Short-term Assessment Research Articles

Assessing change in risk and protective factors: A case study and examination of the Violence Risk Scale-Youth Version, Short Term Assessment of Risk and Treatability: Adolescent Version, and a structured professional judgment approach to rating and formulating change.

Assessing change in risk and protective factors: A case study and examination of the Violence Risk Scale-Youth Version, Short Term Assessment of Risk and Treatability: Adolescent Version, and a structured professional judgment approach to rating and formulating change.

Short-term pitch memory predicts both incidentally and intentionally acquired absolute pitch categories.

Tonal short-term memory has been positively associated with both incidentally acquired absolute pitch memory (e.g., for popular songs) and explicitly learned absolute pitch (AP) categories; however, the relationship between these constructs has not been directly tested within the same individuals. The current study investigated how tonal short-term memory relates to both incidentally and intentionally acquired AP. Participants (n = 192) completed a tonal short-term memory task, an incidental AP task, and an AP categorization task. The tonal short-term assessment involved adjusting a starting tone to match a target tone. The incidental AP task involved judging whether excerpts of popular songs were presented in the correct key. The AP categorization task involved associating six pitch chroma categories with arbitrary labels, including a generalization test that used Shepard tones to discourage pitch height cues. We found that all three pitch measures were positively correlated with one another. Critically, however, we found that tonal short-termmemoryfully mediated the relationship between incidental AP and explicit AP categorization. This finding held even when controlling for musical training and tonal language fluency. Overall, these results suggest that pitch memory is a consistent individual difference measure across different timescales and different measures (e.g., incidental measures, explicit measures). However, tonal short-term memory appears to be foundational to both incidentally acquired and explicitly learned AP categories.

P0230 Prognostic factors and predictive model development for pediatric Inflammatory Bowel Disease with IL-10RA deficiency: A retrospective cohort study

Abstract Background Patients with IL10RA-deficient inflammatory bowel disease (IBD) generally have a poor prognosis, with high mortality and a significant rate of intestinal surgeries. Hematopoietic stem cell transplantation (HSCT) is currently the main cure, but most patients still face death after transplantation. The study analyzes the prognosis of patients without HSCT, aiming to explore factors associated with both mortality and the need for intestinal surgery, as well as to establish short-term prognostic models. Methods The study retrospectively enrolled 138 patients admitted to our center from January 2012 to July 2024. We defined death and intestinal surgery as outcomes and used competing risks analysis, cox regression models, and random survival forest algorithm to explore prognostic factors. Additionally, optimal subset regression, and logistic regression were employed to establish a short-term prognostic model, with the goal of better assessing the severity of the patients' conditions and evaluating the likelihood of long-term survival, as well as the risks of short-term death or surgery. Results The median age of onset of 138 patients was 0.3 months (range: 0.2-1 months), and the median age of admission was 8.1 months (range: 3.0-15.2 months). 21.7% had pure homozygous mutations. The most frequent was c.301C>T，c.537G>A. 32.6% of patients died, of which 73.3% were transplant-related. 35.5% of patients had undergone intestinal surgery. In patients without HSCT, most deaths occurred within the first year, while intestinal surgeries were mainly performed by age four. Cox multivariate analysis identified thalidomide used as an independent protective factor against mortality (HR = 0.09, 95% CI: 0.02-0.46, P = 0.004). Intestinal perforation was a significant risk factor (HR = 9.39, 95% CI: 3.49-25.30, P < 0.001) for the outcome of intestinal surgery. The random survival forest model highlighted thalidomide, mesalazine, intestinal perforation and gross bloody stool as key variables affecting mortality or surgery risk, with thalidomide having the greatest impact. Short-term death model (age of admission, ALB, intestinal perforation) was well distinguished (AUC: 0.945), but poorly calibrated; Short-term surgical models (CRP, PLT, perianal lesions) were moderately distinguished (AUC: 0.799), and the calibration was reasonable. Conclusion Long-term survival is possible for IL10RA-deficient patients without HSCT. However, due to the risk of early-life adverse outcomes, close follow-up remains essential. Thalidomide appears to have the most significant impact on prognosis and may improve disease outcomes. The short-term prognostic assessment model demonstrates good discriminatory ability for distinguishing high-risk from low-risk patients.

A New Short-Term Assessment Condition for Evaluating Nonfunctional Electromyographic Activity of Masseter Muscle During Wakefulness.

Awake bruxism involves masticatory muscle activity during wakefulness, potentially leading to clinical concerns. Accurate electromyography (EMG) assessment is challenging with brief durations. To establish a reliable, short-term measure for nonfunctional masseter muscle activity during wakefulness. Thirty-four healthy participants completed the Oral Behavior Checklist (OBC) and were assessed with an EMG logger (FLA-500-SD) across three sessions. On Day 1, participants performed four tasks (reading, bead-grabbing, video watching and math) for 15 min each in random order. On Day 2, scheduled at least 1 week later, tasks were repeated in a different sequence. On Day 3, participants underwent a 7-h continuous EMG recording during daily activities while maintaining activity diaries. Main outcomes included the mean number of EMG bursts per hour, burst duration, burst peak value relative to maximum voluntary contraction (%MVC) and integral value (μV.s, %MVC.s). Participants (mean age: 28.0 ± 3.1) scored low on AB likelihood per partial OBC results, contrasting with EMG activity levels. Significant differences in EMG parameters were noted across tasks, with consistent values between Days 1 and 2. The reading, video, and math tasks showed strongest correlations with long-term EMG measurements (rs = 0.62-0.66, p < 0.001). Reading task demonstrated high test-retest reliability (ICC > 0.9), with the highest specificity (100%) and positive predictive value, though sensitivity was limited compared with long-term AB measures. EMG measurements during a 15-min reading task may correspond to prolonged monitoring, suggesting the potential for short-task EMG assessments in practice. Integrating such assessments might enhance diagnostic accuracy, although judgement remains essential.

Intra-day, short- and long-term reliability of surface electromyographic measurements during a standardized measurement protocol for lower back pain patients

Background The identification of back muscle dysfunction is a prerequisite for successful rehabilitation. Therefore, surface electromyography can be used for diagnostic and evaluative purposes. However, data quality highly depends on a) variance and inaccuracies in methodological procedures and b) on time-dependent changes, particularly in complex conditions such as chronic low back pain. Objective To assess intra-day, short-term and long-term reliability of a protocol designed for electromyographic measurements of the paraspinal muscles. Methods Three everyday tasks were selected for measurement in two healthy populations (mean age (years): 26.25/30.49 (SD: 7.05/11.03), sex-balanced). The procedure follows a detailed protocol (e.g., including ultrasound, electrode placement, movement commands). Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and minimum detectable change (MDC) were calculated. Results Prone extension task demonstrated excellent test-retest agreement in all timespans (ICC = 0.92–0.96, SEM = 6.08–8.11, MDC = 16.85–22.49). Forward bending reliability ranged from moderate in long-term (ICC = 0.68–0.71, SEM = 1.98–2.52, MDC = 5.48–6.99) to good in intra-day (ICC = 0.76–0.89, SEM = 1.73–2.15, MDC = 4.79–5.95) to excellent in short-term assessment (ICC = 0.97, SEM = 1.07–1.21, MDC = 2.96–3.34). Sitting task showed the lowest test-retest agreement ranging between good to moderate in intra-day (ICC = 0.60–0.77, SEM = 1.22–1.26, MDC = 1.61–3.48)) and short-term reliability (ICC = 0.50–0.75, SEM = 1.24–2.06, MDC = 0.62–4.04) and moderate in long-term reliability (ICC = 0.65–0.71, SEM = 1.43–1.85, MDC = 3.95–5.12). Conclusion Using standardized procedures, surface electromyography can provide reliable data for practitioners in low back pain rehabilitation. Timespan had a limited influence on reliability compared to the type of task performed.

Optimization of Weibull Distribution Parameters with Application to Short-Term Risk Assessment and Strategic Investment Decision-Making&amp;nbsp;

Optimization of Weibull Distribution Parameters with Application to Short-Term Risk Assessment and Strategic Investment Decision-Making&amp;nbsp;

Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome.

This study explored the early diagnosis and prognostic value of copeptin in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). 171 patients with chest pain or myocardial ischemia symptoms were enrolled. Patients with NSTE-ACS were further divided into the non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA). All NSTE-ACS patients were followed up to record the occurrence of Major Adverse Cardiovascular Events (MACEs). Serum copeptin concentration in the NSTE-ACS group was significantly higher than that in the control group. The Area under the curve (AUC) value of copeptin in the diagnosis of NSTE-ACS was 0.798. The combined AUC value of copeptin and hypersensitive troponin I (hs-TnI) to NSTE-ACS increased to 0.930. In addition, copeptin and hs-TnI have been proven to be independent risk factors for MACEs in patients with NSTE-ACS. The use of copeptin in combination with conventional myocardial markers contributes to the early diagnosis and short-term prognosis assessment of NSTE-ACS.

“Fall guys”: влияние видеоигры на конвергентные и дивергентные способности

&lt;p&gt;The study aims to estimate the impact of the video game "Fall Guys" on the convergent and divergent cognitive processes of players with different levels of gaming experience. Convergent processes assessed included short-term memory, selective attention, and mental inhibition. The indicator of divergent processes was verbal fluency. Among 203 surveyed students from the first year of psychology faculties, 147 later participated in the experimental study where 74 participants completed cognitive tests before and after playing the video game, while 73 participants completed tests before and after reading popular science texts printed on a paper blank. The gaming condition involved the popular arcade game "Fall Guys." The battery of cognitive tests included a short-term memory assessment, the Eriksen Flanker Task, the SART task, a short version of J. Raven's Advanced Progressive Matrices, the Guilford Unusual Uses Test, and the Deary-Liewald Task. A total of four sessions were completed based on the number of cognitive indicators. Participants with regular gaming experience showed higher scores in fluid intelligence, reaction speed, verbal fluency, and abilities related to selective attention and mental inhibition compared to non-players. However, short-term video game experience (compared to reading popular science texts) led to a decline in selective attention and mental inhibition but positively affected verbal creativity scores. Therefore, no positive short-term effect of video gaming on convergent processes was identified, though it was observed for verbal fluency scores. The significant differences in cognitive indicators between gamers and non-gamers allow for the discussion of these results in terms of the potential long-term effects of video games on both convergent and divergent processes.&lt;/p&gt;

A Streamlined Approach to Student Stream Prediction Using an Ensemble Machine Learning Model

Finding a stream or course after secondary or senior secondary education is a daunting challenge for students and parents, as numerous options are available in various engineering and non-engineering courses. This decision potentially influences a student’s academic success and career. Most frequently, they take courses with the advice of relatives, neighbors, or career counsellors. Online platforms and Learning Management Systems also exist to offer guidance on stream selection. Still, these systems rely on short-term assessments such as tests, quizzes, or interviews, potentially restricting a student's options. Our research employed the Rajan and Rai (RR) student performance prediction model based on a sophisticated Ensemble Machine Learning approach. Our model incorporates a stack of four multiclass classifiers, namely Decision Tree, k-Nearest Neighbor, Naïve Bayes, and One vs. Rest Support Vector Machine classifiers, and demonstrates a remarkable accuracy rate of 80% for predicting the most suitable academic stream for a student in an Institution. To develop this model, we utilized data from five distinct branches of students. We aim to enhance students' academic success so they can complete their degrees with excellent Grades. Exploring our model in the education sector empowers students with the timely facilities they need for a successful and fulfilling educational journey.

Treatment of patellar luxation with polyethylene sulcal ridge prostheses in 44 feline stifles: a retrospective study.

The aim of this study was to assess the complication rates and long-term outcomes, as well as to refine case selection criteria for cats undergoing trochlear ridge augmentation (TRA) using an ultra-high molecular weight polyethylene implant (UHMWPEI) for the treatment of patellar luxation (PL). The clinical records from two referral veterinary hospitals were searched for cases that fitted defined inclusion criteria. A short-term assessment was based on examination and radiography at 8 weeks postoperatively. The long-term assessment was carried out at least 2 years postoperatively through examination and radiography, and less commonly via questionnaire. A total of 44 stifles in 39 patients with PL grade 2 (n = 19), 3 (n = 22) or 4 (n = 3) met the inclusion criteria. TRA using UHMWPEI was associated with minor complications in 20% of cases and major complications in 7% of cases. Minor complications included seroma formation (n = 5), superficial wound infection (n = 2), prolonged discomfort for a few weeks postoperatively (n = 1) and transient postoperative azotaemia (n = 1). After surgical correction of medial PL, one skeletally immature case developed transient grade 1 lateral PL, which resolved without intervention. Major complications comprised implant removal for ongoing lameness (n = 3). Degenerative joint disease, with mineralisation that was often marked, was noted in 26/35 (74%) cases that were available for radiographic follow-up 2 years or more after TRA. Nevertheless, good or very good long-term functional outcomes were achieved for 93% of cases. The currently available UHMWPEIs were shown to be suitable for treating PL grades 2, 3 or 4 in cats weighing ⩾3 kg. Delaying TRA until growth is completed is advised. The long-term follow-up suggested that the correction of PL in cats with UHMWPEI was sustained and that good function could be expected in the long term. Mineralisation overlying implants was common, but this was not appreciably correlated with adverse functional consequences.

Risk assessment of flash flood under climate and land use and land cover change in Tianshan Mountains, China

Tianshan Mountains in China (CTM) is one of the flash flood-prone areas worldwide, constraining economic development and threatening human safety. We assessed the short-term and long-term future flash flood risk in CTM using a multi-criteria model combined with future climate and Land use and land cover (LULC). The short-term risk assessment results indicated that moderate, high, and extremely high risk areas were mainly located in the northern foothills of the Tianshan Mountain, the southern Junggar Basin, and the northern Tarim Basin, accounting for about 10 % of the total area. The areas classified as high and extremely high risk were distributed in Ili (10,100 km2), Changji (4838 km2), Bortala (1783 km2), and Urumqi (1505 km2). The spatial distributions of future long-term and short-term flash flood risk are similar. There will be an increase in the flash flood risk from 2020 to 2030, mainly in Ili, Changji, and Hami. The flash flood risk in the CTM will decrease under different scenarios from 2030 to 2070. Historical flash flood data from the 1940s to the 2010s indicated that the results of the risk assessment are reasonable. Abundant precipitation from the westerly circulation and the trumpet-shaped topography drove the flash floods in Bortala-shuanghe(BS), Ili, Changji (west), and Urumqi-wujiaqv(UW). Snowmelt flash floods are another important flash flood type in Changji (West) and UW. The dense water system and the undulating terrain led to rainstorm flash floods in high mountainous areas of Aksu and Kashgar, Hami, Kizilsu, and Changji (east). Cultivated land, population, and roads are important risk receptors. The oases, water resource constraints, and the urban scale discontinuity led to the spatial displacement between hazard and risk. The flash flood risk change in the future is more closely related to LUCC than climate change. This study provides support for flash flood risk assessment and management in CTM and other arid inland areas under changed climate and LULC.

Using actigraphy to assess chronotype: Simpler is better

ABSTRACT Actigraphy provides a unique method for objectively measuring sleep activity patterns, but confusion remains about how to use actigraphy data to determine chronotype. To determine the most suitable parameter, this study made a systematic comparison of actigraphy-derived parameters: the average midpoint of sleep of all record days (aMS-acti), cosine parameter (Bathyphase), and non-parametric parameter (L5-mid) in terms of the consistency with subjective chronotype parameters, test–retest reliability, and external validity. More importantly, we proposed multiple Munich Chronotype Questionnaire (MCTQ)-based actigraphy parameters: considering the difference between weekday (MSW-acti) with weekends (MSF-acti) and the sleep debt (MSFsc-acti). The study collected 5 days of actigraphy and scale data from 1,055 young adults, 138 of whom participated in the retest 2 years later. The results showed that, in terms of consistency with subjective chronotype, aMS-acti generally performed better than other actigraphy parameters. In addition, aMS-acti had the highest test–retest reliability and was more closely related to the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Self-Rating Depression Scale (SDS). The results suggest that the simplest parameter (aMS-acti) is superior to traditional cosine and non-parametric parameters and MCTQ-derived parameters for short-term assessment of chronotype.

Short-term treatment response assessment in non-surgical treatment of advanced non-small cell lung cancer based on radiomics of dual-energy CT

PurposeTo build and evaluate a pre-treatment dual-energy CT(DECT)-based clinical-radiomics nomogram for individualized prediction of short-term treatment response to non-surgical treatment in advanced non-small cell lung cancer (NSCLC). MethodsPre-treatment DECT images were retrospectively collected from 98 pathologically confirmed NSCLC with clinical stage III or IV. Short-term treatment response was determined with follow-up CT of 4–6 courses of treatment. Quantitative radiomics metrics of the lesion were extracted from dual-energy mixed images at venous phase. Least absolute shrinkage and selection operator and correlation analysis were used to select the most relevant radiomics features. Radiomics model, clinical model and clinical-radiomics model were established by multivariate logistic regression. The model with the best prediction performance was visualized as a nomogram, and the consistency between the probability of the actual occurrence of the outcome and the probability predicted by the model was measured by calibration curves. ResultsClinical stage, difference in electron density in arteriovenous phase, difference in slope of energy spectrum in arteriovenous phase, and slope of energy spectrum in venous phase of the tumor were significant clinical predictors of therapy response (P < 0.05). The clinical-radiomics model showed a higher predictive capability (AUC: 0.87 and 0.85 in training and validation sets, respectively) than the radiomics models and the clinical model. The clinical-radiomics nomogram integrating the DECT radiomics signature with clinical stage and spectrum parameters showed good calibration and discrimination. ConclusionThe clinical-radiomics nomogram based on pre-treatment DECT showed good performance in predicting clinical response to non-surgical therapy in NSCLC.

Short-term Assessment of Glaucoma Progression in Clinical Trials Using Trend-based Visual Field Progression Analysis

To evaluate the effect of disease stage, frequency and clustering of visual field (VF) tests, inclusion of 1 or both eyes, and 1 (1 arm; before and after a treatment) or 2 groups (2 arms; treatment and control arm) on sample size calculation in clinical trials. Clinical cohort study. A series of VFs were simulated based on test-retest VF data in the early, moderate, and advanced stages of glaucoma with 231, 204, and 226 eyes, respectively. The mean of mean deviation (MD) slope was-0.75 decibels (dB)/year before treatment initiation in the 1-arm trial, and in the control group in the 2-arm trial. Visual field measurements were scheduled as 8 times in 2 years. Sample size calculation in clinical trials. In the 1-arm trial, when only 1 eye was used in each patient, the 80% probability of significance in the moderate stage was observed with sample size=70 eyes. Disease in the early stage and inclusion of both eyes decreased this number to 30 eyes; these decreasing effects were significantly larger than performing 1 or 2 additional VFs at the beginning and end of the observation. Conversely, a greater number of eyes was necessary in advanced stage than in moderate stage. In the 2-arm trial (80% probability of significance, and 1 eye per patient), the 80% probability of significance was observed with sample size=80 eyes in each arm, a tendency that was similar to what observed for the 1-arm trial. Similar tendency was observed in the simulations with much slower VF progression (mean MD slope=-0.25 dB/year). The present study highlights the importance of considering disease stage when planning a clinical trial. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Abstract 4138564: Fitbit-Measured Physical Activity Is Inversely Associated With Incident Atrial Fibrillation Among All Of Us Participants

Background: Studies show that moderate to vigorous physical activity (MVPA) reduces atrial fibrillation (AF) risk. However, these studies used subjective questionnaires or short-term (&lt;1 week) accelerometry assessments. Objective: This study investigated the link between MVPA levels and AF incidence using long-term (1-year) accelerometry data from the NIH All of Us Fitbit database. Methods: The study included All of Us participants who agreed to share electronic health record (EHR) and Fitbit data between January 1, 2016 to July 1, 2022. Among participants without an existing diagnosis of AF, the average weekly minutes of MVPA over the first year of Fitbit use was computed. Incident AF events were identified using validated ICD-10 codes in a five-year follow-up period. The risk of incident AF was evaluated using Cox proportional hazards regression models, for both MVPA as a continuous and a categorical variable (&lt;30, 30-150,151-300, and &gt;300 minutes MVPA per week; aligned with WHO guidelines). Covariates included age, sex, race/ethnicity, BMI, smoking status, and diagnoses of hypertension and diabetes. In a subset of participants with whole genome data, we evaluated if the association between MVPA and AF incidence varied by a participant’s AF genetic risk score (GRS) Results: 6086 participants (mean age 50 years, 71% female, 83% White) had EHR and at least 1 year of Fitbit data. Over the 1-year MVPA assessment period, participants had 41±12 weeks of complete data and a median 202 [241] minutes of MVPA per week. 55 participants (0.9%) experienced incident AF in the five-year follow-up period. In adjusted analysis, every additional hour of MVPA was associated with an 11% reduced risk of AF (HR = 0.89 [0.81,0.98], p = 0.02). There was a step-wise reduction in risk of AF by MVPA category with &lt;30 min/week as the reference: 30-150 (HR = 0.62 [0.24,1.6], p = 0.31), 151-300 (HR = 0.40 [0.15,1.07], p = 0.07), and &gt;300 (HR = 0.35 [0.13,0.95], p = 0.04) ( Figure 1 ). These associations also held after adjusting for GRS. Conclusion: Higher amounts of objectively measured MVPA were inversely associated with risk of incident AF, independent of clinical and genetic risk factors.

Single Strength Training Session Improves Short-Term Memory in Cognitively Preserved Older Adults.

The purpose of the present study was to examine the acute effect of a single aerobic or strength training session on memory of cognitively preserved older adults. In this randomized controlled clinical trial, in the first visit the participants (52.2% men, aged 68.65 ± 2.81years-old, BMI 26.94 ± 4.09), were randomly allocated in one of three groups: AG (aerobic exercise group), SG (strength exercise group, submitted to five exercises with 15 repetitions each), and CG (control group). Participants had a short-term memory assessment (word list memory test) followed by a single exercise session, and were retested immediately after. 24h later, participants were submitted to a long-term memory assessment about the story that was presented in the previous day. Results showed that the SG group had a significant improvement in the word list test, when comparing pre- and post-intervention scores, suggesting that a single strength training session significantly enhances short-term memory in this population.

Statistical Analysis for Quality Control of Monodispersed Polystyrene Particles Certified Reference Materials

Monodispersed polystyrene latex (PSL) particles serve as certified reference materials (CRMs) for ensuring quality, method validation, and calibration of particle size measuring instruments. They were produced in compliance with ISO 17034:2016 standards. However, limitations arise in the quality control of CRM characteristics due to challenges in synthesizing particles of consistent size across multiple batches. It is widely recognized that variations in particle size homogeneity between batches can occur in the particle manufacturing process even when conducted under identical conditions and ingredients. This paper aims to explain and demonstrate statistical analyses conforming to ISO Guide 35:2017 used for quality control and certifying reference values for monodispersed polystyrene particles. The procedure can be divided into three steps: 1) preliminary check by using dynamic light scattering (DLS), 2) preliminary check by using transmission electron microscopy (TEM), and 3) final homogeneity testing, along with short-term and long-term stability assessment and characterization. The described protocol can control the quality of particles from multiple batch productions by establishing criteria at each step to ensure particle size consistency. The certified value of a 100 nm diameter monodispersed polystyrene particle produced by the National Institute of Metrology, Thailand (NIMT) is 105.5 ± 4.6 nm, acceptable for measurement traceability for testing and calibration services. Keywords: Quality control, polystyrene particles, certified reference materials

Building stock energy modeling to assess annual progress in stock energy efficiency and carbon emission reduction of commercial buildings

Short-term progress assessments of carbon dioxide emission reductions are essential for nations to meet their medium/long-term targets. Bottom-up building stock energy modeling (BSEM) methods can contribute to this issue but have not been applied because of the need to represent short-term building stock dynamics in building systems and energy conservation measures (ECMs). To fill this gap, this study developed a BSEM framework that integrates top-down building stock decomposition, including building systems and ECMs, and bottom-up physics-based energy demand quantification using reference building models representing building stock segments. The framework was verified through a case study of a Japanese commercial building stock. The results indicate that the developed model effectively captures the short-term dynamics and contributions of the technologies. Although there are significant errors in estimating some building subsectors and end uses, the model predicts the changes in the aggregated energy consumption with acceptable accuracy. The Japanese 2030 emission reduction target cannot be achieved with the current technology deployment trends; however, the shortfall can be addressed by applying additional measures. Owing to its applicability to diverse building stocks, the framework promotes the use of BSEM for policy assessment and evidence-based policymaking for climate change mitigation.

VI-RADS followed by Photodynamic Transurethral Resection of Non-Muscle-Invasive Bladder Cancer vs White-Light Conventional and Second-resection: the 'CUT-less' Randomised Trial Protocol.

A second transurethral resection of bladder tumour (Re-TURBT) is recommended by European Association of Urology (EAU) Guidelines on non-muscle-invasive bladder cancers (NMIBCs) due to the risk of understaging and/or persistent disease following the primary resection. However, in many cases this may be unnecessary, potentially harmful, and significantly expensive constituting overtreatment. The CUT-less trial aims to combine the preoperative staging accuracy of Vesical Imaging-Reporting and Data System (VI-RADS) and the intraoperative enhanced ability of photodynamic diagnosis (PDD) to overcome the primary TURBT pitfalls thus potentially re-defining criteria for Re-TURBT indications. Single-centre, non-inferiority, phase IV, open-label, randomised controlled trial with 1:1 ratio. The primary endpoint is short-term BC recurrence between the study arms to assess whether patients preoperatively categorised as VI-RADS Score 1 and/or Score 2 (i.e., very-low and low likelihood of MIBC) could safely avoid Re-TURBT by undergoing primary PDD-TURBT. Secondary endpoints include mid- and long-term BC recurrences and progression (i-ii). Also, health-related quality of life (HRQoL) outcomes (iii) and health-economic cost-benefit analysis (iv) will be performed. All patients will undergo preoperative Multiparametric Magnetic Resonance Imaging of the bladder with VI-RADS score determination. A total of 327 patients with intermediate-/high-risk NMIBCs, candidate for Re-TURBT according to EAU Guidelines, will be enrolled over a 3-year period. Participants will be randomised (1:1 ratio) to either standard of care (SoC), comprising primary white-light (WL) TURBT followed by second WL Re-TURBT; or the Experimental arm, comprising primary PDD-TURBT and omitting Re-TURBT. Both groups will receive adjuvant intravesical therapy and surveillance according to risk-adjusted schedules. Measure of the primary outcome will be the relative proportion of BC recurrences between the SoC and Experimental arms within 4.5 months (i.e., any 'early' recurrence detected at first follow-up cystoscopy). Secondary outcomes measures will be the relative proportion of late BC recurrences and/or BC progression detected after 4.5 months follow-up. Additionally, we will compute the HRQoL variation from NMIBC questionnaires modelled over a patient lifetime horizon and the health-economic analyses including a short-term cost-benefit assessment of incremental costs per Re-TURBT avoided and a longer-term cost-utility per quality-adjusted life year gained using 2-year clinical outcomes to drive a lifetime model across the two arms of treatment. ClinicalTrial.gov identifier (ID): NCT05962541; European Union Drug Regulating Authorities Clinical Trials Database (EudraCT) ID: 2023-507307-64-00.

Urban Planning Perspective on Food Resilience Assessment and Practice in the Zhengzhou Metropolitan Area, China

This study aims to assess and analyze the urban food resilience of the Zhengzhou metropolitan area, proposing innovative assessment frameworks and methodologies. Utilizing a dual-level analysis approach that combines long-term planning impact analysis (2000–2020) with short-term resilience assessment (2018–2022), the study integrates public government data and Geographic Information System (GIS) data, employing spatial analysis, Analytic Hierarchy Process (AHP), and fuzzy comprehensive evaluation techniques. Findings from 2000 to 2020 indicate that urban planning within the metropolitan area has significantly impacted the food system. Urbanization has led to reduced agricultural land, but improvements in infrastructure have enhanced the efficiency of the food supply chain. Woodland and grassland areas have remained relatively stable, providing an ecological buffer for the food system. Building on this, the short-term assessment from 2018 to 2022 reveals significant dynamic changes and a continuous improvement trend in food resilience, though there is still room for enhancement. Food supply chain management and emergency preparedness and management contributed the most to overall resilience. Notably, extreme events such as the COVID-19 pandemic and the “7.20 Flood Disaster” prompted the adoption of innovative measures to enhance food resilience. The study develops a multidimensional theoretical framework and assessment system for urban food resilience, offering new perspectives and methods for understanding and enhancing urban food resilience. The results highlight the critical role of urban planning in enhancing food resilience, recommending the integration of the food system into comprehensive urban planning, strengthening regional collaboration, and enhancing public engagement. These findings provide an important basis for policymaking and practice aimed at improving the long-term adaptability and short-term recovery capabilities of urban food systems.