A poisonous plant is one that, when touched or consumed in large enough quantities, can be hazardous or lethal to humans or other animals. These plants can be utilized as herbal medicines with therapeutic effects when used in the right proportions and in small doses. Many plants are harmful to people when consumed or through skin contact with plant chemicals. Poisonous medicinal herbs are used to treat a variety of illnesses, including diabetes, cancer, infections, and fungal growth. According to the review, numerous phytochemical components that have diuretic, purgative, laxative, anti-allergic, and other significant therapeutic effects have been identified in a variety of medicinal plants. If utilized appropriately, poison can be life-giving, calming to the three Doshas, encouraging, and regenerating. The poisonous plants are categorized as Visha and Upvisha in Ayurvedic texts. Agadtantra is an important branch of Ashtanga Ayurveda. The importance of this branch has been described in our Vedas, Epics, and Samhita. Proper description, classification, clinical features, and management of any kind of Visha have been described in this branch. Some poisonous plants are Dhatura, Bhallataka, Vatsanabha, Bhanga, Vach, Kuchala, and Gunja, etc. The Shodhana process is the only bridge between Visha and Aushadhi. Shodhana is the process by which physical, chemical, and natural impurities are removed. It will intensify the potency and effectiveness of the drug and nullify its toxicity. The aim of this review article is to provide a brief overview of the numerous medicinal uses of some poisonous plants.