Introduction. The positive effect of physical activity on the state of bone has been proven by many researchers. Professional sports activity is a model of the constant impact of physical activity on the human body, acting as the most powerful mechanism for activating and mobilizing the functional reserves of an athlete, which, against the background of a progressive increase in the volume, intensity and duration of exposure, shows an increase in the incidence of injuries and stress fractures, one of the leading causes of which is a decrease in bone mineral density (BMD) up to the development of osteoporosis. The risk factors for the development of the pathology of the musculoskeletal system, which have a direct impact on the formation of the BMD, in elite sports include the volume and intensity of training loads, the stereotype of the main competitive exercise, the daily balance of energy intake.The aim is to study is to analyze modern scientific publications on the impact of professional sports activities on bone mineral density.Materials and methods. The review is based on publications from the PubMed, Google Scholar, Cyberleninka, eLIBRARY databases. Preference was given to articles published in refereed sources over the past 10 years.Results. The specificity of the main competitive exercise determines the presence of asymmetry in the distribution of the BMD in athletes, in addition, the level of BMD is higher in the leading limb compared to the opposite. Increasing the qualifications, experience and age of an athlete shows a positive impact on the performance of the BMD, with the exception of certain specializations. A different effect of sports with a high osteogenic effect of shock and weight load on the state of the BMD was noted compared to the general population. Power athletes, combat and game sports athletes have higher levels BMD compared to representatives of cycling, swimming, rowing, triathlon and long-distance running, characterized by the limitation of gravitational (shock) load or a large amount of low-intensity training exposure. Lower BMD were noted in athletes in sports specializations with weight categories, aesthetic and cyclic sports, where the problem of a relative energy deficiency in sport, which negatively affects bone metabolism.Conclusions. In athletes, the volume and intensity of training loads, the stereotype of performing the main competitive exercise, the daily balance of energy intake have a direct impact on the formation of the BMD with the allocation of risk groups for the pathology of the musculoskeletal system in elite sports.