Short Commentary Research Articles

Fighting Inactivity to Improve Health: A Short Commentary

Fighting Inactivity to Improve Health: A Short Commentary

A Short Commentary of Neuronal Ceroid Lipofuscinoses; Phenotypes in Congenital to Preschooler

The classification of neuronal ceroid lipofuscinoses (NCLs) had been clinically divided according to the age at the onset of symptoms: infantile, late infantile, juvenile and adult NCLs. However, this classification cannot always predict the causative gene; i.e., CLN1, for example, causes not only infantile NCL but also late onset infantile and adult NCLs. In 2012, a new classification for the NCLs that takes into account recent genetic and biochemical advances. This short review commentary focuses on the NCLs which might cause symptoms in children from neonate to preschooler age: CLN10 (neonatal), CLN1 (6-48 months), CLN14 (8-24 months), CLN2 (1-6 years), CLN3 (4-7 years), CLN5 (4-6 years), CLN6 (18 months-8 years), CLN7 (2-7 years) and CLN8 (5-10 years). There is no fundamental therapy, but there is the trial of some cures.

Physical Therapy Interventions and Bone Health: A Short Commentary

Risk of osteoporosis is increasing in normal population due to inactivity, dietary eating habits, and sedentary life styles, low calcium intake, less exposure to sun light and hormonal changes. Physical therapy interventions, weight bearing training, jumping intervention in childhood and adolescence, modified step aerobics training, balance training, strength training and water based exercise can be used for treatment and prevention of osteoporosis.

The role of population genetics and its implications in the study of complex-Disease risk

Genetic-association is a prominent word in the biomedical databases appearing in more than one million of publications. This keyword is one of the most used to find phenotypegenotype associations, identifying risk variants that could be used as biomarkers in complex diseases. Nonetheless, this word does not necessarily imply a real association, given that the human populations, as other ones, are dynamic and consequently, an important rate of statistical errors is generated. This situation is not only reflected in the classical case-control genetic association studies. Certainly, the genome-wide association studies, as well as the whole exome sequence, are susceptible of false associations. Latino/Hispanic and African- American populations present a complex genetic architecture due to the disparities in the ancestral background of populations from which they emerged. Ancestry informative markers, Bayesian inferences of a number of subpopulations, hierarchical clustering, and ancestry matching are indispensable tools to reduce the bias caused by the population heterogeneity and the inflated findings. Herein, is a short commentary where a general overview is presented about population genetic parameters and the role of ancestry to identify risk loci and its implications for medical practice. Also, the hint of the consequences of the depreciation of these arguments was done evidencing its consequences.

A Short Commentary about Efficacy of an Flowable Matrix in the Treatment of Diabetic Foot Ulcers

The authors aimed to evaluate the efficacy of an advanced wound matrix (Integra Flowable Wound Matrix, Integra Life Science Corp, Plainsboro, NJ, USA) for treating wounds with irregular geometries versus a wet dressing in sixty patients with diabetic foot ulcers (Grades 3 Wagner ulcer). A randomized clinical trial was conducted in the General Surgery Unit and Geriatric of the Second University of Naples, Italy, in the last 12 months. Forty-seven cases of diabetic foot ulcers were equally and randomly divided into two groups: in a group treated with a wet dressing and expected closure by secondary intention; in another group the lesions were filled with Integra Flowable Wound Matrix and surgical wound edges were either approximated with stitches. The complete healing rate valued at 6 weeks, in the whole study population was 69.56% (Integra Flowable Wound Matrix group, 86.95%, control group, 52.17%; P=0.001). Amputation and re-hospitalization rates were higher in the control group compared to Integra Flowable Wound Matrix group. Therefore the difference was statistically significant. This new porous matrix, allows a closure for the first intention of the lesion by reducing healing time and the demolition surgery. An advanced wound matrix is not associated with side effects, is well tolerated. Ease of use, absence of adverse effects, and a minimal invasive approach by primary intention closure of the lesion, make it appropriate in the management diabetic foot ulcers.

Number of Circulating Endothelial Progenitor Cells as a Predictive Biomarker of Heart Failure

Recent clinical trials have shown that the circulating Endothelial Progenitor Cells (EPCs) may act as a powerful endogenous reparative system in several cardiovascular diseases including Heart Failure (HF). Indeed, endothelial repair and restoring endothelial function is considered a target for several treatment approaches, which are widely used in HF care. It is known that a number of circulating EPCs decreased sufficiently depending on severity of cardiac dysfunction. Moreover, lowered count of EPCs was found promising biomarker of HF-related outcomes. Nowadays there is a large body of evidence regarding considerable discriminant of lowered EPCs with different immune phenotypes in HF with different etiologies. The short commentary is depicted the role of measurement of EPC count in HF individuals aimed to improve the predictive value of contemporary used biomarker-based scales.

Short commentary on Lymphedema after Treatment for Endometrial Cancer

Short commentary on Lymphedema after Treatment for Endometrial Cancer

The Influence of Organizational Respect on Job Satisfaction in the Human Services: Findings from a New York State Multi-Site Job Satisfaction Cross-Sectional Survey – A Short Commentary

The Influence of Organizational Respect on Job Satisfaction in the Human Services: Findings from a New York State Multi-Site Job Satisfaction Cross-Sectional Survey – A Short Commentary

Role of Calcium in Hypertensive Disorders of Pregnancy Current Status of Research a Mini Review

Introduction: Some studies have revealed changes in blood/urinary calcium with inverse relationship between calcium intakes during pregnancy, incidence of preeclampsia. So researchers believe that calcium has a role in etiology of hypertensive disorders during pregnancy. With reduced incidence of preeclampsia after calcium supplementation. So prevention of HDsP and/or their severity are being attempted through oral calcium. Objective: To collect existing information about role of calcium in HDsP for translational program or if needed, research. Material Methods: Present article is based on literature search by available search engines like, Pubmed, Google, Update and others. Studies, reviews and short commentaries were looked into to get desired information. Serum urinary cellular calcium: Normally there is increase in intracellular calcium in pregnancy. It has been reported that this effect is exaggerated in preeclampsia due to significant increase in the membranous calcium content. Researchers also reported that preeclampsia in third trimester was associated with hypocalciuria due to increased tubular reabsorption of calcium. Urinary calcium excretion has been found to be reduced in severe preeclampsia, eclampsia, but decrease could not be used to identify severity of preeclampsia, or predict impending eclampsia. Problem seems to be at the cellular level, needs to be investigated further. Calcium supplementation: Some have reported incidence of preeclampsia greater in women given placebo, compared to calcium-treated, although difference was not significant. Also supplementing calcium in women at high risk of pre-eclampsia was likely to reduce incidence of disease. But others reported that extra calcium did not reduce number of women who suffered, however reduced severity of HDsP. Also smooth-muscle relaxation detected in calcium supplemented women might affect labour onset. Conclusion: There are reports of positive relationship and no effect on reduction in HDsP or their severity. In view of contradictory findings, in depth studies are required to investigate altered serum, urine and cellular calcium, in women with HDsP.

A Short Commentary on “Serotype Determination of Salmonella by xTAG Assay”

A Short Commentary on “Serotype Determination of Salmonella by xTAG Assay”

Integrating Seeking Safety and 12 Step Recovery: A Short Commentary

The relationship between Post-Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD) is frequently observed as a cycle of maladaptive coping. While substance abuse can provide temporary relief, prolonged use exacerbates trauma-related symptoms in the long-term. Comorbidity increases risk for problematic outcomes and thus, there has been increasing emphasis to identify integrated treatment approaches that serve to reduce relapse rates and improve overall well-being. The current commentary proposes that combining Seeking Safety, evidence based treatment, with 12 Step recovery can serve to address the needs of a difficult to treat population

A Short Commentary on the Racial Disparities in Parkinson’s Disease

The etiology of Parkinson Disease (PD) remains elusive, but may include environmental and genetic factors leading to neuronal degeneration [1]. The difference in incidence of PD among different racial groups may provide additional insight into the etiology. In 2004, McInerney-Leo et al. reviewed twenty studies analyzing the prevalence and incidence of PD among Caucasians, African-Americans in the United States and African populations [2]. The differences in prevalence of Parkinson’s disease and Parkinsonism could not be demonstrated because of poor designs and numerous biases, such as referral bias and differences in access to healthcare. Therefore, they were unable to determine the effect of race in PD. Yet, studies continue to suggest that there is a significantly higher prevalence of PD among Caucasians compared to other racial groups [3]

WHAT IS IT LIKE TO BE A BEE?

Do bees have feelings? What would that mean? And if they do have feelings, how should we treat them? Do we have a moral obligation towards insects? A short commentary on M. Bateson, S. Desire, S. E. Gartside, and G. A. Wright, ‘Agitated Honeybees Exhibit Pessimistic Cognitive Biases’, Current Biology 21.12 (2011), 1070–3.

An Early Manuscript Witness of the Homiliaries of Angers and St. Père de Chartres in Bamberg, Staatsbibliothek, MS Msc.Bibl.30a

This article introduces the five bifolia of Bamberg, Staatsbibliothek, MS Msc.Bibl.30a, identifying them as the earliest known manuscript witness combining text from the Homiliaries of Angers and St. Père de Chartres, two Carolingian preaching cycles of unknown origin, written in simple Latin. It provides a thorough study of the materiality of the fragments and their provenance as part of a medieval binding, a partial reconstruction of the original collection from which the fragments were taken, a short linguistic commentary, textual evaluation, and diplomatic transcription of the surviving homilies. The evidence presented here offers new information on the origin, composition, and performance of pastoral addresses to the laity in Carolingian Europe. The article also offers novel perspectives on the transmission of these pastoral addresses and encourages the future critical edition of the Homiliary of Angers.

A medieval Irish legal commentary on wakes and funerals from <em>Anfuigell</em> ‘Wrong judgment’

The medieval Irish legal text Anfuigell ‘Wrong judgment’ is extant in seven main fragments found in five different manuscripts now housed in Dublin, London, and Oxford. Although the text itself is not complete, taking into account the accompanying legal commentary and glosses surrounding the text, Anfuigell and its associated legal material amount to one of the largest bodies of legal matter in the entire corpus of attested medieval Irish law. This text has never been edited and lacks a modern translation and, as such, it constitutes a legal mystery box for scholars. Anfuigell treats a variety of legal topics. One of the text's legal commentaries deals with injuries sustained and illnesses contracted at funerals. This particular aspect of the early Irish legal system has never been discussed by scholars. This article presents an edition and translation of the short legal commentary and discusses how the legal precepts illustrated by the commentary fit within and add to our current knowledge of the laws surrounding injuries and illness. The legal material also contributes to our understanding of medieval mourning practices, including some of the activities which took place at funerals and wakes.

Preconditioned Endothelial Progenitor Cells as Biomarker of Vascular Reparation?

The endothelial progenitor cells (EPCs) have defined as cells positively labeled with both hematopoietic stem cells (CD34) and endothelial cell markers predominantly VEGF receptor-2 (VEGFR2) cumulatively. Therefore, there are at least two types of EPCs labelled as early outgrowth EPCs and late outgrowth EPCs probably distinguished their vascular protective ability. Recent animal and clinical studies have shown that reduced number and weak function of EPCs may not only indicate to higher CV risk, but contribute to the impaired heart and vessels reparation. Interestingly, there are some subpopulations of EPCs especially recruited from peripheral blood cells, which may exhibit very variable pro-angiogenic effect and endothelial repair capacity and they are called “preconditioned” EPCs. The aim of the short commentary is depicted the possibilities to use of measurement of traditionally labeled EPCs as biomarker of cardiovascular risk.

Temporary abdominal closure techniques in open abdomen - a word of caution

The present work represent a short commentary of the article of Coccolini et al. “IROA: International Register of Open Abdomen, preliminary results” published recently in the February issue of WJES. We provide for a succinct commentary of their article and make certain useful suggestions.

Z wyciągów archiwalnych województwa łódzkiego: o metrykach parafialnych drugiej połowy XIX i początku XX wieku

Artykuł jest poświęcony opisowi dokumentów zawartych w księgach metrykalnych pochodzących z przełomu XIX/XX wieku z terenów województwa łódzkiego. Do analizowanych tekstów należą akty urodzenia (chrztu), akty ślubu i akty zgonu. Autorka przedstawia krótką historię kształtowania się tych dokumentów w Polsce od XVI wieku, analizuje ich zawartość, specyficzną budowę, oraz zwraca uwagę na ważniejsze zjawiska językowe. Ponadto w artykule zamieszczono przykłady aktów metrykalnych zarówno w języku polskim, jak i w rosyjskim z uwagi na fakt, iż pod zaborem rosyjskim dokumenty te pisane były po rosyjsku od 1868 roku.

Macropores and preferential flow—a love‐hate relationship

AbstractPreferential flow is of high relevance for runoff generation, transport of chemicals and nutrients, and the transit time distribution of water in the soil or watershed. However, preferential flow effects are generally ignored in lumped hydrological models. And even most physically‐based models ignore macropores and preferential flow features at the soil and hillslope scale. Keith Beven was never satisfied with this situation and he tried again and again to convince the scientific community to focus their research on the complex topic of macropore and preferential flow. Although he recognized how difficult it is to correctly include preferential flow in hydrological models, he made substantial progress defining and describing macropore flow and showing its relevance, developing models to simulate preferential flow, and in particular, the interaction between macropores and the soil matrix. In this short commentary, I reflect on these achievements and outline a vision for research in preferential flow experiments and modeling.

Qualitative Researchers, Heal (and Help) Thyself Too

A persistent lament by qualitative organizational researchers is that qualitative research is not published, published enough, cited enough, or valued by industrial–organizational (I-O) psychologists. Pratt and Bonaccio (2016) present convincing data that there has been an increase in the visibility of qualitative studies throughout many organizational research journals, though some of the flagship journals in I-O psychology are less receptive. Also, they present a series of suggestions that largely entail ways that journal editors and nonqualitative researchers can adapt their attitudes and behaviors to help qualitative research have more of an impact. I agree with those suggestions and think that they should be pursued. On the other hand, I was disappointed that none of the suggestions presented by Pratt and Bonaccio offered things that qualitative researchers might do to make their research more impactful to I-O psychologists. For qualitative research to have a bigger impact in the organizational literature, qualitative researchers need to make changes as well. In this short commentary, I propose three things that qualitative researchers might do to improve their impact within the field of I-O psychology.