Short Residency Research Articles

ECOFEMINISM IN THE NOVELS OF ANURADHA ROY

“Environment” has pretended a significant hazard to “human civilization as well as the mother earth” in current situation. We are on the verge of trench due to widespread abuse of ordinary assets. The rainforests are being cut down, petroleum supplies are rapidly dwindling, seasonal patterns are in disarray, biological disasters are occurring all over the world, and our current situation is precarious. “Women”, on the other hand, have been discouraged in the wider public by male rule for a long time. During the recent few years of the ended century, another notion of “nature & female” composition called “Ecofeminism” arose in response to these circumstances. It is a long-term development that began as a reaction to man's “human-centric” approach to dominating “nature”. The current constraint is to look into “Ecofeminist perspectives” as depicted in a few pieces of international & Indian writing in English. This earth arranged investigation of writing achieves “environmental & female” concern proficiency in the midst of the peruser of becoming “Ecofeminism-cognizant”, consequently taking great consideration of “Mother Nature & female”. “Nature & female” control ideas being one of the central issues of the day, “Ecofeminism” has gone through fast improvement during its short residency since presentation. The interpretive analyzing tool of “nature & women empowerment” writing is commonly concerned to “Environmental & women criticism, Animal & human psychology studies, Green Cultural Studies, Ecosophy, Deep Ecology, Ecofeminism, Ecospiritualism, Ecocriticism and the like”.

Factors affecting the choice of career in family medicine among medical students in Saudi Arabia: a cross-sectional study

Background: Increasing the number of family physicians is one main aspect of the National Transformation Program in Saudi Arabia. Thus, this study aimed to assess factors influencing medical students' choice of family medicine (FM) as a future career in Makkah, Saudi Arabia. Methods: This cross-sectional study was conducted from November 2021 to March 2022 at seven medical schools. The participants were in their clinical years (fourth, fifth, sixth, and interns). A self-administered online questionnaire in English-language was distributed to participants, who were subsequently divided into two groups according to their choice in either FM or other specialties. The questionnaire was utilized to compare the participants' sociodemographic characteristics, factors influencing their choice of career, and knowledge of the National Transformation Program. Results: A total of 422 participants completed the study questionnaire, of which 192 (45.5%) students preferred FM. It was reported by 182 (43.1%) students that a member of their family is a medical professional. Most participants were males (n = 268; 63.5%). Influencing factors included working with patients to address their psychological, social, and lifestyle problems (79.1%), wanting a relatively easy residency (83.4%), working with non-emergent and relatively well patients (78.6%), and preferring a wide and diverse range of cases (85.9%). Conclusion: Factors influencing the choice of FM as a future career were the expansion of the FM training program, shortage of family physicians, short residency, working with non-emergent, relatively well patients, having long-term relationships and a personal bond with patients, and future educational and research opportunities.

The Great Gatsby: A Graphic Novel AdaptationNick: A NovelEl gran GatsbyStepping Out with Scott and Zelda: Touring the Fitzgeralds’ Montgomery

The Great Gatsby: A Graphic Novel AdaptationNick: A NovelEl gran GatsbyStepping Out with Scott and Zelda: Touring the Fitzgeralds’ Montgomery

Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids.

BackgroundWe recently reported on preferential deposition of bare fluorescent diamond particles FDP-NV-700/800nm (FDP-NV) in the liver following intravenous administration to rats. The pharmacokinetics of FDP-NV in that species indicated short residency in the circulation by rapid clearance by the liver. Retention of FDP-NV in the liver was not associated with any pathology. These observations suggested that cancer therapeutics, such as doxorubicin, linked to FDP-NV, could potentially serve for anti-cancer treatment while sparing toxicities of peripheral organs.PurposeTo generate proof-of-concept (POC) and detail mechanisms of action of doxorubicin-coated FDP-NV-700/800nm (FDP-DOX) as a prospective chemotherapeutic for metastatic liver cancer.MethodsFDP-DOX was generated by adsorption chemistry. Experimental design included concentration and time-dependent efficacy studies as compared with naïve (baren) FDP-NV in in vitro liver cancer cells models. Uptake of FDP-NV and FDP-DOX by HepG-2, Hep-3B and hCRC organoids were demonstrated by flow-cytometry and fluorescent microscopy. FDP-DOX pharmacodynamic effects included metabolic as well as cell death biomarkers Annexin V, TUNEL and LDH leakage. DOX desorpted from FDP-DOX was assessed by confocal microscopy and chemical assay of cells fractions.ResultsFDP-DOX efficacy was dose- and time-dependent and manifested in both liver cancer cell lines and human CRC organoids. FDP-DOX was rapidly internalized into cancer cells/organoids leading to cancer growth inhibition and apoptosis. FDP-DOX disrupted cell membrane integrity as evident by LDH release and suppressing mitochondrial metabolic pathways (AlamarBlue assay). Access of free DOX to the nuclei was confirmed by direct UV-Visible fluorescent assay and confocal microscopy of DOX fluorescence.ConclusionThe rapid uptake and profound cancer inhibition observed using FDP-DOX in clinically relevant cancer models, highlight FDP-DOX promise for cancer chemotherapeutics. We also conclude that the in vitro data justify further investment in in vivo POC studies.

Circles, Teenagers, and Henry V: A Short Shakespeare Residency

An accomplished director and Teaching Artist recounts the many engaging dimensions of a student production of Henry V.

Juvenile Chinook Salmon (Oncorhynchus tshawytscha) Utilization of Hawks Creek, a Small and Nonnatal Tributary of the Upper Fraser River

Hawks Creek, a small tributary of the upper Fraser River where there is no record of spawning salmonids, was examined from May to November 1990 for the presence of juvenile salmonids. Age 0+ wild chinook salmon (Oncorhynchus tshawytscha) appeared in May, increased to peak densities of 0.76 fish∙m−2 in late August, and were absent in November. Average residence time of marked chinook juveniles was 9 d. Duration of residency was size dependent, as small fish remained longer than large fish. Rainbow trout (Oncorhynchus mykiss) and mountain whitefish (Prosopium williamsoni) also had a short residency (mean = 21 d). We suggest that unsuitable rearing conditions (e.g., sediment load) in the mainstem Fraser River during the spring and summer favour the use of small, clear, and nonnatal tributaries by juvenile salmonids. Physical and biological explanations are proposed for their temporary use. These salmonid refuge habitats need to be protected.

High prevalence of diabetes in young adult Ethiopian immigrants to Israel.

We performed oral glucose tolerance tests in 158 Ethiopian immigrants to Israel. The subjects were less than 30 yr of age, had lived in Israel less than or equal to 4 yr, and originated from villages in the Gondar and Ambovar regions of Ethiopia. Most had been subjected to famine conditions in Ethiopia and/or extreme hardship in Sudan before or during immigration. All were lean. They revealed a profound change in dietary habits since their arrival in Israel, with consumption of large amounts of refined carbohydrate in place of spicy stews and injura (Ethiopian pita) that had constituted dietary staples in better times in Ethiopia. According to National Diabetes Data Group criteria, 14 (8.9%) of the subjects had diabetes, and another 14 (8.9%) had impaired glucose tolerance. In addition, 13 subjects had a dramatic increase in capillary blood glucose levels (greater than 300 mg/dl) 1 h after ingestion of 75 g glucose, despite fasting and 2-h values well within the normal range, and they complained of associated symptoms during the 1st h of testing. Eleven of 137 men and 3 of 21 women had diabetes; 7 (5.1%) of the men and 7 (33%) of the women had impaired glucose tolerance. These results indicate a high prevalence of diabetes among young adult Ethiopian immigrants of relatively short residency in Israel, for which the factors responsible warrant further investigation.

The fate of the N-formyl-chemotactic peptide receptor in stimulated human granulocytes: subcellular fractionation studies.

Experiments were performed to examine how human granulocytes, stimulated by N-formyl-chemotactic peptides, process the N-formyl peptide receptor. One percent of the surface N-formyl-chemotactic peptide receptors of purified human granulocytes were covalently, specifically, and radioactively labeled at 4 degrees C using the photochemically reactive N-formyl-chemotactic hexapeptide CHO-Nle-Leu-Phe-Nle-[125I] Tyr-N epsilon (6-(4'-azido-2'-nitrophenyl-amino)hexanoyl)-Lys. After incubation in the presence of 500 nM of N-formyl-Met-Leu-Phe at 37 degrees C, the cells were lysed and fractionated by isopycnic surcrose density gradient sedimentation. Receptor-associated radioactivity cosedimented with plasma membrane in fractions from cells kept at 4 degrees C or incubated at 37 degrees C for 2 min or less. Fractionation of cells incubated at 37 degrees C for longer times revealed that the radioactivity sedimented to lower densities coincident with Golgi markers and the site of noncovalently bound and internalized formyl-chemotactic peptide. To follow the redistribution of unoccupied receptors, human granulocytes were stimulated with 500 nM N-formyl-Met-Leu-Phe at 37 degrees C for 5 min, washed, lysed by N2 cavitation, and fractionated by rate zonal sucrose density gradient sedimentation. Compared to unstimulated controls the specific binding of N-formyl-Met-Leu-[3H]Phe decreased 76% +/- 9% in plasma membrane fractions. N-formyl-Met-Leu-[3H]Phe-binding activity associated with an intracellular pool cosedimenting with specific granules remained unchanged. Approximately 20% of the activity lost in the plasma membrane could be accounted for by a redistribution of specific N-formyl-Met-Leu-Phe binding to fractions enriched in azurophil granules. We conclude that the receptor is the carrier in the internalization of the N-formyl-chemotactic peptides to a Golgi-enriched fraction and hypothesize that after a short residency in this fraction, the receptor may dissociate from the ligand and pass onto a fraction cosedimenting with dense granules.