This study was designed to evaluate radiological features of COVID-19 and early lung cancer through High-resolution computed tomography (HRCT) and demonstrated the disparity between them. A retrospective was conducted in the COVID-19 ward, Oncology & Radiology ward of CH& UCHS Lahore & Shifa International Hospital Islamabad & NMU & H Multan from October 14, 2019, to October 14, 2020. A total of 100 COVID-19 patients and 300 patients with pulmonary ground-glass opacities undergoing lung surgery (control group) were included in the study. After propensity score-matched analysis, patients were divided into two groups with 80 matched pairs each. Both groups' clinical, pathological, epidemiological, and radiological characteristics (evaluated through HRCT) were compared. It was observed that COVID-19 patients presented more definite symptoms, were mostly younger men, and had higher BMI (body-mass index). After the radiological analysis of the matched patients, it was revealed that single-lesion patients constituted 17% of COVID-19 cases and 89% of lung cancer cases. Patients in both groups mainly presented peripheral lesions. COVID-19 lesions had more lobes and segments and had various types with patchy forms. On the other hand, lung cancer tended to have only one type and had an oval form. Both COVID-19 and lung cancer showed ground-glass opacities with similar but independent characteristics. These characteristics, combined with pathogen detection, short-term CT examination, and laboratory tests, will aid in improved diagnosis.