Shifts In Trends Research Articles

The Critical Role of Folate in Prenatal Health and a Proposed Shift from Folic Acid to 5-Methyltetrahydrofolate Supplementation

Folate, or vitamin B9, is a water-soluble vitamin essential in periconceptional nutrition. In its active form, tetrahydrofolate, it plays a vital role in DNA methylation and homocysteine breakdown. Maintenance of normal serum folate levels is crucial during pregnancy; deviation from these levels, either in dearth or excess, can lead to various pregnancy and infant complications. This article analyzes existing literature on folate’s absorption pathway in human physiology and reviews the evidence surrounding prenatal supplementation guidelines for folic acid. Prior research supports these guidelines because, in the absence of folate during pregnancy, research has shown an increased incidence of neurodevelopmental defects, food allergies, ophthalmic deficits, and other adverse effects for both mother and child. This significant body of evidence has driven most developed countries to implement folic acid supplementation initiatives, with the World Health Organization recommending a daily 400-µg folic acid supplementation for periconceptional women. As progress continues on a global scale, further efforts should be made to improve folic acid levels in pregnant populations among demographic subgroups. Research supports the use of 5-methyltetrahydrofolate in place of traditional folic acid prenatal supplements based on the increased bioavailability, resistance to genetic polymorphisms, and avoidance of several potential risks associated with folic acid supplements. More research and product development should be done to drive and support this shift in prenatal supplementation trends.

Analysis of Growth Trends, Regional Variations and Productivity Metrics of Apple Cultivation in Himachal Pradesh, India

India has seen a spatial escalation on apple growth and it fostered the country’s economy and employment opportunities of the apple growing states. States of Jammu & Kashmir, Himachal Pradesh, Uttarakhand and Arunachal Pradesh are primarily known for apple production. Therefore, we worked on the secondary data on apple growth trends, its production from the different sources and analyzed it through growth rate, decomposition analysis and instability index techniques to quantify the production metrics and trend shift. Our findings reported that between1973–1974 to 2021–2022, there was an increase found in the global area, productivity and production of apples in Asia and India. The output of apples worldwide has found to be escalated at a compound annual growth rate of 2.51%, whereas, India has experienced a notable rise of 3.40 percent annually. The majority of the apple's area, output and productivity came from the Asian region, with growth rates of 3.38, 5.97, and 2.59 %, respectively. Furthermore, Worldwide scenario on apple cultivation reported that Poland had the highest relative instability in apple productivity (21.44%), followed by India (15.96%), China (12.53%), Turkey (11.18%) and USA (8.61%). Area yield effect was used to explain the rise in apple output in Asia, however, area expansion was found as the primary cause of increase in area under apple production. In Himachal Pradesh, Zone III has the greatest average yearly productivity (4.78%), followed by Zone II (3.35 %) and Zone IV (0.57%). In zones III and IV, the expansion of area (96.93%) and yields (85.13%) was the reason for the increase in apple production, however, in zone II, the yield effect (102.05%) was the only cause found for the increase in apple’s production.

Trend shift in proximal humeral fracture treatment: a detailed review of national shoulder arthroplasty data.

This study aimed to scrutinize nationwide utilization trends of shoulder arthroplasty for proximal humerus fractures (PHFs) using a comprehensive national surgical database. A retrospective study was conducted with 4181 patients who underwent shoulder arthroplasty due to PHF between 2016 and 2022 using national health records. They are grouped as hemiarthroplasty (HA), anatomical total shoulder arthroplasty (TSA), and reverse shoulder arthroplasty (RSA). The patients' demographic data, length of hospital stay, revision histories, transfusion rates, mortality data, trends in arthroplasty methods over the years, the distribution of cases by hospital characteristics and geographical regions were analyzed. Treatment with HA was administered to 22.1% of patients, TSA to 30.2%, and RSA to 47.7%. The lowest revision rate was observed after HA (4.3%), while higher rates were recorded after TSA (7.9%) and RSA (7.4%) (p = 0.019). It was observed that there was a significant increasing trend in RSA rates and a decreasing trend in HA and TSA rates over time (p < 0.001). From 2016 to 2022, there appears to have been a significant increase in the utilization of RSA for the arthroplasty treatment of proximal humeral fractures in Türkiye, and it is used more frequently than HA. However, revision rates after RSA are still higher than those after HA. Level III, retrospective cohort study.

Innovative Marketing Strategies in the Competitive Economic Environment in Sustainable Development Goals (SDGs): A Case Study of Top Glove Manufacturers in Malaysia

Objective: The aim is to identify the key marketing strategies implemented by the manufacturers to achieve growth and sustainable development goals (SDGs) market leadership by glove-producing companies in Malaysia in the highly competitive global marketplace. Theoretical Framework: This paper contributes to the existing literature on the marketing strategies practiced in the manufacturing industries, mainly focusing on the glove manufacturing industry in Malaysia, which ranks as the global supplier of hand gloves in the industrial and medical categories. Taken in total, this work provides a refined appreciation of marketing and innovation’s relationship within a particular sector, and it does so by examining how those Malaysian glove makers who contest global markets leverage creativity in their marketing strategies in response to supply chain interruptions, approving bodies, and shifts in international buying trends. Methodology: Following a case study approach, this study focuses on large glove manufacturers in Malaysia; Top Glove is a crucial player. Hence, secondary sources will be adopted during the data collection stage. Perceptual data is also gathered from workers of key executives, marketing managers, and other industry professionals, which gives a picture of these business entities' marketing campaigns and strategic decision-making procedures. Industry journals, company reports, and market study papers validate secondary data. Results and Discussion: This study reveals that policymakers, manufacturing businesses, and marketing scholars can learn about the necessity of niche-based policies and friendly legal environments to boost innovation and competitiveness within manufacturing industries. It provides recommendations on creating a favorable climate for employing innovative marketing strategies and the possible enlargement of home-based businesses internationally. Originality/Value: Based on the findings and insights gathered from the research on innovative marketing strategies in the competitive global economic environment, particularly focusing on the case study of top glove manufacturers in Malaysia, several recommendations can be proposed to guide businesses in enhancing their marketing approaches and organizational performance

Tourism digital marketing in Indonesia: Current issues, challenges and opportunities

Purpose of the study: Marketing strategies must evolve with shifts in customer trends, behavior, and technological advancements. Academically, marketing has long been a key area of interest for scholars. This study systematically analyzes research references on tourism marketing in Indonesia. Methodology: This analysis draws on national publication data featuring tourism marketing keywords from 2014 to 2024, obtained via web scraping from the Google Scholar database. Additionally, it seeks to identify key concerns, challenges, and opportunities for digital marketing within Indonesia's tourism sector. Main Findings: This review highlights that academic journals cover diverse aspects of tourism marketing, including tourism, social sciences, communication management, and technology. Despite its limited scale, digital marketing is widely explored by scholars across fields. Bali, Bantul, Sleman, and Yogyakarta are frequently studied locations. Indonesian tourism marketing research tends to adopt qualitative approaches, yet a broad spectrum of contexts such as economics, business, communication, entrepreneurship, sociology, anthropology, and creative industries is also examined. Applications of the study: This study's scope is limited by the narrow range of Google Scholar articles. Future research can expand the literature, with key findings serving as hypotheses for further studies. Policymakers and the digital industry can use these insights for tourism product development. It also represents one of the latest ten-year reviews of digital marketing literature in Indonesia. Novelty/Originality of the study: Tourism must use effective marketing and adapt to changing market behaviors. Collaboration among stakeholders, including academics, is key to seizing opportunities and tackling future challenges.

Economic Openness and the Behaviour of Great Ratios in G20 Countries

Most of the macroeconomic models suggest that great ratios of economics should be stable in the long term. Keeping the theoretical consequences in mind, the present study investigates the order of integration of two great ratios, viz. consumption–output and investment–output ratios. The study employs both mean shift and trend shift unit root tests with a structural break to examine the stationarity property of great ratios. This article attempts to analyse the relationship between economic openness and the behaviour of great ratios. Results of the study indicate a balanced growth path for 10 out of 18 G20 countries considered in our analysis. Findings show that countries that have a deficit trade balance with surplus foreign direct investment are more likely to demonstrate a balanced growth path. The multivariate analysis shows evidence in support of the balanced growth hypothesis in 13 of the 18 G20 countries. Of the 18 countries analysed, 8 internationally open and 6 financially open countries provide support for the balanced growth path. JEL: C20, E20, O50

A Chart Review for Epidemiology and Outcome of Fungal Bloodstream Infections Among Neonates in a Tertiary Care Hospital at North India

Background and Aims The risk of fungal bloodstream infection (BSI) and accompanying mortality in neonates varies widely in between centres depending on the region, the population characteristics and the risk factors. Methods This chart review of neonatal cases with fungal BSI admitted in a tertiary care teaching hospital in North India aimed to comprehensively investigate the epidemiology, profile of fungal species (and their susceptibility to various antifungal agents), risk factors, clinical profile and outcomes in these neonates. The study spanned over a one-year period, from September 2022 to August 2023, included all symptomatic neonates with positive blood cultures for fungal pathogen. Results Over one year, 24 out of 1,174 neonates at risk were diagnosed with fungal BSI, with a cumulative risk of 2.0 per 100 neonates. A peak in cases occurred in February. Candida pelliculosa was the predominant species (75% of isolates), while Candida albicans constituted 4.2%. Most isolates were sensitive to fluconazole, except for some fluconazole-resistant Candida pelliculosa (5.5%) and Candida tropicalis (25.0%), which remained susceptible to amphotericin-B and voriconazole. Around 60% of neonates were preterm, 40% had very low birth weight and 37% were small for gestational age. Nearly all had received prior broad-spectrum antibiotics, with 92% receiving prolonged courses over five days. Respiratory support, including intubation and mechanical ventilation, was used in 83% before onset of fungal sepsis. Intriguingly, all neonates had some invasive device in place for more than seven days. Mortality rate of 25% was observed, with preterm birth and gastrointestinal anomalies contributing to adverse outcomes. Conclusions This study confirms the ongoing shift in trend from albicans to non-albicans Candida infections in our region as well. A seasonal peak of fungal sepsis noted in the month of February hinted at potential seasonal variation or lapses in infection control practices during colder months. The analysis of trends in fungal BSI might hold a significance within neonatal intensive care units (NICUs) for the prompt detection of outbreaks. Simultaneously, understanding and analysing risk factors associated with fungal BSI are essential for targeted prevention.

Real world feasibility of patient-based real time quality control (PBRTQC) using five analytes in a South African laboratory

BackgroundPatient-based real-time quality control (PBRTQC) identifies possible bias in methods by utilising shifts in trend of statistical measures in laboratory results. In this study we aimed to compare and optimize various PBRTQC procedures for serum alanine aminotransferase, albumin, calcium, ferritin and sodium. MethodsIn a bias simulation study, we added artificial bias to intervals of patient data and then evaluated the efficiency with which various PBRTQC procedures were able to detect this bias. PBRTQC procedures used included block size, moving statistic calculation, control limits as well as truncation limits. The number of patients till error detection, the false alarm rate as well as validation charts were utilised to select the optimal PBRTQC procedure for each analyte. ResultsThe optimal PBRTQC procedures identified for each analyte were: ALT − MA T0 50 MaxMin; Albumin − MA T5 100 Perc; Calcium − MM T5 50 Perc; Ferritin − MA T0 100 MaxMin; and Sodium − MA T5 75 MaxMin. (T, Truncation limits; Control limits- MA, Moving Average, MM, Moving median; Perc, percentile) ConclusionsThe use of large, real patient datasets allows for the reliable determination of laboratory-specific PBRTQC procedures. This study demonstrates that the moving average calculation excels in both normal and transformed analyte distributions. Whilst, the benefits of PBRTQC procedures are proven, the complex and time-consuming optimisation process may be a barrier to the rapid implementation in under-resourced countries.

Paleoenvironmental characterization and historical trends of polycyclic aromatic hydrocarbons (PAHs) of Nutrias Lagoon, Uruguay

Concentrations of polycyclic aromatic hydrocarbons were assessed in a sediment core retrieved from Nutrias Lagoon, located within the Rocha Lagoon Protected Area along the SE Uruguayan coast. Using a 210Pb chronology, we reconstructed the historical accumulation of polycyclic aromatic hydrocarbons over the past 123 years (1895-2018). This study, the first of its kind in Uruguay, fills a research gap in understanding historical PAH accumulation and source changes. Our examination of dating, geochemical, and sedimentological data unveiled four main events, with minor instances in 1956±5 and 1964±4, and more significant occurrences in 1914±9 and 1997±2. Additionally, two prominent trend shifts were identified, one predating 1900 and the other in 1986±2. Before 1900, a dry spell was apparent, supported by all proxies, alongside a notable surge in heavy polycyclic aromatic hydrocarbons, likely attributed to fires during this arid period. Post-1986±2, a rise in sedimentation rates in the lagoon was observed, possibly due to increased rainfall. Also, the eutrophication of the lagoon over the years can be observed. Furthermore, a recent increase in polycyclic aromatic hydrocarbons influx at the core's surface was linked to the construction of a nearby lagoon bridge and associated roadwork. Our findings suggest that atmospheric deposition constitutes the primary source of polycyclic aromatic hydrocarbons in the lagoon, offering insights into its recent environmental history and basin dynamics. This study establishes a critical baseline for future research in the region and facilitates the development of effective and sustainable environmental management strategies.

Overcoming the Learning Curve in Robot-Assisted Spinal Surgery—How Does It Compare to O-Arm Navigation?

Background: Robotic systems have the potential to significantly enhance the accuracy and outcomes of spinal surgery. Adopting this new technology requires an examination of its learning curve and influencing factors. This study analyzes the learning curve associated with using the Mazor X Stealth Edition system for pedicle screw placement and performs a matched-pair analysis to compare operative durations between robot-assisted and navigation-based surgeries, evaluating the efficiency of the robotic system. Methods: We collected retrospective operative data from patients who underwent robot-assisted pedicle screw placements between December 2020 and June 2024 and conducted a cumulative sum (CuSUM) analysis to assess the learning curve, focusing on the robotic system’s setup duration. Additionally, we compared a group of patients who underwent robot-assisted pedicle screw placements with a pair-matched group who underwent O-arm-based navigation-assisted pedicle screw placements. Results: There was a notable decrease in the robotic setup duration, with a significant shift in trend observed after the first 20 cases. While the initial setup time was 24 minutes, it reduced to 17 minutes in later cases, reflecting a marked improvement in efficiency as the surgeon gained more experience with the robot. Conclusion: Our findings indicate there were no added difficulties using the robotic system compared to the navigation system. Moreover, the learning curve for the robotic system can be quickly surmounted, and it offers clear advantages over previous systems, making it a valuable tool for pedicle screw application.

Social media and health care: a cross-sectional analysis of X (Twitter) posts using the NodeXL platform

Introduction. The landscape of healthcare and medical education is rapidly evolving, driven by the popularity of social media platforms like Facebook, WeChat, and X (Twitter). These platforms have transformed healthcare communication, enabling trainees, medical students, and practitioners to enhance learning and clinical practice. Educators leverage social media to simplify complex medical concepts, fostering continuous learning and professional development. Despite their benefits, social media, notably X (Twitter), boasting over 186 million active users, are susceptible to misinformation, underscoring the importance of verifying data accuracy and identifying influential medical sources. This study aims to identify the most influential sources of health information through X (Twitter) analysis using the NodeXL tool. Methods. Employing a cross-sectional design, this study utilized the NodeXL platform for social media analysis. NodeXL facilitated the identification of prevalent topics in public health discussions on X (Twitter). Influencers, users, and prominent healthcare providers were categorized to assess the credibility of their information. Data collection extended up to March 1, 2024. Results. Analysis revealed that the #hospital hashtag garnered the highest number of tweets among popular healthcare hashtags (6,438 tweets, with 84% being unique). Conversely, #medicalcare and #medicine had the lowest citation counts (58 and 116 respectively). @MahaHealthIE emerged as the most famous account using the #healthservices hashtag. Notable influencers with the #hospital hashtag included YouTube, Narendra Modi, and Al Jazeera English. @GreenSwelfares led in using the #medicalcare hashtag, while YouTube and the World Health Organization (@WHO) were prominent among accounts using #medicine. Conclusion. This study underscores the significance of monitoring social media and tracking key influencers periodically. However, the study's limitation lies in its snapshot nature, failing to capture the dynamic shifts in influencer popularity trends over time.

Shifts in communicable disease trends since the COVID-19 pandemic: a descriptive analysis using Singapore data.

Shifts in communicable disease trends since the COVID-19 pandemic: a descriptive analysis using Singapore data.

Role of Non-Invasive Hemodynamic Forces through Four-Dimensional-Flow Magnetic Resonance Imaging (4D-Flow MRI) in Evaluating Mitral Regurgitation with Preserved Ejection Fraction: Seeking Novel Biomarkers

Mitral regurgitation (MR) is the systolic retrograde flow from the left ventricle (LV) to the left atrium. Despite the recognized importance of hemodynamic force (HDF) in cardiology, its exploration in MR has been limited. Therefore, we aimed to explore non-invasively assessed HDF as a novel biomarker for evaluating MR utilizing 4D-flow MRI. The study cohort comprised 15 healthy controls (19–61 years, 53% men) and 26 MR patients with preserved ejection fraction (EF) (33–75 years, trivial–severe, 54% men). The HDF analysis involved the semi-automatic calculation of systolic–diastolic root mean square (RMS), average, and transverse/longitudinal ratio across three directions (S-L: septal–lateral, I-A: inferior–anterior, and B-A: basal–apical) using Segment, v2.2 R6410 (Lund, Sweden, Medviso). A noticeable trend shift emerged in HDF as the MR severity increased (p-value &lt; 0.05). The MR severity demonstrated a noteworthy correlation with systolic RMS B-A, average B-A, diastolic average B-A, systolic average S-L, B-A, and systolic–diastolic ratio (rho = 0.621, 0.457, 0.317, 0.318, 0.555, −0.543, −0.35, respectively; p-value &lt; 0.05). HDF significantly correlated with LV function (end-diastolic volume, end-systolic volume, EF, and mass; p-value &lt; 0.05). Systolic RMS B-A and diastolic RMS S-L emerged as significant predictors of MR (Beta, 95% CI [3.253, 1.204–5.301], [5.413, 0.227–10.6], p-value &lt; 0.05). This study emphasizes HDF as a potential hemodynamic biomarker for evaluating MR.

ELT in Nepal: Changing Teacher's Role in the Present Context

This reflective paper highlights English Language Teaching (ELT) practices in Nepal, focusing on various context and dilemmas such as choosing between monolingual or multilingual approaches, using local versus international materials, and selecting authentic versus inauthentic sources. It also examines the use of textbooks written by native or non-native writers and addressed obstacles and coping strategies involved. Additionally, the reflection discusses the major roles of English teachers in Nepal as a teacher, a researcher and a practitioner. ELT in Nepal has gone significant changes mirroring global shifts in ELT trends and practices. These changes include evolving attitude towards ELT, shifting goals of ELT, new teaching methods, updated curriculum design, revised teaching content and assessment, changes in medium of instruction, changing roles of teachers. Despite some ongoing confusions, ELT movement is progressing smoothly. This reflection is based on a review of relevant articles on ELT in Nepal and my personal experience as an EFL teacher in Nepal for more than18 years.

The Emergence and Transformation of the Lithium-ion Battery Industry in Shenzhen

This paper has charted the dynamic evolution of Shenzhen's lithium-ion battery (LiB) industry through four distinctive stages, thereby elucidating the complex interplay between industrial growth, policy interventions, and technological advancements. The framework illustrated not only the vital role of resource pool at each stage of the LiB industry's evolution but also underscored how shifts in industry trends reciprocally influenced the structure of resource pool. In the first stage, the nascent LiB in Shenzhen was driven by local companies, operating on a traditional manufacturing model based on public knowledge. It benefited from the urban development advantages of Shenzhen, including its strategic location, industrial structure, and supportive government policies, setting the stage for subsequent evolution. The second stage marked the formation of a comprehensive industry chain, encompassing both upstream and downstream sectors, driven by the increasing demand for LiBs and the proliferation of consumer electronics manufacturing in Shenzhen. The expansion was not just in capacity but also in the scope, fostering a more interconnected and resilient industry ecosystem. The third stage witnessed a strategic shift from low value-added consumer electronic batteries to high value-added power batteries, propelled by national policy guidance and increased R&amp;D investments. This shift was crucial in transitioning from conventional consumer electronics batteries to more sophisticated and lucrative energy solutions for automotive and industrial uses. The current stage, the fourth, is characterized by continuous innovation, talent development, and an emphasis on synergistic innovation between universities and enterprises. The establishment of intermediary organizations helped to promote the integration of resources and standardized division of labour within the innovation ecosystem. Throughout these stages, Shenzhen's LiB industry has navigated through varying challenges and opportunities, demonstrating remarkable adaptability and resilience. The LiB industry has continually responded to changes in the resource pool, adjusting interaction mechanisms to catalyse growth and innovation. Meanwhile, transformations in the industry have informed resource pool establishments, creating a dynamic feedback loop.

Heart disease and heart failure: Trends and disparities in mortality rates in the United States from 2000 to 2020

Study objectiveTo describe the age, sex and racial disparities in mortality rates for heart disease (HD) and heart failure (HF) in the United States (US) between 2000 and 2020. DesignThis was an ecological study with trend analysis of mortality rates. SettingUnited States. ParticipantsAdults aged 18 years and above. Main outcomes measuresMortality rates per 100,000 for HD and HF. ResultsThere was a significant decrease in the age-standardized mortality rate for HD over the past two decades (from 343.5 per 100,000 cases to 215.1 per 100,000 cases, p < 0.001). HD mortality rates were significantly higher in males (p < 0.001), non-Hispanic blacks (p < 0.001) and in adults aged 65+ (p < 0.001) and 75+ (p < 0.001). There was no significant change in the age-standardized mortality rate for HF (from 26.9 per 100,000 cases to 25.7 per 100,000 cases (p = 0.706)) due to a reversal in the trend beyond 2011. Though the HF mortality rates were significantly lower in males (p = 0.001), and not significantly different in non-Hispanic blacks and non-Hispanic whites, there were shifts in trends beyond 2016, with higher rates in males and in non-Hispanic blacks compared to non-Hispanic whites. ConclusionsIn summary, this study underscores significant reductions in heart disease mortality rates over the past two decades, alongside persistent disparities among different demographic groups. It also highlights emerging trends in heart failure mortality rates in particular population subgroups in recent years, necessitating further exploration to inform targeted interventions and policies.

Spatiotemporal variability and trends of intra-seasonal rainfall and temperature in the drought-prone districts of Northwestern Ethiopia

Agriculture in Ethiopia is highly dictated by spatial patterns and temporal distributions of climate variables. The analysis of these climate variables is crucial for understanding the impacts on agricultural productivity. This study aimed to analyze spatiotemporal variability and trends of intra-seasonal rainfall and temperature using site-specific daily data from the Ethiopian Meteorology Institute (1992–2021). Standardized methods explore variability, while Mann–Kendall tests identify trends, using the Modified version for data with autocorrelation. Inverse Distance Weighted interpolation was employed for spatial analysis of rainfall, length of growing season, and temperature. The findings identified that Kiremt dominated the mono-modal rainfall pattern, contributing 72%-86% of total annual rainfall. The study found that the season typically begins early on June 13 in Adiszemen, and July 6 in Arbgebiya and ends between October 6 and October 26. The duration of the season varied across locations, averaging 95 days at Ebenat and 148 days at Adiszemen. The seasonal rainfall anomaly index shows identical patterns between ENSO episodes and seasonal rainfall. These findings inform decision-making and adaptation strategies for ENSO-driven rainfall variability. Temperatures showed predictable seasonal patterns, but have significantly increased over time, with maximum and minimum temperatures rising 0.014 °C to 0.421 °C and 0.027 °C to 0.485 °C per year respectively. This warming trend is negatively impacting water, crops, and livestock, requiring adaptation measures to build regional resilience. This study underscores the critical impact of climate variability on agriculture in the study area. The findings reveal shifts in rainfall patterns and temperature trends, providing essential insights for adapting agricultural practices.

1123P Melanoma incidence and mortality decline in younger adults in Sweden: Start of a shift in the upgoing trend?

1123P Melanoma incidence and mortality decline in younger adults in Sweden: Start of a shift in the upgoing trend?

Mortality in the United States - Provisional Data, 2023.

Final annual mortality data from the National Vital Statistics System for a given year are typically released 11 months after the end of the calendar year. Provisional data, which are based on preliminary death certificate data, provide an early estimate of deaths before the release of final data. In 2023, a provisional total of 3,090,582 deaths occurred in the United States. The age-adjusted death rate per 100,000 population was 884.2 among males and 632.8 among females; the overall rate, 750.4, was 6.1% lower than in 2022 (798.8). The overall rate decreased for all age groups. Overall age-adjusted death rates in 2023 were lowest among non-Hispanic multiracial (352.1) and highest among non-Hispanic Black or African American persons (924.3). The leading causes of death were heart disease, cancer, and unintentional injury. The number of deaths from COVID-19 (76,446) was 68.9% lower than in 2022 (245,614). Provisional death estimates provide an early signal about shifts in mortality trends. Timely and actionable data can guide public health policies and interventions for populations experiencing higher mortality.

Laryngeal cancer relative survival trends from 1972 to 2021 in the Nordic countries.

Changes in treatment approaches, characterised by the shift from laryngectomy to a focus on organ-preserving methods may have potentially resulted in lower survival. We aim to identify differences in survival trends for laryngeal cancer (LC) in the Nordic countries over a period of 50 years, and discuss the potential impact of factors such as changes in treatment protocols. Five-year relative survival (RS) data from 1972 to 2021 were obtained from the NORDCAN database 2.0 which included 33,692 LC cases, of which 85% were diagnosed among men. In the NORDCAN database, the age-standardised RS is calculated using the Pohar Perme estimator with individual International Cancer Survival Standards weights. Joinpoint regression models were used to assess potential shifts in trend over the years in RS. While Denmark and Norway demonstrated an increasing trend in 5-year RS from 1972 to 2021, in Finland and Sweden, the 5-year RS among men remained static, without any discernible significant trend. Over the 30-year period from 1992-1996 to 2017-2021, RS improved by 9, 4, 13, and 2 percentage points in Denmark, Finland, Norway, and Sweden, respectively. Among women in Sweden, a linear negative trend was observed, noticeable as a 16 percentage-point decline in 5-year RS from the earliest to the latest period. The underlying causes for the differences in survival trends remain unclear. Besides differences in treatment protocols, several other factors can affect RS making the interpretation of RS trends challenging.