we formulate a very tight upper bound for the bit error rate (BER), accounting for index modulation errors, CFO distortion, and multipath fading.The presented analytical formulations capture the unique characteristics of OFDM-IM systems and facilitate precise performance evaluation. The findings yield valuable insights into mitigating CFO-induced BER degradation through appropriate system parameter selection and CFO compensation techniques. Moreover, this investigation makes significant contributions towards designing reliable OFDM-IM communication links resilient to the combined effects of index modulation, frequency offsets, and dispersive channel conditions.

AXIN2 promotes degradation of AXIN1 through tankyrase in colorectal cancer cells.

AXIN1 and AXIN2 are homologous proteins that inhibit the Wnt/β-catenin signaling pathway, which is frequently hyperactive in colorectal cancer. Stabilization of AXIN1 and AXIN2 by inhibiting their degradation through tankyrase (TNKS) allows the attenuation of Wnt signaling in cancer, attracting interest for potential targeted therapy. Here, we found that knockout or knockdown of AXIN2 in colorectal cancer cells increased the protein stability of AXIN1. The increase in AXIN1 overcompensated for the loss of AXIN2 with respect to protein levels; however, functionally it did not because loss of AXIN2 activated the pathway. Moreover, AXIN2 was highly essential in the context of TNKS inhibition because TNKS-targeting small-molecule inhibitors completely failed to inhibit Wnt signaling and to stabilize AXIN1 in AXIN2 knockout cells. The increased AXIN1 protein stability and the impaired stabilization by TNKS inhibitors indicated disrupted TNKS-AXIN1 regulation in AXIN2 knockout cells. Concordantly, mechanistic studies revealed that co-expression of AXIN2 recruited TNKS to AXIN1 and stimulated TNKS-mediated degradation of transiently expressed AXIN1 wild-type and AXIN1 mutants with impaired TNKS binding. Taken together, our data suggest that AXIN2 promotes degradation of AXIN1 through TNKS in colorectal cancer cells by directly linking the two proteins, and these findings may be relevant for TNKS inhibition-based colorectal cancer therapies.

Investigation of calendaring parameters on the microstructure of graphite anodes within lithium-ion batteries: Insights from ultrasonic testing

The study explores the application of ultrasonic testing to analyse the impact of the calendaring process on the microstructure of graphite anodes within a lithium-ion battery. It examines the correlation between calendaring parameters such as roll gap and line speed, and their impacts on ultrasonic signal characteristics.Our study reveals that different sample thicknesses responded differently to the calendaring process. Specifically, the amplitude of the first peak increased for thinner samples (<45 μm) post-calendaring, indicating improved material uniformity, whereas thicker samples (>50 μm) demonstrated increase in Time of Flight with reduced attenuation in acoustic signal. Notably, thinner electrodes (45 μm) exhibit a substantial density increase from 0.95 to 1.6 gr/cm³, surpassing the density gain in thicker electrodes (100 μm) which rise from 1.0 to 1.3 gr/cm³ under identical calendaring conditions.This initial study confirms that a clear correlation exists between the properties of the acoustic waveform and variations in the calendaring process parameters. These results will form the basis of a future study investigating the possible in-line sensing, process control and quality assessment of electrode manufacture. The data obtained from this study's characterisation process has the potential to underpin a data-driven model to predict calendaring performance using machine-learning methods.

Selective removal of variable thickness multilayer materials based on photoelectric detection

An ultrafast laser processing system with near-axis monochromatic photoelectric detection for selective removal of variable thickness multilayer materials is proposed. The correlation between signal evolution and ablation progress of silver layer with the variable thickness is established, and a signal attenuation threshold is determined to ensure non-removal of the substrate, providing criteria for the processing strategy combining high and low energies. The proposed strategy is experimentally validated, which balances the quality of low-energy removal and the efficiency of high-energy removal.

Hydroelectric Plant Safety: Real-Time Monitoring Utilizing Fiber-Optic Sensors.

In the context of hydroelectric plants, this article emphasizes the imperative of robust monitoring strategies. The utilization of fiber-optic sensors (FOSs) emerges as a promising approach due to their efficient optical transmission, minimal signal attenuation, and resistance to electromagnetic interference. These optical sensors have demonstrated success in diverse structures, including bridges and nuclear plants, especially in challenging environments. This article culminates with the depiction of the development of an array of sensors featuring Fiber Bragg Gratings (FBGs). This array is designed to measure deformation and temperature in protective grids surrounding the turbines at the Santo Antônio Hydroelectric Plant. Implemented in a real-world scenario, the device identifies deformation peaks, indicative of water flow obstructions, thereby contributing significantly to the safety and operational efficiency of the plant.

Ultrastable fluorinated copolypeptide nanodroplets of loaded mixed liquids with low vaporization threshold

The expansion of ultrasound molecular imaging applications warrants a reduction in ultrasound contrast agent size and significant advancement in the in vivo stability of shell-stabilized bubbles. The shift from first to second-generation ultrasound contrast agents was marked by an improvement in stability as air was replaced by hydrophobic gases like perfluoropropane and sulfur hexafluoride. Further enhancements may be facilitated by focusing on strategies to retain the encapsulated gas within the ultrasound contrast agent shell despite extreme mechanical deformations. In this study, we developed a novel ultrasound contrast agent with a unique shell structure and a specially-formulated, low-boiling fluorinated liquid interior, resulting in superior stability during repeated and prolonged ultrasound-induced oscillations. Our ultra-stable nanodroplets can withstand sustained in vitro ultrasound exposure with minimal signal attenuation and can induce significant signal enhancement and delay in signal attenuation in the kidney, liver, and tumor tissues during in vivo experiments. Furthermore, encapsulating photosensitizers within these nanodroplets and leveraging photothermal effects could further augment the ultrasound imaging signal and verify its efficacy in tumor therapy. The creation of highly stable nanodroplets opens immense potential to augment the role of ultrasound in molecular imaging, therapy, and drug delivery.

Pim Kinase Inhibition Disrupts CXCR4 Signalling in Megakaryocytes and Platelets by Reducing Receptor Availability at the Surface.

A key step in platelet production is the migration of megakaryocytes to the vascular sinusoids within the bone marrow. This homing is mediated by the chemokine CXCL12 and its receptor CXCR4. CXCR4 is also a positive regulator of platelet activation and thrombosis. Pim-1 kinase has been shown to regulate CXCR4 signalling in other cell types, and we have previously described how Pim kinase inhibitors attenuate platelet aggregation to CXCL12. However, the mechanism by which Pim-1 regulates CXCR4 signalling in platelets and megakaryocytes has yet to be elucidated. Using human platelets, murine bone marrow-derived megakaryocytes, and the megakaryocyte cell line MEG-01, we demonstrate that pharmacological Pim kinase inhibition leads to reduced megakaryocyte and platelet function responses to CXCL12, including reduced megakaryocyte migration and platelet granule secretion. Attenuation of CXCL12 signalling was found to be attributed to the reduced surface expression of CXCR4. The decrease in CXCR4 surface levels was found to be mediated by rapid receptor internalisation, in the absence of agonist stimulation. We demonstrate that pharmacological Pim kinase inhibition disrupts megakaryocyte and platelet function by reducing constitutive CXCR4 surface expression, decreasing the number of receptors available for agonist stimulation and signalling. These findings have implications for the development and use of Pim kinase inhibitors for the treatment of conditions associated with elevated circulating levels of CXCL12/SDF1α and increased thrombotic risk.

Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression

The Wnt/Wingless signaling pathway plays critical roles in metazoan development and energy metabolism, but its role in regulating lipid homeostasis remains not fully understood. Here, we report that the activation of canonical Wnt/Wg signaling promotes lipolysis while concurrently inhibiting lipogenesis and fatty acid β-oxidation in both larval and adult adipocytes, as well as cultured S2R+ cells, in Drosophila. Using RNA-sequencing and CUT&RUN (Cleavage Under Targets & Release Using Nuclease) assays, we identified a set of Wnt target genes responsible for intracellular lipid homeostasis. Notably, active Wnt signaling directly represses the transcription of these genes, resulting in decreased de novo lipogenesis and fatty acid β-oxidation, but increased lipolysis. These changes lead to elevated free fatty acids and reduced triglyceride (TG) accumulation in adipocytes with active Wnt signaling. Conversely, downregulation of Wnt signaling in the fat body promotes TG accumulation in both larval and adult adipocytes. The attenuation of Wnt signaling also increases the expression of specific lipid metabolism-related genes in larval adipocytes, wing discs, and adult intestines. Taken together, these findings suggest that Wnt signaling-induced transcriptional repression plays an important role in regulating lipid homeostasis by enhancing lipolysis while simultaneously suppressing lipogenesis and fatty acid β-oxidation.

FireSonic: Design and Implementation of an Ultrasound Sensing-Based Fire Type Identification System.

Accurate and prompt determination of fire types is essential for effective firefighting and reducing damage. However, traditional methods such as smoke detection, visual analysis, and wireless signals are not able to identify fire types. This paper introduces FireSonic, an acoustic sensing system that leverages commercial speakers and microphones to actively probe the fire using acoustic signals, effectively identifying fire types. By incorporating beamforming technology, FireSonic first enhances signal clarity and reliability, thus mitigating signal attenuation and distortion. To establish a reliable correlation between fire type and sound propagation, FireSonic quantifies the heat release rate (HRR) of flames by analyzing the relationship between fire-heated areas and sound wave propagation delays. Furthermore, the system extracts spatiotemporal features related to fire from channel measurements. The experimental results demonstrate that FireSonic attains an average fire type classification accuracy of 95.5% and a detection latency of less than 400 ms, satisfying the requirements for real-time monitoring. This system significantly enhances the formulation of targeted firefighting strategies, boosting fire response effectiveness and public safety.

Enhanced Ultra-Wideband Communication System with OFDM Modulation: Performance Analysis in LOS and NLOS Conditions

Ultra-wideband (UWB) communication systems, employing Orthogonal Frequency Division Multiplexing (OFDM) modulation, are renowned for their high data rates, low power consumption, and robust performance in multipath environments. However, these systems face significant challenges in varying propagation conditions, specifically under Line-of-Sight (LOS) and Non-Line-of-Sight (NLOS) scenarios. In LOS conditions, the signal travels directly from the transmitter to the receiver without obstructions, typically resulting in optimal performance characterized by high transmission efficiency, strong Signal-to-Noise Ratio (SNR), low Bit Error Rate (BER), and maximum throughput. Conversely, NLOS conditions involve obstructions and reflections that cause multipath propagation and signal degradation. This leads to reduced transmission efficiency, lower SNR, higher BER, and diminished throughput. This study examines the performance of an UWB communication system using OFDM modulation in both LOS and NLOS conditions. The performance metrics evaluated include transmission efficiency, SNR,BER, and throughput. In LOS conditions, the system demonstrates high transmission efficiency, superior SNR, minimal BER, and maximum throughput due to the unobstructed signal path. In contrast, NLOS conditions result in decreased transmission efficiency, lower SNR, increased BER, and reduced throughput due to signal attenuation and multipath effects. These findings highlight the significant impact of environmental conditions on UWB-OFDM system performance and underscore the importance of optimizing such systems for reliable communication in varied deployment scenarios.

Experimental Study on the Damage of Bridge Concrete in a Fire Environment Based on the Impact Echo Method

Abstract To accurately assess the damage degree of bridge structures in a fire environment, fire damage test studies were conducted on the C30 and C50 concrete specimens at different temperatures (room temperature, 100°C∼700°C) based on the impact echo method. In addition, the variation rules of mass, impact echo signal, dynamic modulus of elasticity Ed, and static and dynamic modulus of elasticity ratios (Ec/Ed) with overfire temperature were obtained. The results show the following: (1) at ablation temperature ≤ 300°C, the main frequency of the impact echo signal is single, the peak value is obvious, the signal attenuation is fast, and the change is uniform; at ablation temperature &amp;gt; 300°C, the main frequency is frequent, there is more than one peak, and the vibration duration of the phenomenon is longer. (2) After fire damage, the specimen’s dynamic modulus of elasticity Ed is in a cubic relationship with the overfire temperature. (3) In engineering practice, the static and dynamic modulus of elasticity (Ec/Ed) ratio is classically based on Lydon and Balendran’s formula, which is usually used for derivation at room temperature. This article found that the formula can be extended to the rough estimation at lower temperatures (≤200°C), and the model proposed in this article can be used for the derivation of the static modulus of elasticity Ec and the dynamic modulus of elasticity Ed at high temperatures. In summary, the impact echo method can be used to quantitatively assess the damage state of bridges after fire. After the signal time-frequency domain conversion, a qualitative assessment of the degree of concrete damage can be made. Furthermore, a quantitative assessment of bridge concrete after fire damage can be made using the model proposed in this article.

Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection

IntroductionInsulin resistance (IR) is associated with multiple pathological features. Although p53- or TRIB3-orchestrated IR is extensively studied in adipose tissue and liver, the role of p53-TRIB3 axis in myocardial IR remains unknown, and more importantly target-directed therapies of myocardial IR are missing. ObjectivesConsidering the beneficial effects of sulforaphane (SFN) on cardiovascular health, it is of particular interest to explore whether SFN protects against myocardial IR with a focus on the regulatory role of p53-TRIB3 axis. MethodsMouse models including cardiac specific p53-overexpressing transgenic (p53-cTg) mice and Trib3 knockout (Trib3-KO) mice, combined with primary cardiomyocytes treated with p53 activator (nutlin-3a) and inhibitor (pifithrin-α, PFT-α), or transfected with p53-shRNA and Trib3-shRNA, followed by multiple molecular biological methodologies, were used to investigate the role of p53-TRIB3 axis in SFN actions on myocardial IR. ResultsHere, we report that knockdown of p53 rescued cardiac insulin-stimulated AKT phosphorylation, while up-regulation of p53 by nutlin-3a or p53-cTg mice blunted insulin sensitivity in cardiomyocytes under diabetic conditions. Diabetic attenuation of AKT-mediated cardiac insulin signaling was markedly reversed by SFN in p53-Tgfl/fl mice, but not in p53-cTg mice. Importantly, we identified TRIB3 was elevated in p53-cTg diabetic mice, and confirmed the physical interaction between p53 and TRIB3. Trib3-KO diabetic mice displayed improved insulin sensitivity in the heart. More specifically, the AMPKα-triggered CHOP phosphorylation and degradation were essential for p53 on the transcriptional regulation of Trib3. ConclusionOverall, these results indicate that inhibiting the p53-TRIB3 pathway by SFN plays an unsuspected key role in the improvement of myocardial IR, which may be a promising strategy for attenuating diabetic cardiomyopathy (DCM) in diabetic patients.

Influence of short-term refrigeration on collagen-dependent signalling mechanisms in stored platelets

Platelet concentrates (PC) are used to treat patients with thrombocytopenia and hemorrhage, but there is still the demand to find the optimal strategy for temperature-dependent storage of PC. Recently, we could show that cold storage for 1 h (short-term refrigeration) is sufficient to induce enhanced platelet responsiveness. The aim of this study was to investigate effects of cold storage on collagen-dependent activating signalling pathways in platelets from apheresis-derived PC (APC).APC on day 1 or day 2 of storage, were either continuously kept at room temperature (RT, 22 °C), or for comparison, additionally kept at cold temperature (CT, 4 °C) for 1 h. CD62P expression was determined by flow cytometry. Western Blot technique was used to analyze collagen-induced phosphorylation of p38, ERK1/2 or Akt/PKB and its inhibition by prostaglandin E1 (PGE1) or nitric monoxide donor. Adhesion of platelets on collagen-coated surfaces and intracellular phosphorylation of vasodilator-stimulated phosphoprotein (VASP) was visualized by immune fluorescence microscopy.CD62P expression was increased after short-term refrigeration. CT exposition for 1 h induced an elevation of basal ERK1/2 phosphorylation and an alleviation of PGE1- or DEA/NO-suppressed ERK1/2 phosphorylation in APC on day 1 and 2 of storage. Similar, but more moderate effects were observable for p38 phosphorylation. Akt/PKB phosphorylation was increased only in APC on day 2. Refrigeration for 1 h promoted platelet adhesion and reduced basal VASP phosphorylation in adherent platelets.The attenuation of inhibitory signalling in short-term refrigerated stored platelets is associated with enhanced reactivity of activating signalling pathways, especially ERK1/2. Functionally, these processes correlate with increased adhesion of refrigerated platelets on collagen-coated surfaces. The results help to further optimize temperature-dependent strategies for platelet storage.

Probe Absorption Spectroscopy As a Tool to Study the Excited States in a Cooperative System of Two Organic Molecules

The applicability of the method for measuring the probe absorption and gain spectra in a system of quantum emitters excited by a resonant driving field for studying cooperative photoluminescence is considered. The gain and attenuation of a probe signal in the system of two quantum emitters with the dipole–dipole interaction have been calculated for the conditions of observing the cooperative photoluminescence of a pair of impurity molecules described in the literature and close to them. The resulting dependences demonstrate the structure of excited collective molecular states, which can be used to reconstruct the positions of molecules in a matrix and to determine the difference in their photophysical properties. Thus, the probe absorption and gain spectra can be used to analyze the photoluminescence of quantum-entangled particles and to transform light signals.