The flooding process of a damaged ship is very complicated and it closely relates to the ship survivability and life security. Therefore, it is very necessary to master the process of water flooding and its influencing factors. There are many approaches for the studies, such as the static one, the quasi-static one, and the full-time domain one, etc. In this paper, the Smoothed Particle Hydrodynamics (SPH) method combined with the strip theory is used to study the flooding process of a damaged ship cabin in full-time domain and three kinds of cabins are studied. The displacement, velocity, and rolling angle of the cabin during the process are compared and analyzed. Firstly, the flooding processes of damaged cabins with different opening positions, and opening sizes are simulated and the responses of the damaged cabins to the flooding hydrodynamics are obtained. Then, the effects of the barriers in the cabin on the flooding process are studied. Some reasonable suggestions are put forward to provide references for the anti-sinking design of ships.