Well-cuttings, wireline logs and limited core and outcrop data were used to generate a regional, three-dimensional sequence framework for Upper Mississippian (Chesterian), Greenbrier Group carbonates in the Appalachian foreland basin, West Virginia, USA. The resulting maps were used to document the stratigraphic response of the basin to tectonics and to glacio-eustasy during the transition into ice-house conditions. The ramp facies include inner ramp red beds and aeolianites, lagoonal muddy carbonates, mid-ramp ooid and skeletal grainstone shoal complexes, and outer ramp wackestone–mudstone, that grades downslope into laminated silty lime mudstone. The facies make up fourth-order sequences, a few metres to over 90 m (300 ft) thick. The sequences are bounded along the ramp margin by lowstand sandstones and calcareous siltstones. On the ramp, sequence boundaries are overlain by thin transgressive siliciclastics and aeolianites, and only a few are calichified. Maximum flooding surfaces on the outer ramp lie beneath deeper water facies that overlie lowstand to transgressive siliciclastic or carbonate units. On the shallow ramp, maximum flooding surfaces overlie siliciclastic-prone transgressive systems tracts, that are overlain by highstand carbonates with significant grainstone units interlayered with lagoonal lime mudstones. The fourth-order sequences are the major mappable subsurface units; they are bundled into weak composite sequences which are bounded by red beds. In spite of differential subsidence rates across the foreland basin (1 to 3 cm/k.y. up to 25 cm/k.y.), eustatic sea-level changes controlled regional sequence development. Thrust-load induced differential subsidence of fault-blocks, coupled with in-plane stress, controlled the rapid basinward thickening of the depositional wedge, whose thickness and facies were influenced by subtle structures such as arches trending at high angles as well as parallel to the margin.