Sialadenoma Papilliferum Research Articles

Skin adnexal and salivary gland neoplasms. Similarities and differences of selected patients

Benign and malignant skin adnexal neoplasms, especially glandular lesions, show morphologically striking similarities to salivary gland tumors. On the other hand, histological and clinical differences are evident, and knowledge of their existence is important for adequate treatment and reliable prognostication. In this review similarities and differences of selected entities are briefly described and discussed. The following entities are reviewed: cylindroma (vs. membranous variant of basal cell adenoma), sebaceoma (vs. sebaceous adenoma), syringocystadenoma papilliferum (vs. sialadenoma papilliferum), chondroid syringoma (vs. pleomorphic adenoma), cutaneous myoepithelioma (vs. myoepithelioma of salivary glands), cutaneous malignant myoepithelioma (vs. malignant myoepithelioma of salivary glands), cutaneous adenoid cystic carcinoma (vs. adenoid cystic carcinoma of salivary glands), and mucinous eccrine carcinoma (vs. mucous carcinoma of salivary glands).

Oral inverted ductal papilloma

Anoralpapillomaisabenignsurfacetumourthatcan present anywhere in the oral cavity. Micro-scopically,itisanexophytic,finger-likegrowthofstratifiedsquamousepitheliumonathinfibrovas-cular core of loose connective tissue. Papillomaswithahistologicalendophyticorinvertedpatternof growth are rare. Benign papillary lesions thatseem to originate from the salivary ductal sys-temincludeintraductalpapilloma,invertedductalpapilloma, and sialadenoma papilliferum. Previ-ously,theyhavebeenincludedinthecategoriesofmonomorphicadenomaorductaladenoma.

Sialadenoma papilliferum of the hard palate: report of 2 cases and immunohistochemical evaluation.

This study reports on the clinical and histologic features of 2 previously unreported cases of sialadenoma papilliferum. Immunohistochemical analysis of one of the cases demonstrated that the ductal cell component shows both epithelial and myoepithelial differentiation.

Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature

The term ductal papilloma is used to identify a group of 3 rare benign papillary salivary gland tumors known as inverted ductal papilloma, sialadenoma papilliferum, and intraductal papilloma. They represent adenomas with unique papillary features and arise from the salivary gland duct system. We describe the clinical and microscopic features of 19 new cases of ductal papillomas and combine them with 116 cases previously published in the English-language medical literature. These 19 cases were composed of 13 inverted ductal papillomas, 3 sialadenoma papilliferums, and 3 intraductal papillomas. Collectively, these 19 ductal papillomas occurred most commonly in the sixth to eighth decade of life, with an average patient age of 54 years. Men predominated 1.37:1. The sialadenoma papilliferums presented as papillary lesions clinically with all 3 misinterpreted as squamous papillomas by the surgeons. The inverted ductal papillomas and intraductal papillomas appeared as submucosal nodules. The lip and the palate were the most common locations for inverted ductal papilloma and sialadenoma papilliferum, respectively. The sites for the 3 intraductal papillomas were the parotid papilla of the Stensen’s duct, the upper lip, and the buccal mucosa. With light microscopy, inverted ductal papillomas appeared to arise from the excretory ducts near the mucosal surface, whereas intraductal papillomas appeared to arise from the excretory ducts at a deeper level. Sialadenoma papilliferum had a more complex histology, with a biphasic growth pattern of exophytic papillary and endophytic components. All 19 cases were treated by surgical excision. Follow-up information was available in only 2 cases, both inverted ductal papillomas. Neither case recurred during a 20-year period. Sialadenoma papilliferum, with a literature-derived recurrence rate of 10% to 15%, seems to assert a more significant biological behavior than inverted ductal papilloma and intraductal papilloma. Our findings justify the separation of these 3 entities based on clinical and histologic parameters. They are tumors of adulthood and, in addition, have in common their relationship to the excretory duct system, their anatomical distribution, and their general behavior. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:68-77)

Sialadenoma papilliferum of the hard palate: A case report and review of literature

Sialadenoma papilliferum of the hard palate: A case report and review of literature

Sialadenoma papilliferum: an immunohistochemical study of five cases.

Sialadenoma papilliferum (SP) is a rare, benign, salivary gland tumor which most commonly arises in the palate. It has a typical biphasic gross and microscopic appearance which distinguishes this tumor from other papillary-like tumors of the oral cavity. This study reports the clinico-pathologic features of 5 new cases and analyzes the morphologic and immunophenotypic features of their cell components. Adluminal epithelial cells of duct-like structures appeared immunoreactive to cytokeratin 19 and to S-100 protein antibodies; two subsets of basally-located cells were identified by means of immunohistochemistry. One cell subset expressed cytokeratin 14, S-100 protein, GFAP, vimentin and smooth muscle actin immunoreactivity; this antigenic profile is consistent with myoepithelial differentiation. The second subset of basal cells expressed cytokeratins 13 and 14 reactivity but it was negative to all other antibodies. Anti-CD 1a and anti-S-100 protein antibodies revealed distinct cells with dendritic processes which resembled Langerhans cells. The extralobular location of SP, the continuity between neoplastic duct-like structures and the surface epithelium along with the presence, within the excretory ducts adjacent to the tumour, of lesions which possibly precede the development of SP give further strength to the hypothesis of an origin from the excretory ducts of this tumor. Langerhans cells seem to be present in sialadenoma papilliferum but their role in this tumor is still unclear.

Recurrent sialadenoma papilliferum of the buccal mucosa

Sialadenoma papilliferum is a rare, benign, exophytic tumour of the salivary glands. The prognosis is exceptionally good. Since the lesion was first described, 30 cases have been reported in the English literature, and only one of these is known to have recurred. A case of sialadenoma papilliferum occurring in the buccal mucosa with recurrence three years after local excision, is presented. The literature is briefly discussed.

口底部に発生した乳頭状唾液腺腫の１例

We report a case of sialadenoma papilliferum of the oral floor. A 68-years-old woman visited our hospital in December 1993 complaining of a mass of the right side of the oral floor. A ball-like protrusion, measuring 6 × 6 × 5 mm, with sharp margins was found at the right side of the oral floor. The lesion was suspected to be a papilloma, and tumorectomy was performed under local anesthesia. Pathohistologic examination revealed a papillary sialadenoma, first reported by Abrams. The patient has done well since the operation. Tumors of the oral floor have not previously been reported in the literature.

The rare sialadenoma papilliferum: Report of a case and review of the literature

Sialadenoma papilliferum is a rare benign tumor of salivary gland origin. A case is described of a 46-year-old man with an exophytic lesion at the junction of the hard and soft palate. The literature is briefly discussed.

Sialadenoma Papilliferum

Sialadenoma papilliferum is a tumor of salivary tissues that has considerable histologic and biologic similarities to analogous tumors of the eccrine apparatus of the skin. Thus far found only at intraoral and parotid gland sites, sialadenoma papilliferum usually has the clinical course of a benign, locally significant lesion.

Coexpression of intermediate-sized filaments in sialadenoma papilliferum and other salivary gland neoplasms

The neoplastic cells present in a sialadenoma pappiliferum were found by immunoperoxidase method and immunofluorescent staining technique to co-express 3 different types of intermediate-sized filaments (IFs) defined by monoclonal antibodies to cytokeratin, vimentin and desmin. When other salivary gland tumors such as 18 pleomorphic adenomas, 15 adenolymphomas, 2 oxyphilic adenomas, 7 mucoepidermoid tumors, 5 acinic cell tumors, 8 adenoid cystic carcinomas and 6 adenocarcinomas were examined immunohistochemically for the expression of IFs, no tumors with all 3 types of IFs observed in sialadenoma papilliferum were found.

Sialadenoma papilliferum: Report of case and review of literature

Sialadenoma papilliferum: Report of case and review of literature

Sialadenoma papilliferum

Sialadenoma papilliferum is a rare benign papillary intraoral tumour most frequently affecting men over the age of 50. The tumour bears many similarities to adenolymphoma of the parotid and may be considered a variant of the latter. A case is presented and the literature is reviewed.

Sialocystadenoma papilliferum of the palate

The clinical and histological data concerning a case of sial -( ocyst )-adenoma papilliferum of the palate are presented. Ten cases of sialadenoma papilliferum have been reported to date. The lesion is characterized by several distinct clinical and histological features resembling in many aspects the syringocystadenoma papilliferum of the skin. Because of the invariable presence of more or less cystically dilated salivary gland ducts we propose to denote the lesion as sialocyst -adenoma papilliferum. Generally these neoplasms behave as benign tumours with an indolent and asymptomatic clinical course, although a single case of a malignant counterpart has been reported. An adequate local excision seems to be the treatment of choice. An accurate follow-up is required.

Intraoral papillary squamous cell tumor of the soft palate with features of sialadenoma papilliferum-? malignant sialadenoma papilliferum

An unusual, recurring, squamous papillary tumor involving and possibly arising from minor salivary gland excretory ducts in the palate is presented. Similarity to sialadenoma papilliferum and upper respiratory tract papillomatosis is noted. A paraglandular cystic mass with some resemblance to the palatal lesion, and a solitary lymph node with papillary squamous epithelial deposits was found in a radical neck dissection. We suggest that the lymph node lesion represents a metastasis which may have arisen from the palatal lesion, and therefore propose the concept of a possible malignant analogue of sialadenoma papilliferum.

Sialadenoma papilliferum of the oral cavity

Sialadenoma papilliferum is a rare tumor of salivary gland origin. A review of the English-language literature indicates that only four cases have been reported. This article describes the clinical and histologic characteristics of an additional case occurring on the left retromolar pad.

Sialadenoma papilliferum

Two previously unreported cases of sialadenoma papilliferum are presented. This brings the total number of reported cases of this entity to five. A review of the literature and a discussion of the histopathologic characteristics and possible histogenesis of the sialadenoma papilliferum are included.

Sialadenoma papilliferum of the oral cavity: Report of a case

Sialadenoma papilliferum is a rare, recently reported, salivary gland tumor with distinctive morphologic and clinical features. Morphologically, these lesions exhibit a prominent exophytic and papillary growth pattern and appear to arise from extralobular salivary gland ducts. Clinically, they are asymptomatic and slow growing and must be differentiated from other papillary lesions, including squamous-cell papilloma, verrucous carcinoma, and warty dyskeratoma.

Sialadenoma papilliferum. A previously unreported salivary gland tumor.

This report presents the clinical and morphological features of a previously unreported distinctive neoplasm of salivary gland origin. It appears to be quite similar morphologically to the syringadenoma papilliferum of sweat gland origin which tends to support the close relationship that exists between neoplasms of salivary and sweat gland origin. We propose the name sialadenoma papilliferum for this distinct tumor.