Personal Exposure to Fine Particulate Matter and C- Reactive Protein among Patients with PeriodontosisAbstract Number:1543 Kai-Jen Chuang*, Tsung-Han Yang, Shin-ichi Masumi Kai-Jen Chuang* Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, Taiwan, E-mail Address: [email protected] Search for more papers by this author , Tsung-Han Yang Division of Occlusion & Maxillofacial Reconstruction, Kyushu Dental University., Japan Search for more papers by this author , and Shin-ichi Masumi Division of Occlusion & Maxillofacial Reconstruction, Kyushu Dental University, Japan Search for more papers by this author AbstractThe association between particulate matter (PM) and cardiovascular effects among patients with cardiopulmonary diseases has been well-documented in previous studies. It is still unknown whether patients with periodontosis are vulnerable to short-term PM exposure. We conducted a cross-sectional study on two panels of adult subjects, 30 adult patients with periodontosis and 30 healthy adults, in order to evaluate whether fine particulate matter (PM2.5) was associated with high-sensitivity C-reactive protein (hs-CRP) among patients with periodontal disease. We repeated collected each subjects’ blood samples, measured hs-CRP and monitored 12-hour average (0800-2000 hours) personal PM2.5 exposure four times during 2012. We used mixed-effects models to estimate the association between PM2.5 and hs-CRP, adjusted for cardiovascular risk factors. We found a 10 µg/m3 increase in PM2.5 was associated with 3.42% (95%CI: 1.5, 3.3; p<0.001) increase in hs-CRP for the overall effect of personal PM2.5 exposure. The effects were greater among adult patients with periodontosis. For healthy adult panel, a 10 µg/m3 increase in PM2.5 was associated 1.24% (95%CI: 0.21, 2.27; p<0.001) increase in hs-CRP. For adult patient panel, a 10 µg/m3 increase in PM2.5 was associated 8.42% (95%CI: 6.31, 10.53; p<0.001) increase in hs-CRP. In conclusion, personal exposure to PM2.5 was associated with increase in hs-CRP among adult subjects. Such association could be modified by periodontal diseases.