The Red Shell is defined as the volume of normal surrounding radiated tissue that will be permanently damaged. We examined the relationship of radiobiological equivalent dose (BED) and fractionation on a small radiosurgical target, computed using a variety of α/β ratios. For each calculation, a 2-cm spherical target received a spherical radiation dose cloud (with no margin) and a 10% fall-off per 2 mm from the sphere's center. The Red Shell was defined as the volume of normal tissue that received at least a BED equivalent to 2 Gy x 30. First, we used a BED equivalent to the BED for 12.5 Gy x 4 for various tumor α/β ratios (20, 10, 5.15, 3 and 1.5 Gy) and fractionation schemes (1 to 10 fractions). Second, using an α/β ratio of 10 Gy, various 3-fraction schedules (with fractional doses of 30, 28.7, 20, 15 and 10 Gy) were plotted along with their corresponding BEDs from 1 - 10 fractions. Red Shell volumes were individually calculated to analyze the fractionation effect for different α/β ratios and prescription doses. In the first set of calculations with a BED equivalent to that of 12.5 Gy x 4, an increase in fractionation was most beneficial in reducing the Red Shell volume when the α/β ratio was high. The greatest benefit was seen within the first few fractions. When the α/β ratio was low, an increase in fractionation was detrimental. With α/β ratio of 5.15 Gy, all fractionation schemes had the same Red Shell volume. In the second set of calculations, the greatest Red Shell volume reduction with increased fractionation was seen with the lowest BED equivalent to 10 Gy x 3; the least volume reduction was seen with the highest BED. There was a detrimental effect to fractionation with the highest BED at 30 Gy x 3. For α/β ratios resulting in a BED equivalent to 28.7 Gy x 3, all fractionation schemes had the same Red Shell volume. Multiple interrelated factors, particularly α/β ratio and BED, affect Red Shell volume in our calculations. Increased fractionation was not always beneficial, and was detrimental when the α/β ratio was low or if the BED was very high . Differences in normal tissue radiation sensitivity were not included in our calculations, and will be a focus of our future efforts.