This study proposed a novel lightweight bolt-connected concrete sandwich wall panel structure with the advantages of thermal insulation, construction efficiency, demountability and remountability. The seismic design of the structure was employed a non-equivalent cast-in-place method, resulting in appropriate configurations of horizontal and vertical bolted joints. Subsequently, a shaking table test was carried out to investigate the damage pattern, dynamic characteristics and dynamic responses of a full-scale structure. The test results demonstrated that the overall damage was moderate, which exerted a few impacts on the structural capacity or integrity. The global responses, including small displacement response, minor torsion response, and high energy dissipation capacity were found, as well as local responses, such as small strains in the steel plates and a slight loss of bolt prestress. The maximum inter-story drift ratio was below the elastoplastic inter-story drift ratio limit θu = 1/120 defined in Chinese code GB 50011. In general, the structure presented high lateral stiffness and sufficient capacity against high-intensity ground motions. A numerical model was developed, wherein precast components were established by multi-layer shell elements and bolted joints were simulated by 3-DoF nonlinear springs. Linear modal and nonlinear time history analyses were performed and compared with the experimental results. The simulation results showed good agreement with the experimental ones, confirming the ability of the model to capture global responses.