Ayurveda is a system of medicines practicing in India anciently. The concepts and belief of ayurveda based on logical reasoning and experimental observations. Ayurveda not only mentioned approaches of disease prevention but also described preventive measure to maintain good health status. The therapeutic measures of ayurveda not only involves use of medicine but also utilizes other approaches such as; Panchakarma. Panchakarma is a Shodhana Chikitsa and approved as vital therapy for the management of various disorders. Panchakarma offer various therapeutic benefits such as; detoxification, improved circulation, relief spasm and pain. The efficacy of Panchakarma also well proven in pain related diseases. This article presented role of Panchakarma in pain W.S.R. to Sciatica, Spondylitis and Osteoarthritis. Keywords: Ayurveda, Panchakarma, Shodhana Chikitsa, Shoola roga, Sciatica.