Re-Os analyses were performed on suspended loads and coarser grained bank sediments of the Brahmaputra River system. Re and Os concentrations of these sediments vary from 7 to 1154 ppt and from 3 to 173 ppt, respectively. 187Os/ 188Os ratios range from 0.178 to 6.8, and thus vary from nearly mantle to very radiogenic crustal values. Nevertheless, most of the sediments have 187Os/ 188Os ratios less than 1.5, and nearly all of the samples of the Brahmaputra main channel have ratios less than 1.2. Thus, as previously suggested, the Brahmaputra is much less radiogenic than the Ganga. The Siang River, the northern extension of the Brahmaputra, is quite radiogenic in Os despite receiving sediments from the Tsangpo River, which flows along a suture zone with ultramafic outcrops. The Brahmaputra main channel has a fairly constant 187Os/ 188Os ratio even though its tributaries contribute sediments with very heterogeneous Os isotopic compositions. These data, along with the corresponding Nd isotopic compositions, suggest that about 60–90% of the sediment in the Brahmaputra system is derived from Himalayan formations (Higher Himalaya and Lesser Himalaya) whereas 10–40% comes from ophiolite-bearing sequences, perhaps eastern equivalents of those of the Transhimalayan Plutonic Belt. Os data also confirm previously published Sr and Nd results, indicating that about half of the sediments delivered to the Brahmaputra are supplied by the Siang River, while the Himalayan and the eastern tributaries account for 40 and 10%, respectively. The lower 187Os/ 188Os of the Brahmaputra River compared to that of the Ganga is due to two factors. One is the more limited presence of the Lesser Himalaya and hence the lower black shale content of the eastern Himalaya. The other is the non-radiogenic Os supplied by the eastern and southern tributaries, reflecting the presence of mantle-derived lithologies in this region. Despite the lower sediment supply from these tributaries, they contribute greatly to the Os budget of the Brahmaputra River. This study indicates that the Brahmaputra River has little effect on the present-day seawater Os budget. However, reconsideration of this budget suggests that the Ganga, which provides the most radiogenic Os of major rivers studied to date, may have significant impact on the marine Os isotopic composition. The Indo-Asian collision cannot be excluded as an important cause of the increase in the marine 187Os/ 188Os over the past 16 million years until the contributions of all of the rivers draining the Himalayan Tibetan Plateau are known.