Nanoparticles found in rock avalanches and natural faults were inferred to be the reason for the ultra-low shear resistance of the materials along the shear surface. Nevertheless, this inference has not been physically verified yet. To investigate the role of nanoparticles in the shear behavior of granular materials, we conducted a series of ring shear tests on silicon dioxide nanoparticles (SN), silica sand (S8), and mixtures of the S8 with different contents of SN, under varying normal stresses (σ) and shear velocities (V). Our results showed that the shear strength (μ) of SN is high when σ is small (≤ 215 kPa at our test range), even though the maximum shear velocity is about 210 cm/s, but shows a great decrease under higher σ (≥ 619 kPa). The shear strength of mixtures varied with SN content. For S8 (M0) and the mixture of 10% SN (M10), when sheared under small σ, μ first decreased slightly with increasing V when V is smaller than 1 cm/s, after that it increased slightly with further increase of V. Nevertheless, this kind of shear-rate dependent behavior was not observed in the tests under higher σ. When the content of SN in the mixture was <20%, μ increased with the increase of SN content. However, with further increase of SN content, μ decreased. Under high normal stress conditions, distinctive powder rolls were observed on the shear surface formed on the tests. When the mixtures with lower SN content (≤50%), the powder rolls were not observed. We inferred that powder rolls can be produced under high SN content and high normal stress conditions, and this structure altered the particle movement mode from sliding friction to rolling resistance, resulting in a significant decrease in the shear strength. These findings provide valuable insights into the shear behavior of granular materials with nanoparticles and then provide evidence for a better understanding of the high mobility of rock avalanches.