Due to impaired cardiac autonomic function (CAF), kidney and kidney-pancreas transplant recipients are at increased risk for sudden cardiac death. Exercise has been identified as means of improving CAF. This study evaluated the effect of a short term (4 month) exercise intervention on long-term cardiac autonomic function using 24-hour heart rate variability indices (HRV) in 14 kidney and kidney pancreas transplant recipients. At 2 months post-transplant, recipients began a 4-month exercise program prescribed at 95 percent of VANT and then either engaged in a 6-month home walking program (Ex; n = 9) or ceased exercising (QuitEx, n = 5). 24-hour measures of HRV reflecting parasympathetic (HF) and sympathetic (SDANN) modulation and circadian fluctuation (SDNN) were obtained at 2, 6 and 12 month post-transplant. Groups were similar in age, gender, race, and transplant type. Data were analyzed using repeated-measures ANOVA. The exercise intervention resulted in improved CAF which was sustained in those who quit exercising, while those who continued exercising exhibited further gains in sympathetic modulation of heart rate and circadian fluctuation with values approaching those seen in healthy controls. *p < 0.5 Within group from 2 month time point; pˆ < 0.5 Within group from 6 month time point.Table
Read full abstract