642 Background: “Fast-track” protocols are multimodal programs that when applied to colorectal surgery, permit a reduction in morbidity, hospital stay and a faster recovery after the surgery. Most of these protocols are associated to laparoscopic surgery. However it is possible to reproduce these results with open surgery, when laparoscopy is not an option (lack of material or medical experience or in low-resource scenario). Methods: Main objective: 1) Apply a fast-track protocol, designed to our patients that have colon malignancies and are submitted to colon resections through an open procedure 2) To study the peri-operative morbidity in the first 30 days after surgery. We conducted a pilot study with 30 patients in 2007. After assuring the feasibility of this protocol we started to apply it regularly in 2009; 177 patients underwent to fast track open colorectal surgery until July 2011. Main studied outcomes were duration of the surgical procedure, pain control, postoperative complications, and length of hospital stay. Other variables included patient (demographic characteristics, BMI, ASA and POSSUM scores), tumour (TNM status) and surgery (type) related variables. Results: 54,8% of the patients were male. Median age was 63 years old (Min.: 36; Máx.: 79). 53,7% had sigmoid or rectosigmoid tumors. Most were classified as pT3N0 tumors. In 89% of the patients, epidural catheter was placed. 92,7% had a vertical median abdominal incision with a median of 19 cm (Min.: 10; Máx.: 30). The most performed surgery was the sigmoid colectomy and the anterior rectosigmoid resection. 89,3% tolerated oral clear liquids, 2 hours after surgery. 31,6% of the patients referred nauseas or vomits in the post-operative period. 83,6% didn't refer pain after the surgery. 2,83% had an anastomotic fistula and had to be reoperated (similarly to historical data). 36,7% were discharged at day three after surgery and 87% have been discharged by the 5th day. Conclusions: The “Fast-track” protocol applied to open colon surgery is feasible, doesn’t increase the morbidity or mortality and permits shorter hospital stays and is not expensive. To its success contribute the detailed information to the patient, the formation and the motivation of the health care people involved.