By taking a cable-stayed-suspension hybrid bridge with main span of 1400 m as example, seismic response of the bridge under the horizontal and vertical seismic excitations is investigated numerically by response spectrum analysis and time history analysis, its seismic performance is discussed and compared to the cable-stayed bridge and suspension bridge with the same main span, and considering the aspect of seismic performance, the feasibility of using cable-stayed-suspension hybrid bridge in super long-span bridges is discussed. Under the horizontal seismic action, the effects of structural design parameters including the cable sag to span ratio, the suspension to span ratio, the side span length, the subsidiary piers in side spans, the girder supporting system and the deck form etc on the seismic performance of the bridge are investigated by response spectrum analysis, and the favorable values of these design parameters are proposed.