Shrinkage Of Bodies Research Articles

Shrinkage of ZrO2 green bodies manufactured by vat photopolymerization 3D printing

Shrinkage of ZrO2 green bodies manufactured by vat photopolymerization 3D printing

Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation

ΑbstractIn Parkinson’s disease (PD), Lewy pathology deposits in the cerebral cortex, but how the pathology disrupts cortical circuit integrity and function remains poorly understood. To begin to address this question, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. We reported that αSyn aggregates accumulate in the motor cortex in a layer- and cell-subtype-specific pattern. Specifically, αSyn aggregates-bearing intratelencephalic neurons (ITNs) showed hyperexcitability, increased input resistance, and decreased cell capacitance, which were associated with impaired HCN channel function. Morphologically, the αSyn aggregates-bearing ITNs showed shrinkage of cell bodies and loss of dendritic spines. Last, we showed that partial dopamine depletion is not sufficient to alter thalamocortical transmission to cortical pyramidal neurons. Our results provide a novel mechanistic understanding of cortical circuit dysfunction in PD.

Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation.

Dysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in Parkinson disease (PD). While cortical function is known to be suppressed by abnormal basal ganglia output following dopaminergic degeneration, it remains to be determined how the deposition of Lewy pathology disrupts cortical circuit integrity and function. Moreover, it is also unknown whether cortical Lewy pathology and midbrain dopaminergic degeneration interact to disrupt cortical function in late-stage. To begin to address these questions, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. Using this model system, we reported that αSyn aggregates accumulate in the motor cortex in a layer- and cell-subtype-specific pattern. Particularly, intratelencephalic neurons (ITNs) showed earlier accumulation and greater extent of αSyn aggregates relative to corticospinal neurons (CSNs). Moreover, we demonstrated that the intrinsic excitability and inputs resistance of αSyn aggregates-bearing ITNs in the secondary motor cortex (M2) are increased, along with a noticeable shrinkage of cell bodies and loss of dendritic spines. Last, neither the intrinsic excitability of CSNs nor their thalamocortical input was altered by a partial striatal dopamine depletion associated with αSyn pathology. Our results documented motor cortical neuronal hyperexcitability associated with αSyn aggregation and provided a novel mechanistic understanding of cortical circuit dysfunction in PD.

Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation.

Dysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in Parkinson disease (PD). While cortical function is known to be suppressed by abnormal basal ganglia output following dopaminergic degeneration, it remains to be determined how the deposition of Lewy pathology disrupts cortical circuit integrity and function. Moreover, it is also unknown whether cortical Lewy pathology and midbrain dopaminergic degeneration interact to disrupt cortical function in late-stage. To begin to address these questions, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. Using this model system, we reported that αSyn aggregates accumulate in the motor cortex in a layer- and cell-subtype-specific pattern. Particularly, intratelencephalic neurons (ITNs) showed earlier accumulation and greater extent of αSyn aggregates relative to corticospinal neurons (CSNs). Moreover, we demonstrated that the intrinsic excitability and inputs resistance of αSyn aggregates-bearing ITNs in the secondary motor cortex (M2) are increased, along with a noticeable shrinkage of cell bodies and loss of dendritic spines. Last, neither the intrinsic excitability of CSNs nor their thalamocortical input was altered by a partial striatal dopamine depletion associated with αSyn pathology. Our results documented motor cortical neuronal hyperexcitability associated with αSyn aggregation and provided a novel mechanistic understanding of cortical circuit dysfunction in PD.

Rebound of surface and terrestrial water resources in Mongolian plateau following sustained depletion

Rebound of surface and terrestrial water resources in Mongolian plateau following sustained depletion

Dust in Western Iran: the emergence of new sources in response to shrinking water bodies

We detected sources of dust in the Middle East that contribute to dust events in Western Iran in different seasons. By the analysis of the synoptic data, we identified 309 dusty days in Western Iran during the period 2000–2016. A dusty day is diagnosed if under low horizontal visibility (< 1 km), the dust in suspension is reported at least once a day in at least three synoptic stations. We identified dust sources in the Middle East based on the analysis of the MOD04L2 data from MODIS, the backward HYSPLIT trajectory model, and synoptic conditions. The most influential sources affecting Western Iran are located on the shore and northwest of Lake Tharthar, Hour-al-Azim Marsh, the shore of Razzaza, Habbaniyah Lakes, and West Hammar Marsh, which contributed to 110, 79, 59, 56, and 51 dusty days, respectively. The fluctuation of the surface water area largely contributes to the variability of dusty days in Western Iran. Indeed, the peak dust activity in Western Iran was during the period 2008–2012 in response to the substantial shrinkage of the main water bodies in Iraq. The main sources of dust influencing Western Iran are located in northern and eastern Saudi Arabia in spring, Deir ez-Zur in Syria’s Aleppo and Raqqa in summer, and Syria’s Homs and Al-Hasakah in winter and spring. Sources of dust in Western Iraq and in most parts of entire Iraq have, respectively, led to the formation of summer and spring dust events in Western Iran. Decreased precipitation in the Middle East from autumn 2007 to 2012 and the occurrence of severe droughts have also contributed to the shrinkage of lakes and wetlands, as well as the reduced agricultural productivity in the Middle East, all of which contributed to the intensification of dust activity in Western Iran in recent decades.

Investigation of the effects of red clay on the structural properties of chamotted clay bodies

Chamotte means fired clay. It is also called Grog and it can have many particle sizes, from fine to coarse. The composition formed by the addition of chamotte to various clay compositions is called chamotte mud (CM). The most preferred and widely used muds in the production of artistic ceramic products are chamotte mud and red pottery mud (R-PM). The sintering, linear shrinkage, water absorption, and color properties of these muds vary depending on their components and firing temperatures. Chamotte mud has properties that make it suitable for use at high temperatures (1150-1200 oC). The obtained products, however, have a high-water absorption value, because it deforms in high-temperature firings, the red Kınık pottery mud used in the study is typically used for artistic productions at low temperatures such as 900-1000 oC. Ceramic artists may prefer to combine and use both types of mud to enhance the color effects and shaping properties in their works. &#x0D; The aim of this study is to reduce water absorption of the body while increasing firing shrinkage, in other words, increasing shrinkage during sintering by adding red pottery mud to chamotte mud and also to optimize the tendency of the R-PM to undergo deformation with temperature. As a result, the products obtained, particularly those produced for artistic outdoor use, will have a longer lifetime. In experimental studies, 6 recipes were produced by combining chamotte and red mud in specific ratios, and the changes in properties such as water absorption, linear shrinkage, color, gloss, microstructure, and sintering behavior of ceramic bodies as a result of firing at 1160 oC were investigated.

Geomechanical substantiation of the parameters for the mining system with ore shrinkage in the combined mining of steep-dipping ore bodies

Purpose. The research purpose is to substantiate a rational technology for mining steep-dipping ore bodies based on a complex of geomechanical studies in combined mining of deposits. Methods. Analysis of existing constructive methods for calculating the optimal mining system parameters when mining under-open-pit ore reserves in the zone of influence of surface mining operations, taking into account the natural stress-strain state of the rock mass. Numerical modeling is used to study the geomechanical processes occurring in the mass during the mining of under-open-pit reserves of steep-dipping ore bodies in order to substantiate the mining system with ore shrinkage. The geotechnical mapping of mine workings is conducted directly in the face to determine the mass rating. Findings. The calculation of the optimal parameters for the stope chamber, inter-chamber and inter-level pillars based on a complex of geomechanical studies has shown that the more intense horizontal stresses act in the bottom of the blocks and in the inter-block pillars, in which a large number of board gates have been driven. Originality. For the first time, using high-precision programs and given the nonuniform distribution of horizontal and vertical stresses acting in the mass for the Abyz Mine conditions, it has been revealed that when mining an individual block, the maximum horizontal stresses around the mined-out space reach 10-15 MPa; when mining a group of blocks – 20-25 MPa. Practical implications. The research results can be used in planning and mining with shrinkage of steep-dipping ore bodies during mining of under-open-pit reserves.

Preparation of porous Y2SiO5 ceramics with high porosity and extremely low thermal conductivity for radome applications

It is well known that aqueous gel-casting is challenging to prepare high-porosity ceramics due to the considerable drying shrinkage, cracking, and deformation of green bodies during drying caused by the high surface tension of water. Porous Y 2 SiO 5 ceramics with high porosity were prepared by introducing carbon fibers as a support material in the drying process of aqueous gel-casting to reduce shrinkage during drying. Burning out the carbon fibers after drying does not negatively affect the properties of the porous ceramic. As prepared green bodies by aqueous gel-casting have low shrinkages of 8.69%–6.81% during drying processes and high compressive strength of 13.73 ± 1.55–10.66∼0.49 MPa. The higher compressive strength of the green body has a positive significance for processing porous ceramics into special-shaped structures. As prepared porous Y 2 SiO 5 ceramics have high porosity of 73.94%–87.71%, lightweights of 1.16–0.55 g•cm 3 , extremely low thermal conductivities of 0.134 ± 0.006 to 0.051 ± 0.001 W•m −1 •k −1 , relatively low dielectric constants of 2.34–1.58, and tan δ are lower than 1.25 × 10 −3 . Porous Y 2 SiO 5 ceramics with excellent dielectric properties and thermal insulation properties meet the requirements of thermal insulation and wave transmission integration of radome materials. Aqueous gel-casting also enriches the preparation methods of high-porosity Y 2 SiO 5 ceramics.

A Novel Preparation of Special-Shaped Phosphors-in-Glass by Gel Casting with Isobam for High-Power WLEDs Lighting.

Phosphors-in-glass (PiGs) regarded as a promising phosphor-converter for white light emitting diodes (WLEDs) is being researched widely. However, there are few reports on the effect of changing the shape of PiGs on the color rendering index (CRI) and heat dissipation of WLEDs. In this paper, gel casting with Isobam was first attempted in preparing special-shaped PiGs successfully. It exhibited that 76 wt.% was the optimum solid content based on the rheological properties of slurry and the shrinkage of green bodies. The sintering rate should be kept at a low speed and glass transition temperature (Tg) of glass powders must be higher than sublimation temperatures (Ts) of APS and Isobam. The CRI of PiGs was increased by about 27% after changing the shape of PiGs from cylinder to dome. Most importantly, operating temperature also reduced effectively the increase of the surface area of PiGs. Therefore, changing the shape of PiGs by gel casting with Isobam is a creative way for high-power WLEDs lighting.

Climate Change Vulnerability Assessment: An Evaluation of Social Dimension

Climate change vulnerability is the function of exposure, sensitivity, and adaptive capacity of its natural and socioeconomic systems. Following spatial “scale” of the assessment, administrative-territorial units were selected for this study. A field survey questionnaire was used to collect data for the study based on the sample size of 500 questionnaires that was administered to household heads in the study area. In the questionnaire, questions were designed to give respondents the opportunity to choose from several alternatives given in the instrument while descriptive statistics was for the analysis of data. Descriptive statistics analysis based on mean ranking was carried out to identify the level of peoples’ vulnerability to climate change in the study area. The exposure assessment was based on the response analysis of baseline information. The sensitivity assessment for the study was analyzed by using physiographical and socioeconomic characteristics, described by a set of specific indicators and responses of the residents. The adaptive capacity was captured by general economic and agricultural indicators, taking into consideration the major occupation the predominant lifestyle of the residents. Through a ranking approach, the relative vulnerability of each ATU was calculated by summing its sensitivity and adaptive capacity ranks; the latter were obtained as combinations of their primary indicator ranks, arranged in an increasing and decreasing order, respectively. The major climate change exposure pathway in the study area were reduction in green environment, decrease in total annual rainfall, warmer weather, early cessation of rainfall, late on-set of rainfall and shrinkage of water bodies. The major sensitivity to climate change was decrease in crop yield, whereas increase in cost of food crops, drought incidents, famine, poverty, indiscriminate falling down of trees and disaster. It was also established that the major adaptive strategies to climate change in the study area were irrigation farming, use of organic manure, planting of drought tolerant varieties and early planting.

Highly porous LAS-SiC ceramic with near-zero thermal expansion prepared via aqueous gel-casting combined with adding pore-forming agents

The main problem during preparing high porosity ceramics via aqueous gel-casting is the large drying shrinkage of green bodies. In this work, carbon fibers with high aspect ratio were introduced into aqueous gel-casting processes, which significantly inhibited the drying shrinkage of green bodies by overlapping fibers. At the same time, exhaustible carbon fibers sintered in air also act as sacrificial templates to further improve the porosity. Through the above method, porous LAS/SiC ceramics with high porosity and near-zero expansion were prepared. Drying shrinkage of the green bodies was reduced from 25.2% to 5.7% with the increase of fibers. The porosity of the obtained LAS/SiC ceramic is as high as 76.2%. When the fibers content is 20 vol% and LAS to SiC volume ratio is 6: 4, the composite has maximum value of compression and bending strength (18.2 and 14.0 MPa) and near-zero CTE (0.9 × 10−6 /K).

Deep learning techniques for observing the impact of the global warming from satellite images of water-bodies.

Global warming is a threat to modern human civilization. There are different reasons for speed up the global average temperature. The consequences are catastrophic for human existence. Seafloor rise, drought, flood, wildfire, dry riverbed are some of the consequences. This paper analyzes the changes in boundaries of different water bodies such as fresh-water lakes and glacial lakes. Over time, the area covered by a water body has been varied due to human interventions or natural causes. Here, variants of Detectron2 instance segmentation architectures have been employed to detect a water-body and compute the changes in its area from the time-lapsed images captured over 32 years, that is, 1984 to 2016. The models are validated using water-bodies images taken by the Sentinel-2 Satellite and compared based on the average precision (AP), 99.95 and 94.51 at AP_{50} and AP_{75} metrics, respectively. In addition, an ensemble approach has also been introduced for the efficient identification of shrinkage or expansion of water bodies.

Magma Chamber Formation by Dike Accretion and Crustal Melting: 2D Thermo‐Compositional Model With Emphasis on Eruptions and Implication for Zircon Records

AbstractWe present a 2D thermo‐elastic model of a magma body formation in a granitic crust by injection of rhyolitic or basaltic dikes and sills. Elastic analytical solutions enable the computation of rock displacement in response to magma intrusion and evacuation during volcanic eruptions. Phase diagrams for magma and rocks govern melting/crystallization behavior and temperature evolution in 16 million computational cells. Calculated temperature histories are used to predict zircon crystallization/dissolution, their ages, and isotopic ratios within individual batches of magma and rocks. Incremental dike injection naturally generates magma batches of melt that form kilometer‐wide clusters appearing in different parts of the domain with diverse shapes, horizontal and vertical interconnectivity. The volume of eruptive melt strongly depends on magma influx rates Q, the width of the injection region W, and eruptions. For example, rhyolitic dike injection with Q = 0.125 m3/s with W = 5 km during 100 ka generates ∼50 km3 of eruptive melt while no significant melt forms if W = 10 km. Injection of basaltic dikes into the granitic crust generates comparable amounts of rhyolitic melt from dike‐residual and country rocks. High injection intensities produce magma reservoirs capable of large eruptions, while repetitive eruptions lead to shrinkage of magma bodies. High heat input causes host rock zircons to lose a significant portion of their old cores. Magmatic zircons in the periphery form quickly due to rapid cooling of intruded dikes while in the central part crystals can grow during several hundreds of ka. The model predicts highly heterogeneous O and Hf isotopic ratios recorded in zircons.

Induction of apoptosis in A431 cells via ROS generation and p53-mediated pathway by chloroform fraction of Argemone mexicana (Pepaveraceae).

Argemone mexicana(Pepaveraceae) is an important medicinal plant commonly known as 'maxican prickly poppy' and is traditionally used to treat skin diseases. In the present study, the extract/fractions of aerial parts of A. mexicana after carrying out the organoleptic characteristics were sequentially extracted with the solvents of increasing polarities. Total fractions were examined for their radical scavenging activities in DPPH and DNA nicking assays. Among all, maximum antioxidant activity was shown by chloroform fraction (AmC) in DPPH assay with IC50 of 26.12 μg/ml, and DNA nicking assay showed 80.91% protective potential. The AmC fraction was analyzed for its antibacterial, cytotoxic potential, cell cycle analysis, mitochondrial membrane potential (MMP) and accumulation of reactive oxygen species (ROS) using A431 cell line. The AmC fraction exhibited remarkable antibacterial activity against bacterial strains in the order Klebsiella pneumoniae> Bacillussubtilis> Salmonella typhi> Staphylococcus epidermidis. The cytotoxic potential of the AmC fraction was analyzed in skin epidermoid carcinoma (A431) cells, osteosarcoma (MG-63) and cervical (HeLa) cell lines with a GI50 value of 47.04 μg/ml, 91.46 μg/ml and 102.90 μg/ml, respectively. The AmC fraction was extended further to explore its role in cell death using A431 cell line. Phase contrast and scanning electron microscopic studies on A431 cells exhibited all the characteristics indicative of apoptosis, viz., viability loss, cell shrinkage, cell rounding-off, DNA fragmentation and formation of apoptotic bodies. Flow cytometric analysis revealed enhanced ROS level, decreased MMP and arrest cell cycle at the G0/G1 phase further strengthened cell death by apoptosis. Increased expressions of apoptotic markers (p53, PUMA, cyt c, Fas and Apaf-1) were confirmed by RT-qPCR analysis. Furthermore, the AmC fraction was subjected to ultra-high-performance liquid chromatography, which revealed the presence of different polyphenols in the order: caffeic acid> epicatechin> kaempferol> chlorogenic acid> gallic acid> catechin> ellagic acid >umbeliferone> quercetin> coumaric acid. A critical analysis of results revealed that the AmC fraction induced cell death in epidermoid carcinoma cells via ROS and p53-mediated apoptotic pathway which may be ascribed to the presence of polyphenols in it.

Fabrication and properties of alumina ceramics shaped by digital light processing as an additive manufacturing technology

AbstractCeramic slurries with different contents of Al2O3 were formulated and alumina ceramic parts with promising surface morphology were fabricated by using digital light processing photopolymerization‐based additive manufacturing technology. The factors influencing curing depth of the slurries were studied, while the effects of powder content on shrinkage of the green bodies and microstructure, density, and hardness of the sintered bodies were evaluated. Although the curing depth was decreased with increasing content of Al2O3, all the five groups of slurries could be well cured, as the exposure time was set to be 16 s. According to TG‐DTG curves, the weight loss of the samples was completed at about 580°C. Samples from the slurries with 70 and 75 wt.% Al2O3 had dense microstructure, without obvious cracks at both the macro‐ and micro‐scales. Furthermore, with increasing content of Al2O3 in slurries, the bulk density and hardness of sintered bodies were increased. It is believed that our results could be used as a reference for the fabrication of alumina ceramics through additive manufacturing technology.

Fish Singgang Extracts as a Potential Anti-Proliferative against Colon Cancer Cell Lines (HT-29, HCT-116, CT-26)

Aim: To investigate anti-proliferative effect of three types of Terengganu singgang extracts on colon cancer cell lines (HT-29, HCT-116, CT-26).&#x0D; Study Design: Experimental study.&#x0D; Place and Duration of Study: Central Laboratory, Tissue Culture Laboratory, Universiti Sultan Zainal Abidin, Terengganu between April 2019 and July 2019.&#x0D; Methodology: Samples comprised three types of singgang dish, which were prepared, cooked, and then extracted with distilled water and ethanol (EtOH) in different strengths, 50%, 70%, and 100%.These singgang samples were chub mackerel (ST), Indian mackerel (SK),and a control sample with no fish (SC). Extracts were analyzed for their anti-proliferative effect by MTT-based assay. Then, the morphological of cell apoptotic changes was observed using light inverted microscope.&#x0D; Results: Experimental assays showed that the SC sample extracted in 100% EtOH produced the highest yield (3.7%).The extract of ST in aqueous (0.27 (0.11)) yielded the most cytotoxic value, followed by extract SK in 100% EtOH (0.28 (0.10)) and extract SC in 50% EtOH (0.20 (0.08)). Then, the anti-proliferative effect was confirmed with morphological changes of cell which were characterized by cell shrinkage, membrane blebbing, and fragmentation of apoptotic bodies after 24, 48 and 72 hours of treatment.&#x0D; Conclusion: In conclusion, the ST extract showed the best anti-proliferative effect.

Bioefficacy of Lemongrass and Tea Tree Essential Oils Against House Fly, Musca domestica.

The management of house fly, Musca domestica has become immensely important to prevent epidemics of many detrimental diseases. In view of this objective, the present study demonstrates the efficacy of lemongrass (LG) and tea tree essential oils (TTEOs) against M. domestica. The TTEO proved to be more lethal against larvae and adults of M. domestica depicting an LC50 at 14.88 mg/ dm3 which was 17.19 mg/ dm3 for LGEO. In contrast, pupicidal effect of LGEO was much higher (LD50, 14.49 µl/0.25L) as compared to TTEO. The LGEO drastically reduced the total body sugar, glycogen and protein contents by 3.29, 2.95 and 7.56 fold, respectively, contrasting with high influence of TTEO on lipid content of the late 3rd instar larvae. A considerable reduction in gut enzymes secretion was observed due to treatment of EOs thereby altering gut physiology of the insect. Moreover, significant inhibition of acetylcholine esterase (AchE) was also observed with LGEO at LC50 concentration (5.33 mg/ml) inhibiting insect neurotransmission. The gas chromatography-mass spectrometric (GC-MS) analysis of the LGEO showed 12 major compounds dominated by Citral whereas TTEO contained only 5 major compounds. Further analysis by field emission scanning electron microscopy (FESEM) revealed distortion and shrinkage of larval bodies caused by the treatment of EOs. These overall observations brand LG and TT-EOs as potential organic-insecticides against M. domestica.Graphic Supplementary InformationThe online version of this article (10.1007/s40011-020-01220-z) contains supplementary material, which is available to authorized users.

Fish fauna of Uttarakhand, India: Present status, Diversity and Conservation

Extensive Ichthyofaunal survey of various water resources of Uttarkhand was carried out for the period of more than 15 years (2004-2019). The main objective of this paper is to know the district wise status, distribution and to recommend the strategy for the conservation and management of fishes of the state, so that clear-cut idea could be drawn, for further research and policy planning. In the present paper a total of 132 species of fish belonging to 67 genera, 27 families and 8 orders have been reported. The district wise distribution of fish represented a maximum of 101 species from Nainital, followed by 81 species from Dehradun, 75 species from Haridwar, 73 species from Udham Singh Nagar, 59 species from Pauri Garhwal, 37 species from Rudrapryag, 36 species from Almora, 35 species from Chamoli, 34 species from Bageshwar, while 32 species from Pithoragarh and Champawat and 29 species each from Uttarkashi and Tehri Garhwal. Besides these 10 species (7.5%) are in the category of Endangered, while 10 species (7.5%) are exotic in nature and 11 species (8.3%) are endemic to the Uttarakhand state. On the basis of fish catch the dominant species in upper region (hill area) are Schizothoracine species (which forms appox. 60% of fish catch) and in the plains dominant species are Barilius species (which forms 40% of fish catch) etc. Besides this after the careful observation and constant monitoring, some major factors responsible for the depletion of fish resources were listed out which include over exploitation of fish resources, lack of fish policy/laws, deforestation, destruction of spawning ground, shrinkage of water bodies, pollution/weed infestation in water bodies, introduction of exotic fish, construction of dams (which effect fish migration) and lack of awareness among masses. Moreover, the conservation and management strategy for fish has also been discussed in detail.

Monitoring Spatiotemporal Evolution of Urban Heat Island Effect and Its Dynamic Response to Land Use/Land Cover Transition in 1987–2016 in Wuhan, China

Monitoring the relationship between the urban heat island (UHI) effect and land use/land cover (LULC) is of great significance in land use planning to adapt to climate change. However, the dynamic response of the UHI effect to LULC change over space and time has not been deeply studied. In this study, a transfer matrix method was carried out to monitor the class-to-class transitions between different LULC types, as well as those between different NLST (normalized land surface temperature) levels over space and time. The spatiotemporal correlation and dynamic coupling between UHI variation and LULC change from 1987 to 2016 were simulated based on multi-temporal remote sensing data in Wuhan, China. The results showed that high temperature (level V) and sub-high temperature (level IV) were mainly concentrated in construction land, while the majority of low temperature (level I) was distributed in water bodies. During the study period, the most notable changes were the rapid increase in construction land, as well as the continuous shrinkage of farmland and water bodies. The inward transfer of construction land was mainly from farmland and water bodies, with the transferred area of 218.3 km2 (69.2%) and 78.9 km2 (25.0%). These transitions were mainly responsible for the thermal deterioration in the study area. The transition of farmland to construction land contributed the most (66.3% and 81.6%) to thermal deterioration in the original medium temperature area (level III). The transition of water bodies to construction land was the main driving force in rapidly upgrading NLST level I into level IV (55.8%) and level V (58.6%). These findings provided detailed information for decision support in optimizing land use structure to fight against the thermal deterioration caused by urbanization.