Shift In Perspective Research Articles

1 - Soft Power Diplomacy

For decades, and despite sanctions and turbulent relations with major international actors since the 1960s, Cuba has managed to assert itself in the international system. A small island with very limited natural resources, Cuba leveraged its international affairs on its provision of healthcare. This article investigates the role and impact of Cuban medical assistance in Africa. It proceeds from the premise that soft power has useful explanatory value in understanding the Cuba–Africa diplomatic intercourse. The article argues that despite its political ideology and limited political freedoms, Cuba established itself as a model and prominent player in the unique and consistent provision of healthcare and humanitarian assistance to the African continent, and in the development of Africa’s healthcare systems, for more than sixty years. It has also offered community-based healthcare training, which most African countries consider to be more relevant and cost-effective than hospital-based training. Furthermore, the Cuban training gave African medical students a shift in perspective and orientation to focus on public service, not profit-making.

How the dark genome enlightens the molecular mechanisms of diseases

How the dark genome enlightens the molecular mechanisms of diseases In this article, Antoinette van Ouwerkerk and Salvatore Spicuglia from INSERM highlight the significance of regulatory variants within the non-coding genome – often referred to as the ‘dark genome’ – in influencing gene expression and disease. The major genetic cause of human disease has historically been thought to be mutations within coding genes. However, there has been a shift in perspective over recent years, with more attention now being paid to the role of the non-coding regions in the genome. Intense research in this area has revealed that the non-coding genome contributes to gene-regulatory networks that serve to control where and when sets of genes are expressed. In turn, dysregulation of gene expression due to changes or alterations in the non-coding genome drastically impacts the aetiology of different diseases.

The Impact of COVID-19 Vaccine Controversy on Parents' Perceptions of Routine Vaccinations.

Background The COVID-19 pandemic has significantly influenced public perceptions and behaviors related to vaccination. Understanding parental attitudes, knowledge gaps, and vaccination practices post-pandemic is crucial for informing effective public health strategies. This study aimed to investigate parental attitudes, knowledge, and practices toward routine childhood vaccination in the post-COVID-19 era, emphasizing shifts in perspectives and implications for vaccination strategies. Methodology A cross-sectional survey was conducted among 498 parents to assess their attitudes, knowledge, and practices regarding vaccination. Data were analyzed using descriptive statistics, chi-square tests, and t-tests where applicable, with p-values <0.05 considered statistically significant. Results The study revealed diverse parental attitudes toward vaccination post-COVID-19. While a majority (72.9%) maintained positive attitudes toward vaccination schedules and benefits, concerns regarding vaccine safety and efficacy were noted. Knowledge gaps persisted, with 16.5% strongly agreeing that children's vaccinations are weak and have no impact on disease prevention. Despite high adherence to vaccination schedules (68.9%), motivations behind vaccine administration were questioned, as 48.2% strongly disagreed that vaccination was solely for regulatory purposes. Conclusions Post-COVID-19, parental attitudes toward vaccination have evolved, reflecting increased concerns about safety and efficacy. Addressing knowledge gaps, combating misinformation, and enhancing trust in vaccination programs are imperative. Tailored communication strategies, education campaigns, and policy interventions are essential to promote vaccination acceptance and safeguard public health resilience in the post-pandemic era.

“I Quit”

Abstract This article examines concussion in 1990s wrestling, specifically during the World Wrestling Federation's (WWF) “Attitude Era,” an epoch marked by intense physicality and boundary-pushing narratives. Conventional discourse about concussion in sports typically centers on the inherent risks and regulations associated with athletic competition. However, to truly comprehend the nature and frequency of concussions in the Attitude Era, it is imperative to consider wrestling, especially in the WWF context, as primarily an entertainment medium rather than a conventional sporting endeavor. This perspective shift necessitates an exploration into the production pressures, viewer expectations, and dramatic storytelling that often overshadowed wrestler safety during live broadcasts. Importantly, this reconsideration of wrestling can offer broader insights into the intersection of entertainment, commercial broadcasting, and injury in televised sports at large. As the lines between spectacle and competition blur across various broadcast sports, the wrestling case study underscores the urgent need for a nuanced approach that incorporates the imperatives of entertainment in understanding and mitigating risks such as concussion.

Artistic heritage conservation: the relevance and cultural value of Guangzhou clan building paintings to traditional rituals from a kinship perspective through perceptual assessment and data mining

The study of clan paintings reveals a shift in perspective from art aesthetics to cultural connotations to cultural identity, yet literature seldom discusses the relationship between art and kinship culture. Taking the murals of ancestral hall architecture in Guangzhou as an example, this paper utilizes text mining to identify factors influencing its decorative art. It reveals the traditional rites' artistic expression through dimensions of characters' demeanor and the transmission of content values, offering a fresh perspective for heritage value research. Findings: (1) themes and implications are mostly oriented towards positive value transmission, transitioning from idealistic layman life to the realism of lower-class existence, emphasizing humanization; (2) the extroverted portrayal of characters contrasts with the dignified, restrained etiquette of traditional rites, with some characters' portrayal and facial expressions exuding approachability; (3) murals conveying positive emotions are mostly related to longevity, auspiciousness, fortune, and heroic deeds, while those conveying negative emotions mainly involve elderly male figures, reflecting a content bias related to characters; (4) historical allusion murals with complex content reduce the emotional resonance and arousal efficiency of the viewer; (5) incomplete mural content increases negative emotions in perceivers, highlighting the impact of mural preservation on emotional resonance. To delve into the formation of clan painting art, it is essential not only to interpret the diversity of its patterns but also to demonstrate the representation of its social attributes in decorative art. The formation of clan painting decorative art exhibits kinship cultural attributes, epitomizing the essence of traditional ceremonial thought.

A Copernican revolution of multigenic analysis: A retrospective study on clinical exome sequencing in unclear genetic disorders

Despite the inevitable shift in medical practice towards a deeper understanding of disease etiology and progression through multigenic analysis, the profound historical impact of Mendelian diseases cannot be overlooked. These diseases, such as cystic fibrosis and thalassemia, are characterized by a single variant in a single gene leading to clinical conditions, and have significantly shaped our medical knowledge and treatments. In this respect, the monogenic approach inevitably results in the underutilization of Next-Generation Sequencing (NGS) data.Herein, a retrospective study was performed to assess the diagnostic value of the clinical exome in 32 probands with specific phenotypic characteristics (patients with autoinflammation and immunological dysregulation, N = 20; patients diagnosed with Hemolytic uremic syndrome N = 9; and patients with Waldenström macroglobulinemia, N = 3). A gene enrichment analysis was performed using the *. VCF file generated by SOPHiA-DDM-v4. This analysis selected a subset of genes containing pathogenic or likely pathogenic variants with autosomal dominant (AD) inheritance. In addition, all variants of uncertain significance (VUS) were included, filtered by AD inheritance mode, the presence of compound heterozygotes, and a minor allele frequency (MAF) cutoff of 0.05 %.The aim of the pipeline described here is based on a perspective shift that focuses on analyzing patients’ gene assets, offering new light on the complex interplay between genetics and disease presentation. Integrating this approach into clinical practices could significantly enhance the management of patients with rare genetic disorders.

The epistemic grammar of bioinspired technologies: Shifting the focus from nature to scientific practices

This article philosophically addresses the promise of biomimetic design, according to which mimicking natural forms can provide better, more sustainable and less risky engineering solutions. Focusing on the grammar of scientific practices, the article establishes an epistemological basis for biomimetic technology that explores the creative interaction between technology and nature. The epistemological framework shows that bioinspired objects are autonomous with specific properties. They must be evaluated in their ability to fulfill the biomimetic promise in local applications and contexts. The article presents three results. First, it presents a philosophical framework that deepens the understanding of the relationship between sustainability and bioinspired technologies and allows for a retrospective assessment of their sustainability. Second, it points out that the scientific framework emerging from bioinspired technologies is based on collaboration, interdisciplinarity, and a holistic approach to scientific inquiry. Third, it encourages a shift in perspective from the ontology of bioinspired design to the epistemic grammar of its production.

SillyPutty: Improved clustering by optimizing the silhouette width.

Clustering is an important task in biomedical science, and it is widely believed that different data sets are best clustered using different algorithms. When choosing between clustering algorithms on the same data set, reseachers typically rely on global measures of quality, such as the mean silhouette width, and overlook the fine details of clustering. However, the silhouette width actually computes scores that describe how well each individual element is clustered. Inspired by this observation, we developed a novel clustering method, called SillyPutty. Unlike existing methods, SillyPutty uses the silhouette width for individual elements as a tool to optimize the mean silhouette width. This shift in perspective allows for a more granular evaluation of clustering quality, potentially addressing limitations in current methodologies. To test the SillyPutty algorithm, we first simulated a series of data sets using the Umpire R package and then used real-workd data from The Cancer Genome Atlas. Using these data sets, we compared SillyPutty to several existing algorithms using multiple metrics (Silhouette Width, Adjusted Rand Index, Entropy, Normalized Within-group Sum of Square errors, and Perfect Classification Count). Our findings revealed that SillyPutty is a valid standalone clustering method, comparable in accuracy to the best existing methods. We also found that the combination of hierarchical clustering followed by SillyPutty has the best overall performance in terms of both accuracy and speed. Availability: The SillyPutty R package can be downloaded from the Comprehensive R Archive Network (CRAN).

Do Cases Generate Bad AI Law?

There’s an AI governance problem, but it’s not (just) the one you think. The problem is that our judicial system is already regulating the deployment of AI systems—yet we are not coding what is happening in the courts as privately driven AI regulation. That’s a mistake. AI lawsuits here and now are determining who gets to seek redress for AI injuries; when and where emerging claims are resolved; what is understood as a cognizable AI harm (and what is not), and why that is so. This Essay exposes how our judicial system is regulating AI today and critically assesses the governance stakes. When we do not adequately recognize how the generative AI cases being decided by today’s judges are already operating as a type of AI regulation, we fail to consider which emerging tendencies of adjudication about AI are likely to make good or bad AI law. For instance, litigation may do good agenda-setting and deliberative work as well as surface important information about the operation of private AI systems. But adjudication of AI issues can be bad too, given the risk of overgeneralization from particularized facts; the potential for too much homogeneity in the location of lawsuits and the kinds of litigants; and the existence of fundamental tensions between social concerns and current legal precedents. If we overlook these dynamics, we risk missing a vital lesson: AI governance requires better accounting for the interactive relationship between regulation of AI through the judicial system and more traditional public regulation of AI. Shifting our perspective creates space to consider new AI governance possibilities. For instance, litigation incentives (such as motivations for bringing a lawsuit or motivations to settle) or the types of remedies available may open up or close down further regulatory development. This shift in perspective also allows us to see how considerations that on their face have nothing to do with AI—such as access to justice measures and the role of judicial minimalism—in fact shape the path of AI regulation through the courts. Today’s AI lawsuits provide an early opportunity to expand AI governance toolkits and to understand AI adjudication and public regulation as complementary regulatory approaches. We should not throw away our shot.

Anticipatory Development Foresight: An approach for international and multilateral organizations

AbstractMotivationIn the three years before 2023, we have seen multiple parallel crises—from climate emergencies to economic instability, dramatic increases in costs of living, and political insecurities. Looming larger than the risks is the resultant uncertainty. Development agents, including governments, are historically unprepared for managing converging crisis. When risks are analysed and governed in narrow ways, the historically oppressed and excluded continue to carry the brunt of impact.PurposeThis article reflects on the question: How can institutions, including governments, become more anticipatory against this backdrop, to ensure that their policy and investment choices do not leave anyone behind due to lack of preparedness?Approach and methodsIt draws insights from the United Nations Development Programme (UNDP) in Asia and the Pacific's efforts since 2020 to apply more future‐fit planning and programming, recognizing that foresight is not an end in itself, but a mechanism for shaping more anticipatory institutions. It is based on qualitative learning synthesized from over three years of work to establish new systems, capabilities and processes for UNDP and its partners to engage in anticipatory risk and planning.FindingsPractices rooted in strategic foresight and anticipation can support institutions to incorporate long‐term thinking in planning and analysis, but their translation into development decisions and investments requires shifts in perspectives and risk appetite. Historically, strategic foresight has not been mainstreamed within international organizations and governments owing to: failing to embed anticipation into core systems and processes; giving more attention to tools and building skills than to the demand for alternative decision‐making models and to risk tolerance; relying overly on external support and static models; insufficiently attending to organizational culture and relational drivers of thinking and action.Policy implicationsWe suggest four interconnected levers to help sustain impact and equity when bringing anticipatory approaches into policy processes: ensure design elasticity to encourage local, context‐specific models of anticipatory decision‐making; build anticipatory systems as a base to understand future risks, harms, and correlating impacts; interrogate what counts as legitimate and relevant evidence for policy decisions; cultivate imagination as an act of inquiry.

Oral translanguaging in telecollaboration: Effects on EFL learner intercultural awareness, learning and communicative competence

This study reported the intercultural communicative competence (ICC) development of twenty-one Taiwanese English as a Foreign Language (EFL) college students who participated in a five-week Taiwan-New Zealand telecollaboration program, Kindling, in a multimodal online environment. To this end we investigated 1) the association between their oral translanguaging practices and development of ICC, and 2) aspects of intercultural learning that impacted their translanguaging experience. Data included recordings of group-based online communication and reflection notes on their online Quality Talk (QT) discussions, to which we applied content analysis based on ICC framework. The findings indicated that oral translanguaging facilitated students' development of positive attitudes toward intercultural awareness and learning. Analysis of the cultural comparisons and perspective shifts recorded in their QT reflection notes revealed ways in which students experienced dynamic aspects of intercultural learning through oral translanguaging. These results encourage researchers and practitioners to provide opportunities for language learners’ ICC development and intercultural learning through oral translanguaging opportunities in digitally mediated socialization through telecollaboration.

Rethinking continuity in primary care for people with mesothelioma.

Mesothelioma is a terminal disease that is linked to asbestos exposure. Continuity is difficult for GPs, and other healthcare professionals (HCPs), to provide within the current NHS primary care system, but is highly valued by people with mesothelioma. To understand the experiences of continuity in primary care among people with mesothelioma, their close persons, and their HCPs; how they achieve this (or not); and how it affects their healthcare service use. Realist case studies of patient journeys through the healthcare system (involving longitudinal interviews with people with mesothelioma, their close persons, and HCPs; and exploration of the organisational context). Data analysis allowed understanding of hidden mechanisms (resources and reasoning), triggered in certain contexts, leading to specific outcomes. Forty-eight interviews (involving 9 patients, 8 close persons, and 12 HCPs) were undertaken (totalling 30.8 hours/1848 minutes). Context-Mechanism-Outcome configurations related to: challenges unique to mesothelioma; capacity of patients/close persons/HCPs to facilitate continuity; multidisciplinary (MDT) approach differs from the family doctor model; and 'the NHS primary care system is broken'. Patients perceive their continuity needs to be unmet by the inflexible primary care system, which needs to adapt to a society in which people receive increasingly novel treatments and live longer with complex healthcare needs. A societal perspective shift is required to understand that an MDT now shares responsibility for care, rather than an individual family doctor. Policy documents continue to focus on access, and still do not advocate strongly enough for continuity, despite unequivocal evidence demonstrating its worth.

Unveiling human vulnerability and a new interspecies scaling law for brain injury under blast loading

The common belief that animals with larger heads are more tolerated to brain injury faces challenges under the extreme conditions of blast loading. Recent studies indicate that humans, who have notably larger heads than other species of similar body weight, exhibit a unique vulnerability. Integrating animal experimental data, advanced head modeling, and pressure propagation theories, this research elucidates the injury mechanisms across species as the blast wave transitions from the extremely hard skull to the extremely soft brain. We propose a new interspecies scaling law based on consistent peaks of intracranial pressure, rather than head size, to redefine the translation from animal exposure thresholds to human risk assessment. This shift in perspective underscores the imperative to comprehensively consider both head geometry and size in predicting tolerance to blast brain injury, moving beyond simplistic size-based comparisons. Our study's insights contribute significantly to redefining injury risk models and fostering innovative prevention strategies against blast-induced traumatic brain injury (bTBI).

AKASA Framework as a Pedagogical Too: A Literature Review and Implications for Transformative Learning

This paper explores the potential of the AKASA (Awareness, Knowledge, Attitude, Skills, Action) framework as a pedagogical tool for fostering transformative learning in the context of environmental education. A comprehensive literature review synthesizes existing research on the effectiveness of AKASA in enhancing environmental knowledge and awareness among learners. While findings indicate positive impacts on knowledge and awareness, further investigation is needed to understand the framework's influence on attitudes, skills, and actions. This paper argues that transformative learning, characterized by critical reflection and a shift in perspective, can be fostered through AKASA by incorporating experiential learning, systems thinking, and opportunities for action. Integrating AKASA with transformative learning principles presents a promising approach to cultivating environmentally literate and engaged citizens.

A Compendium of Radiation Safety Practices That Can Complement Organizational Worker Well-being Initiatives.

Organizations are learning that efforts to protect the health and safety of their workers from risks both at work and outside of work yield great dividends in the form of increased productivity, morale, and reduced healthcare costs. This realization has given rise to a variety of worker well-being initiatives that span far beyond the typical boundaries of traditional workplace health and safety programs. Examples include providing information and services on diet, exercise, personal habits, and mental health issues. Interestingly, the radiation safety profession has been historically involved with a series of progressive worker well-being practices that perhaps are not fully appreciated by the broader well-being community. These include the ability to comprehensively track occupational doses, training regarding doses arising from outside the workplace (such as medical procedures and environmental exposures), and fetal protection policies, to name a few. Described here is the shift in perspective from health and safety merely for the workplace to a more holistic approach, but the degree to which the actions may be implemented varies. Included then is a compendium of radiation safety practices that may be possibly folded into the discussion of larger organizational well-being efforts.

Amyloid-β in Alzheimer's disease: Structure, toxicity, distribution, treatment, and prospects.

Amyloid-β (Aβ) is a pivotal biomarker in Alzheimer's disease (AD), attracting considerable attention from numerous researchers. There is uncertainty regarding whether clearing Aβ is beneficial or harmful to cognitive function. This question has been a central topic of research, especially given the lack of success in developing Aβ-targeted drugs for AD. However, with the Food and Drug Administration's approval of Lecanemab as the first anti-Aβ medication in July 2023, there is a significant shift in perspective on the potential of Aβ as a therapeutic target for AD. In light of this advancement, this review aims to illustrate and consolidate the molecular structural attributes and pathological ramifications of Aβ. Furthermore, it elucidates the determinants influencing its expression levels while delineating the gamut of extant Aβ-targeted pharmacotherapies that have been subjected to clinical or preclinical evaluation. Subsequently, a comprehensive analysis is presented, dissecting the research landscape of Aβ across the domains above, culminating in the presentation of informed perspectives. Concluding reflections contemplate the supplementary advantages conferred by nanoparticle constructs, conceptualized within the framework of multivalent theory, within the milieu of AD diagnosis and therapeutic intervention, supplementing conventional modalities.

Drivers for Clustering and Inter-Project Collaboration—A Case of Horizon Europe Projects

This paper investigates the drivers and dynamics of clustering and inter-project collaboration within the framework of the Horizon Europe and Horizon 2020 projects. Leveraging a survey-based approach, we examine key themes surrounding the perception of clustering, the willingness to share information under legal confidentiality, and motivations for engaging with partners from different projects. The survey instrument, implemented via Microsoft Forms, was distributed among the consortia of eight EU projects participating in the SOLID4B cluster. Notably, the questionnaire was meticulously crafted based on an in-depth analysis of the SOLID4B case and comprehensive discussions with project coordinators and communication and dissemination managers from all participating projects. These discussions aimed to establish a clear roadmap for the cluster, ensuring the questionnaire’s relevance and usefulness for all participants. Data analysis was conducted within the same platform, facilitating efficient data processing and visualization. Our findings reveal that a significant majority of respondents (48 out of 55) perceive clustering as a valuable asset, indicative of a positive shift in perspectives. Challenges related to confidentiality were addressed through nuanced insights, with respondents demonstrating a willingness to share routine best practices, significant breakthroughs, and deliverables within a legally protected framework. Furthermore, a robust majority (40 out of 55) expressed a keen interest in collaborative endeavors, underscoring a collective drive to extend activities beyond individual project boundaries. The study highlights the importance of clustering with other projects in maximizing the impact of the Horizon program, extending stakeholder networks, and sharing knowledge and achievements in research and innovation. These insights contribute to a deeper understanding of the motivations and challenges surrounding clustering and collaboration within the Horizon Europe and Horizon 2020 projects. Ultimately, the findings pave the way for informed strategies aimed at fostering a dynamic and interconnected research community.

What makes audiences resilient to disinformation? Integrating micro, meso, and macro factors based on a systematic literature review

Abstract Despite increased attention since 2015, there is little consensus on why audiences believe or share disinformation. In our study, we propose a shift in analytical perspective by applying the concept of resilience. Through a systematic literature review (n = 95), we identify factors that have been linked to individuals’ resilience and vulnerability to disinformation thus far. Our analysis reveals twelve factors: thinking styles, political ideology, worldview and beliefs, pathologies, knowledge, emotions, (social) media use, demographics, perceived control, trust, culture, and environment. By applying the results to the socio-ecological model (SEM), we provide a comprehensive view on what constitutes resilience to disinformation, delineate between different levels of influence, and identify relevant gaps in research. Our conceptualization contributes to an under-theorized field, in which the term resilience is much used yet rarely sufficiently defined.

Enabling Alarm-Based Fault Prediction for Smart Meters in District Heating Systems: A Danish Case Study

District heating companies utilize smart meters that generate alarms that indicate faults in their sensors and installations. If these alarms are not tended to, the data cannot be trusted, and the applications that utilize them will not perform properly. Currently, smart meter data are mostly used for billing, and the district heating company is obligated to ensure the data quality. Here, retrospective correction of data is possible using the alarms; however, identification of sensor problems earlier can help improve the data quality. This paper is undertaken in collaboration with a district heating company in which not all of these alarms are tended to. This is due to various barriers and misconceptions. A shift in perspective must happen, both to utilize the current alarms more efficiently and to permit the incorporation of predictive capabilities of alarms to enable smart solutions in the future and improve data quality now. This paper proposes a prediction framework for one of the alarms in the customer installation. The framework can predict sensor faults to a high degree with a precision of 88% and a true positive rate of 79% over a prediction horizon of 24 h. The framework uses a modified definition of an alarm and was tested using a selection of machine learning methods with the optimization of hyperparameters and an investigation into prediction horizons. To the best of our knowledge, this is the first instance of such a methodology.

Institutional effects on family business internationalization: a systematic review

Abstract Family firms play a vital role in the global business landscape, significantly impacting their home countries GDP. These firms diverge from non-family counterparts in their internationalization strategies, yet they stand to gain substantial benefits from international expansion. Beyond economic considerations, family resources and values introduce non-economic factors that challenge traditional economic theories. This study leverages an institutional approach to illuminate the multifaceted influences shaping family firms’ internationalization, encompassing positive and adverse dynamics. The integration of institutional theory marks a recent shift in understanding family firm internationalization, encompassing institutional and economic geography perspectives. To foster discourse and guide future research, this paper systematically reviews peer-reviewed articles covering over a decade, from 2010 to 2023. It identifies formal and informal institutional elements, alongside economic geography factors, that either facilitate or impede family firms’ internationalization. This review underscores existing knowledge gaps at the nexus of institutional theory, economic geography, internationalization, and family business studies. Notably, the systematic literature review uncovered a limited corpus of only 41 articles, indicating the need for more research exploring the synergy between economic geography and institutional factors in the context of diverse internationalization strategies. Furthermore, the review highlights the underexplored terrain within social institutions and economic geography, revealing a notable gap in the extant research.