Τhe ventilation in the ship engine rooms is an essential issue concerning finest performance of engines and diesel generators as well as electric motors. The present study has aimed at the analysis of temperature distribution inside the ship main engine room. In the same way, attempts have been made to identify those points with considerable thermal concentration in main engine room space, so that proper ventilation systems could be engineered and utilized and favorable thermal conditions could be realized. The CFD approach has been utilized in order to analyze impact of the designed ventilation system on the temperature distribution pattern. The Inlet layout and area have been analyzed under a variety of scenarios in order to decrease the average temperature and eliminate the heat concentrations in various points of the engine room. The temperature distribution and location and area of ventilation air inlet have been studied in different modes resulted in temperature distribution pattern, heat concentration outline and average volumetric temperature level in each mode. The results indicated that considerable circulating air volume is required compared to those levels suggested by common practices, calculations and standards in order to eliminate the heat concentration.