In this study, 4 classification algorithms were employed to characterize the influence of road determinants on roadway crash severity with actual crash data. The crash data were obtained from crash records in Texas, USA, from January 2020 to April 2021. The prediction model of crash severity utilized 12 road-related features—including shoulder types, shoulder width, and curb types—as well as 10 other features—such as weather and illumination conditions—as input features. Three crash severity levels—“Minor Damage,” “Moderate Damage,” and “Severe Damage”—were used as output features. Decision tree, support vector machines, and multi-layer perceptron were employed to compare their prediction performance with the XGBoost model. The results show that the XGBoost model yields the best performance among the 4 algorithms. The overall accuracy, average precision, average recall, and average F1 score of the XGBoost model were 82.65%, 0.83, 0.82, and 0.82, respectively. Besides, SHapley Additive exPlanations (SHAP) and partial dependence plots were used to interpret the model results. Among the road-related features, the most influential one is the median width. Greater crash severity is related to paved right shoulder and curb. These findings are helpful for the design and planning of road safety.