CFD simulations are conducted for zero-speed damaged passenger ship SSRC in calm water and waves with 6DOF motions including flooding procedure in calm water, roll decay in calm water and motions in regular beam waves for various wavelengths. The simulations model the 6DOF soft spring experimental mount, the one- and two-room flooding compartment configurations, including both intact and damaged conditions. For flooding and roll decay, simulations show ability to predict the trend of increases in roll period and damping due to flooding, as reported in ITTC. The damping magnitudes were often under-predicted with large errors while the roll period and compartment water height were well predicted. Two-room compartment simulation showed three times larger damping than one-room compartment cases whereas the roll period was similar for both conditions. For wave cases, all motions show primarily 1st order responses, except for parametric roll condition which shows large ½ harmonic responses for the intact ship. The 2nd order responses are small for both damaged and intact ship. The larger roll period and damping for the damaged ship shift the peak of responses to smaller wave frequency and reduce the amplitude of responses. The average error is often large for 1st order intact ship pitch and damaged ship surge and pitch. The errors are larger for most ½ and 2nd order responses. Large errors could be partially due to the complex mounting system in the experiment. Overall, current CFD results show better predictions than those reported for potential flow solvers even though the computational cost is larger.