Domoic acid is heterocyclic amino acid neurotoxin and the principal toxin associated with amnesic shellfish poisoning (ASP) produced by certain species of marine diatom. It can bio accumulated at high concentrations in the shellfish tissues when the toxic phytoplankton is high in concentration in the surrounding waters. Ingestion of domoic acid contaminated shellfish leads to ASP, which is characterized by both gastrointestinal and neurological symptoms, including severe headache, seizures, tremors, and either temporary or permanent memory loss.Herein, the detection of domoic acid is carried out through an enzymatic immunoassay that uses magnetic beads as support of the immunoreaction and screen-printed electrodes as suitable detector of the enzymatic product. Thereby, the immunological reaction is performed in solution, where the domoic acid, antigen, domoic acid labeled with horseradish peroxidase are incubated with the rabbit IgG antibody against domoic acid. Subsequently, the antibody-antigen complex is captured by the anti-rabbit IgG modified magnetic beads. Then, the magnetic beads are deposited onto the electrode surface with the help of the magnet placed under the screen printed electrode. Finally, the analytical signal is obtained by amperometric detection of the product enzymatically generated from the mixture of H2O2and 3,3,5,5-tetramethylbenzidine (TMB).The use of magnetic beads provides the capability to preconcentrate the sample and avoid the poisoning of the electrode surface through non specific absorptions.The experimental conditions of the magneto-immunological assay has been optimized and a calibration curve has been obtained between 0-2 ng/mL domoic acid, being able to detect down to 100 pg/mL domoic acid. Acknowledgements This work has been carried out in the framework of FLAshMoB project. This project is funded by the MarTERA partners; Italian Ministry of Education, Universities and Research (MIUR), French National Research Agency (ANR) and Spanish Centre for the Development of Industrial Technology (CDTI) and co-funded by the European Union.