Hydropower as a part of the family of renewable energy sources represents an engineering and scientific field which inspires researchers to work on development of the systems and sub-systems in a way of optimizing the whole energy transformation process to obtain more efficient, flexible and reliable hydropower operation with the best possible water to energy ratio. This research is part of a Horizon 2020 HydroFlex project by the Norwegian University of Science and Technology (NTNU), where the main goal is development of a flexible hydropower generation. The guide vane cascade is one of the most crucial stationary sub-systems of the hydraulic turbine and is a subject of this study. Its re-design for obtaining a quality “flow-feeding” of a variable speed high head Francis turbine is developed. Having this goal in mind, a MATLAB code was generated, based on several key parameters, such as initial energy conditions as net head and turbine discharge at best efficiency point (BEP). Turbine runner geometrical constraints are taken into account during this process, while using recommendations for some initial guide vane calculations such as their number, inlet and outlet diameter, guide vane axis diameter, delivery angles etc. Using an inverse Euler turbine equation, the operating range of the turbine was calculated for a variable speed and discharge conditions, keeping the shock-free flow for all states at the runner’s inlet, as it is the most favourable inflow condition. For those operating points, the flow streamlines angles were obtained at the guide vanes leading and trailing edges. With an interpolating mathematical functions between the angles of the leading and trailing edges, the camber lines of the hydrofoils were obtained for further guide vane cascade geometry development. This algorithm can be implemented on any given runner geometry. The guide vane design is then exported into ANSYS Workbench for further numerical tests, such as CFD simulations for verifying the hydrodynamic characteristics and FEM analysis for verifying the structural integrity of this sub-system for variable speed operating conditions.