To explore the relationship between patient safety management and each aspect of nurses' workload and to report the moderating effects of the perceived importance of patient safety management on these relationships. As the importance of patient safety is emphasized, nurses' work demands, including patient identification, infection control, and prevention of falls and pressure ulcers, are increasing. However, differences according to hospital type and nurses' increased workload have not been considered when measuring nurses' workload. This study used a cross-sectional research design and an online survey, adhering to the STROBE reporting guidelines. The study population consisted of 215 shift-work nurses employed in tertiary or general hospitals in Korea. Data were collected in January 2024. Patient safety management activities had a positive effect on the pace and amount of work, emotional workload, and mental workload, and a negative effect on work organization (interruption). The perceived importance of patient safety management negatively moderated the effects of perceived patient safety management activities on emotional workload and work organization. This study clarifies the relationship between patient safety activities and each aspect of nurses' workload. The additional demands on nurses due to patient safety management activities should be considered when measuring their workloads and determining adequate nurse staffing levels. To manage the burden of nurses' work demands effectively, it is essential to maintain adequate staffing levels and continuously monitor the patient safety climate. This approach will increase nurses' perception of the importance of patient safety management. Continuous education on patient safety should also be provided.
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