Short Scales Research Articles

Public greenspace and mental wellbeing among mid-older aged adults: Findings from the HABITAT longitudinal study

We explored temporal associations between public greenspace and adults’ mental wellbeing. Participants (n = 5,906) aged 40–65 years at baseline had data at >2 post-baseline waves of HABITAT, a multilevel longitudinal study (2007–16) in Brisbane, Australia. Participants self-reported mental wellbeing (short Warwick-Edinburgh Mental Wellbeing Scale) and neighbourhood self-selection reasons at Waves 2–5 (2009-11-13-16). We examined associations between Δgreenspace (within 1 km of home) and Δmental wellbeing using a linear fixed effects model, adjusting for time-varying confounders. Mental wellbeing increased (β = 1.75; 95% Confidence Interval:0.25–3.26) with greenspace exposure, adjusting for self-selection. Urban planning and policy initiatives to increase public greenspace may benefit mental wellbeing.

A cross-lagged analysis of the relationship between short video overuse behavior and depression among college students.

Watching short videos on mobile phones is currently a very prevalent phenomenon. It has been found in research that excessive use of short videos is closely related to depression. The aim of this study is to investigate the relationship between short video overuse behavior and depression among college students as well as the gender differences that are present in such relationship. A follow-up measurement was conducted on 331 college students using the Short Video Usage Behavior Scale and the Epidemic Research Center Depression Scale with an interval of 2 months. (1) Correlation analysis revealed a significant positive correlation between short video overuse behavior and depression, whether measured at the same or different time points, repeated measures ANOVA indicates that short video overuse behavior and depression have strong stability within the interval between two measurements. (2) Pre-test short video overuse behavior could significantly and positively predict post-test depression, whereas pre-test depression could not significantly predict post-test short video overuse behavior. (3) The cross-lagged effect between short video overuse behavior and depression showed no gender differences. These findings indicate that, for college students, short video overuse behavior may increase the risk of depression, whereas depression cannot induce short video overuse behavior.

Intervention with strategic metacognitive training in a population of elders with subjective cognitive decline

Objectives: this research, conducted at the University Hospital of Alessandria, aimed to assess the impact of strategic metacognitive training on cognitive abilities, well-being, and the reduction of depressive symptoms in an elderly population. Materials and Methods: the study included a sample of 11 subjects, aged 66 to 81 years, exhibiting subjective cognitive decline. They had to learn mnemonic strategies and, through the metacognitive task, reflecting on the learning and application processes. The training included 10 sessions, once a week. Cognitive functioning was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) in pre-test and post-test evaluations. Ad hoc tests were employed to investigate the effects of practice and generalization. Well-being, measured through the Psychological Wellbeing Questionnaire (BEN-SSC), and depressive status, assessed with the 15-item short form Geriatric Depression Scale (sfGDS), were also evaluated before and after the intervention. Results: the cognitive measurements yielded no significant findings, except for a tendency toward significance in the visuospatial and language ability index of the RBANS, indicating a slight improvement. Regarding well-being and mood, also here no results emerged in favor of significance. The only significant data was a reduction in personal satisfaction according to the BEN-SSC. Conclusions: the obtained results may be explained by potential inadequacies in the methodology, specifically in the structure and planning of the training. However, participants expressed interest in this type of intervention, demonstrating adherence in other training program.

Impact of Facilitation on Cognitive Flow in a Novel Diabetes Management Rehearsal Game for Health Professions Education: Mixed Methods, Open-Label, Superiority Randomized Controlled Trial.

Though the prevalence of diabetes is set to increase, most serious game solutions typically target patient self-management and education. Few games target health care professions education, and even fewer consider the factors that may increase their efficacies. The impact of facilitation, a prominent feature of health professions education, is examined in the context of a rehearsal-based diabetes management serious game. In this mixed methods, open-label, superiority randomized controlled trial, we compare student performance, attitudes, and perceptions of a rehearsal-based diabetes management game for health care professionals. Student participants were randomized into 2 groups to play a diabetes management game. The control group played the game alone, and the intervention group played the same game alongside a facilitator tasked to moderate overall challenge levels and address queries. Both groups were administered the Flow Short Scale, a 13-item measure rated on a 7-point Likert scale ranging from 1 ("not at all") to 7 ("very much") immediately after the game. Students were then invited to voluntary focus group discussions to elicit their attitudes and perceptions of the game. Findings were subject to between-group comparisons and inductive thematic analysis respectively. A total of 48 (26 control, 22 intervention) clinical-year undergraduates from the Lee Kong Chian School of Medicine in Singapore participated in this study, with 18 continuing to the focus group discussions. Flow Short Scale results indicated the superiority of the intervention group for overall flow (t46=-2.17, P=.04) and the absorption subdomain (t46=-2.6, P=.01). Qualitative results indicated students viewed facilitation as helpful and appropriate, and were able to identify improvable elements of the game's theoretical foundations and overall design. While serious games are efficacious means of rehearsing previously learned knowledge, facilitation allows for their efficiency to be greatly increased. Such increases are likely crucial in the coming years with the increased digitization of health care professions education and the prevalence of diabetes. ClinicalTrials.gov NCT05637749; https://www.clinicaltrials.gov/study/NCT05637749.

What is good? Exploring the applicability of a one item measure as a proxy for measuring acceptance in driver-vehicle interaction studies

New driver assistance systems play an important role to rise safety and comfort in todays´ traffic. Those systems should be developed with the needs of the user in mind and tested for the users´ requirements. In this, user acceptance is a central variable of interest – both in scientific and in practical applications of user-centered research on driver assistance systems. In some cases, applied research settings need simplified measurements in order to be efficiently applicable in the driving situations. In the present paper, we explored the applicability and validity of a single-item acceptance measurement (SIAM) for practical study settings covering the attitude towards using new driver assistance systems. To provide a theoretical framing, we tested the one-item measure against the widely used Technology Acceptance Model (TAM) and the van der Laan acceptance scale (VDL) in a driving simulator study. Participants experienced four different complex driving scenarios using a driver assistance system. Acceptance was measured repeatedly throughout the drive. The results supported construct validity for the SIAM, correlating with the VDL. The SIAM further predicted the intention to use the system. Being carefully aware of the psychometric drawbacks of short scales and acknowledging the importance of multi-item scales, the SIAM is promising for efficiently approaching the acceptance of driver assistance systems in applied settings.

Clinical effects of perineural dexmedetomidine or magnesium sulphate as adjuvants to ropivacaine in dogs undergoing tibial plateau leveling osteotomy

The study aimed to compare the quality of perioperative analgesia, the motor block duration, and the effects on main cardiovascular parameters of dexmedetomidine (1 μg/kg/nerve block) or magnesium sulphate (2 mg/kg/nerve block) as adjuvants to 0.3% ropivacaine for sciatic and saphenous nerves block in dogs undergoing tibial plateau leveling osteotomy (TPLO). Dogs randomly received perineural dexmedetomidine-ropivacaine (D group), magnesium sulphate-ropivacaine (M group), or ropivacaine (C group). Fentanyl was administered in case of intraoperative nociception. Postoperative pain was assessed using the Short Form-Glasgow Composite Measure Pain Scale (SF-GCMPS) and VAS scale. The duration of motor blockade and intra- and postoperative cardiovascular parameters were also recorded. Group M required significantly more fentanyl than D group (p = 0.04). Group M had a significantly higher SF-GCMPS score than group C at 4 (p = 0.002) and 5 h after extubation (p = 0.01), and a significantly higher VAS score than group D at 3 h after extubation (p = 0.03), and at 4 h if compared to group C (p = 0.009). No significant differences regarding the duration of motor blockade were detected between groups (p = 0.07). The heart rate was significantly lower in group D than in M and C groups intraoperatively and during the first 1.5 h post extubation. The addition of dexmedetomidine or magnesium sulphate as adjuvants to perineural ropivacaine did not improve the quality of perioperative analgesia and did not prolong the motor blockade in dogs undergoing sciatic and saphenous nerves block for TPLO surgery.

Multimorbidity, health Literacy, and quality of life among older adults in an urban slum in India: a community-based cross-sectional study

BackgroundIndia is experiencing a rising burden of chronic disease multimorbidity due to an aging population and epidemiological transition. Older adults residing in urban slums are especially vulnerable due to challenges in managing multimorbidity amid deprived living conditions. This study aimed to assess the prevalence of multimorbidity, associated health literacy, and quality of life impact in this population.MethodsA community-based cross-sectional study was conducted among 800 adults aged ≥ 65 years in an urban slum in Gujarat, India. Data on sociodemographics, physical and mental health conditions, health literacy (HLS-SF-47), quality of life (Short Form-12 scale), and social determinants of health were collected. Multimorbidity is ≥ 2 physical or mental health conditions in one person.ResultsThe prevalence of multimorbidity was 62.5% (500/800). Multimorbidity was significantly associated with lower physical component summary (PCS) and mental component summary (MCS) scores on the SF-12 (p < 0.001). After adjusting for sociodemographic variables, the odds ratio of 0.81 indicates that for every 1 unit increase in the health literacy score, the odds of having multimorbidity decrease by 19%. Older age within the older adult cohort (per year increase) was associated with greater odds of multimorbidity (AOR 1.05, 95% CI 1.02–1.09). Physical inactivity (AOR 1.68, 95% CI 1.027–2.77) and lack of social support (AOR 1.57, 95% CI 1.01–2.45) also increased the likelihood of multimorbidity.ConclusionThere is a substantial burden of multimorbidity among urban slum dwellers aged ≥ 65 years in India, strongly linked to modifiable risk factors like poor health literacy and social determinants of health. Targeted interventions are essential to alleviate this disproportionate burden among urban slum older adults.

The role of intermediaries in connecting individuals to local physical activity – protocol for a pilot feasibility trial

BackgroundIntermediaries are health-related workers who facilitate connections to local physical activities. Intermediaries deliver interventions by receiving referrals, conducting assessments, connecting referred individuals to activities and/or services in the community, and following up with them over time. However, it is unclear whether individuals who are referred to physical activities by an intermediary improve their physical activity levels, and what their perspectives and experiences are of participating in this intervention. To date there has been a lack of studies investigating the effect of this intervention on physical activity using appropriate outcome measures. MethodsThis will be a mixed methods pilot feasibility study. Participants will be individuals referred or self-referred to an intermediary and connected to local physical activities. Participants will be recruited through two types of intermediary services in Ireland; social prescribing and local sports partnerships. A total of 30 participants will be recruited (15 per service). Baseline demographic information will be taken upon enrolment to the study and three questionnaires will be completed: the International Physical Activity Questionnaire - Short Form, Self-Efficacy for Exercise Scale and Short Warwick Edinburgh Mental Well-being Scale. The questionnaires will be repeated after 12 weeks and in addition semi-structured interviews will be carried out to explore intervention content and delivery, as well as acceptability of the intervention and evaluation design. DiscussionThis overall aim of this proposed study is to investigate the feasibility of an intervention delivered by an intermediary to improve physical activity and health-related outcomes of community-dwelling individuals. RegistrationClinicalTrials.gov (NCT06260995).

Using PFG‐NMR and iGC to Study Diffusion and Adsorption in Heterogeneous Catalysts

AbstractMass transport in porous systems is inherently complex, but at the same also of utmost importance for large‐scale industrial processes such as heterogeneous catalysis. For each of the different length scales of diffusive motion potentially involved or relevant, specific characterization techniques have been developed and successfully applied over the years – including, but not limited to pulsed field gradient nuclear magnetic resonance (PFG‐NMR) spectroscopy, zero length column (ZLC) measurements and inverse gas chromatography (iGC). While each of these methods can deliver detailed information on certain types of diffusion, none of them are capable of delivering a full picture of mass transport across multiple length scales alone. In this context, the goal of the present work was to evaluate the technical feasibility and characterization potential of the hyphenated combination of PFG‐NMR and iGC in a coupled experimental setup. Challenges, advantages, and limitations of this approach are discussed using the example of propane adsorption and diffusion in two different zeolite catalysts (Mg(H)‐ZSM‐5 and Silicalite‐1). It is shown that the simultaneous detection of self‐diffusion on short length scales (as probed by PFG‐NMR) and transport diffusion covering longer distances (detectable by iGC) cannot be realized under the used conditions, essentially due to the lack of kinetic control at higher reactant loadings. The key advantage of the developed coupled setup is the ability of the iGC instrument to provide defined and readily variable levels of catalyst loading, which enables advanced pore connectivity studies by PFG‐NMR and yields thermodynamic data on reactant adsorption at the same time.

Capturing Flow Experiences in Everyday Life: A Comparison of Recall and Momentary Measurement

In a real-life study using time-based ambulatory assessment, we investigated how to unobtrusively capture within-subject and between-subject variations in flow in everyday life. We compared two observation approaches, momentary states, and coverage, which differed in the reference of flow reports and sampling frequency. Depending on condition, participants (N = 38) answered either ten or five queries per day that referred to the current state or the last two hours (n = 1442 observations in total). We found no effect of either approach on compliance, flow intensity, or flow reports over time. However, the approaches differed with respect to flow probability reports, within-subject variability in flow reports, and perceived burden. In addition, we introduced a reduced three-item version of the Flow Short Scale. Our results indicate acceptable to good reliability as well as concurrent, convergent and discriminant validity of this scale. Based on our findings, we recommend that the choice of observation approach for capturing everyday flow depends on the outcome of interest, the targeted comparison within- or between-subjects, and the expected task variability of the participants. Limitations regarding our sampling procedure and the retrospective assessment of flow experiences are discussed.

Polynomial Equivalence of Complexity Geometries

This paper proves the polynomial equivalence of a broad class of definitions of quantum computational complexity. We study right-invariant metrics on the unitary group—often called `complexity geometries&amp;apos; following the definition of quantum complexity proposed by Nielsen—and delineate the equivalence class of metrics that have the same computational power as quantum circuits. Within this universality class, any unitary that can be reached in one metric can be approximated in any other metric in the class with a slowdown that is at-worst polynomial in the length and number of qubits and inverse-polynomial in the permitted error. We describe the equivalence classes for two different kinds of error we might tolerate: Killing-distance error, and operator-norm error. All metrics in both equivalence classes are shown to have exponential diameter; all metrics in the operator-norm equivalence class are also shown to give an alternative definition of the quantum complexity class BQP. My results extend those of Nielsen et al., who in 2006 proved that one particular metric is polynomially equivalent to quantum circuits. The Nielsen et al. metric is incredibly highly curved. I show that the greatly enlarged equivalence class established in this paper also includes metrics that have modest curvature. I argue that the modest curvature makes these metrics more amenable to the tools of differential geometry, and therefore makes them more promising starting points for Nielsen&amp;apos;s program of using differential geometry to prove complexity lowerbounds. In a previous paper my collaborators and I—inspired by the UV/IR decoupling that happens in the phenomenon of renormalization—conjectured that high- dimensional metrics that look very different at short scales will often nevertheless give rise at long scales to the same emergent effective geometry. The results of this paper provide evidence for those conjectures, since many complexity metrics that have radically different penalty factors and therefore radically different short- distance properties are shown to belong to the same long-distance equivalence class.

Mapping intersectional sociodemographic inequalities in measurement and prevalence of depressive symptoms: a intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy using data from a population-based nationwide survey in Germany

ObjectivesUnderstanding how social categories like gender, migration background, lesbian/gay/bisexual/transgender (LGBT) status, education, and their intersections affect health outcomes is crucial. Challenges include avoiding stereotypes and fairly assessing health outcomes. This paper aims to demonstrate how to analyze these aspects. Study Design and SettingThe study used data from N = 19,994 respondents from the German Socio-Economic Panel 2021 data collection. Variations between and within intersectional social categories regarding depressive symptoms and self-reported depression diagnosis were analyzed. We employed intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy to assess the impact of gender, lesbian/gay/bisexual/transgender status, migration, education, and their interconnectedness. A Configuration-Frequency Analysis assessed typicality of intersections. Differential Item Functioning analysis was conducted to check for biases in questionnaire items. ResultsIntersectional multilevel analysis of individual heterogeneity and discriminatory accuracy analysis revealed significant interactions between these categories for depressive symptoms and depression diagnosis. The Configuration-Frequency Analysis showed that certain combinations of social categories occurred less frequently compared to their expected distribution. The Differential Item Functioning analysis showed no significant bias in a depression short scale across social categories. ConclusionResults reveal interconnectedness between the social categories, affecting depressive symptoms and depression probabilities. More privileged groups had significant protective effects, while those with less societal privileges showed significant hazardous effects. Statistical significance was found in some interactions between categories. The variance within categories outweighs that between them, cautioning against individual-level conclusions.

Association between grit and depressive symptoms among medical students, moderated by academic performance

ABSTRACT Depression amongst medical students is a crucial matter. Grit, which is a potentially modifiable psychological factor, has been inversely linked to depressive symptoms. However, it remains unclear how grit is associated with depression. This study aims to examine the relationship between grit and depressive symptoms and to further investigate the potential effect modification by academic performance on the association between grit and depression among medical students. We focus on the total grit score and its subscales, namely perseverance of effort and consistency of interest. A cross-sectional study was conducted using data from second-year medical students at Tokyo Medical and Dental University in Japan from 2020 to 2023. The participants responded to questionnaire surveys comprising the Center for Epidemiologic Studies Depression Scale and the Short Grit Scale. Linear regression analysis was performed to assess the association between grit and depressive symptoms. We also tested for effect modification by first-year Grade Point Average (GPA) on the association between grit and depression. The total grit score and its subscales, perseverance of effort and consistency of interest, were all inversely associated with depressive symptoms (b = −4.7 [95%CI − 6.7 to − 2.6], b = −3.7 [95%CI − 5.3 to − 2.1], b = −1.8 [95%CI − 3.5 to − 0.2], respectively). While the interaction term for the total grit score and GPA was not significant, the interaction term for perseverance of effort and GPA was significant, indicating that the association between perseverance of effort and depression was stronger among the higher-achieving students. The interaction term for consistency of interest and GPA was also significant, indicating that the association was stronger among the lower-achieving students. We reveal a novel aspect of the association between grit and depressive symptoms in light of academic performance. The findings will contribute to future research on depression amongst medical students.

Intention to Quit Smoking Scale: Development and Validation

Smoking cessation efforts are made in many countries and the results of these efforts should be measured. Therefore, there is a need for a short, feasible and validated scale that can measure the intention to quit smoking. The purpose of this study is to investigate the psychometric properties of the “Intention to Quit Smoking Scale (IQSS)”. Validity and reliability properties of the scale were examined. A total of 497 people were included in the study. First, 20 candidate items were prepared based on literature review and expert opinions and the scale with candidate items were subjected to a pilot test. The dimensional structure was determined statistically using confirmatory factor analysis and confirmed by confirmatory factor analysis. Cronbach’s α coefficient, CR and AVE values were calculated to examine internal consistency, composite reliability and convergent validity. A scale with one factor consisting of eight items was obtained. The fit indices of the single factor structure were at an acceptable level (X2/df 1.77, GFI 0.94, AGFI 0.88, CFI 0.98, NFI 0.97, RMSEA 0.079). Cronbach's alpha for IQSS was 0.943. CR was 0.95 and AVE was 0.96. The test-retest consistency of the scale was high (r=0.856). Correlations with “Smoking Cessation Success Prediction Scale” and its sub-dimensions showed that the scale provided concurrent validity (r=0.669; 0.698; 0.721 respectively). The IQSS is a short, reliable and valid scale that can measure the intention to quit smoking at the time of measurement and it can be easily used in future studies.

Measuring mental well-being: validation of the Polish version of the Short Warwick Edinburgh Mental Wellbeing Scale (SWEMWBS)

Aim. The purpose of the conducted research was to adapt and evaluate the psychometric properties of the Polish version of the SWEMWBS.Method. To assess the structure of the tool and its internal consistency, data were used from 557 individuals between the ages of 25 and 63 years. To assess the validity of the SWEMWBS, 277 individuals between aged 20 to 46 years took participation.Results. Validation studies conducted on the Polish version of the SWEMWBS show that the scale is a reliable and accurate tool for measuring mental well-being. The results of confirmatory factor analysis confirmed the scale’s one-factor structure. The reliability of the scale calculated using Cronbach’s alpha α = 0.84, McDonald’s omega ω = 0.83, and Gutmann’s lambda λ = 0.83 was good. The study also confirmed the validity of the scale. The SWEMWBS was moderately positively correlated with resilience and health behaviours. We observed moderate negative correlations between well-being and depressiveness.Conclusions. The study showed that the SWEMWBS is a brief tool for measuring mental well-being with good psychometric properties.

Why Do People Watch Pornography? Cross-Cultural Validation of the Pornography Use Motivations Scale (PUMS) and Its Short Form (PUMS-8)

ABSTRACT Motivations for pornography use may vary across gender identities, sexual orientations, and geographical regions, warranting examination to promote individual and public health. The aims of this study were to validate the Pornography Use Motivations Scale (PUMS) in a diverse, multicultural sample, and develop a short form (PUMS-8) that can assess a wide range of pornography use motivations. Using data from 42 countries (N = 75,117; Mage = 32.07; SDage = 12.37), enabled us to thoroughly evaluate the dimensionality, validity, and reliability of the Pornography Use Motivations Scale (PUMS), leading to the development of the more concise PUMS-8 short scale. Additionally, language-, nationality-, gender-, and sexual-orientation-based measurement invariance tests were conducted to test the comparability across groups. Both the PUMS and the PUMS-8 assess eight pornography use motivations, and both demonstrated excellent psychometric properties. Sexual Pleasure emerged as the most frequent motivation for pornography use across countries, genders, and sexual orientations, while differences were observed concerning other motivations (e.g. self-exploration was more prevalent among gender-diverse individuals than men or women). The motivational background of pornography use showed high similarity in the examined countries. Both the PUMS and the PUMS-8 are reliable and valid measurement tools to assess different types of motivations for pornography use across countries, genders, and sexual orientations. Both scales are recommended for use in research and clinical settings.

Examining network structure of impulsivity and depression in adolescents and young adults: A two-sample study

BackgroundDepression ranks as one of the top five contributors to ill health in youth, the most formative period in life. Extensive research has highlighted the significant role of impulsivity in understanding depression. However, there has been limited exploration into how each dimension of impulsivity uniquely affect depressive symptoms, especially across crucial developmental stages like adolescence and young adulthood. MethodsThis study investigates the unique relationships between impulsivity (assessed by the short UPPS-P scale) and depression (assessed by the Patient Health Questionnaire-9) via network analysis. We analysed data from a total of 2296 participants, comprising 858 adolescents aged 14–17 years and 1438 young adults aged 18–25 years, to estimate both a combined network and age-group specific networks. Key features of the networks, including their structure, global connectivity, and bridge nodes, were compared. ResultsThe results indicated that age differentially impacts individual depression symptoms, both directly and indirectly, via impulsivity dimensions. The comparison test revealed consistent network structures between the two age groups, with several robust pathways, such as lack of perseverance to concentration difficulties, sensation seeking to suicidal ideation, and negative urgency to feelings of worthlessness. Negative urgency and lack of perseverance were identified as bridge nodes across the two networks. LimitationsThe study employed a cross-sectional design, which limits the ability to estimate causal or temporal relationships. ConclusionsThe current findings highlight the significance of tailoring intervention strategies to individual symptom profiles and assessing negative urgency and lack of perseverance as potential early targets for depression among youth.

Riluzole for Degenerative Cervical Myelopathy

The modified Japanese Orthopaedic Association (mJOA) scale is the most common scale used to represent outcomes of degenerative cervical myelopathy (DCM); however, it lacks consideration for neck pain scores and neglects the multidimensional aspect of recovery after surgery. To use a global statistical approach that incorporates assessments of multiple outcomes to reassess the efficacy of riluzole in patients undergoing spinal surgery for DCM. This was a secondary analysis of prespecified secondary end points within the Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-PROTECT) trial, a multicenter, double-blind, phase 3 randomized clinical trial conducted from January 2012 to May 2017. Adult surgical patients with DCM with moderate to severe myelopathy (mJOA scale score of 8-14) were randomized to receive either riluzole or placebo. The present study was conducted from July to December 2023. Riluzole (50 mg twice daily) or placebo for a total of 6 weeks, including 2 weeks prior to surgery and 4 weeks following surgery. The primary outcome measure was a difference in clinical improvement from baseline to 1-year follow-up, assessed using a global statistical test (GST). The 36-Item Short Form Health Survey Physical Component Score (SF-36 PCS), arm and neck pain numeric rating scale (NRS) scores, American Spinal Injury Association (ASIA) motor score, and Nurick grade were combined into a single summary statistic known as the global treatment effect (GTE). Overall, 290 patients (riluzole group, 141; placebo group, 149; mean [SD] age, 59 [10.1] years; 161 [56%] male) were included. Riluzole showed a significantly higher probability of global improvement compared with placebo at 1-year follow-up (GTE, 0.08; 95% CI, 0.00-0.16; P = .02). A similar favorable global response was seen at 35 days and 6 months (GTE for both, 0.07; 95% CI, -0.01 to 0.15; P = .04), although the results were not statistically significant. Riluzole-treated patients had at least a 54% likelihood of achieving better outcomes at 1 year compared with the placebo group. The ASIA motor score and neck and arm pain NRS combination at 1 year provided the best-fit parsimonious model for detecting a benefit of riluzole (GTE, 0.11; 95% CI, 0.02-0.16; P = .007). In this secondary analysis of the CSM-PROTECT trial using a global outcome technique, riluzole was associated with improved clinical outcomes in patients with DCM. The GST offered probability-based results capable of representing diverse outcome scales and should be considered in future studies assessing spine surgery outcomes.

New Classical Integrable Systems from Generalized TT[over ¯]-Deformations.

We introduce and study a novel class of classical integrable many-body systems obtained by generalized TT[over ¯] deformations of free particles. Deformation terms are bilinears in densities and currents for the continuum of charges counting asymptotic particles of different momenta. In these models, which we dub "semiclassical Bethe systems" for their link with the dynamics of Bethe ansatz wave packets, many-body scattering processes are factorized, and two-body scattering shifts can be set to an almost arbitrary function of momenta. The dynamics is local but inherently different from that of known classical integrable systems. At short scales, the geometry of the deformation is dynamically resolved: either particles are slowed down (more space available), or accelerated via a novel classical particle-pair creation and annihilation process (less space available). The thermodynamics both at finite and infinite volumes is described by the equations of (or akin to) the thermodynamic Bethe ansatz, and at large scales generalized hydrodynamics emerge.

Model-based indices of juvenile Pacific salmon abundance highlight species-specific seasonal distributions and impacts of changes to survey design

Changes in survey implementation can bias traditional design-based indices of abundance, particularly for migratory species where local abundance can vary at short temporal scales. Spatiotemporal model-based estimators provide a flexible alternative that can better account for changes in the timing and location of surveys. Here we develop a geostatistical model, a generalized linear mixed effects model with Gaussian Markov random fields, that is sufficiently flexible to account for changes in survey design, as well as seasonal and interannual variability in abundance and spatial distribution. We then apply this model to a suite of migratory species—juvenile Pacific salmon—with survey data collected from southern British Columbia’s continental shelf over the previous 25 years. Juvenile Pacific salmon showed species-specific spatial distributions with considerable seasonal variability. While the location of species-specific hot spots varied among years, seasonal variation in distributions were greater than interannual variation. We found that a shift from standard transects and opportunistic sampling to a random stratified survey design resulted in lower estimates of abundance for four of five juvenile Pacific salmon species; however, these differences were not significant after accounting for other sampling attributes. Trends in abundance for several species shifted when models included survey and diel effects. Our approach provides a means of deriving indices of abundance for migratory species from surveys with variable effort in time and space. Ultimately such indices can be used to better understand the ecological mechanisms regulating productivity by linking distribution and abundance to environmental drivers.